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Q5U3Q6

- CIP4_DANRE

UniProt

Q5U3Q6 - CIP4_DANRE

Protein

Cdc42-interacting protein 4 homolog

Gene

trip10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei166 – 1661Mediates end-to-end attachment of dimersBy similarity

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro
    2. endocytosis Source: UniProtKB-KW

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cdc42-interacting protein 4 homolog
    Alternative name(s):
    Thyroid receptor-interacting protein 10 homolog
    Gene namesi
    Name:trip10
    Synonyms:cip4
    ORF Names:zgc:101777
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-041114-105. trip10a.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cytoplasmcell cortex By similarity. Lysosome By similarity. Cell membrane By similarity

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB-SubCell
    2. cytoskeleton Source: UniProtKB-SubCell
    3. lysosome Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Cdc42-interacting protein 4 homologPRO_0000261442Add
    BLAST

    Proteomic databases

    PRIDEiQ5U3Q6.

    Interactioni

    Subunit structurei

    Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000040854.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U3Q6.
    SMRiQ5U3Q6. Positions 10-288, 484-539.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6565FCHPROSITE-ProRule annotationAdd
    BLAST
    Repeati352 – 42372REMAdd
    BLAST
    Domaini480 – 54162SH3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 288288F-BAR domainBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili67 – 259193By similarityAdd
    BLAST
    Coiled coili335 – 42389By similarityAdd
    BLAST

    Domaini

    The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation By similarity.By similarity

    Sequence similaritiesi

    Belongs to the FNBP1 family.Curated
    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 1 REM (Hr1) repeat.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG323796.
    HOGENOMiHOG000231767.
    HOVERGENiHBG002489.
    KOiK07196.
    PhylomeDBiQ5U3Q6.

    Family and domain databases

    InterProiIPR028498. CIP4.
    IPR001060. FCH_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR12602:SF7. PTHR12602:SF7. 1 hit.
    PfamiPF00611. FCH. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00055. FCH. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50133. FCH. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U3Q6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDWGTELWDQ YDILDKHTQS GLDLVDKYMK FVKERTDIEQ NYAKQLRNLT    50
    KKYSPKRGSK EEQECRFSNH QAFLDILNEM NDYAGQRELI AENMMINICV 100
    ELNKYLQELK QERKMHLSEA KKSQQSLEAM YKQLDNSKKR FEREWREAEK 150
    AAQYADKTDQ DLNATKADVE KAKQQAHLRT HIAEDCKNDY AAQLQKYNKG 200
    QSQFYFTDMP QIFNKLQDMD ERRIKKMAQG YILFADTERH VMPIIGKCLE 250
    GMTRAGTNVN ARNDSMVLIE QHKSGFERPG DLDFEDYSQG INRASSDSSL 300
    GTPKGPLELL GKNKNKTFRL FNKKSKFTPE KPVDTEGFTH LPPEQRRKRL 350
    QQKIDDMSKE LQKEMDQSEA LGKMKDVYEK NPQMGDPASL APQIGQTAQN 400
    MDRLRGELNK YESWLAEAGG RGDSIRYSTH SINNNGAHNP NSHDGSCTLF 450
    SPGALSDETD PSQAIYTEFD DEFEEEELAT PIGQCTALYN FPGSSEGTIS 500
    MQEGEVLAVV EEDKGDGWTR VRRNNGDEGY IPTSYATITL NK 542
    Length:542
    Mass (Da):62,195
    Last modified:December 7, 2004 - v1
    Checksum:i6BF6D6EDE2279409
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085435 mRNA. Translation: AAH85435.1.
    RefSeqiNP_001007404.1. NM_001007403.1.
    UniGeneiDr.36299.

    Genome annotation databases

    GeneIDi492762.
    KEGGidre:492762.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085435 mRNA. Translation: AAH85435.1 .
    RefSeqi NP_001007404.1. NM_001007403.1.
    UniGenei Dr.36299.

    3D structure databases

    ProteinModelPortali Q5U3Q6.
    SMRi Q5U3Q6. Positions 10-288, 484-539.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000040854.

    Proteomic databases

    PRIDEi Q5U3Q6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 492762.
    KEGGi dre:492762.

    Organism-specific databases

    CTDi 492762.
    ZFINi ZDB-GENE-041114-105. trip10a.

    Phylogenomic databases

    eggNOGi NOG323796.
    HOGENOMi HOG000231767.
    HOVERGENi HBG002489.
    KOi K07196.
    PhylomeDBi Q5U3Q6.

    Miscellaneous databases

    NextBioi 20865259.
    PROi Q5U3Q6.

    Family and domain databases

    InterProi IPR028498. CIP4.
    IPR001060. FCH_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR12602:SF7. PTHR12602:SF7. 1 hit.
    Pfami PF00611. FCH. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00055. FCH. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50133. FCH. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiCIP4_DANRE
    AccessioniPrimary (citable) accession number: Q5U3Q6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3