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Q5U3T3 (CNEPB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CTD nuclear envelope phosphatase 1B

EC=3.1.3.16
Alternative name(s):
Dullard-like protein
Serine/threonine-protein phosphatase dullard-B
Gene names
Name:ctdnep1b
Synonyms:dullardl
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Nucleus membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the dullard family.

Contains 1 FCP1 homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245CTD nuclear envelope phosphatase 1B
PRO_0000297971

Regions

Transmembrane7 – 2923Helical; Potential
Domain58 – 225168FCP1 homology

Sequences

Sequence LengthMass (Da)Tools
Q5U3T3 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 3EE081D5A3BA78DF

FASTA24528,504
        10         20         30         40         50         60 
MLKTRQCLLG VRTFHGVTSR IWSFFLYILR KHIRTIIQYQ TVRYDILSLS PISRNRLNNV 

        70         80         90        100        110        120 
KRKILVLDLD ETLIHSHHDG VLRPTVRPGT PPDFILKVVI DKHPVRFFVH KRPHVDFFLE 

       130        140        150        160        170        180 
VVSQWYELVV FTASMEIYGS AVADKLDNNK AILKRRYYRQ HCTLDSGSYI KDLSVVHDDL 

       190        200        210        220        230        240 
SSVVILDNSP GAYRSHPDNA IPIKSWFSDP SDTALLNLLP MLDALRFPAD VRSVLSRNLH 


QHRLW 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC085403 mRNA. Translation: AAH85403.1.
RefSeqNP_001007441.1. NM_001007440.1.
UniGeneDr.27169.

3D structure databases

ProteinModelPortalQ5U3T3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000103636.

Proteomic databases

PRIDEQ5U3T3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID492799.
KEGGdre:492799.

Organism-specific databases

CTD492799.
ZFINZDB-GENE-041114-152. ctdnep1b.

Phylogenomic databases

eggNOGCOG5190.
HOVERGENHBG098153.
InParanoidQ5U3T3.
KOK17617.
PhylomeDBQ5U3T3.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamPF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02251. HIF-SF_euk. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20865297.

Entry information

Entry nameCNEPB_DANRE
AccessionPrimary (citable) accession number: Q5U3T3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families