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Q5U3T3

- CNEPB_DANRE

UniProt

Q5U3T3 - CNEPB_DANRE

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Protein

CTD nuclear envelope phosphatase 1B

Gene

ctdnep1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling By similarity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. nuclear envelope organization Source: UniProtKB
  2. positive regulation of triglyceride biosynthetic process Source: UniProtKB
  3. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
CTD nuclear envelope phosphatase 1B (EC:3.1.3.16)
Alternative name(s):
Dullard-like protein
Serine/threonine-protein phosphatase dullard-B
Gene namesi
Name:ctdnep1b
Synonyms:dullardl
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041114-152. ctdnep1b.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. Nem1-Spo7 phosphatase complex Source: UniProtKB
  5. nuclear envelope Source: UniProtKB
  6. nuclear membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245CTD nuclear envelope phosphatase 1BPRO_0000297971Add
BLAST

Proteomic databases

PRIDEiQ5U3T3.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103636.

Structurei

3D structure databases

ProteinModelPortaliQ5U3T3.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 225168FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the dullard family.Curated
Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5190.
HOVERGENiHBG098153.
InParanoidiQ5U3T3.
KOiK17617.
PhylomeDBiQ5U3T3.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U3T3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKTRQCLLG VRTFHGVTSR IWSFFLYILR KHIRTIIQYQ TVRYDILSLS
60 70 80 90 100
PISRNRLNNV KRKILVLDLD ETLIHSHHDG VLRPTVRPGT PPDFILKVVI
110 120 130 140 150
DKHPVRFFVH KRPHVDFFLE VVSQWYELVV FTASMEIYGS AVADKLDNNK
160 170 180 190 200
AILKRRYYRQ HCTLDSGSYI KDLSVVHDDL SSVVILDNSP GAYRSHPDNA
210 220 230 240
IPIKSWFSDP SDTALLNLLP MLDALRFPAD VRSVLSRNLH QHRLW
Length:245
Mass (Da):28,504
Last modified:December 7, 2004 - v1
Checksum:i3EE081D5A3BA78DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085403 mRNA. Translation: AAH85403.1.
RefSeqiNP_001007441.1. NM_001007440.1.
UniGeneiDr.27169.

Genome annotation databases

GeneIDi492799.
KEGGidre:492799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085403 mRNA. Translation: AAH85403.1 .
RefSeqi NP_001007441.1. NM_001007440.1.
UniGenei Dr.27169.

3D structure databases

ProteinModelPortali Q5U3T3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000103636.

Proteomic databases

PRIDEi Q5U3T3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 492799.
KEGGi dre:492799.

Organism-specific databases

CTDi 492799.
ZFINi ZDB-GENE-041114-152. ctdnep1b.

Phylogenomic databases

eggNOGi COG5190.
HOVERGENi HBG098153.
InParanoidi Q5U3T3.
KOi K17617.
PhylomeDBi Q5U3T3.

Miscellaneous databases

NextBioi 20865297.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCNEPB_DANRE
AccessioniPrimary (citable) accession number: Q5U3T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3