ID   Q5U406_MOUSE            Unreviewed;       512 AA.
AC   Q5U406;
DT   07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   07-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 153.
DE   SubName: Full=Zinc finger protein 78 {ECO:0000313|EMBL:AAH85322.1, ECO:0000313|Ensembl:ENSMUSP00000104199.3};
GN   Name=Zfp78 {ECO:0000313|EMBL:AAH85322.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000104199.3, ECO:0000313|MGI:MGI:107783};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH85322.1};
RN   [1] {ECO:0000313|EMBL:AAH85322.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C3H/He mice {ECO:0000313|EMBL:AAH85322.1};
RC   TISSUE=Osteoblast {ECO:0000313|EMBL:AAH85322.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000104199.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104199.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000104199.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104199.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC085322; AAH85322.1; -; mRNA.
DR   RefSeq; NP_001020334.1; NM_001025163.1.
DR   RefSeq; XP_017177795.1; XM_017322306.1.
DR   RefSeq; XP_017177796.1; XM_017322307.1.
DR   STRING; 10090.ENSMUSP00000147154; -.
DR   PaxDb; 10090-ENSMUSP00000104199; -.
DR   DNASU; 330463; -.
DR   Ensembl; ENSMUST00000108559.3; ENSMUSP00000104199.3; ENSMUSG00000055150.16.
DR   Ensembl; ENSMUST00000207347.2; ENSMUSP00000147154.2; ENSMUSG00000055150.16.
DR   GeneID; 330463; -.
DR   KEGG; mmu:330463; -.
DR   UCSC; uc009fbf.1; mouse.
DR   AGR; MGI:107783; -.
DR   CTD; 330463; -.
DR   MGI; MGI:107783; Zfp78.
DR   VEuPathDB; HostDB:ENSMUSG00000055150; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000165333; -.
DR   OMA; WETRWIT; -.
DR   OrthoDB; 4760110at2759; -.
DR   TreeFam; TF337055; -.
DR   BioGRID-ORCS; 330463; 0 hits in 78 CRISPR screens.
DR   ChiTaRS; Zfp81; mouse.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000055150; Expressed in animal zygote and 109 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR47772:SF4; REDUCED EXPRESSION 2-RELATED; 1.
DR   PANTHER; PTHR47772; ZINC FINGER PROTEIN 200; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 11.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00042}.
FT   DOMAIN          14..85
FT                   /note="KRAB"
FT                   /evidence="ECO:0000259|PROSITE:PS50805"
FT   DOMAIN          205..232
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          233..260
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          261..288
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          289..316
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          317..344
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          345..372
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          373..400
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          401..428
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          429..456
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          457..484
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          485..512
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
SQ   SEQUENCE   512 AA;  58921 MW;  BA0200A8DA492D78 CRC64;
     MTVELMKAML QEAVTFNDVA IDFSPEEWDW LNPAQRSLYR TVVLENYRNL VSVGACISKP
     SLISLLEHGK EPWEVKGQVT GSRVQGGKSV QKTHELSLRQ LVFEDVAVEN TTSLGCESLT
     SGRKQKCKDL LDRQMSQEIF NLKETVTHKG THTKEIGYKH TESLKSAHLD SVEENIYTHK
     SNKKSFSKNP KVWKYKKIWA GKTIFKCNEC EKTFTHSSAV TVHQRIHTGE KPYQCTVCGK
     AFKQSHHLAQ HHTTHTHEKL FQCEECKKAF SQNSYLTVHR RIHTGEKPYK CKECAKSFRQ
     PAHLAQHHRI HTGEKPYKCE ICGKAFNHSM SLTGHQRVHS GEKPYKCKDC GKAFRQSIHL
     VVHSRIHTGE EPYECNECGK TFRESSQLTI HQRNHTGEKP FECKQCGKFF NRSAYLARHQ
     KIHTGEKPYE CNECGKTFTH AAYLIRHKRV HTGEKPYKCA ECGKAFGDGS SRAQHQRLHT
     GQRPYVCEKC GRAFRRKSSL NCHQRYHTGK KL
//