Q5U395 (CNEPA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CTD nuclear envelope phosphatase 1A
EC=3.1.3.16

Alternative name(s):
Serine/threonine-protein phosphatase dullard-A

Gene names

Name:	ctdnep1a
Synonyms:	dullard

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Serine/threonine phosphatase which may be required for proper nuclear membrane morphology. May antagonize BMP signaling By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Nucleus membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the dullard family. Contains 1 FCP1 homology domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Nucleus
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nuclear envelope organization Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein serine/threonine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	CTD nuclear envelope phosphatase 1A		PRO_0000297970
Regions
	Transmembrane	7 – 29	23	Helical; Potential
	Domain	58 – 225	168	FCP1 homology

Sequences

	Sequence		Length	Mass (Da)
	Q5U395 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: E98068959A2CCE2A	FASTA	245	28,507
	10 20 30 40 50 60 MLKTRQCLLG IRTFLGVTSR IWSFFLYILR KHLRTIIQYQ TVRYDILPLS PISRNRLNAV 70 80 90 100 110 120 KRKILVLDLD ETLIHSHHDG VLRPTVRPGT PPDFILKVVI DKHPVRFFVH KRPHVDFFLE 130 140 150 160 170 180 VVSQWYELVV FTASMEIYGS AVADKLDNNR GILKRRYYRQ HCTLDLGSYI KDLSVVHSDL 190 200 210 220 230 240 SSIVILDNSP GAYRSHPDNA IPIKSWFSDP SDTALLNLLP MLDALRFTSD VRSVLSRNLH QHRLW

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC085649 mRNA. Translation: AAH85649.1.
IPI	IPI00512264.
RefSeq	NP_001007310.1. NM_001007309.1.
UniGene	Dr.78429.
3D structure databases
HSSP	HSSP built from PDB template 1TA0 based on UniProtKB Q9GZU7.
ProteinModelPortal	Q5U395.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5U395.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000029889; ENSDARP00000036009; ENSDARG00000016519.
GeneID	492343.
KEGG	dre:492343.
NMPDR	fig|7955.3.peg.18884.
Organism-specific databases
CTD	492343.
ZFIN	ZDB-GENE-041114-177. dullard.
Phylogenomic databases
eggNOG	fiNOG13204.
GeneTree	ENSGT00550000075053.
HOGENOM	HBG603876.
HOVERGEN	HBG098153.
InParanoid	Q5U395.
OMA	SRNRLGQ.
OrthoDB	EOG4J6RRP.
PhylomeDB	Q5U395.
Gene expression databases
ArrayExpress	Q5U395.
Bgee	Q5U395.
Family and domain databases
InterPro	IPR011948. Dullard_phosphatase. IPR023214. HAD-like_dom. IPR004274. NIF. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 1 hit.
KO	K01090.
Pfam	PF03031. NIF. 1 hit. [Graphical view]
SMART	SM00577. CPDc. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR02251. HIF-SF_euk. 1 hit.
PROSITE	PS50969. FCP1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CNEPA_DANRE

Accession

Primary (citable) accession number: Q5U395

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	December 7, 2004
Last modified:	November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program