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Protein
Submitted name:

Coagulation factor II (Thrombin) receptor

Gene

F2r

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • thrombin receptor activity Source: RGD

GO - Biological processi

  • activation of MAPKK activity Source: RGD
  • blood coagulation Source: RGD
  • establishment of synaptic specificity at neuromuscular junction Source: RGD
  • G-protein coupled receptor signaling pathway Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • positive regulation of calcium ion transport Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
  • positive regulation of smooth muscle contraction Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • protein kinase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • release of sequestered calcium ion into cytosol Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_292179. Thrombin signalling through proteinase activated receptors (PARs).
REACT_306851. Peptide ligand-binding receptors.
REACT_323052. Common Pathway of Fibrin Clot Formation.
REACT_353304. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Coagulation factor II (Thrombin) receptorImported
Gene namesi
Name:F2rImported
ORF Names:rCG_44761Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2586. F2r.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • neuromuscular junction Source: RGD
  • plasma membrane Source: RGD
  • postsynaptic membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065624.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOVERGENiHBG108233.
KOiK03914.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003912. Protea_act_rcpt.
IPR000935. Thrmbn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01428. PROTEASEAR.
PR00908. THROMBINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRRLLLVA VGLSLCGPLL SSRVPMRQPE SERMYATPYA TPNPRSFFLR
60 70 80 90 100
NPSEDTFEQF PLGDEEEKNE SIPLEGRAVY LNKSRFPPMP PPPFISEDAS
110 120 130 140 150
GYLTSPWLTL FIPSVYTFVF IVSLPLNILA IAVFVFRMKV KKPAVVYMLH
160 170 180 190 200
LAMADVLFVS VLPFKISYYF SGTDWQFGSG MCRFATAAFY CNMYASIMLM
210 220 230 240 250
TVISIDRFLA VVYPIQSLSW RTLGRANFTC VVIWVMAIMG VVPLLLKEQT
260 270 280 290 300
TQVPGLNITT CHDVLNETLL HGFYSYYFSA FSAIFFLVPL IISTVCYTSI
310 320 330 340 350
IRCLSSSAVA NRSKKSRALF LSAAVFCIFI VCFGPTNVLL IVHYLLLSDS
360 370 380 390 400
PGTETAYFAY LLCVCVSSVS CCIDPLIYYY ASSECQKHLY SILCCRESSD
410 420 430
SNSCNSTGQL MPSKMDTCSS HLNNSIYKKL LA
Length:432
Mass (Da):48,343
Last modified:December 7, 2004 - v1
Checksum:i360447E604CD02CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085759 mRNA. Translation: AAH85759.1.
CH473955 Genomic DNA. Translation: EDM10103.1.
RefSeqiNP_037082.2. NM_012950.2.
UniGeneiRn.2609.

Genome annotation databases

GeneIDi25439.
KEGGirno:25439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085759 mRNA. Translation: AAH85759.1.
CH473955 Genomic DNA. Translation: EDM10103.1.
RefSeqiNP_037082.2. NM_012950.2.
UniGeneiRn.2609.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065624.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25439.
KEGGirno:25439.

Organism-specific databases

CTDi2149.
RGDi2586. F2r.

Phylogenomic databases

HOVERGENiHBG108233.
KOiK03914.

Enzyme and pathway databases

ReactomeiREACT_292179. Thrombin signalling through proteinase activated receptors (PARs).
REACT_306851. Peptide ligand-binding receptors.
REACT_323052. Common Pathway of Fibrin Clot Formation.
REACT_353304. G alpha (q) signalling events.

Miscellaneous databases

NextBioi606655.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003912. Protea_act_rcpt.
IPR000935. Thrmbn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01428. PROTEASEAR.
PR00908. THROMBINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.

Entry informationi

Entry nameiQ5U324_RAT
AccessioniPrimary (citable) accession number: Q5U324
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: July 22, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.