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Q5U324

- Q5U324_RAT

UniProt

Q5U324 - Q5U324_RAT

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Protein
Submitted name:

Coagulation factor II (Thrombin) receptor

Gene

F2r

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. thrombin receptor activity Source: Ensembl

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. connective tissue replacement involved in inflammatory response wound healing Source: Ensembl
  3. homeostasis of number of cells within a tissue Source: Ensembl
  4. negative regulation of cell proliferation Source: Ensembl
  5. negative regulation of renin secretion into blood stream Source: Ensembl
  6. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  7. platelet activation Source: Ensembl
  8. positive regulation of blood coagulation Source: Ensembl
  9. positive regulation of cell migration Source: Ensembl
  10. positive regulation of collagen biosynthetic process Source: Ensembl
  11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  12. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  13. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  14. positive regulation of interleukin-6 secretion Source: Ensembl
  15. positive regulation of interleukin-8 secretion Source: Ensembl
  16. positive regulation of JAK-STAT cascade Source: Ensembl
  17. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  18. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  19. positive regulation of Rho protein signal transduction Source: Ensembl
  20. positive regulation of transcription, DNA-templated Source: Ensembl
  21. positive regulation of vasoconstriction Source: Ensembl
  22. regulation of interleukin-1 beta production Source: Ensembl
  23. response to lipopolysaccharide Source: Ensembl
  24. STAT protein import into nucleus Source: Ensembl
  25. tyrosine phosphorylation of STAT protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_250028. Peptide ligand-binding receptors.
REACT_262448. Thrombin signalling through proteinase activated receptors (PARs).
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Coagulation factor II (Thrombin) receptorImported
Gene namesi
Name:F2rImported
ORF Names:rCG_44761Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2586. F2r.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. platelet dense tubular network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ5U324.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOVERGENiHBG108233.
KOiK03914.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003912. Protea_act_rcpt.
IPR000935. Thrmbn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01428. PROTEASEAR.
PR00908. THROMBINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U324-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPRRLLLVA VGLSLCGPLL SSRVPMRQPE SERMYATPYA TPNPRSFFLR
60 70 80 90 100
NPSEDTFEQF PLGDEEEKNE SIPLEGRAVY LNKSRFPPMP PPPFISEDAS
110 120 130 140 150
GYLTSPWLTL FIPSVYTFVF IVSLPLNILA IAVFVFRMKV KKPAVVYMLH
160 170 180 190 200
LAMADVLFVS VLPFKISYYF SGTDWQFGSG MCRFATAAFY CNMYASIMLM
210 220 230 240 250
TVISIDRFLA VVYPIQSLSW RTLGRANFTC VVIWVMAIMG VVPLLLKEQT
260 270 280 290 300
TQVPGLNITT CHDVLNETLL HGFYSYYFSA FSAIFFLVPL IISTVCYTSI
310 320 330 340 350
IRCLSSSAVA NRSKKSRALF LSAAVFCIFI VCFGPTNVLL IVHYLLLSDS
360 370 380 390 400
PGTETAYFAY LLCVCVSSVS CCIDPLIYYY ASSECQKHLY SILCCRESSD
410 420 430
SNSCNSTGQL MPSKMDTCSS HLNNSIYKKL LA
Length:432
Mass (Da):48,343
Last modified:December 7, 2004 - v1
Checksum:i360447E604CD02CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085759 mRNA. Translation: AAH85759.1.
CH473955 Genomic DNA. Translation: EDM10103.1.
RefSeqiNP_037082.2. NM_012950.2.
UniGeneiRn.2609.

Genome annotation databases

GeneIDi25439.
KEGGirno:25439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085759 mRNA. Translation: AAH85759.1 .
CH473955 Genomic DNA. Translation: EDM10103.1 .
RefSeqi NP_037082.2. NM_012950.2.
UniGenei Rn.2609.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25439.
KEGGi rno:25439.

Organism-specific databases

CTDi 2149.
RGDi 2586. F2r.

Phylogenomic databases

HOVERGENi HBG108233.
KOi K03914.

Enzyme and pathway databases

Reactomei REACT_250028. Peptide ligand-binding receptors.
REACT_262448. Thrombin signalling through proteinase activated receptors (PARs).
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 606655.

Gene expression databases

Genevestigatori Q5U324.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003912. Protea_act_rcpt.
IPR000935. Thrmbn_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01428. PROTEASEAR.
PR00908. THROMBINR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.

Entry informationi

Entry nameiQ5U324_RAT
AccessioniPrimary (citable) accession number: Q5U324
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)