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Protein

Sigma intracellular receptor 2

Gene

Tmem97

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.By similarity

Miscellaneous

Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile. Sigma-2 receptors are identified by radioligand-binding studies as a binding site with high affinity for di-o-tolylguanidine (DTG) and haloperidol.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sigma intracellular receptor 2By similarity
Short name:
Sigma-2 receptorBy similarity
Short name:
Sigma2 receptorBy similarity
Alternative name(s):
Transmembrane protein 97
Gene namesi
Name:Tmem97
Synonyms:S2rBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1307423. Tmem97.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 68ExtracellularSequence analysisAdd BLAST38
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 99CytoplasmicSequence analysis10
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 140ExtracellularSequence analysisAdd BLAST20
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 176CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002545701 – 176Sigma intracellular receptor 2Add BLAST176

Proteomic databases

PaxDbiQ5U3Y7.
PRIDEiQ5U3Y7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000022657.
GenevisibleiQ5U3Y7. RN.

Interactioni

Subunit structurei

Interacts with NPC1.By similarity

Protein-protein interaction databases

MINTiMINT-4577553.
STRINGi10116.ENSRNOP00000011834.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 158EXPERAPROSITE-ProRule annotationAdd BLAST149

Sequence similaritiesi

Belongs to the TMEM97/sigma-2 receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX1Z. Eukaryota.
ENOG4111RR6. LUCA.
GeneTreeiENSGT00390000007149.
HOGENOMiHOG000031140.
HOVERGENiHBG079913.
InParanoidiQ5U3Y7.
OMAiEWLLGLY.
OrthoDBiEOG091G0P5K.
PhylomeDBiQ5U3Y7.
TreeFamiTF300241.

Family and domain databases

InterProiView protein in InterPro
IPR033118. EXPERA.
IPR016964. Transmembrane_97.
PIRSFiPIRSF031032. TMP_97_prd. 1 hit.
PROSITEiView protein in PROSITE
PS51751. EXPERA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U3Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVTARRCV EWLLGLYFVS HIPITMFIDL QALLPPELYP QEFSNLLRWY
60 70 80 90 100
SKEFKDPLMQ EPPVWFKSFL FCELVFQLPF FPIAAYAFFK GSCRWIRIPA
110 120 130 140 150
IIYAVHTITT LIPILYTILF EDFSKAIAFK GQRPENFRER LTLVGVYAPY
160 170
LIIPLILLLF MLRNPYYKFE EKRKKK
Length:176
Mass (Da):20,946
Last modified:December 7, 2004 - v1
Checksum:i949F3A588243B486
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085344 mRNA. Translation: AAH85344.1.
RefSeqiNP_001008335.1. NM_001008334.1.
UniGeneiRn.20057.

Genome annotation databases

EnsembliENSRNOT00000011808; ENSRNOP00000011834; ENSRNOG00000022657.
GeneIDi303330.
KEGGirno:303330.

Similar proteinsi

Entry informationi

Entry nameiSGMR2_RAT
AccessioniPrimary (citable) accession number: Q5U3Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 7, 2004
Last modified: September 27, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families