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Protein

Vacuolar-sorting protein SNF8

Gene

snf8

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-DRE-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar-sorting protein SNF8
Alternative name(s):
ESCRT-II complex subunit VPS22
Gene namesi
Name:snf8
ORF Names:si:dkey-220f10.1, zgc:101578
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-041114-117 snf8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002152121 – 258Vacuolar-sorting protein SNF8Add BLAST258

Proteomic databases

PaxDbiQ5U3V9
PRIDEiQ5U3V9

Expressioni

Gene expression databases

BgeeiENSDARG00000058076

Interactioni

Subunit structurei

Component of the endosomal sorting required for transport complex II (ESCRT-II), composed of SNF8, VPS25 and VPS36.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000075332

Structurei

3D structure databases

ProteinModelPortaliQ5U3V9
SMRiQ5U3V9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 50Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the SNF8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3341 Eukaryota
ENOG410XPVM LUCA
GeneTreeiENSGT00390000007843
HOGENOMiHOG000170930
HOVERGENiHBG079872
InParanoidiQ5U3V9
KOiK12188
OMAiQYWLPAL
OrthoDBiEOG091G0GWO
PhylomeDBiQ5U3V9
TreeFamiTF105950

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR016689 ESCRT-2_cplx_Snf8
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12806 PTHR12806, 1 hit
PIRSFiPIRSF017215 ESCRT2_Vps22, 1 hit
SUPFAMiSSF46785 SSF46785, 2 hits

Sequencei

Sequence statusi: Complete.

Q5U3V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRRGVGAGA IAKKKLAEAK YKERGSVLAE DQIAQMSKQL DTFKTHLEEF
60 70 80 90 100
ASKHKQEIRK SSQFRVQFQE MCATIGVDPL ASGKGFWSEM LGVGDFYYEL
110 120 130 140 150
GVQIIEVCLA LKHRNGGLIT LDELHHRVLK GRGKFAQDVS QDDLVRAIKK
160 170 180 190 200
LKAMGNGFGM IPVGGTYLVQ SVPAELNMDH TVVLQLAEKK GYVTVSEIRE
210 220 230 240 250
SLKWEKERAC HVLDHLLKEG LAWLDSQAAG EPQYWLPALF SELLSQDVTP

EEANQMTP
Length:258
Mass (Da):28,850
Last modified:February 26, 2008 - v2
Checksum:iFAD0433268F65F62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88S → P in AAH85373 (Ref. 2) Curated1
Sequence conflicti119I → T in CAM12249 (PubMed:17490614).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR926135 Genomic DNA Translation: CAK05456.1
BC085373 mRNA Translation: AAH85373.1
AM422108 mRNA Translation: CAM12249.2
RefSeqiNP_001007413.1, NM_001007412.1
UniGeneiDr.84729

Genome annotation databases

EnsembliENSDART00000080888; ENSDARP00000075332; ENSDARG00000058076
GeneIDi492771
KEGGidre:492771

Similar proteinsi

Entry informationi

Entry nameiSNF8_DANRE
AccessioniPrimary (citable) accession number: Q5U3V9
Secondary accession number(s): A4VAK8, Q1L8C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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