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Protein

CUB domain-containing protein 1

Gene

Cdcp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.

Names & Taxonomyi

Protein namesi
Recommended name:
CUB domain-containing protein 1
Alternative name(s):
Membrane glycoprotein gp140
Transmembrane and associated with src kinases
CD_antigen: CD318
Gene namesi
Name:Cdcp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2442010. Cdcp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 666ExtracellularSequence analysisAdd BLAST637
Transmembranei667 – 687HelicalSequence analysisAdd BLAST21
Topological domaini688 – 833CytoplasmicSequence analysisAdd BLAST146

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000022625030 – 833CUB domain-containing protein 1Add BLAST804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi122N-linked (GlcNAc...)Sequence analysis1
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Glycosylationi270N-linked (GlcNAc...)Sequence analysis1
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1
Glycosylationi342N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi476 ↔ 499By similarity
Modified residuei731PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5 (By similarity).By similarity
N-glycosylated.By similarity
A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on the N-terminal side. Converted to p80 by plasmin, a trypsin-like protease (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei368 – 369Cleavage; by ST14/MT-SP1By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ5U462.
PaxDbiQ5U462.
PeptideAtlasiQ5U462.
PRIDEiQ5U462.

PTM databases

iPTMnetiQ5U462.
PhosphoSitePlusiQ5U462.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035498.
CleanExiMM_CDCP1.
GenevisibleiQ5U462. MM.

Interactioni

Subunit structurei

Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. Also interacts SRC and PRKCG/protein kinase C gamma (By similarity).By similarity

Protein-protein interaction databases

IntActiQ5U462. 1 interactor.
STRINGi10090.ENSMUSP00000042057.

Structurei

3D structure databases

ProteinModelPortaliQ5U462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini417 – 540CUBAdd BLAST124

Sequence similaritiesi

Contains 1 CUB domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJR2. Eukaryota.
ENOG4110CXF. LUCA.
GeneTreeiENSGT00390000010209.
HOGENOMiHOG000111498.
HOVERGENiHBG081070.
InParanoidiQ5U462.
KOiK06732.
OMAiSIKRLCI.
OrthoDBiEOG091G01M3.
PhylomeDBiQ5U462.
TreeFamiTF331392.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSACGFSV ALLGALLLGT ARLLRGTEAS EIALPQRSGV TVSIKLGNPA
60 70 80 90 100
LPVKICYIVM SRQHITELII RPGERKSFTF SCSNPEKHFV LKIEKNIDCM
110 120 130 140 150
SGPCPFGEVH LQPSTSELPI LNRTFIWDVR AHKSIGLELQ FATPRLRQIG
160 170 180 190 200
PGESCADGVT HSISGHIDAT EVRIGTFCSN GTVSRIKMQE GVKMALHLPW
210 220 230 240 250
FHRRNVSGFS IANRSSIKRL CIIESVFEGE GSATLMSANY PGGFPEDELM
260 270 280 290 300
TWQFVVPAHL RASVSFLNFN VSNCERKEER VEYYIPGSTT NPEVFRLEDK
310 320 330 340 350
QPGNMAGNFN LSLQGCDQDA QSPGILRLQF QVLVQRPQDE SNKTYMVDLS
360 370 380 390 400
RERTMSLTIE PRPVKHGRRF VPGCFVCLES RTCSTNVTLT AGSIHKISFL
410 420 430 440 450
CDDLTRLWVN VEKTLSCLDH RYCYRQSFKL QVPDYILQLP VQLHDFSWKL
460 470 480 490 500
LVPKDKLSLM LVPGQKLQQH TQERPCNTSF GYHVTSTTPG QDLYFGSFCS
510 520 530 540 550
GGSIEKIQVK QNSSVTLRAY APSFQQEVSK QGLIVSYTPY FKEEGIFTVT
560 570 580 590 600
PDTKNKVYLR SPNWDRGLPA LSSVSWNISV PSNQVACLTV LKERSGLACQ
610 620 630 640 650
SGRAFMIIQE QQSRAEEIFS LEEEVLPKPS FHHHSFWVNI SNCSPMNGKQ
660 670 680 690 700
LDLLFWVTLT PRTVDLAVVI GAAGGGALLL FALVLIICFV KKKKKVDKGP
710 720 730 740 750
AVGIYNGNVN TQMPQTQKFP KGRKDNDSHV YAVIEDTMVY GHLLQDSGGS
760 770 780 790 800
FIQPEVDTYR PFQGPMGDCP PTPPPLFSRT PTAKFTAEEL APSSPPESES
810 820 830
EPYTFSHPNK GEIGVRETDI PLLHTQGPVE TEE
Length:833
Mass (Da):92,726
Last modified:December 7, 2004 - v1
Checksum:i1F1423DD595C6B27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011340 mRNA. Translation: AAH11340.1.
BC050137 mRNA. Translation: AAH50137.1.
BC085253 mRNA. Translation: AAH85253.1.
CCDSiCCDS23657.1.
RefSeqiNP_598735.2. NM_133974.3.
UniGeneiMm.27519.

Genome annotation databases

EnsembliENSMUST00000039229; ENSMUSP00000042057; ENSMUSG00000035498.
GeneIDi109332.
KEGGimmu:109332.
UCSCiuc009sfz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011340 mRNA. Translation: AAH11340.1.
BC050137 mRNA. Translation: AAH50137.1.
BC085253 mRNA. Translation: AAH85253.1.
CCDSiCCDS23657.1.
RefSeqiNP_598735.2. NM_133974.3.
UniGeneiMm.27519.

3D structure databases

ProteinModelPortaliQ5U462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5U462. 1 interactor.
STRINGi10090.ENSMUSP00000042057.

PTM databases

iPTMnetiQ5U462.
PhosphoSitePlusiQ5U462.

Proteomic databases

MaxQBiQ5U462.
PaxDbiQ5U462.
PeptideAtlasiQ5U462.
PRIDEiQ5U462.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039229; ENSMUSP00000042057; ENSMUSG00000035498.
GeneIDi109332.
KEGGimmu:109332.
UCSCiuc009sfz.1. mouse.

Organism-specific databases

CTDi64866.
MGIiMGI:2442010. Cdcp1.

Phylogenomic databases

eggNOGiENOG410IJR2. Eukaryota.
ENOG4110CXF. LUCA.
GeneTreeiENSGT00390000010209.
HOGENOMiHOG000111498.
HOVERGENiHBG081070.
InParanoidiQ5U462.
KOiK06732.
OMAiSIKRLCI.
OrthoDBiEOG091G01M3.
PhylomeDBiQ5U462.
TreeFamiTF331392.

Miscellaneous databases

PROiQ5U462.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035498.
CleanExiMM_CDCP1.
GenevisibleiQ5U462. MM.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDCP1_MOUSE
AccessioniPrimary (citable) accession number: Q5U462
Secondary accession number(s): Q810J0, Q921M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.