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Protein

Transmembrane protein 97

Gene

Tmem97

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 97
Gene namesi
Name:Tmem97
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1307423. Tmem97.

Subcellular locationi

  • Nucleus membrane By similarity
  • Rough endoplasmic reticulum By similarity
  • Cell membrane By similarity
  • Lysosome By similarity
  • Membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Localized in sterol-depleted cells at cell membrane and in lysosomes.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 68ExtracellularSequence analysisAdd BLAST38
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 99CytoplasmicSequence analysis10
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 140ExtracellularSequence analysisAdd BLAST20
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 176CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Lysosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002545701 – 176Transmembrane protein 97Add BLAST176

Proteomic databases

PaxDbiQ5U3Y7.
PRIDEiQ5U3Y7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000022657.
GenevisibleiQ5U3Y7. RN.

Interactioni

Subunit structurei

Interacts with NPC1.By similarity

Protein-protein interaction databases

MINTiMINT-4577553.
STRINGi10116.ENSRNOP00000011834.

Structurei

3D structure databases

ProteinModelPortaliQ5U3Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 158EXPERAPROSITE-ProRule annotationAdd BLAST149

Sequence similaritiesi

Belongs to the TMEM97 family.Curated
Contains 1 EXPERA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX1Z. Eukaryota.
ENOG4111RR6. LUCA.
GeneTreeiENSGT00390000007149.
HOGENOMiHOG000031140.
HOVERGENiHBG079913.
InParanoidiQ5U3Y7.
OMAiFKGGCKW.
OrthoDBiEOG091G0P5K.
PhylomeDBiQ5U3Y7.
TreeFamiTF300241.

Family and domain databases

InterProiIPR033118. EXPERA.
IPR016964. Transmembrane_97.
[Graphical view]
PIRSFiPIRSF031032. TMP_97_prd. 1 hit.
PROSITEiPS51751. EXPERA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U3Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVTARRCV EWLLGLYFVS HIPITMFIDL QALLPPELYP QEFSNLLRWY
60 70 80 90 100
SKEFKDPLMQ EPPVWFKSFL FCELVFQLPF FPIAAYAFFK GSCRWIRIPA
110 120 130 140 150
IIYAVHTITT LIPILYTILF EDFSKAIAFK GQRPENFRER LTLVGVYAPY
160 170
LIIPLILLLF MLRNPYYKFE EKRKKK
Length:176
Mass (Da):20,946
Last modified:December 7, 2004 - v1
Checksum:i949F3A588243B486
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085344 mRNA. Translation: AAH85344.1.
RefSeqiNP_001008335.1. NM_001008334.1.
UniGeneiRn.20057.

Genome annotation databases

EnsembliENSRNOT00000011808; ENSRNOP00000011834; ENSRNOG00000022657.
GeneIDi303330.
KEGGirno:303330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085344 mRNA. Translation: AAH85344.1.
RefSeqiNP_001008335.1. NM_001008334.1.
UniGeneiRn.20057.

3D structure databases

ProteinModelPortaliQ5U3Y7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4577553.
STRINGi10116.ENSRNOP00000011834.

Proteomic databases

PaxDbiQ5U3Y7.
PRIDEiQ5U3Y7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011808; ENSRNOP00000011834; ENSRNOG00000022657.
GeneIDi303330.
KEGGirno:303330.

Organism-specific databases

CTDi27346.
RGDi1307423. Tmem97.

Phylogenomic databases

eggNOGiENOG410IX1Z. Eukaryota.
ENOG4111RR6. LUCA.
GeneTreeiENSGT00390000007149.
HOGENOMiHOG000031140.
HOVERGENiHBG079913.
InParanoidiQ5U3Y7.
OMAiFKGGCKW.
OrthoDBiEOG091G0P5K.
PhylomeDBiQ5U3Y7.
TreeFamiTF300241.

Miscellaneous databases

PROiQ5U3Y7.

Gene expression databases

BgeeiENSRNOG00000022657.
GenevisibleiQ5U3Y7. RN.

Family and domain databases

InterProiIPR033118. EXPERA.
IPR016964. Transmembrane_97.
[Graphical view]
PIRSFiPIRSF031032. TMP_97_prd. 1 hit.
PROSITEiPS51751. EXPERA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM97_RAT
AccessioniPrimary (citable) accession number: Q5U3Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.