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Protein

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

Gene

Asap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri440 – 463C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Alternative name(s):
Development and differentiation-enhancing factor-like 1
Gene namesi
Name:Asap3
Synonyms:Ddefl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2684986. Asap3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328881 – 904Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3Add BLAST904

Proteomic databases

MaxQBiQ5U464.
PaxDbiQ5U464.
PRIDEiQ5U464.

PTM databases

iPTMnetiQ5U464.
PhosphoSitePlusiQ5U464.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036995.
GenevisibleiQ5U464. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041899.

Structurei

3D structure databases

ProteinModelPortaliQ5U464.
SMRiQ5U464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 394PHPROSITE-ProRule annotationAdd BLAST93
Domaini425 – 550Arf-GAPPROSITE-ProRule annotationAdd BLAST126
Repeati584 – 616ANK 1Add BLAST33
Repeati620 – 649ANK 2Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili142 – 169Sequence analysisAdd BLAST28
Coiled coili249 – 273Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi702 – 708Poly-Glu7
Compositional biasi773 – 869Ser-richAdd BLAST97

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri440 – 463C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0521. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000230570.
HOVERGENiHBG051327.
InParanoidiQ5U464.
KOiK12488.
OMAiIIQNGGH.
OrthoDBiEOG091G022H.
PhylomeDBiQ5U464.
TreeFamiTF325156.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR028775. ASAP3.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR23180:SF271. PTHR23180:SF271. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQLSVAEF LAVTAEDLSS PAGAAAFAAK MPRCRGAALA REEALEGDQA
60 70 80 90 100
ILQRIKKAVR AIHSSGLGHV ETEEHYREAV EALGNSHLSQ NSHELSTGFL
110 120 130 140 150
NLAVFTREVA ALFKNLVQNL NNIVSFPLDS LMKGHLRDGR HDSKKHLEKA
160 170 180 190 200
WKDYESKVAK LEKERDRARF PGGSHGVMSQ DTQRERRVFQ LHMCEYLVKA
210 220 230 240 250
GESQVKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLSPFI DKLAASVHGL
260 270 280 290 300
RQAQEEELHK LTQLRDSLRG MLHLESREDH PNRKNSGGGY SIHQHQGNKQ
310 320 330 340 350
FGTEKVGFLY KKSDGIRRVW QKRKCGVKYG CLTISHSMIN RPPVKLPLLT
360 370 380 390 400
CQVRPNPEEK RCFDLVTHNR TYHFHAEDEQ ECEAWVSVLQ NSKDEALSNA
410 420 430 440 450
FHGEPSGGQW SWGTRLDTEP HDLTNMLVAE VKSRPGNDRC CDCGAADPTW
460 470 480 490 500
LSTNLGVLTC IQCSGVHREL GVRFSRIQSL TLDLLGPSEL LLALNIGNSH
510 520 530 540 550
FNEVMEAHLP SHGSPKPSAE SDMSSRRNYI VAKYVEHKFA RHSTPDPQKL
560 570 580 590 600
RTAICSRDLL SVLEAFANGQ DFGQLLPGPD GQAPGELALH LAIRVASHAS
610 620 630 640 650
LPIVDFLIQN GGHLDAKAAD GNTALHCAAL HGQLDCLKLL LRGRAPVGAV
660 670 680 690 700
NDAGETALDI ARNRQHKECE ELLEQAQAGT LAFPLHMDYH WGHSMEHGFD
710 720 730 740 750
SEEEEEEEKH CPSKPPAQAC WGSVRLDISN KTYETVATPG PATTQSQSED
760 770 780 790 800
SPPPLPIKNS SRTIVLGRAG HCSGDRSDLP SLRSESPEAL ENRSSPASSS
810 820 830 840 850
SSLTSSVEPG GLSQAPSSPE EGLQESASIS RPGLASGTTS AEVYLPVKFS
860 870 880 890 900
SESTRSYRRG GRSLEDSPSA RQPLCSRRHI PVGLVEGDGS KIGVLPDSLQ

LLHD
Length:904
Mass (Da):99,276
Last modified:December 7, 2004 - v1
Checksum:iA8B0A6BFCDA3D95D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085250 mRNA. Translation: AAH85250.1.
CCDSiCCDS18802.1.
RefSeqiNP_001008233.1. NM_001008232.2.
UniGeneiMm.77788.

Genome annotation databases

EnsembliENSMUST00000047526; ENSMUSP00000041899; ENSMUSG00000036995.
GeneIDi230837.
KEGGimmu:230837.
UCSCiuc008vhu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085250 mRNA. Translation: AAH85250.1.
CCDSiCCDS18802.1.
RefSeqiNP_001008233.1. NM_001008232.2.
UniGeneiMm.77788.

3D structure databases

ProteinModelPortaliQ5U464.
SMRiQ5U464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041899.

PTM databases

iPTMnetiQ5U464.
PhosphoSitePlusiQ5U464.

Proteomic databases

MaxQBiQ5U464.
PaxDbiQ5U464.
PRIDEiQ5U464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047526; ENSMUSP00000041899; ENSMUSG00000036995.
GeneIDi230837.
KEGGimmu:230837.
UCSCiuc008vhu.2. mouse.

Organism-specific databases

CTDi55616.
MGIiMGI:2684986. Asap3.

Phylogenomic databases

eggNOGiKOG0521. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000230570.
HOVERGENiHBG051327.
InParanoidiQ5U464.
KOiK12488.
OMAiIIQNGGH.
OrthoDBiEOG091G022H.
PhylomeDBiQ5U464.
TreeFamiTF325156.

Miscellaneous databases

PROiQ5U464.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036995.
GenevisibleiQ5U464. MM.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR028775. ASAP3.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR23180:SF271. PTHR23180:SF271. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASAP3_MOUSE
AccessioniPrimary (citable) accession number: Q5U464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.