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Q5U324

- Q5U324_RAT

UniProt

Q5U324 - Q5U324_RAT

Protein
Submitted name:

Coagulation factor II (Thrombin) receptor

Gene

F2r

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. thrombin receptor activity Source: Ensembl

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. connective tissue replacement involved in inflammatory response wound healing Source: Ensembl
    3. homeostasis of number of cells within a tissue Source: Ensembl
    4. negative regulation of cell proliferation Source: Ensembl
    5. negative regulation of renin secretion into blood stream Source: Ensembl
    6. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    7. platelet activation Source: Ensembl
    8. positive regulation of blood coagulation Source: Ensembl
    9. positive regulation of cell migration Source: Ensembl
    10. positive regulation of collagen biosynthetic process Source: Ensembl
    11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    12. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    13. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    14. positive regulation of interleukin-6 secretion Source: Ensembl
    15. positive regulation of interleukin-8 secretion Source: Ensembl
    16. positive regulation of JAK-STAT cascade Source: Ensembl
    17. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    18. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    19. positive regulation of Rho protein signal transduction Source: Ensembl
    20. positive regulation of transcription, DNA-templated Source: Ensembl
    21. positive regulation of vasoconstriction Source: Ensembl
    22. regulation of interleukin-1 beta production Source: Ensembl
    23. response to lipopolysaccharide Source: Ensembl
    24. STAT protein import into nucleus Source: Ensembl
    25. tyrosine phosphorylation of STAT protein Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Coagulation factor II (Thrombin) receptorImported
    Gene namesi
    Name:F2rImported
    ORF Names:rCG_44761Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi2586. F2r.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. platelet dense tubular network Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ5U324.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG108233.
    InParanoidiQ5U324.
    KOiK03914.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003912. Protea_act_rcpt.
    IPR000935. Thrmbn_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01428. PROTEASEAR.
    PR00908. THROMBINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U324-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPRRLLLVA VGLSLCGPLL SSRVPMRQPE SERMYATPYA TPNPRSFFLR    50
    NPSEDTFEQF PLGDEEEKNE SIPLEGRAVY LNKSRFPPMP PPPFISEDAS 100
    GYLTSPWLTL FIPSVYTFVF IVSLPLNILA IAVFVFRMKV KKPAVVYMLH 150
    LAMADVLFVS VLPFKISYYF SGTDWQFGSG MCRFATAAFY CNMYASIMLM 200
    TVISIDRFLA VVYPIQSLSW RTLGRANFTC VVIWVMAIMG VVPLLLKEQT 250
    TQVPGLNITT CHDVLNETLL HGFYSYYFSA FSAIFFLVPL IISTVCYTSI 300
    IRCLSSSAVA NRSKKSRALF LSAAVFCIFI VCFGPTNVLL IVHYLLLSDS 350
    PGTETAYFAY LLCVCVSSVS CCIDPLIYYY ASSECQKHLY SILCCRESSD 400
    SNSCNSTGQL MPSKMDTCSS HLNNSIYKKL LA 432
    Length:432
    Mass (Da):48,343
    Last modified:December 7, 2004 - v1
    Checksum:i360447E604CD02CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085759 mRNA. Translation: AAH85759.1.
    CH473955 Genomic DNA. Translation: EDM10103.1.
    RefSeqiNP_037082.2. NM_012950.2.
    UniGeneiRn.2609.

    Genome annotation databases

    GeneIDi25439.
    KEGGirno:25439.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085759 mRNA. Translation: AAH85759.1 .
    CH473955 Genomic DNA. Translation: EDM10103.1 .
    RefSeqi NP_037082.2. NM_012950.2.
    UniGenei Rn.2609.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25439.
    KEGGi rno:25439.

    Organism-specific databases

    CTDi 2149.
    RGDi 2586. F2r.

    Phylogenomic databases

    HOVERGENi HBG108233.
    InParanoidi Q5U324.
    KOi K03914.

    Miscellaneous databases

    NextBioi 606655.

    Gene expression databases

    Genevestigatori Q5U324.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003912. Protea_act_rcpt.
    IPR000935. Thrmbn_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01428. PROTEASEAR.
    PR00908. THROMBINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: KidneyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.

    Entry informationi

    Entry nameiQ5U324_RAT
    AccessioniPrimary (citable) accession number: Q5U324
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 7, 2004
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)