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Q5U3F8

- 3HAO_DANRE

UniProt

Q5U3F8 - 3HAO_DANRE

Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

haao

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

    Catalytic activityi

    3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

    Cofactori

    Fe2+ ion.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461DioxygenUniRule annotation
    Metal bindingi50 – 501Iron; catalyticUniRule annotation
    Metal bindingi56 – 561Iron; catalyticUniRule annotation
    Binding sitei56 – 561SubstrateUniRule annotation
    Metal bindingi94 – 941Iron; catalyticUniRule annotation
    Binding sitei98 – 981SubstrateUniRule annotation
    Binding sitei108 – 1081SubstrateUniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
    2. ferrous iron binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    4. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00330.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
    Alternative name(s):
    3-hydroxyanthranilate oxygenaseUniRule annotation
    Short name:
    3-HAOUniRule annotation
    3-hydroxyanthranilic acid dioxygenaseUniRule annotation
    Short name:
    HADUniRule annotation
    Gene namesi
    Name:haao
    ORF Names:zgc:103585
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-041114-89. haao.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2872873-hydroxyanthranilate 3,4-dioxygenasePRO_0000245466Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000091014.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U3F8.
    SMRiQ5U3F8. Positions 6-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 163163Domain A (catalytic)UniRule annotationAdd
    BLAST
    Regioni164 – 18017LinkerUniRule annotationAdd
    BLAST
    Regioni181 – 287107Domain BUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the 3-HAO family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG77058.
    HOGENOMiHOG000218448.
    HOVERGENiHBG000018.
    KOiK00452.
    PhylomeDBiQ5U3F8.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00825. 3_HAO.
    InterProiIPR010329. 3hydroanth_dOase.
    IPR016700. 3hydroanth_dOase_met.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR15497. PTHR15497. 1 hit.
    PfamiPF06052. 3-HAO. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
    SUPFAMiSSF51182. SSF51182. 2 hits.
    TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5U3F8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNQSLHVNI DKWIAENETS FLPPVCNKLM FFYQLNIMYV GGPNVRKDYH    50
    IEEGEELFYQ VRGDMVLKVI ENGKHKDVHI REGEMFLLPA RIPHSPQRQA 100
    NTVGLVIERR RLSKETDGLR YFVANSTEVL FERWFYCENL GTQLVPIIKE 150
    FMDSKENETG KPDPANPIKP APYPLNTMNV MTPFSFREWV EKQKPVLASG 200
    CPVDMFGEQF ETETLLFGSG TSANKRRTDG WIWQLEGLSN VFMNGKEYSL 250
    TAGDCLLIFG ETEYKWQRSQ DCVALYVAQD PDRKRPY 287
    Length:287
    Mass (Da):33,239
    Last modified:December 7, 2004 - v1
    Checksum:iA5A2B050B823F038
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085560 mRNA. Translation: AAH85560.1.
    RefSeqiNP_001007391.1. NM_001007390.1.
    UniGeneiDr.37102.

    Genome annotation databases

    GeneIDi492518.
    KEGGidre:492518.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085560 mRNA. Translation: AAH85560.1 .
    RefSeqi NP_001007391.1. NM_001007390.1.
    UniGenei Dr.37102.

    3D structure databases

    ProteinModelPortali Q5U3F8.
    SMRi Q5U3F8. Positions 6-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000091014.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 492518.
    KEGGi dre:492518.

    Organism-specific databases

    CTDi 23498.
    ZFINi ZDB-GENE-041114-89. haao.

    Phylogenomic databases

    eggNOGi NOG77058.
    HOGENOMi HOG000218448.
    HOVERGENi HBG000018.
    KOi K00452.
    PhylomeDBi Q5U3F8.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00330 .

    Miscellaneous databases

    NextBioi 20865078.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00825. 3_HAO.
    InterProi IPR010329. 3hydroanth_dOase.
    IPR016700. 3hydroanth_dOase_met.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR15497. PTHR15497. 1 hit.
    Pfami PF06052. 3-HAO. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
    SUPFAMi SSF51182. SSF51182. 2 hits.
    TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry namei3HAO_DANRE
    AccessioniPrimary (citable) accession number: Q5U3F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3