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Protein

G-protein coupled receptor-associated sorting protein 1

Gene

Gprasp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor-associated sorting protein 1
Short name:
GASP-1
Gene namesi
Name:Gprasp1
Synonyms:Kiaa0443
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1917418 Gprasp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002390511 – 1347G-protein coupled receptor-associated sorting protein 1Add BLAST1347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei295PhosphoserineCombined sources1
Modified residuei619PhosphoserineCombined sources1
Modified residuei626PhosphoserineCombined sources1
Modified residuei860PhosphothreonineBy similarity1
Modified residuei862PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U4C1
PeptideAtlasiQ5U4C1
PRIDEiQ5U4C1

PTM databases

iPTMnetiQ5U4C1
PhosphoSitePlusiQ5U4C1

Expressioni

Tissue specificityi

Expressed in the brain, with higher expression in the hippocampus, hypothalamus and olfactory bulb.1 Publication

Gene expression databases

BgeeiENSMUSG00000043384
GenevisibleiQ5U4C1 MM

Interactioni

Subunit structurei

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as delta opioid receptor/OPRD1, beta-2 adrenergic receptor/ADRB2 and D4 dopamine receptor/DRD4 as well as D2 dopamine receptor/DRD2. Interacts with PER1 (By similarity). Interacts with BECN2; the interaction is direct.By similarity1 Publication

Protein-protein interaction databases

BioGridi212084, 1 interactor
IntActiQ5U4C1, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ5U4C1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1109 – 1112Poly-Leu4

Sequence similaritiesi

Belongs to the GPRASP family.Curated

Phylogenomic databases

eggNOGiENOG410IIBK Eukaryota
ENOG410XUVQ LUCA
GeneTreeiENSGT00550000074488
HOVERGENiHBG057167
InParanoidiQ5U4C1
OMAiCEPESSA
OrthoDBiEOG091G01QA
PhylomeDBiQ5U4C1
TreeFamiTF335652

Family and domain databases

InterProiView protein in InterPro
IPR006911 ARM-rpt_dom
IPR016024 ARM-type_fold
PfamiView protein in Pfam
PF04826 Arm_2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5U4C1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRAEVEPGA QAKAENKPGD ENANAAEVEP EAPLVVRPKV RTQIMTGARP
60 70 80 90 100
KVKPKGTPGA RPKGETSTPG GAYAKCKPKA IPIARSKHDA QVWAPNKFRG
110 120 130 140 150
ESMSKMGKQC QISAADPPLL SNDSGMVAQA KCLPVDRELA NMDTESIPKK
160 170 180 190 200
ANSPAGFQPS YGSEEGTNMG SWYRARPVPK GEAYENSDFK WADKPSGSPS
210 220 230 240 250
FWNRDEASTR FRPRKSMKAN NRFRHMAKQE ANTMPRHKNK QEFYNISSSD
260 270 280 290 300
SEDESGKTPW FWPKDKTKVW SKPKEEPNSR SWFRSKKEVR VESTSGSECE
310 320 330 340 350
NPTKSLFWSG EEAKSRSKPR ARKGVNMRAR QQAKREACSD AMSGAIDTNK
360 370 380 390 400
KESWFLPEEK ANVFSKSKTK KEPRTRAVPK EEVKTKARAS TKQEARPEEE
410 420 430 440 450
VLVGAWFWDT QESTMADRIS IKTTFVEEEP IVGDWFWSEE EASVDSETCH
460 470 480 490 500
TSRPRAKEEQ VSSFCLGSGK KSSMESGPKA TSKSMPVAKE DEVVIGSWFW
510 520 530 540 550
ADDEEINLQA DDESIFGSWF WGTGENSLRS VGVNCEKMPK AGEKEVTDSW
560 570 580 590 600
FWAGDVNTEA EVEEQARSAS TKATIFVPWF WSEKQPNMDL GSEPCSDIMA
610 620 630 640 650
GAEEEPIIGP WFWAKVDNSV EAEVNSKSSL EDEEEPIRSP WFGAREQTDM
660 670 680 690 700
KYAAGIRYKP MAEAEDANKK SCVWAKEPCL YPTNRECLKS TLGEKEDTVD
710 720 730 740 750
PWLWSNNYPR TKTITGSWLW AAEEGNIDDE TGEKIKLPTL EDNAFNSWFW
760 770 780 790 800
KENEESIVEA PKREEFRPEA EEEDIIGSWF WAGDEDRFEP AAKINEENKI
810 820 830 840 850
ASEDEDTVGS WFWGNEEASL EAVRRGTFES APGIKEEKVT GSWFWTDKAK
860 870 880 890 900
VGAGSQTVET GSETEEEAIF ESLIWAAKKD SIQAGVKRVS KPKDDGNIAV
910 920 930 940 950
GSWLWSSDKA TKEAKTLIVS EASPENGKES VVKFGSRAKD EVINKTGSGD
960 970 980 990 1000
NCKHSTEAET IVGAWFWEGD EASFESNPVP VCKAVCEPES SAEHEPDPSR
1010 1020 1030 1040 1050
RPQSWDEVTV QFKAGPWGKA GFPPMNPFRF PKEAASLFAE MFGGKPKLVE
1060 1070 1080 1090 1100
VGPEREPEPQ FPFQYDPSYR SVREIREHLK ARESAQPENW SCNCIQCELR
1110 1120 1130 1140 1150
IGSEEFEELL LLMDRNRDPF IHEISKIAMG MRGASQFTRD FIRNSGVVSL
1160 1170 1180 1190 1200
IEALLNYPSS RVRTRFLENM VRMAPPYPDL NMIETYVCQI CEDTFDYDLD
1210 1220 1230 1240 1250
SPDQLSGLTM ITHLTATSDY HKVVVNYLAG FFYLLNSGNT KTRFHVLKLL
1260 1270 1280 1290 1300
LNLSENLVMT KRLLVTDSVS EFMDLINREE SDENIQIVLA IFETISKHIQ
1310 1320 1330 1340
KEALFSDDDD DDEEEDAVNL EPFISAFREA EKIAKELKRK PGNQKAP
Length:1,347
Mass (Da):151,745
Last modified:December 7, 2004 - v1
Checksum:i1FD29E59CBF91B59
GO
Isoform 2 (identifier: Q5U4C1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-473: Missing.

Show »
Length:874
Mass (Da):98,825
Checksum:i403D64EEC544823D
GO

Sequence cautioni

The sequence BAC41425 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti942V → L in BAC41425 (PubMed:12465718).Curated1
Sequence conflicti943I → F in BAC30259 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0190801 – 473Missing in isoform 2. 1 PublicationAdd BLAST473

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093241 mRNA Translation: BAC41425.1 Different initiation.
AL683822 Genomic DNA Translation: CAM27375.1
BC027187 mRNA Translation: AAH27187.1
BC085157 mRNA Translation: AAH85157.1
AK039156 mRNA Translation: BAC30259.1
AK050919 mRNA Translation: BAC34459.2
AK083192 mRNA Translation: BAC38803.1
CCDSiCCDS30409.1 [Q5U4C1-1]
RefSeqiNP_001004359.1, NM_001004359.2 [Q5U4C1-1]
NP_001005385.1, NM_001005385.1 [Q5U4C1-1]
NP_080357.4, NM_026081.5 [Q5U4C1-1]
UniGeneiMm.271980

Genome annotation databases

EnsembliENSMUST00000113144; ENSMUSP00000108769; ENSMUSG00000043384 [Q5U4C1-1]
ENSMUST00000113145; ENSMUSP00000108770; ENSMUSG00000043384 [Q5U4C1-1]
ENSMUST00000113147; ENSMUSP00000108772; ENSMUSG00000043384 [Q5U4C1-1]
ENSMUST00000166554; ENSMUSP00000132225; ENSMUSG00000043384 [Q5U4C1-1]
GeneIDi67298
KEGGimmu:67298
UCSCiuc009uhn.1 mouse [Q5U4C1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGASP1_MOUSE
AccessioniPrimary (citable) accession number: Q5U4C1
Secondary accession number(s): A2AGB6
, Q8BKR8, Q8BUN4, Q8BYK9, Q8CHF4, Q8R095
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 7, 2004
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health