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Q5U3Q6 (CIP4_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cdc42-interacting protein 4 homolog
Alternative name(s):
Thyroid receptor-interacting protein 10 homolog
Gene names
Name:trip10
Synonyms:cip4
ORF Names:zgc:101777
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis By similarity.

Subunit structure

Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity. Cytoplasmcell cortex By similarity. Lysosome By similarity. Cell membrane By similarity.

Domain

The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation By similarity.

Sequence similarities

Belongs to the FNBP1 family.

Contains 1 FCH domain.

Contains 1 REM (Hr1) repeat.

Contains 1 SH3 domain.

Ontologies

Keywords
   Biological processEndocytosis
   Cellular componentCell membrane
Cytoplasm
Cytoskeleton
Lysosome
Membrane
   DomainCoiled coil
SH3 domain
   LigandLipid-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin cytoskeleton organization

Inferred from electronic annotation. Source: InterPro

endocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell cortex

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

lysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542Cdc42-interacting protein 4 homolog
PRO_0000261442

Regions

Domain1 – 6565FCH
Repeat352 – 42372REM
Domain480 – 54162SH3
Region1 – 288288F-BAR domain By similarity
Coiled coil67 – 259193 By similarity
Coiled coil335 – 42389 By similarity

Sites

Site1661Mediates end-to-end attachment of dimers By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5U3Q6 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 6BF6D6EDE2279409

FASTA54262,195
        10         20         30         40         50         60 
MDWGTELWDQ YDILDKHTQS GLDLVDKYMK FVKERTDIEQ NYAKQLRNLT KKYSPKRGSK 

        70         80         90        100        110        120 
EEQECRFSNH QAFLDILNEM NDYAGQRELI AENMMINICV ELNKYLQELK QERKMHLSEA 

       130        140        150        160        170        180 
KKSQQSLEAM YKQLDNSKKR FEREWREAEK AAQYADKTDQ DLNATKADVE KAKQQAHLRT 

       190        200        210        220        230        240 
HIAEDCKNDY AAQLQKYNKG QSQFYFTDMP QIFNKLQDMD ERRIKKMAQG YILFADTERH 

       250        260        270        280        290        300 
VMPIIGKCLE GMTRAGTNVN ARNDSMVLIE QHKSGFERPG DLDFEDYSQG INRASSDSSL 

       310        320        330        340        350        360 
GTPKGPLELL GKNKNKTFRL FNKKSKFTPE KPVDTEGFTH LPPEQRRKRL QQKIDDMSKE 

       370        380        390        400        410        420 
LQKEMDQSEA LGKMKDVYEK NPQMGDPASL APQIGQTAQN MDRLRGELNK YESWLAEAGG 

       430        440        450        460        470        480 
RGDSIRYSTH SINNNGAHNP NSHDGSCTLF SPGALSDETD PSQAIYTEFD DEFEEEELAT 

       490        500        510        520        530        540 
PIGQCTALYN FPGSSEGTIS MQEGEVLAVV EEDKGDGWTR VRRNNGDEGY IPTSYATITL 


NK 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC085435 mRNA. Translation: AAH85435.1.
RefSeqNP_001007404.1. NM_001007403.1.
UniGeneDr.36299.

3D structure databases

ProteinModelPortalQ5U3Q6.
SMRQ5U3Q6. Positions 10-288, 484-539.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000040854.

Proteomic databases

PRIDEQ5U3Q6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID492762.
KEGGdre:492762.

Organism-specific databases

CTD492762.
ZFINZDB-GENE-041114-105. trip10a.

Phylogenomic databases

eggNOGNOG323796.
HOGENOMHOG000231767.
HOVERGENHBG002489.
KOK07196.
PhylomeDBQ5U3Q6.

Family and domain databases

InterProIPR028498. CIP4.
IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR12602:SF7. PTHR12602:SF7. 1 hit.
PfamPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTSM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20865259.
PROQ5U3Q6.

Entry information

Entry nameCIP4_DANRE
AccessionPrimary (citable) accession number: Q5U3Q6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families