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Q5U3Q6

- CIP4_DANRE

UniProt

Q5U3Q6 - CIP4_DANRE

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Protein

Cdc42-interacting protein 4 homolog

Gene
trip10, cip4, zgc:101777
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661Mediates end-to-end attachment of dimers By similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
  2. endocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42-interacting protein 4 homolog
Alternative name(s):
Thyroid receptor-interacting protein 10 homolog
Gene namesi
Name:trip10
Synonyms:cip4
ORF Names:zgc:101777
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041114-105. trip10a.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cytoplasmcell cortex By similarity. Lysosome By similarity. Cell membrane By similarity

GO - Cellular componenti

  1. cell cortex Source: UniProtKB-SubCell
  2. cytoskeleton Source: UniProtKB-SubCell
  3. lysosome Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Cdc42-interacting protein 4 homologPRO_0000261442Add
BLAST

Proteomic databases

PRIDEiQ5U3Q6.

Interactioni

Subunit structurei

Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures By similarity.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000040854.

Structurei

3D structure databases

ProteinModelPortaliQ5U3Q6.
SMRiQ5U3Q6. Positions 10-288, 484-539.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6565FCHAdd
BLAST
Repeati352 – 42372REMAdd
BLAST
Domaini480 – 54162SH3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 288288F-BAR domain By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili67 – 259193 By similarityAdd
BLAST
Coiled coili335 – 42389 By similarityAdd
BLAST

Domaini

The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation By similarity.

Sequence similaritiesi

Belongs to the FNBP1 family.
Contains 1 FCH domain.
Contains 1 REM (Hr1) repeat.
Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG323796.
HOGENOMiHOG000231767.
HOVERGENiHBG002489.
KOiK07196.
PhylomeDBiQ5U3Q6.

Family and domain databases

InterProiIPR028498. CIP4.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR12602:SF7. PTHR12602:SF7. 1 hit.
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U3Q6-1 [UniParc]FASTAAdd to Basket

« Hide

MDWGTELWDQ YDILDKHTQS GLDLVDKYMK FVKERTDIEQ NYAKQLRNLT    50
KKYSPKRGSK EEQECRFSNH QAFLDILNEM NDYAGQRELI AENMMINICV 100
ELNKYLQELK QERKMHLSEA KKSQQSLEAM YKQLDNSKKR FEREWREAEK 150
AAQYADKTDQ DLNATKADVE KAKQQAHLRT HIAEDCKNDY AAQLQKYNKG 200
QSQFYFTDMP QIFNKLQDMD ERRIKKMAQG YILFADTERH VMPIIGKCLE 250
GMTRAGTNVN ARNDSMVLIE QHKSGFERPG DLDFEDYSQG INRASSDSSL 300
GTPKGPLELL GKNKNKTFRL FNKKSKFTPE KPVDTEGFTH LPPEQRRKRL 350
QQKIDDMSKE LQKEMDQSEA LGKMKDVYEK NPQMGDPASL APQIGQTAQN 400
MDRLRGELNK YESWLAEAGG RGDSIRYSTH SINNNGAHNP NSHDGSCTLF 450
SPGALSDETD PSQAIYTEFD DEFEEEELAT PIGQCTALYN FPGSSEGTIS 500
MQEGEVLAVV EEDKGDGWTR VRRNNGDEGY IPTSYATITL NK 542
Length:542
Mass (Da):62,195
Last modified:December 7, 2004 - v1
Checksum:i6BF6D6EDE2279409
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085435 mRNA. Translation: AAH85435.1.
RefSeqiNP_001007404.1. NM_001007403.1.
UniGeneiDr.36299.

Genome annotation databases

GeneIDi492762.
KEGGidre:492762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085435 mRNA. Translation: AAH85435.1 .
RefSeqi NP_001007404.1. NM_001007403.1.
UniGenei Dr.36299.

3D structure databases

ProteinModelPortali Q5U3Q6.
SMRi Q5U3Q6. Positions 10-288, 484-539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000040854.

Proteomic databases

PRIDEi Q5U3Q6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 492762.
KEGGi dre:492762.

Organism-specific databases

CTDi 492762.
ZFINi ZDB-GENE-041114-105. trip10a.

Phylogenomic databases

eggNOGi NOG323796.
HOGENOMi HOG000231767.
HOVERGENi HBG002489.
KOi K07196.
PhylomeDBi Q5U3Q6.

Miscellaneous databases

NextBioi 20865259.
PROi Q5U3Q6.

Family and domain databases

InterProi IPR028498. CIP4.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR12602:SF7. PTHR12602:SF7. 1 hit.
Pfami PF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiCIP4_DANRE
AccessioniPrimary (citable) accession number: Q5U3Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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