Reviewed, UniProtKB/Swiss-Prot Q5U3T3 (DULDB_DANRE)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein phosphatase dullard-B
    EC=3.1.3.16
Alternative name(s):
    Dullard-like protein

Gene names

Name:

dullardl

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Serine/threonine phosphatase which may be required for proper nuclear membrane morphology. May antagonize BMP signaling By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Nucleus membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the dullard family. Contains 1 FCP1 homology domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Nucleus
Domain	Transmembrane
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	nuclear envelope organization Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear envelope Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	protein serine/threonine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Serine/threonine-protein phosphatase dullard-B		PRO_0000297971
Regions
	Transmembrane	7 – 29	23	Potential
	Domain	58 – 225	168	FCP1 homology

Sequences

	Sequence		Length	Mass (Da)
	Q5U3T3-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 3EE081D5A3BA78DF	FASTA	245	28,504
	10 20 30 40 50 60 MLKTRQCLLG VRTFHGVTSR IWSFFLYILR KHIRTIIQYQ TVRYDILSLS PISRNRLNNV 70 80 90 100 110 120 KRKILVLDLD ETLIHSHHDG VLRPTVRPGT PPDFILKVVI DKHPVRFFVH KRPHVDFFLE 130 140 150 160 170 180 VVSQWYELVV FTASMEIYGS AVADKLDNNK AILKRRYYRQ HCTLDSGSYI KDLSVVHDDL 190 200 210 220 230 240 SSVVILDNSP GAYRSHPDNA IPIKSWFSDP SDTALLNLLP MLDALRFPAD VRSVLSRNLH QHRLW

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC085403 mRNA. Translation: AAH85403.1.
IPI	IPI00490449.
RefSeq	NP_001007441.1.
UniGene	Dr.27169
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q5U3T3.
Genome annotation databases
Ensembl	ENSDART00000028064; ENSDARP00000021202; ENSDARG00000035781; Danio rerio. [Genome view] ENSDART00000109644; ENSDARP00000103636; ENSDARG00000035781; Danio rerio. [Genome view]
GeneID	492799.
KEGG	dre:492799.
Organism-specific databases
CTD	492799.
ZFIN	ZDB-GENE-041114-152. dullardl.
Phylogenomic databases
HOVERGEN	Q5U3T3.
Enzyme and pathway databases
BRENDA	3.1.3.16. 96826.
Gene expression databases
Bgee	Q5U3T3.
Family and domain databases
InterPro	IPR011948. Dullard. IPR004274. NIF. [Graphical view]
Pfam	PF03031. NIF. 1 hit. [Graphical view]
SMART	SM00577. CPDc. 1 hit. [Graphical view]
TIGRFAMs	TIGR02251. HIF-SF_euk. 1 hit.
PROSITE	PS50969. FCP1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DULDB_DANRE

Accession

Primary (citable) accession number: Q5U3T3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	December 7, 2004
Last modified:	October 13, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project