Q5U3N5 (PPTC7_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase PTC7 homolog
EC=3.1.3.16

Gene names

Name:	pptc7
ORF Names:	zgc:101865

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Magnesium or manganese Potential.
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Protein phosphatase PTC7 homolog		PRO_0000328747
Regions
	Domain	31 – 290	260	PP2C-like
Sites
	Metal binding	71	1	Manganese 1 By similarity
	Metal binding	71	1	Manganese 2 By similarity
	Metal binding	72	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	216	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5U3N5 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: CFBE68867FF6E238	FASTA	297	32,343
	10 20 30 40 50 60 MLSVLSYGRL VARAVIGGLS QTDSRDYSLV SASFGFGKDF RKGILKKGMC YGDDACFIAR 70 80 90 100 110 120 HRSADVLGVA DGVGGWRDYG VDPSQFSGTL MRTCERLVKE GRFVPSNPVG ILTTSYYELL 130 140 150 160 170 180 QNKVPLLGSS TACIVVLDRQ SHRLHTANLG DSGFLVVRGG EVVHRSDEQQ HYFNTPFQLS 190 200 210 220 230 240 IAPPEAEGSV LSDSPDAADS SSFDVQLGDI ILTATDGLFD NMPDYMILQE LKKLKNTNYE 250 260 270 280 290 STQQTAKSIA EQAHVLAYDP NYMSPFAQFA CDNGLNVRGG KPDDITVLLS IVAEYTD

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Larva.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC085459 mRNA. Translation: AAH85459.1.
IPI	IPI00506180.
RefSeq	NP_001007379.1. NM_001007378.1.
UniGene	Dr.37361.
3D structure databases
ProteinModelPortal	Q5U3N5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	492506.
KEGG	dre:492506.
Organism-specific databases
CTD	492506.
ZFIN	ZDB-GENE-041114-74. pptc7a.
Phylogenomic databases
eggNOG	COG0631.
HOGENOM	HOG000239282.
HOVERGEN	HBG060636.
InParanoid	Q5U3N5.
OrthoDB	EOG41RPVT.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. [Graphical view]
Pfam	PF07228. SpoIIE. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
ProtoNet	Search...
Other
NextBio	20865065.

Entry information

Entry name

PPTC7_DANRE

Accession

Primary (citable) accession number: Q5U3N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	December 7, 2004
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program