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Q5U395

- CNEPA_DANRE

UniProt

Q5U395 - CNEPA_DANRE

Protein

CTD nuclear envelope phosphatase 1A

Gene

ctdnep1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. nuclear envelope organization Source: UniProtKB
    2. positive regulation of triglyceride biosynthetic process Source: UniProtKB
    3. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    ReactomeiREACT_226028. Depolymerisation of the Nuclear Lamina.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CTD nuclear envelope phosphatase 1A (EC:3.1.3.16)
    Alternative name(s):
    Serine/threonine-protein phosphatase dullard-A
    Gene namesi
    Name:ctdnep1a
    Synonyms:dullard
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 5

    Organism-specific databases

    ZFINiZDB-GENE-041114-177. ctdnep1a.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. Nem1-Spo7 phosphatase complex Source: UniProtKB
    5. nuclear envelope Source: UniProtKB
    6. nuclear membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245CTD nuclear envelope phosphatase 1APRO_0000297970Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ5U395.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U395.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 225168FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the dullard family.Curated
    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5190.
    GeneTreeiENSGT00550000075053.
    HOVERGENiHBG098153.
    InParanoidiQ5U395.
    KOiK17617.
    OMAiLLGIRTF.
    OrthoDBiEOG7MKW6W.
    PhylomeDBiQ5U395.
    TreeFamiTF313962.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U395-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKTRQCLLG IRTFLGVTSR IWSFFLYILR KHLRTIIQYQ TVRYDILPLS    50
    PISRNRLNAV KRKILVLDLD ETLIHSHHDG VLRPTVRPGT PPDFILKVVI 100
    DKHPVRFFVH KRPHVDFFLE VVSQWYELVV FTASMEIYGS AVADKLDNNR 150
    GILKRRYYRQ HCTLDLGSYI KDLSVVHSDL SSIVILDNSP GAYRSHPDNA 200
    IPIKSWFSDP SDTALLNLLP MLDALRFTSD VRSVLSRNLH QHRLW 245
    Length:245
    Mass (Da):28,507
    Last modified:December 7, 2004 - v1
    Checksum:iE98068959A2CCE2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085649 mRNA. Translation: AAH85649.1.
    RefSeqiNP_001007310.1. NM_001007309.1.
    XP_005165199.1. XM_005165142.1.
    UniGeneiDr.78429.

    Genome annotation databases

    EnsembliENSDART00000029889; ENSDARP00000036009; ENSDARG00000016519.
    GeneIDi492343.
    KEGGidre:492343.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085649 mRNA. Translation: AAH85649.1 .
    RefSeqi NP_001007310.1. NM_001007309.1.
    XP_005165199.1. XM_005165142.1.
    UniGenei Dr.78429.

    3D structure databases

    ProteinModelPortali Q5U395.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000029889 ; ENSDARP00000036009 ; ENSDARG00000016519 .
    GeneIDi 492343.
    KEGGi dre:492343.

    Organism-specific databases

    CTDi 492343.
    ZFINi ZDB-GENE-041114-177. ctdnep1a.

    Phylogenomic databases

    eggNOGi COG5190.
    GeneTreei ENSGT00550000075053.
    HOVERGENi HBG098153.
    InParanoidi Q5U395.
    KOi K17617.
    OMAi LLGIRTF.
    OrthoDBi EOG7MKW6W.
    PhylomeDBi Q5U395.
    TreeFami TF313962.

    Enzyme and pathway databases

    Reactomei REACT_226028. Depolymerisation of the Nuclear Lamina.

    Miscellaneous databases

    NextBioi 20864912.

    Gene expression databases

    Bgeei Q5U395.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiCNEPA_DANRE
    AccessioniPrimary (citable) accession number: Q5U395
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3