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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

haao

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (kmo), Kynurenine 3-monooxygenase (kmo), Kynurenine 3-monooxygenase (kmo)
  2. Kynureninase (kynu)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (haao), 3-hydroxyanthranilate 3,4-dioxygenase (haao), 3-hydroxyanthranilate 3,4-dioxygenase (haao)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46DioxygenUniRule annotation1
Metal bindingi50Iron; catalyticUniRule annotation1
Metal bindingi56Iron; catalyticUniRule annotation1
Binding sitei56SubstrateUniRule annotation1
Metal bindingi94Iron; catalyticUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Binding sitei108SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
Name:haao
ORF Names:zgc:103585
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041114-89 haao

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002454661 – 2873-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST287

Proteomic databases

PaxDbiQ5U3F8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi7955.ENSDARP00000091014

Structurei

3D structure databases

ProteinModelPortaliQ5U3F8
SMRiQ5U3F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 163Domain A (catalytic)UniRule annotationAdd BLAST163
Regioni164 – 180LinkerUniRule annotationAdd BLAST17
Regioni181 – 287Domain BUniRule annotationAdd BLAST107

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3995 Eukaryota
ENOG4111GH8 LUCA
HOGENOMiHOG000218448
HOVERGENiHBG000018
InParanoidiQ5U3F8
KOiK00452
PhylomeDBiQ5U3F8

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00825 3_HAO, 1 hit
InterProiView protein in InterPro
IPR010329 3hydroanth_dOase
IPR016700 3hydroanth_dOase_met
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR15497 PTHR15497, 2 hits
PfamiView protein in Pfam
PF06052 3-HAO, 1 hit
PIRSFiPIRSF017681 3hydroanth_dOase_animal, 1 hit
SUPFAMiSSF51182 SSF51182, 2 hits
TIGRFAMsiTIGR03037 anthran_nbaC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U3F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNQSLHVNI DKWIAENETS FLPPVCNKLM FFYQLNIMYV GGPNVRKDYH
60 70 80 90 100
IEEGEELFYQ VRGDMVLKVI ENGKHKDVHI REGEMFLLPA RIPHSPQRQA
110 120 130 140 150
NTVGLVIERR RLSKETDGLR YFVANSTEVL FERWFYCENL GTQLVPIIKE
160 170 180 190 200
FMDSKENETG KPDPANPIKP APYPLNTMNV MTPFSFREWV EKQKPVLASG
210 220 230 240 250
CPVDMFGEQF ETETLLFGSG TSANKRRTDG WIWQLEGLSN VFMNGKEYSL
260 270 280
TAGDCLLIFG ETEYKWQRSQ DCVALYVAQD PDRKRPY
Length:287
Mass (Da):33,239
Last modified:December 7, 2004 - v1
Checksum:iA5A2B050B823F038
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085560 mRNA Translation: AAH85560.1
RefSeqiNP_001007391.1, NM_001007390.1
UniGeneiDr.37102

Genome annotation databases

GeneIDi492518
KEGGidre:492518

Similar proteinsi

Entry informationi

Entry namei3HAO_DANRE
AccessioniPrimary (citable) accession number: Q5U3F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 7, 2004
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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