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Q5U483

- G251B_XENLA

UniProt

Q5U483 - G251B_XENLA

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Protein

Procollagen galactosyltransferase 1-B

Gene

colgalt1-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen.By similarity

Catalytic activityi

UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].

GO - Molecular functioni

  1. procollagen galactosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen galactosyltransferase 1-B (EC:2.4.1.50)
Alternative name(s):
Collagen beta(1-O)galactosyltransferase 1-B
Glycosyltransferase 25 family member 1-B
Hydroxylysine galactosyltransferase 1-B
Gene namesi
Name:colgalt1-b
Synonyms:glt25d1-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6253736. colgalt1.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 611587Procollagen galactosyltransferase 1-BPRO_0000309540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi568 – 5681N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5U483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi608 – 6114Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG058097.
KOiK11703.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U483-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQAGVERLL KGLQILVLVL RLSAGYFPEE RWNPESPFRS PTVLIAVLAR
60 70 80 90 100
NSEGSLPEVL GALDRLHYPK ERISLWVATD HNFDNTSQIL REWLINVQNQ
110 120 130 140 150
YHHVEWRPQE HPRWFRDEES PKHWSHSRYE YVMKLRQAAL TSAREMWADY
160 170 180 190 200
IFFLDADNLL TNSETLNLLI AENKTVVAPM LESRAAYSNF WCGMTTQGYY
210 220 230 240 250
RRTPAYMPIR RRERQGCFPV PMVHSTFLID LRKEASQQLD FYPPHADYTW
260 270 280 290 300
AFDDIIVFAF SCRQAEVQMF LCNKEIYGYL PVPLRSHSTL LDETDNFLHT
310 320 330 340 350
KLEAMVKGPQ VHPSSFVTIP KKVPDKMSFD EVFLINLKHR QDRRERMKRT
360 370 380 390 400
LYELQIDFKL VDAVYGKMLN QSNVTEMGIK MLPGYKDPYH GRPLTRGEMG
410 420 430 440 450
CFLSHYNIWK EISERNLEVS AVLEDDLRFE IFFKRRLQTL LHDLEIAKLD
460 470 480 490 500
WDLIYLGRKR MQVDEPEEPV PGVRNLVVSD YSYWTLGYLI SLRGARKLLN
510 520 530 540 550
AEPLGKMLPV DEFLPVMYDK HPISDYSSHF STRDLRAFSV EPLLLYPTHY
560 570 580 590 600
TGDKGYISDT ETSVLWDNVT QPTDWDRAKS RKTHQQEKLR SEALNTPSMG
610
SPFDNTARDE L
Length:611
Mass (Da):71,607
Last modified:December 7, 2004 - v1
Checksum:i63AED42791D52B08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085226 mRNA. Translation: AAH85226.1.
RefSeqiNP_001088623.1. NM_001095154.1.
UniGeneiXl.13613.

Genome annotation databases

GeneIDi495521.
KEGGixla:495521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085226 mRNA. Translation: AAH85226.1 .
RefSeqi NP_001088623.1. NM_001095154.1.
UniGenei Xl.13613.

3D structure databases

ProteinModelPortali Q5U483.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT25. Glycosyltransferase Family 25.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 495521.
KEGGi xla:495521.

Organism-specific databases

CTDi 495521.
Xenbasei XB-GENE-6253736. colgalt1.

Phylogenomic databases

HOVERGENi HBG058097.
KOi K11703.

Family and domain databases

Gene3Di 3.90.550.10. 2 hits.
InterProi IPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01755. Glyco_transf_25. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiG251B_XENLA
AccessioniPrimary (citable) accession number: Q5U483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3