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Q5U3Q6

- CIP4_DANRE

UniProt

Q5U3Q6 - CIP4_DANRE

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Protein

Cdc42-interacting protein 4 homolog

Gene

trip10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661Mediates end-to-end attachment of dimersBy similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
  2. endocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42-interacting protein 4 homolog
Alternative name(s):
Thyroid receptor-interacting protein 10 homolog
Gene namesi
Name:trip10
Synonyms:cip4
ORF Names:zgc:101777
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041114-105. trip10a.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cytoplasmcell cortex By similarity. Lysosome By similarity. Cell membrane By similarity

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-KW
  2. lysosome Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Cdc42-interacting protein 4 homologPRO_0000261442Add
BLAST

Proteomic databases

PRIDEiQ5U3Q6.

Interactioni

Subunit structurei

Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000040854.

Structurei

3D structure databases

ProteinModelPortaliQ5U3Q6.
SMRiQ5U3Q6. Positions 10-288, 484-539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6565FCHPROSITE-ProRule annotationAdd
BLAST
Repeati352 – 42372REMAdd
BLAST
Domaini480 – 54162SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 288288F-BAR domainBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili67 – 259193By similarityAdd
BLAST
Coiled coili335 – 42389By similarityAdd
BLAST

Domaini

The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).By similarity

Sequence similaritiesi

Belongs to the FNBP1 family.Curated
Contains 1 FCH domain.PROSITE-ProRule annotation
Contains 1 REM (Hr1) repeat.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG323796.
HOGENOMiHOG000231767.
HOVERGENiHBG002489.
InParanoidiQ5U3Q6.
KOiK07196.
PhylomeDBiQ5U3Q6.

Family and domain databases

InterProiIPR028498. CIP4.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR12602:SF7. PTHR12602:SF7. 1 hit.
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U3Q6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDWGTELWDQ YDILDKHTQS GLDLVDKYMK FVKERTDIEQ NYAKQLRNLT
60 70 80 90 100
KKYSPKRGSK EEQECRFSNH QAFLDILNEM NDYAGQRELI AENMMINICV
110 120 130 140 150
ELNKYLQELK QERKMHLSEA KKSQQSLEAM YKQLDNSKKR FEREWREAEK
160 170 180 190 200
AAQYADKTDQ DLNATKADVE KAKQQAHLRT HIAEDCKNDY AAQLQKYNKG
210 220 230 240 250
QSQFYFTDMP QIFNKLQDMD ERRIKKMAQG YILFADTERH VMPIIGKCLE
260 270 280 290 300
GMTRAGTNVN ARNDSMVLIE QHKSGFERPG DLDFEDYSQG INRASSDSSL
310 320 330 340 350
GTPKGPLELL GKNKNKTFRL FNKKSKFTPE KPVDTEGFTH LPPEQRRKRL
360 370 380 390 400
QQKIDDMSKE LQKEMDQSEA LGKMKDVYEK NPQMGDPASL APQIGQTAQN
410 420 430 440 450
MDRLRGELNK YESWLAEAGG RGDSIRYSTH SINNNGAHNP NSHDGSCTLF
460 470 480 490 500
SPGALSDETD PSQAIYTEFD DEFEEEELAT PIGQCTALYN FPGSSEGTIS
510 520 530 540
MQEGEVLAVV EEDKGDGWTR VRRNNGDEGY IPTSYATITL NK
Length:542
Mass (Da):62,195
Last modified:December 7, 2004 - v1
Checksum:i6BF6D6EDE2279409
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085435 mRNA. Translation: AAH85435.1.
RefSeqiNP_001007404.1. NM_001007403.1.
UniGeneiDr.36299.

Genome annotation databases

GeneIDi492762.
KEGGidre:492762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085435 mRNA. Translation: AAH85435.1 .
RefSeqi NP_001007404.1. NM_001007403.1.
UniGenei Dr.36299.

3D structure databases

ProteinModelPortali Q5U3Q6.
SMRi Q5U3Q6. Positions 10-288, 484-539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000040854.

Proteomic databases

PRIDEi Q5U3Q6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 492762.
KEGGi dre:492762.

Organism-specific databases

CTDi 492762.
ZFINi ZDB-GENE-041114-105. trip10a.

Phylogenomic databases

eggNOGi NOG323796.
HOGENOMi HOG000231767.
HOVERGENi HBG002489.
InParanoidi Q5U3Q6.
KOi K07196.
PhylomeDBi Q5U3Q6.

Miscellaneous databases

NextBioi 20865259.
PROi Q5U3Q6.

Family and domain databases

InterProi IPR028498. CIP4.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR12602:SF7. PTHR12602:SF7. 1 hit.
Pfami PF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiCIP4_DANRE
AccessioniPrimary (citable) accession number: Q5U3Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3