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Protein

Protein phosphatase PTC7 homolog

Gene

pptc7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+Curated, Mn2+Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi71 – 711Manganese 1By similarity
Metal bindingi71 – 711Manganese 2By similarity
Metal bindingi72 – 721Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi216 – 2161Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PTC7 homolog (EC:3.1.3.16)
Gene namesi
Name:pptc7
ORF Names:zgc:101865
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041114-74. pptc7a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Protein phosphatase PTC7 homologPRO_0000328747Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5U3N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 290260PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000239282.
HOVERGENiHBG060636.
InParanoidiQ5U3N5.
KOiK17508.
PhylomeDBiQ5U3N5.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U3N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSVLSYGRL VARAVIGGLS QTDSRDYSLV SASFGFGKDF RKGILKKGMC
60 70 80 90 100
YGDDACFIAR HRSADVLGVA DGVGGWRDYG VDPSQFSGTL MRTCERLVKE
110 120 130 140 150
GRFVPSNPVG ILTTSYYELL QNKVPLLGSS TACIVVLDRQ SHRLHTANLG
160 170 180 190 200
DSGFLVVRGG EVVHRSDEQQ HYFNTPFQLS IAPPEAEGSV LSDSPDAADS
210 220 230 240 250
SSFDVQLGDI ILTATDGLFD NMPDYMILQE LKKLKNTNYE STQQTAKSIA
260 270 280 290
EQAHVLAYDP NYMSPFAQFA CDNGLNVRGG KPDDITVLLS IVAEYTD
Length:297
Mass (Da):32,343
Last modified:December 7, 2004 - v1
Checksum:iCFBE68867FF6E238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085459 mRNA. Translation: AAH85459.1.
RefSeqiNP_001007379.1. NM_001007378.1.
UniGeneiDr.37361.

Genome annotation databases

GeneIDi492506.
KEGGidre:492506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085459 mRNA. Translation: AAH85459.1.
RefSeqiNP_001007379.1. NM_001007378.1.
UniGeneiDr.37361.

3D structure databases

ProteinModelPortaliQ5U3N5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi492506.
KEGGidre:492506.

Organism-specific databases

CTDi492506.
ZFINiZDB-GENE-041114-74. pptc7a.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000239282.
HOVERGENiHBG060636.
InParanoidiQ5U3N5.
KOiK17508.
PhylomeDBiQ5U3N5.

Miscellaneous databases

NextBioi20865065.
PROiQ5U3N5.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Larva.

Entry informationi

Entry nameiPPTC7_DANRE
AccessioniPrimary (citable) accession number: Q5U3N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 7, 2004
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.