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Protein

Cdc42-interacting protein 4 homolog

Gene

trip10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei166Mediates end-to-end attachment of dimersBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEndocytosis
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42-interacting protein 4 homolog
Alternative name(s):
Thyroid receptor-interacting protein 10 homolog
Gene namesi
Name:trip10
Synonyms:cip4
ORF Names:zgc:101777
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041114-105 trip10a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002614421 – 542Cdc42-interacting protein 4 homologAdd BLAST542

Proteomic databases

PRIDEiQ5U3Q6

Interactioni

Subunit structurei

Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5U3Q6
SMRiQ5U3Q6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 264F-BARPROSITE-ProRule annotationAdd BLAST264
Domaini340 – 417REM-1PROSITE-ProRule annotationAdd BLAST78
Domaini480 – 541SH3PROSITE-ProRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili67 – 259By similarityAdd BLAST193
Coiled coili335 – 423By similarityAdd BLAST89

Domaini

The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).By similarity

Sequence similaritiesi

Belongs to the FNBP1 family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

HOGENOMiHOG000231767
HOVERGENiHBG002489
InParanoidiQ5U3Q6
KOiK07196
PhylomeDBiQ5U3Q6

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR028498 CIP4
IPR031160 F_BAR
IPR001060 FCH_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR43990:SF2 PTHR43990:SF2, 2 hits
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS51860 REM_1, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U3Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGTELWDQ YDILDKHTQS GLDLVDKYMK FVKERTDIEQ NYAKQLRNLT
60 70 80 90 100
KKYSPKRGSK EEQECRFSNH QAFLDILNEM NDYAGQRELI AENMMINICV
110 120 130 140 150
ELNKYLQELK QERKMHLSEA KKSQQSLEAM YKQLDNSKKR FEREWREAEK
160 170 180 190 200
AAQYADKTDQ DLNATKADVE KAKQQAHLRT HIAEDCKNDY AAQLQKYNKG
210 220 230 240 250
QSQFYFTDMP QIFNKLQDMD ERRIKKMAQG YILFADTERH VMPIIGKCLE
260 270 280 290 300
GMTRAGTNVN ARNDSMVLIE QHKSGFERPG DLDFEDYSQG INRASSDSSL
310 320 330 340 350
GTPKGPLELL GKNKNKTFRL FNKKSKFTPE KPVDTEGFTH LPPEQRRKRL
360 370 380 390 400
QQKIDDMSKE LQKEMDQSEA LGKMKDVYEK NPQMGDPASL APQIGQTAQN
410 420 430 440 450
MDRLRGELNK YESWLAEAGG RGDSIRYSTH SINNNGAHNP NSHDGSCTLF
460 470 480 490 500
SPGALSDETD PSQAIYTEFD DEFEEEELAT PIGQCTALYN FPGSSEGTIS
510 520 530 540
MQEGEVLAVV EEDKGDGWTR VRRNNGDEGY IPTSYATITL NK
Length:542
Mass (Da):62,195
Last modified:December 7, 2004 - v1
Checksum:i6BF6D6EDE2279409
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085435 mRNA Translation: AAH85435.1
RefSeqiNP_001007404.1, NM_001007403.1
UniGeneiDr.36299

Genome annotation databases

GeneIDi492762
KEGGidre:492762

Similar proteinsi

Entry informationi

Entry nameiCIP4_DANRE
AccessioniPrimary (citable) accession number: Q5U3Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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