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Q5U483 (G251B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Procollagen galactosyltransferase 1-B

EC=2.4.1.50
Alternative name(s):
Collagen beta(1-O)galactosyltransferase 1-B
Glycosyltransferase 25 family member 1-B
Hydroxylysine galactosyltransferase 1-B
Gene names
Name:colgalt1-b
Synonyms:glt25d1-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length611 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen By similarity.

Catalytic activity

UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the glycosyltransferase 25 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionprocollagen galactosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 611587Procollagen galactosyltransferase 1-B
PRO_0000309540

Regions

Motif608 – 6114Prevents secretion from ER By similarity

Amino acid modifications

Glycosylation851N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation3701N-linked (GlcNAc...) Potential
Glycosylation3731N-linked (GlcNAc...) Potential
Glycosylation5681N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5U483 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 63AED42791D52B08

FASTA61171,607
        10         20         30         40         50         60 
MSQAGVERLL KGLQILVLVL RLSAGYFPEE RWNPESPFRS PTVLIAVLAR NSEGSLPEVL 

        70         80         90        100        110        120 
GALDRLHYPK ERISLWVATD HNFDNTSQIL REWLINVQNQ YHHVEWRPQE HPRWFRDEES 

       130        140        150        160        170        180 
PKHWSHSRYE YVMKLRQAAL TSAREMWADY IFFLDADNLL TNSETLNLLI AENKTVVAPM 

       190        200        210        220        230        240 
LESRAAYSNF WCGMTTQGYY RRTPAYMPIR RRERQGCFPV PMVHSTFLID LRKEASQQLD 

       250        260        270        280        290        300 
FYPPHADYTW AFDDIIVFAF SCRQAEVQMF LCNKEIYGYL PVPLRSHSTL LDETDNFLHT 

       310        320        330        340        350        360 
KLEAMVKGPQ VHPSSFVTIP KKVPDKMSFD EVFLINLKHR QDRRERMKRT LYELQIDFKL 

       370        380        390        400        410        420 
VDAVYGKMLN QSNVTEMGIK MLPGYKDPYH GRPLTRGEMG CFLSHYNIWK EISERNLEVS 

       430        440        450        460        470        480 
AVLEDDLRFE IFFKRRLQTL LHDLEIAKLD WDLIYLGRKR MQVDEPEEPV PGVRNLVVSD 

       490        500        510        520        530        540 
YSYWTLGYLI SLRGARKLLN AEPLGKMLPV DEFLPVMYDK HPISDYSSHF STRDLRAFSV 

       550        560        570        580        590        600 
EPLLLYPTHY TGDKGYISDT ETSVLWDNVT QPTDWDRAKS RKTHQQEKLR SEALNTPSMG 

       610 
SPFDNTARDE L 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC085226 mRNA. Translation: AAH85226.1.
RefSeqNP_001088623.1. NM_001095154.1.
UniGeneXl.13613.

3D structure databases

ProteinModelPortalQ5U483.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT25. Glycosyltransferase Family 25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID495521.
KEGGxla:495521.

Organism-specific databases

CTD495521.
XenbaseXB-GENE-6253736. colgalt1.

Phylogenomic databases

HOVERGENHBG058097.
KOK11703.

Family and domain databases

InterProIPR002654. Glyco_trans_25.
[Graphical view]
PfamPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG251B_XENLA
AccessionPrimary (citable) accession number: Q5U483
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 7, 2004
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families