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Q5U395 (CNEPA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CTD nuclear envelope phosphatase 1A

EC=3.1.3.16
Alternative name(s):
Serine/threonine-protein phosphatase dullard-A
Gene names
Name:ctdnep1a
Synonyms:dullard
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Nucleus membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the dullard family.

Contains 1 FCP1 homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245CTD nuclear envelope phosphatase 1A
PRO_0000297970

Regions

Transmembrane7 – 2923Helical; Potential
Domain58 – 225168FCP1 homology

Sequences

Sequence LengthMass (Da)Tools
Q5U395 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: E98068959A2CCE2A

FASTA24528,507
        10         20         30         40         50         60 
MLKTRQCLLG IRTFLGVTSR IWSFFLYILR KHLRTIIQYQ TVRYDILPLS PISRNRLNAV 

        70         80         90        100        110        120 
KRKILVLDLD ETLIHSHHDG VLRPTVRPGT PPDFILKVVI DKHPVRFFVH KRPHVDFFLE 

       130        140        150        160        170        180 
VVSQWYELVV FTASMEIYGS AVADKLDNNR GILKRRYYRQ HCTLDLGSYI KDLSVVHSDL 

       190        200        210        220        230        240 
SSIVILDNSP GAYRSHPDNA IPIKSWFSDP SDTALLNLLP MLDALRFTSD VRSVLSRNLH 


QHRLW 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC085649 mRNA. Translation: AAH85649.1.
RefSeqNP_001007310.1. NM_001007309.1.
XP_005165199.1. XM_005165142.1.
UniGeneDr.78429.

3D structure databases

ProteinModelPortalQ5U395.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000029889; ENSDARP00000036009; ENSDARG00000016519.
GeneID492343.
KEGGdre:492343.

Organism-specific databases

CTD492343.
ZFINZDB-GENE-041114-177. ctdnep1a.

Phylogenomic databases

eggNOGCOG5190.
GeneTreeENSGT00550000075053.
HOVERGENHBG098153.
InParanoidQ5U395.
KOK17617.
OMALLGIRTF.
OrthoDBEOG7MKW6W.
PhylomeDBQ5U395.
TreeFamTF313962.

Gene expression databases

BgeeQ5U395.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamPF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02251. HIF-SF_euk. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20864912.

Entry information

Entry nameCNEPA_DANRE
AccessionPrimary (citable) accession number: Q5U395
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families