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Protein

Rab-like protein 6

Gene

Rabl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 578GTPSequence analysis
Nucleotide bindingi100 – 1045GTPSequence analysis
Nucleotide bindingi177 – 1793GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-like protein 6
Alternative name(s):
GTP-binding protein Parf
Rab-like protein 1
Short name:
RBEL1
Gene namesi
Name:Rabl6
Synonyms:Parf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442633. Rabl6.

Subcellular locationi

  • Nucleus Curated
  • Cytoplasm By similarity

  • Note: Predominantly cytoplasmic.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Rab-like protein 6PRO_0000274224Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei436 – 4361PhosphoserineCombined sources
Modified residuei438 – 4381PhosphoserineCombined sources
Modified residuei480 – 4801PhosphoserineCombined sources
Modified residuei482 – 4821PhosphoserineCombined sources
Modified residuei483 – 4831PhosphoserineCombined sources
Modified residuei594 – 5941PhosphoserineCombined sources
Modified residuei597 – 5971PhosphothreonineCombined sources
Modified residuei637 – 6371PhosphoserineCombined sources
Modified residuei638 – 6381PhosphoserineCombined sources
Modified residuei644 – 6441PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5U3K5.
MaxQBiQ5U3K5.
PaxDbiQ5U3K5.
PeptideAtlasiQ5U3K5.
PRIDEiQ5U3K5.

PTM databases

iPTMnetiQ5U3K5.
PhosphoSiteiQ5U3K5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015087.
CleanExiMM_B230208H17RIK.
GenevisibleiQ5U3K5. MM.

Interactioni

Protein-protein interaction databases

BioGridi230648. 1 interaction.
STRINGi10090.ENSMUSP00000058746.

Structurei

3D structure databases

ProteinModelPortaliQ5U3K5.
SMRiQ5U3K5. Positions 45-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 279241Small GTPase-likeAdd
BLAST
Regioni652 – 69039Interaction with CDKN2ABy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
GeneTreeiENSGT00390000016002.
HOVERGENiHBG080325.
InParanoidiQ5U3K5.
OMAiATQMLSF.
OrthoDBiEOG091G05OK.
PhylomeDBiQ5U3K5.
TreeFamiTF313974.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF08477. Roc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U3K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSALKKLVG SEQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG
60 70 80 90 100
DRNTGKTALW HRLQGKKFVE EYIPTQEIQV TSIHWNYKTT DDVVKVEVWD
110 120 130 140 150
VVDKGKCKKR GDGLKTENDP QEAESELALD AEFLDVYKNC NGVVMMFDIT
160 170 180 190 200
KQWTFNYVLR ELPKVPTHVP VCVLGNYRDM GEHRVILPDD VRDFIEHLDR
210 220 230 240 250
PPGSSYFRYA ESSMKNSFGL KYLHKFFNIP FLQLQRETLL RQLETNQLDI
260 270 280 290 300
DATLEELSVQ QETEDQNYSI FLEMMEARSR GHASPLAANG QSPSSGSQSP
310 320 330 340 350
VVPPSAVSTG SSSPSTPQPA PQLSLGVSST CPSAPSPVPS LEAMPSSVHS
360 370 380 390 400
SAPAPTPAPA PAPAQRRSII SRLFGTSPAA EVTPSPPEPA PALEAPARVQ
410 420 430 440 450
NVEDFVPEDG LDRSFLEDTS VPKDKKVGAK GPQQDSDSDD GEALGGNPMV
460 470 480 490 500
AGFQDDVDIE DQTHGKSLLP SDPMPSKNIS LSSEEEAEGL AGHPRVAPQQ
510 520 530 540 550
CSEPETKWSS TKVSHPQKKR APTRGTPPWS DGLTTDDSER PQEGKDKQVS
560 570 580 590 600
SESDPEGPIA AQMLSFVMDD PDFESDESDT QRRMGRFPVR EDLSDVTDED
610 620 630 640 650
TGPAQPPPPS KLPGAFRLKN DSDLFGLGLE EMGPKESSDE DRDSKLPSKE
660 670 680 690 700
KKKKKKKSKE EEEKTTKKKS KHKKSKDKEE GKEDRKKKRK PPRSKEQKAA
710 720
DELEAFLGGG APGSRHPGGG DYEEL
Length:725
Mass (Da):79,831
Last modified:September 19, 2006 - v2
Checksum:iB538A8420DC04964
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti520 – 5201R → G in BAE42583 (PubMed:16141072).Curated
Sequence conflicti670 – 6701S → K in AAH58585 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045520 mRNA. Translation: BAC32404.1.
AK081440 mRNA. Translation: BAC38220.1.
AK171643 mRNA. Translation: BAE42583.1.
AK162461 mRNA. Translation: BAE36932.1.
AL732590 Genomic DNA. Translation: CAM25173.1.
BC023692 mRNA. Translation: AAH23692.1.
BC058585 mRNA. Translation: AAH58585.1.
BC085507 mRNA. Translation: AAH85507.2.
CCDSiCCDS38076.1.
RefSeqiNP_001019787.2. NM_001024616.1.
UniGeneiMm.29600.
Mm.443064.

Genome annotation databases

EnsembliENSMUST00000058137; ENSMUSP00000058746; ENSMUSG00000015087.
GeneIDi227624.
KEGGimmu:227624.
UCSCiuc008isr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045520 mRNA. Translation: BAC32404.1.
AK081440 mRNA. Translation: BAC38220.1.
AK171643 mRNA. Translation: BAE42583.1.
AK162461 mRNA. Translation: BAE36932.1.
AL732590 Genomic DNA. Translation: CAM25173.1.
BC023692 mRNA. Translation: AAH23692.1.
BC058585 mRNA. Translation: AAH58585.1.
BC085507 mRNA. Translation: AAH85507.2.
CCDSiCCDS38076.1.
RefSeqiNP_001019787.2. NM_001024616.1.
UniGeneiMm.29600.
Mm.443064.

3D structure databases

ProteinModelPortaliQ5U3K5.
SMRiQ5U3K5. Positions 45-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230648. 1 interaction.
STRINGi10090.ENSMUSP00000058746.

PTM databases

iPTMnetiQ5U3K5.
PhosphoSiteiQ5U3K5.

Proteomic databases

EPDiQ5U3K5.
MaxQBiQ5U3K5.
PaxDbiQ5U3K5.
PeptideAtlasiQ5U3K5.
PRIDEiQ5U3K5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058137; ENSMUSP00000058746; ENSMUSG00000015087.
GeneIDi227624.
KEGGimmu:227624.
UCSCiuc008isr.1. mouse.

Organism-specific databases

CTDi55684.
MGIiMGI:2442633. Rabl6.

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
GeneTreeiENSGT00390000016002.
HOVERGENiHBG080325.
InParanoidiQ5U3K5.
OMAiATQMLSF.
OrthoDBiEOG091G05OK.
PhylomeDBiQ5U3K5.
TreeFamiTF313974.

Miscellaneous databases

PROiQ5U3K5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015087.
CleanExiMM_B230208H17RIK.
GenevisibleiQ5U3K5. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF08477. Roc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRABL6_MOUSE
AccessioniPrimary (citable) accession number: Q5U3K5
Secondary accession number(s): A2AJB0
, Q3TAT5, Q3TRU4, Q6PDP8, Q8BFS4, Q8CGJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: September 19, 2006
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.