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Protein

CTD nuclear envelope phosphatase 1A

Gene

ctdnep1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_291942. Depolymerisation of the Nuclear Lamina.

Names & Taxonomyi

Protein namesi
Recommended name:
CTD nuclear envelope phosphatase 1A (EC:3.1.3.16)
Alternative name(s):
Serine/threonine-protein phosphatase dullard-A
Gene namesi
Name:ctdnep1a
Synonyms:dullard
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-041114-177. ctdnep1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245CTD nuclear envelope phosphatase 1APRO_0000297970Add
BLAST

Expressioni

Gene expression databases

BgeeiQ5U395.

Structurei

3D structure databases

ProteinModelPortaliQ5U395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 225168FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the dullard family.Curated
Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5190.
GeneTreeiENSGT00550000075053.
HOVERGENiHBG098153.
InParanoidiQ5U395.
KOiK17617.
OMAiRYFRQHC.
OrthoDBiEOG7MKW6W.
PhylomeDBiQ5U395.
TreeFamiTF313962.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTRQCLLG IRTFLGVTSR IWSFFLYILR KHLRTIIQYQ TVRYDILPLS
60 70 80 90 100
PISRNRLNAV KRKILVLDLD ETLIHSHHDG VLRPTVRPGT PPDFILKVVI
110 120 130 140 150
DKHPVRFFVH KRPHVDFFLE VVSQWYELVV FTASMEIYGS AVADKLDNNR
160 170 180 190 200
GILKRRYYRQ HCTLDLGSYI KDLSVVHSDL SSIVILDNSP GAYRSHPDNA
210 220 230 240
IPIKSWFSDP SDTALLNLLP MLDALRFTSD VRSVLSRNLH QHRLW
Length:245
Mass (Da):28,507
Last modified:December 7, 2004 - v1
Checksum:iE98068959A2CCE2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085649 mRNA. Translation: AAH85649.1.
RefSeqiNP_001007310.1. NM_001007309.1.
XP_005165199.1. XM_005165142.2.
UniGeneiDr.78429.

Genome annotation databases

EnsembliENSDART00000029889; ENSDARP00000036009; ENSDARG00000016519.
GeneIDi492343.
KEGGidre:492343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085649 mRNA. Translation: AAH85649.1.
RefSeqiNP_001007310.1. NM_001007309.1.
XP_005165199.1. XM_005165142.2.
UniGeneiDr.78429.

3D structure databases

ProteinModelPortaliQ5U395.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000029889; ENSDARP00000036009; ENSDARG00000016519.
GeneIDi492343.
KEGGidre:492343.

Organism-specific databases

CTDi492343.
ZFINiZDB-GENE-041114-177. ctdnep1a.

Phylogenomic databases

eggNOGiCOG5190.
GeneTreeiENSGT00550000075053.
HOVERGENiHBG098153.
InParanoidiQ5U395.
KOiK17617.
OMAiRYFRQHC.
OrthoDBiEOG7MKW6W.
PhylomeDBiQ5U395.
TreeFamiTF313962.

Enzyme and pathway databases

ReactomeiREACT_291942. Depolymerisation of the Nuclear Lamina.

Miscellaneous databases

NextBioi20864912.
PROiQ5U395.

Gene expression databases

BgeeiQ5U395.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCNEPA_DANRE
AccessioniPrimary (citable) accession number: Q5U395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 7, 2004
Last modified: April 29, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.