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Protein

G-protein coupled receptor 39

Gene

Gpr39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Zn2+ acts as a agonist (By similarity). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death.By similarity2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171ZincBy similarity
Metal bindingi19 – 191ZincBy similarity

GO - Molecular functioni

GO - Biological processi

  • adult feeding behavior Source: MGI
  • cellular response to zinc ion Source: MGI
  • cholesterol homeostasis Source: MGI
  • diet induced thermogenesis Source: MGI
  • gastric emptying Source: MGI
  • glucose homeostasis Source: MGI
  • negative regulation of gastric acid secretion Source: MGI
  • positive regulation of insulin secretion Source: MGI
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  • positive regulation of release of sequestered calcium ion into cytosol Source: MGI
  • regulation of lipid metabolic process Source: MGI
  • regulation of membrane potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 39
Gene namesi
Name:Gpr39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918361. Gpr39.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularBy similarityAdd
BLAST
Transmembranei35 – 5521Helical; Name=1By similarityAdd
BLAST
Topological domaini56 – 6914CytoplasmicBy similarityAdd
BLAST
Transmembranei70 – 8920Helical; Name=2By similarityAdd
BLAST
Topological domaini90 – 10920ExtracellularBy similarityAdd
BLAST
Transmembranei110 – 13122Helical; Name=3By similarityAdd
BLAST
Topological domaini132 – 15120CytoplasmicBy similarityAdd
BLAST
Transmembranei152 – 17221Helical; Name=4By similarityAdd
BLAST
Topological domaini173 – 21745ExtracellularBy similarityAdd
BLAST
Transmembranei218 – 24225Helical; Name=5By similarityAdd
BLAST
Topological domaini243 – 28341CytoplasmicBy similarityAdd
BLAST
Transmembranei284 – 30522Helical; Name=6By similarityAdd
BLAST
Topological domaini306 – 32318ExtracellularBy similarityAdd
BLAST
Transmembranei324 – 34421Helical; Name=7By similarityAdd
BLAST
Topological domaini345 – 456112CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3341584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456G-protein coupled receptor 39PRO_0000069566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi11 ↔ 191PROSITE-ProRule annotation
Disulfide bondi108 ↔ 210PROSITE-ProRule annotation
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Modified residuei397 – 3971PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ5U431.
PaxDbiQ5U431.
PRIDEiQ5U431.

PTM databases

iPTMnetiQ5U431.
PhosphoSiteiQ5U431.

Expressioni

Tissue specificityi

Expression is detected in septumamygdala, parietal cells, enterocytes, neurons and pancreas, in peripheral organs such as the duodenum and kidney but not in the pituitary and hypothalamus.2 Publications

Gene expression databases

CleanExiMM_GPR39.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027581.

Chemistry

BindingDBiQ5U431.

Structurei

3D structure databases

ProteinModelPortaliQ5U431.
SMRiQ5U431. Positions 30-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000077769.
HOVERGENiHBG051809.
InParanoidiQ5U431.
PhylomeDBiQ5U431.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSGSNHI CSRVIDHSHV PEFEVATWIK ITLILVYLII FVVGILGNSV
60 70 80 90 100
TIRVTQVLQK KGYLQKEVTD HMVSLACSDI LVFLIGMPME FYSIIWNPLT
110 120 130 140 150
TPSYALSCKL HTFLFETCSY ATLLHVLTLS FERYIAICHP FKYKAVSGPR
160 170 180 190 200
QVKLLIGFVW VTSALVALPL LFAMGIEYPL VNVPTHKGLN CNLSRTRHHD
210 220 230 240 250
EPGNSNMSIC TNLSNRWEVF QSSIFGAFAV YLVVLASVAF MCWNMMKVLM
260 270 280 290 300
KSKQGTLAGT GPQLQLRKSE SEESRTARRQ TIIFLRLIVV TLAVCWMPNQ
310 320 330 340 350
IRRIMAAAKP KHDWTRTYFR AYMILLPFSD TFFYLSSVVN PLLYNVSSQQ
360 370 380 390 400
FRKVFWQVLC CRLTLQHANQ EKRQRARFIS TKDSTSSARS PLIFLASRRS
410 420 430 440 450
NSSSRRTNKV FLSTFQTEAK PGEAKPQPLS PESPQTGSET KPAGSTTENS

LQEQEV
Length:456
Mass (Da):51,589
Last modified:December 7, 2004 - v1
Checksum:iEDF5DFB455D0A5CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085285 mRNA. Translation: AAH85285.1.
AY255549 mRNA. Translation: AAO85061.1.
CCDSiCCDS48344.1.
UniGeneiMm.32727.

Genome annotation databases

UCSCiuc007ckh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085285 mRNA. Translation: AAH85285.1.
AY255549 mRNA. Translation: AAO85061.1.
CCDSiCCDS48344.1.
UniGeneiMm.32727.

3D structure databases

ProteinModelPortaliQ5U431.
SMRiQ5U431. Positions 30-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027581.

Chemistry

BindingDBiQ5U431.
ChEMBLiCHEMBL3341584.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ5U431.
PhosphoSiteiQ5U431.

Proteomic databases

MaxQBiQ5U431.
PaxDbiQ5U431.
PRIDEiQ5U431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007ckh.2. mouse.

Organism-specific databases

MGIiMGI:1918361. Gpr39.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000077769.
HOVERGENiHBG051809.
InParanoidiQ5U431.
PhylomeDBiQ5U431.

Miscellaneous databases

PROiQ5U431.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GPR39.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR39_MOUSE
AccessioniPrimary (citable) accession number: Q5U431
Secondary accession number(s): Q80UC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 7, 2004
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Was originally reported to be the receptor of obestatin. However, numerous reports concluded that GPR39 was not the receptor for obestatin (PubMed:16959833).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.