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Q5U4C1

- GASP1_MOUSE

UniProt

Q5U4C1 - GASP1_MOUSE

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Protein

G-protein coupled receptor-associated sorting protein 1

Gene
Gprasp1, Kiaa0443
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN1P1/BECN2.1 Publication

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. endosome to lysosome transport Source: UniProtKB
  2. G-protein coupled receptor catabolic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor-associated sorting protein 1
Short name:
GASP-1
Gene namesi
Name:Gprasp1
Synonyms:Kiaa0443
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1917418. Gprasp1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13471347G-protein coupled receptor-associated sorting protein 1PRO_0000239051Add
BLAST

Proteomic databases

MaxQBiQ5U4C1.
PaxDbiQ5U4C1.
PRIDEiQ5U4C1.

PTM databases

PhosphoSiteiQ5U4C1.

Expressioni

Tissue specificityi

Expressed in the brain, with higher expression in the hippocampus, hypothalamus and olfactory bulb.1 Publication

Gene expression databases

BgeeiQ5U4C1.
GenevestigatoriQ5U4C1.

Interactioni

Subunit structurei

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4 as well as D2 dopamine receptor/DRD2. Interacts with PER1 By similarity. Interacts with BECN1P1/BECN2; the interaction is direct.1 Publication

Protein-protein interaction databases

IntActiQ5U4C1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5U4C1.
SMRiQ5U4C1. Positions 1108-1160.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1109 – 11124Poly-Leu

Sequence similaritiesi

Belongs to the GPRASP family.

Phylogenomic databases

eggNOGiNOG136667.
GeneTreeiENSGT00550000074488.
HOVERGENiHBG057167.
InParanoidiA2AGB6.
OMAiQADDESI.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ5U4C1.
TreeFamiTF335652.

Family and domain databases

InterProiIPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5U4C1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTRAEVEPGA QAKAENKPGD ENANAAEVEP EAPLVVRPKV RTQIMTGARP     50
KVKPKGTPGA RPKGETSTPG GAYAKCKPKA IPIARSKHDA QVWAPNKFRG 100
ESMSKMGKQC QISAADPPLL SNDSGMVAQA KCLPVDRELA NMDTESIPKK 150
ANSPAGFQPS YGSEEGTNMG SWYRARPVPK GEAYENSDFK WADKPSGSPS 200
FWNRDEASTR FRPRKSMKAN NRFRHMAKQE ANTMPRHKNK QEFYNISSSD 250
SEDESGKTPW FWPKDKTKVW SKPKEEPNSR SWFRSKKEVR VESTSGSECE 300
NPTKSLFWSG EEAKSRSKPR ARKGVNMRAR QQAKREACSD AMSGAIDTNK 350
KESWFLPEEK ANVFSKSKTK KEPRTRAVPK EEVKTKARAS TKQEARPEEE 400
VLVGAWFWDT QESTMADRIS IKTTFVEEEP IVGDWFWSEE EASVDSETCH 450
TSRPRAKEEQ VSSFCLGSGK KSSMESGPKA TSKSMPVAKE DEVVIGSWFW 500
ADDEEINLQA DDESIFGSWF WGTGENSLRS VGVNCEKMPK AGEKEVTDSW 550
FWAGDVNTEA EVEEQARSAS TKATIFVPWF WSEKQPNMDL GSEPCSDIMA 600
GAEEEPIIGP WFWAKVDNSV EAEVNSKSSL EDEEEPIRSP WFGAREQTDM 650
KYAAGIRYKP MAEAEDANKK SCVWAKEPCL YPTNRECLKS TLGEKEDTVD 700
PWLWSNNYPR TKTITGSWLW AAEEGNIDDE TGEKIKLPTL EDNAFNSWFW 750
KENEESIVEA PKREEFRPEA EEEDIIGSWF WAGDEDRFEP AAKINEENKI 800
ASEDEDTVGS WFWGNEEASL EAVRRGTFES APGIKEEKVT GSWFWTDKAK 850
VGAGSQTVET GSETEEEAIF ESLIWAAKKD SIQAGVKRVS KPKDDGNIAV 900
GSWLWSSDKA TKEAKTLIVS EASPENGKES VVKFGSRAKD EVINKTGSGD 950
NCKHSTEAET IVGAWFWEGD EASFESNPVP VCKAVCEPES SAEHEPDPSR 1000
RPQSWDEVTV QFKAGPWGKA GFPPMNPFRF PKEAASLFAE MFGGKPKLVE 1050
VGPEREPEPQ FPFQYDPSYR SVREIREHLK ARESAQPENW SCNCIQCELR 1100
IGSEEFEELL LLMDRNRDPF IHEISKIAMG MRGASQFTRD FIRNSGVVSL 1150
IEALLNYPSS RVRTRFLENM VRMAPPYPDL NMIETYVCQI CEDTFDYDLD 1200
SPDQLSGLTM ITHLTATSDY HKVVVNYLAG FFYLLNSGNT KTRFHVLKLL 1250
LNLSENLVMT KRLLVTDSVS EFMDLINREE SDENIQIVLA IFETISKHIQ 1300
KEALFSDDDD DDEEEDAVNL EPFISAFREA EKIAKELKRK PGNQKAP 1347
Length:1,347
Mass (Da):151,745
Last modified:December 7, 2004 - v1
Checksum:i1FD29E59CBF91B59
GO
Isoform 2 (identifier: Q5U4C1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-473: Missing.

Show »
Length:874
Mass (Da):98,825
Checksum:i403D64EEC544823D
GO

Sequence cautioni

The sequence BAC41425.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 473473Missing in isoform 2. VSP_019080Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti942 – 9421V → L in BAC41425. 1 Publication
Sequence conflicti943 – 9431I → F in BAC30259. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093241 mRNA. Translation: BAC41425.1. Different initiation.
AL683822 Genomic DNA. Translation: CAM27375.1.
BC027187 mRNA. Translation: AAH27187.1.
BC085157 mRNA. Translation: AAH85157.1.
AK039156 mRNA. Translation: BAC30259.1.
AK050919 mRNA. Translation: BAC34459.2.
AK083192 mRNA. Translation: BAC38803.1.
CCDSiCCDS30409.1. [Q5U4C1-1]
RefSeqiNP_001004359.1. NM_001004359.2. [Q5U4C1-1]
NP_001005385.1. NM_001005385.1. [Q5U4C1-1]
NP_080357.4. NM_026081.5. [Q5U4C1-1]
UniGeneiMm.271980.

Genome annotation databases

EnsembliENSMUST00000113144; ENSMUSP00000108769; ENSMUSG00000043384. [Q5U4C1-1]
ENSMUST00000113145; ENSMUSP00000108770; ENSMUSG00000043384. [Q5U4C1-1]
ENSMUST00000113147; ENSMUSP00000108772; ENSMUSG00000043384. [Q5U4C1-1]
ENSMUST00000166554; ENSMUSP00000132225; ENSMUSG00000043384. [Q5U4C1-1]
GeneIDi67298.
KEGGimmu:67298.
UCSCiuc009uhn.1. mouse. [Q5U4C1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093241 mRNA. Translation: BAC41425.1 . Different initiation.
AL683822 Genomic DNA. Translation: CAM27375.1 .
BC027187 mRNA. Translation: AAH27187.1 .
BC085157 mRNA. Translation: AAH85157.1 .
AK039156 mRNA. Translation: BAC30259.1 .
AK050919 mRNA. Translation: BAC34459.2 .
AK083192 mRNA. Translation: BAC38803.1 .
CCDSi CCDS30409.1. [Q5U4C1-1 ]
RefSeqi NP_001004359.1. NM_001004359.2. [Q5U4C1-1 ]
NP_001005385.1. NM_001005385.1. [Q5U4C1-1 ]
NP_080357.4. NM_026081.5. [Q5U4C1-1 ]
UniGenei Mm.271980.

3D structure databases

ProteinModelPortali Q5U4C1.
SMRi Q5U4C1. Positions 1108-1160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5U4C1. 1 interaction.

PTM databases

PhosphoSitei Q5U4C1.

Proteomic databases

MaxQBi Q5U4C1.
PaxDbi Q5U4C1.
PRIDEi Q5U4C1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113144 ; ENSMUSP00000108769 ; ENSMUSG00000043384 . [Q5U4C1-1 ]
ENSMUST00000113145 ; ENSMUSP00000108770 ; ENSMUSG00000043384 . [Q5U4C1-1 ]
ENSMUST00000113147 ; ENSMUSP00000108772 ; ENSMUSG00000043384 . [Q5U4C1-1 ]
ENSMUST00000166554 ; ENSMUSP00000132225 ; ENSMUSG00000043384 . [Q5U4C1-1 ]
GeneIDi 67298.
KEGGi mmu:67298.
UCSCi uc009uhn.1. mouse. [Q5U4C1-1 ]

Organism-specific databases

CTDi 9737.
MGIi MGI:1917418. Gprasp1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG136667.
GeneTreei ENSGT00550000074488.
HOVERGENi HBG057167.
InParanoidi A2AGB6.
OMAi QADDESI.
OrthoDBi EOG70PBZ0.
PhylomeDBi Q5U4C1.
TreeFami TF335652.

Miscellaneous databases

ChiTaRSi GPRASP1. mouse.
NextBioi 324156.
PROi Q5U4C1.
SOURCEi Search...

Gene expression databases

Bgeei Q5U4C1.
Genevestigatori Q5U4C1.

Family and domain databases

InterProi IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view ]
Pfami PF04826. Arm_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Brain and Eye.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-379 AND 943-1347 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo, Hippocampus and Hypothalamus.
  5. "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
    Simonin F., Karcher P., Boeuf J.J.-M., Matifas A., Kieffer B.L.
    J. Neurochem. 89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."
    He C., Wei Y., Sun K., Li B., Dong X., Zou Z., Liu Y., Kinch L.N., Khan S., Sinha S., Xavier R.J., Grishin N.V., Xiao G., Eskelinen E.L., Scherer P.E., Whistler J.L., Levine B.
    Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BECN1P1/BECN2.

Entry informationi

Entry nameiGASP1_MOUSE
AccessioniPrimary (citable) accession number: Q5U4C1
Secondary accession number(s): A2AGB6
, Q8BKR8, Q8BUN4, Q8BYK9, Q8CHF4, Q8R095
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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