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Protein

Tubulin-specific chaperone E

Gene

tbce

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin-folding protein; involved in the second step of the tubulin folding pathway.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone E
Alternative name(s):
Tubulin-folding cofactor E
Gene namesi
Name:tbce
ORF Names:zgc:123075
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 11

Organism-specific databases

ZFINiZDB-GENE-051030-120. tbce.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835421 – 521Tubulin-specific chaperone EAdd BLAST521

Proteomic databases

PaxDbiQ5U378.
PRIDEiQ5U378.

Expressioni

Gene expression databases

BgeeiENSDARG00000044634.
ExpressionAtlasiQ5U378. differential.

Interactioni

Subunit structurei

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000065584.

Structurei

3D structure databases

ProteinModelPortaliQ5U378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 68CAP-GlyPROSITE-ProRule annotationAdd BLAST45
Repeati147 – 168LRR 1Add BLAST22
Repeati173 – 194LRR 2Add BLAST22
Repeati199 – 220LRR 3Add BLAST22
Repeati224 – 245LRR 4Add BLAST22
Repeati247 – 268LRR 5Add BLAST22
Repeati271 – 292LRR 6Add BLAST22
Repeati301 – 322LRR 7Add BLAST22
Domaini335 – 377LRRCTAdd BLAST43

Sequence similaritiesi

Belongs to the TBCE family.Curated
Contains 1 CAP-Gly domain.PROSITE-ProRule annotation
Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3207. Eukaryota.
ENOG410YS3M. LUCA.
GeneTreeiENSGT00530000063405.
HOGENOMiHOG000154513.
HOVERGENiHBG084170.
InParanoidiQ5U378.
OMAiVSLRNCA.
OrthoDBiEOG091G07V5.
PhylomeDBiQ5U378.
TreeFamiTF313455.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000938. CAP-Gly_domain.
IPR032675. L_dom-like.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF01302. CAP_GLY. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
SM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLDEAVGRR VCCDGERGTV RYVGPVPPTA GVWLGVEWDH PERGKHDGSH
60 70 80 90 100
DGVRYFTCRH PTGGSFVRPQ KASFGVDYVT ALKQRYEVEI EEVTAEEMKI
110 120 130 140 150
SSKTVVMVGF ENVKKKQSVK NLTEVGLRRC EVSAPGPENE IRNTTPFVQS
160 170 180 190 200
LDLSGNLLSS WEVLAAITEQ LDSLQELHLS HNRLSISSAP SSLSSAFSHL
210 220 230 240 250
RVLSINSCAL TWTQVLHCAP MWQQVEELYL ADNNITELLR PEHVLQALTV
260 270 280 290 300
LDLSNNQIAQ ETVLEISHLP RLERLNLSST SLSEIKFSDV PAGKKTTLFP
310 320 330 340 350
ALKELLLDDN NISEWRVVNE LEKLPSLVYL SCRRNPLLHK EKNLETARQI
360 370 380 390 400
MIARLGQLEL LDMRQILSDE RRGAELDYCK MFGSAWLRAG GHREAEKNNP
410 420 430 440 450
NTDFMTEHPR YLTLIQKYGA PDEGELREQK PFALKNQLLT ITFLCPEDLE
460 470 480 490 500
RKPIEKKLPG SMIVQKVKGL LHRLLKLPGV ELKLTYTCAK MADREIEIDN
510 520
DLKPLQFYSV EDGDKILVRW S
Length:521
Mass (Da):59,043
Last modified:February 7, 2006 - v2
Checksum:iF6533A652A98685E
GO

Sequence cautioni

The sequence AAH85669 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085669 mRNA. Translation: AAH85669.1. Different initiation.
RefSeqiNP_001035078.2. NM_001039989.2.
XP_005155982.1. XM_005155925.3.
UniGeneiDr.84734.

Genome annotation databases

EnsembliENSDART00000171837; ENSDARP00000132970; ENSDARG00000099921.
GeneIDi664760.
KEGGidre:664760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085669 mRNA. Translation: AAH85669.1. Different initiation.
RefSeqiNP_001035078.2. NM_001039989.2.
XP_005155982.1. XM_005155925.3.
UniGeneiDr.84734.

3D structure databases

ProteinModelPortaliQ5U378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000065584.

Proteomic databases

PaxDbiQ5U378.
PRIDEiQ5U378.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000171837; ENSDARP00000132970; ENSDARG00000099921.
GeneIDi664760.
KEGGidre:664760.

Organism-specific databases

CTDi6905.
ZFINiZDB-GENE-051030-120. tbce.

Phylogenomic databases

eggNOGiKOG3207. Eukaryota.
ENOG410YS3M. LUCA.
GeneTreeiENSGT00530000063405.
HOGENOMiHOG000154513.
HOVERGENiHBG084170.
InParanoidiQ5U378.
OMAiVSLRNCA.
OrthoDBiEOG091G07V5.
PhylomeDBiQ5U378.
TreeFamiTF313455.

Miscellaneous databases

PROiQ5U378.

Gene expression databases

BgeeiENSDARG00000044634.
ExpressionAtlasiQ5U378. differential.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000938. CAP-Gly_domain.
IPR032675. L_dom-like.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF01302. CAP_GLY. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
SM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBCE_DANRE
AccessioniPrimary (citable) accession number: Q5U378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: November 30, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.