Q5U3Q6 (CIP4_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cdc42-interacting protein 4 homolog

Alternative name(s):
Thyroid receptor-interacting protein 10 homolog

Gene names

Name:	trip10
Synonyms:	cip4
ORF Names:	zgc:101777

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	542 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis By similarity.
Subunit structure	Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity. Cytoplasm › cell cortex By similarity. Lysosome By similarity. Cell membrane By similarity.
Domain	The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation By similarity.
Sequence similarities	Belongs to the FNBP1 family. Contains 1 FCH domain. Contains 1 REM (Hr1) repeat. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cell membrane Cytoplasm Cytoskeleton Lysosome Membrane
Domain	Coiled coil SH3 domain
Ligand	Lipid-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 542	542	Cdc42-interacting protein 4 homolog		PRO_0000261442
Regions
	Domain	1 – 65	65	FCH
	Repeat	352 – 423	72	REM
	Domain	480 – 541	62	SH3
	Region	1 – 288	288	F-BAR domain By similarity
	Coiled coil	67 – 259	193	By similarity
	Coiled coil	335 – 423	89	By similarity
Sites
	Site	166	1	Mediates end-to-end attachment of dimers By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5U3Q6 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 6BF6D6EDE2279409	FASTA	542	62,195
	10 20 30 40 50 60 MDWGTELWDQ YDILDKHTQS GLDLVDKYMK FVKERTDIEQ NYAKQLRNLT KKYSPKRGSK 70 80 90 100 110 120 EEQECRFSNH QAFLDILNEM NDYAGQRELI AENMMINICV ELNKYLQELK QERKMHLSEA 130 140 150 160 170 180 KKSQQSLEAM YKQLDNSKKR FEREWREAEK AAQYADKTDQ DLNATKADVE KAKQQAHLRT 190 200 210 220 230 240 HIAEDCKNDY AAQLQKYNKG QSQFYFTDMP QIFNKLQDMD ERRIKKMAQG YILFADTERH 250 260 270 280 290 300 VMPIIGKCLE GMTRAGTNVN ARNDSMVLIE QHKSGFERPG DLDFEDYSQG INRASSDSSL 310 320 330 340 350 360 GTPKGPLELL GKNKNKTFRL FNKKSKFTPE KPVDTEGFTH LPPEQRRKRL QQKIDDMSKE 370 380 390 400 410 420 LQKEMDQSEA LGKMKDVYEK NPQMGDPASL APQIGQTAQN MDRLRGELNK YESWLAEAGG 430 440 450 460 470 480 RGDSIRYSTH SINNNGAHNP NSHDGSCTLF SPGALSDETD PSQAIYTEFD DEFEEEELAT 490 500 510 520 530 540 PIGQCTALYN FPGSSEGTIS MQEGEVLAVV EEDKGDGWTR VRRNNGDEGY IPTSYATITL NK

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC085435 mRNA. Translation: AAH85435.1.
IPI	IPI00484484.
RefSeq	NP_001007404.1. NM_001007403.1.
UniGene	Dr.36299.
3D structure databases
HSSP	HSSP built from PDB template 2CT4 based on UniProtKB Q15642.
ProteinModelPortal	Q5U3Q6.
SMR	Q5U3Q6. Positions 10-288, 484-539.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000040854.
Proteomic databases
PRIDE	Q5U3Q6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	492762.
KEGG	dre:492762.
Organism-specific databases
ZFIN	ZDB-GENE-041114-105. zgc:101777.
Phylogenomic databases
eggNOG	NOG323796.
HOGENOM	HOG000231767.
HOVERGEN	HBG002489.
KO	K07196.
OrthoDB	EOG4RBQJD.
Family and domain databases
InterPro	IPR001060. FCH_dom. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00611. FCH. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
SMART	SM00055. FCH. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50133. FCH. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20865259.

Entry information

Entry name

CIP4_DANRE

Accession

Primary (citable) accession number: Q5U3Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program