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Protein

G-protein coupled receptor 39

Gene

Gpr39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Zn2+ acts as an agonist (By similarity). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17ZincBy similarity1
Metal bindingi19ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • adult feeding behavior Source: MGI
  • cellular response to zinc ion Source: MGI
  • cholesterol homeostasis Source: MGI
  • diet induced thermogenesis Source: MGI
  • gastric emptying Source: MGI
  • glucose homeostasis Source: MGI
  • negative regulation of gastric acid secretion Source: MGI
  • positive regulation of insulin secretion Source: MGI
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  • positive regulation of release of sequestered calcium ion into cytosol Source: MGI
  • regulation of lipid metabolic process Source: MGI
  • regulation of membrane potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 39
Gene namesi
Name:Gpr39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918361. Gpr39.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 55Helical; Name=1By similarityAdd BLAST21
Topological domaini56 – 69CytoplasmicBy similarityAdd BLAST14
Transmembranei70 – 89Helical; Name=2By similarityAdd BLAST20
Topological domaini90 – 109ExtracellularBy similarityAdd BLAST20
Transmembranei110 – 131Helical; Name=3By similarityAdd BLAST22
Topological domaini132 – 151CytoplasmicBy similarityAdd BLAST20
Transmembranei152 – 172Helical; Name=4By similarityAdd BLAST21
Topological domaini173 – 217ExtracellularBy similarityAdd BLAST45
Transmembranei218 – 242Helical; Name=5By similarityAdd BLAST25
Topological domaini243 – 283CytoplasmicBy similarityAdd BLAST41
Transmembranei284 – 305Helical; Name=6By similarityAdd BLAST22
Topological domaini306 – 323ExtracellularBy similarityAdd BLAST18
Transmembranei324 – 344Helical; Name=7By similarityAdd BLAST21
Topological domaini345 – 456CytoplasmicBy similarityAdd BLAST112

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3341584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695661 – 456G-protein coupled receptor 39Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 191PROSITE-ProRule annotation
Disulfide bondi108 ↔ 210PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Modified residuei397PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ5U431.
PaxDbiQ5U431.
PRIDEiQ5U431.

PTM databases

iPTMnetiQ5U431.
PhosphoSitePlusiQ5U431.

Expressioni

Tissue specificityi

Expression is detected in septumamygdala, parietal cells, enterocytes, neurons and pancreas, in peripheral organs such as the duodenum and kidney but not in the pituitary and hypothalamus.2 Publications

Gene expression databases

CleanExiMM_GPR39.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027581.

Chemistry databases

BindingDBiQ5U431.

Structurei

3D structure databases

ProteinModelPortaliQ5U431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000077769.
HOVERGENiHBG051809.
InParanoidiQ5U431.
PhylomeDBiQ5U431.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSGSNHI CSRVIDHSHV PEFEVATWIK ITLILVYLII FVVGILGNSV
60 70 80 90 100
TIRVTQVLQK KGYLQKEVTD HMVSLACSDI LVFLIGMPME FYSIIWNPLT
110 120 130 140 150
TPSYALSCKL HTFLFETCSY ATLLHVLTLS FERYIAICHP FKYKAVSGPR
160 170 180 190 200
QVKLLIGFVW VTSALVALPL LFAMGIEYPL VNVPTHKGLN CNLSRTRHHD
210 220 230 240 250
EPGNSNMSIC TNLSNRWEVF QSSIFGAFAV YLVVLASVAF MCWNMMKVLM
260 270 280 290 300
KSKQGTLAGT GPQLQLRKSE SEESRTARRQ TIIFLRLIVV TLAVCWMPNQ
310 320 330 340 350
IRRIMAAAKP KHDWTRTYFR AYMILLPFSD TFFYLSSVVN PLLYNVSSQQ
360 370 380 390 400
FRKVFWQVLC CRLTLQHANQ EKRQRARFIS TKDSTSSARS PLIFLASRRS
410 420 430 440 450
NSSSRRTNKV FLSTFQTEAK PGEAKPQPLS PESPQTGSET KPAGSTTENS

LQEQEV
Length:456
Mass (Da):51,589
Last modified:December 7, 2004 - v1
Checksum:iEDF5DFB455D0A5CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085285 mRNA. Translation: AAH85285.1.
AY255549 mRNA. Translation: AAO85061.1.
CCDSiCCDS48344.1.
UniGeneiMm.32727.

Genome annotation databases

UCSCiuc007ckh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085285 mRNA. Translation: AAH85285.1.
AY255549 mRNA. Translation: AAO85061.1.
CCDSiCCDS48344.1.
UniGeneiMm.32727.

3D structure databases

ProteinModelPortaliQ5U431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027581.

Chemistry databases

BindingDBiQ5U431.
ChEMBLiCHEMBL3341584.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ5U431.
PhosphoSitePlusiQ5U431.

Proteomic databases

MaxQBiQ5U431.
PaxDbiQ5U431.
PRIDEiQ5U431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007ckh.2. mouse.

Organism-specific databases

MGIiMGI:1918361. Gpr39.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000077769.
HOVERGENiHBG051809.
InParanoidiQ5U431.
PhylomeDBiQ5U431.

Miscellaneous databases

PROiQ5U431.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GPR39.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR39_MOUSE
AccessioniPrimary (citable) accession number: Q5U431
Secondary accession number(s): Q80UC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Was originally reported to be the receptor of obestatin. However, numerous reports concluded that GPR39 was not the receptor for obestatin (PubMed:16959833).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.