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Q5U395

- CNEPA_DANRE

UniProt

Q5U395 - CNEPA_DANRE

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Protein
CTD nuclear envelope phosphatase 1A
Gene
ctdnep1a, dullard
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. nuclear envelope organization Source: UniProtKB
  2. positive regulation of triglyceride biosynthetic process Source: UniProtKB
  3. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_226028. Depolymerisation of the Nuclear Lamina.

Names & Taxonomyi

Protein namesi
Recommended name:
CTD nuclear envelope phosphatase 1A (EC:3.1.3.16)
Alternative name(s):
Serine/threonine-protein phosphatase dullard-A
Gene namesi
Name:ctdnep1a
Synonyms:dullard
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-041114-177. ctdnep1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Nem1-Spo7 phosphatase complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. endoplasmic reticulum membrane Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
  5. nuclear envelope Source: UniProtKB
  6. nuclear membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245CTD nuclear envelope phosphatase 1A
PRO_0000297970Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5U395.

Structurei

3D structure databases

ProteinModelPortaliQ5U395.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 225168FCP1 homology
Add
BLAST

Sequence similaritiesi

Belongs to the dullard family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5190.
GeneTreeiENSGT00550000075053.
HOVERGENiHBG098153.
InParanoidiQ5U395.
KOiK17617.
OMAiLLGIRTF.
OrthoDBiEOG7MKW6W.
PhylomeDBiQ5U395.
TreeFamiTF313962.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U395-1 [UniParc]FASTAAdd to Basket

« Hide

MLKTRQCLLG IRTFLGVTSR IWSFFLYILR KHLRTIIQYQ TVRYDILPLS    50
PISRNRLNAV KRKILVLDLD ETLIHSHHDG VLRPTVRPGT PPDFILKVVI 100
DKHPVRFFVH KRPHVDFFLE VVSQWYELVV FTASMEIYGS AVADKLDNNR 150
GILKRRYYRQ HCTLDLGSYI KDLSVVHSDL SSIVILDNSP GAYRSHPDNA 200
IPIKSWFSDP SDTALLNLLP MLDALRFTSD VRSVLSRNLH QHRLW 245
Length:245
Mass (Da):28,507
Last modified:December 7, 2004 - v1
Checksum:iE98068959A2CCE2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085649 mRNA. Translation: AAH85649.1.
RefSeqiNP_001007310.1. NM_001007309.1.
XP_005165199.1. XM_005165142.1.
UniGeneiDr.78429.

Genome annotation databases

EnsembliENSDART00000029889; ENSDARP00000036009; ENSDARG00000016519.
GeneIDi492343.
KEGGidre:492343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085649 mRNA. Translation: AAH85649.1 .
RefSeqi NP_001007310.1. NM_001007309.1.
XP_005165199.1. XM_005165142.1.
UniGenei Dr.78429.

3D structure databases

ProteinModelPortali Q5U395.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000029889 ; ENSDARP00000036009 ; ENSDARG00000016519 .
GeneIDi 492343.
KEGGi dre:492343.

Organism-specific databases

CTDi 492343.
ZFINi ZDB-GENE-041114-177. ctdnep1a.

Phylogenomic databases

eggNOGi COG5190.
GeneTreei ENSGT00550000075053.
HOVERGENi HBG098153.
InParanoidi Q5U395.
KOi K17617.
OMAi LLGIRTF.
OrthoDBi EOG7MKW6W.
PhylomeDBi Q5U395.
TreeFami TF313962.

Enzyme and pathway databases

Reactomei REACT_226028. Depolymerisation of the Nuclear Lamina.

Miscellaneous databases

NextBioi 20864912.

Gene expression databases

Bgeei Q5U395.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCNEPA_DANRE
AccessioniPrimary (citable) accession number: Q5U395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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