Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

Gene

Asap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri440 – 463C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Development and differentiation-enhancing factor-like 1
Gene namesi
Name:Asap3
Synonyms:Ddefl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2684986 Asap3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328881 – 904Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3Add BLAST904

Proteomic databases

MaxQBiQ5U464
PaxDbiQ5U464
PRIDEiQ5U464

PTM databases

iPTMnetiQ5U464
PhosphoSitePlusiQ5U464

Expressioni

Gene expression databases

BgeeiENSMUSG00000036995
GenevisibleiQ5U464 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041899

Structurei

3D structure databases

ProteinModelPortaliQ5U464
SMRiQ5U464
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 394PHPROSITE-ProRule annotationAdd BLAST93
Domaini425 – 550Arf-GAPPROSITE-ProRule annotationAdd BLAST126
Repeati584 – 616ANK 1Add BLAST33
Repeati620 – 649ANK 2Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili142 – 169Sequence analysisAdd BLAST28
Coiled coili249 – 273Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi702 – 708Poly-Glu7
Compositional biasi773 – 869Ser-richAdd BLAST97

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri440 – 463C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0521 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00760000118874
HOGENOMiHOG000230570
HOVERGENiHBG051327
InParanoidiQ5U464
KOiK12488
OMAiIIQNGGH
OrthoDBiEOG091G022H
PhylomeDBiQ5U464
TreeFamiTF325156

Family and domain databases

CDDicd00204 ANK, 1 hit
cd13251 PH_ASAP, 1 hit
Gene3Di1.20.1270.60, 1 hit
2.30.29.30, 1 hit
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR028775 ASAP3
IPR011993 PH-like_dom_sf
IPR037844 PH_ASAP
IPR001849 PH_domain
PANTHERiPTHR23180:SF271 PTHR23180:SF271, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01412 ArfGap, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00105 ArfGap, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF103657 SSF103657, 2 hits
SSF48403 SSF48403, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQLSVAEF LAVTAEDLSS PAGAAAFAAK MPRCRGAALA REEALEGDQA
60 70 80 90 100
ILQRIKKAVR AIHSSGLGHV ETEEHYREAV EALGNSHLSQ NSHELSTGFL
110 120 130 140 150
NLAVFTREVA ALFKNLVQNL NNIVSFPLDS LMKGHLRDGR HDSKKHLEKA
160 170 180 190 200
WKDYESKVAK LEKERDRARF PGGSHGVMSQ DTQRERRVFQ LHMCEYLVKA
210 220 230 240 250
GESQVKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLSPFI DKLAASVHGL
260 270 280 290 300
RQAQEEELHK LTQLRDSLRG MLHLESREDH PNRKNSGGGY SIHQHQGNKQ
310 320 330 340 350
FGTEKVGFLY KKSDGIRRVW QKRKCGVKYG CLTISHSMIN RPPVKLPLLT
360 370 380 390 400
CQVRPNPEEK RCFDLVTHNR TYHFHAEDEQ ECEAWVSVLQ NSKDEALSNA
410 420 430 440 450
FHGEPSGGQW SWGTRLDTEP HDLTNMLVAE VKSRPGNDRC CDCGAADPTW
460 470 480 490 500
LSTNLGVLTC IQCSGVHREL GVRFSRIQSL TLDLLGPSEL LLALNIGNSH
510 520 530 540 550
FNEVMEAHLP SHGSPKPSAE SDMSSRRNYI VAKYVEHKFA RHSTPDPQKL
560 570 580 590 600
RTAICSRDLL SVLEAFANGQ DFGQLLPGPD GQAPGELALH LAIRVASHAS
610 620 630 640 650
LPIVDFLIQN GGHLDAKAAD GNTALHCAAL HGQLDCLKLL LRGRAPVGAV
660 670 680 690 700
NDAGETALDI ARNRQHKECE ELLEQAQAGT LAFPLHMDYH WGHSMEHGFD
710 720 730 740 750
SEEEEEEEKH CPSKPPAQAC WGSVRLDISN KTYETVATPG PATTQSQSED
760 770 780 790 800
SPPPLPIKNS SRTIVLGRAG HCSGDRSDLP SLRSESPEAL ENRSSPASSS
810 820 830 840 850
SSLTSSVEPG GLSQAPSSPE EGLQESASIS RPGLASGTTS AEVYLPVKFS
860 870 880 890 900
SESTRSYRRG GRSLEDSPSA RQPLCSRRHI PVGLVEGDGS KIGVLPDSLQ

LLHD
Length:904
Mass (Da):99,276
Last modified:December 7, 2004 - v1
Checksum:iA8B0A6BFCDA3D95D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085250 mRNA Translation: AAH85250.1
CCDSiCCDS18802.1
RefSeqiNP_001008233.1, NM_001008232.2
UniGeneiMm.77788

Genome annotation databases

EnsembliENSMUST00000047526; ENSMUSP00000041899; ENSMUSG00000036995
GeneIDi230837
KEGGimmu:230837
UCSCiuc008vhu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiASAP3_MOUSE
AccessioniPrimary (citable) accession number: Q5U464
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: December 7, 2004
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health