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Reviewed, UniProtKB/Swiss-Prot Q5U3F8 (3HAO_DANRE)

Last modified February 9, 2010. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
      Short name=HAD
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO
Gene names
Name: haao
ORF Names: zgc:103585
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.

Cofactor

Fe2+ ion By similarity.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

pyridine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2872873-hydroxyanthranilate 3,4-dioxygenase
PRO_0000245466

Sites

Metal binding501Iron; catalytic By similarity
Metal binding561Iron; catalytic By similarity
Metal binding941Iron; catalytic By similarity
Binding site461Dioxygen By similarity
Binding site561Substrate By similarity
Binding site981Substrate By similarity
Binding site1081Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5U3F8-1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: A5A2B050B823F038

FASTA28733,239
        10         20         30         40         50         60 
MTNQSLHVNI DKWIAENETS FLPPVCNKLM FFYQLNIMYV GGPNVRKDYH IEEGEELFYQ 

        70         80         90        100        110        120 
VRGDMVLKVI ENGKHKDVHI REGEMFLLPA RIPHSPQRQA NTVGLVIERR RLSKETDGLR 

       130        140        150        160        170        180 
YFVANSTEVL FERWFYCENL GTQLVPIIKE FMDSKENETG KPDPANPIKP APYPLNTMNV 

       190        200        210        220        230        240 
MTPFSFREWV EKQKPVLASG CPVDMFGEQF ETETLLFGSG TSANKRRTDG WIWQLEGLSN 

       250        260        270        280 
VFMNGKEYSL TAGDCLLIFG ETEYKWQRSQ DCVALYVAQD PDRKRPY 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC085560 mRNA. Translation: AAH85560.1.
IPIIPI00509740.
RefSeqNP_001007391.1.
UniGeneDr.37102

3D structure databases

SMRQ5U3F8. Positions 6-287.
ModBaseSearch...

Genome annotation databases

EnsemblENSDART00000100241; ENSDARP00000091014; ENSDARG00000076487; Danio rerio. [Genome view]
GeneID492518.
KEGGdre:492518.

Organism-specific databases

ZFINZDB-GENE-041114-89. zgc:103585.

Phylogenomic databases

HOVERGENQ5U3F8.
PhylomeDBQ5U3F8.

Enzyme and pathway databases

BRENDA1.13.11.6. 96826.

Gene expression databases

BgeeQ5U3F8.

Family and domain databases

InterProIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR011051. Cupin_RmlC_type.
[Graphical view]
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_DANRE
AccessionPrimary (citable) accession number: Q5U3F8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 7, 2004
Last modified: February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents