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Protein

Astrocytic phosphoprotein PEA-15

Gene

Pea15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-112409. RAF-independent MAPK1/3 activation.
R-RNO-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Astrocytic phosphoprotein PEA-15
Alternative name(s):
15 kDa phosphoprotein enriched in astrocytes
Gene namesi
Name:Pea15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1306055. Pea15.

Subcellular locationi

  • Cytoplasm

  • Note: Associated with microtubules.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130Astrocytic phosphoprotein PEA-15PRO_0000252682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611PhosphoserineCombined sources
Modified residuei90 – 901PhosphoserineCombined sources
Modified residuei104 – 1041PhosphoserineCombined sources
Modified residuei116 – 1161PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U318.
PRIDEiQ5U318.

PTM databases

iPTMnetiQ5U318.
PhosphoSiteiQ5U318.

Expressioni

Gene expression databases

BgeeiENSRNOG00000046996.
GenevisibleiQ5U318. RN.

Interactioni

Subunit structurei

Binds RPS6KA3, MAPK3 and MAPK1. Interacts with CASP8 and FADD. Transient interaction with PLD1 and PLD2 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-57338N.
IntActiQ5U318. 1 interaction.
STRINGi10116.ENSRNOP00000064962.

Structurei

3D structure databases

ProteinModelPortaliQ5U318.
SMRiQ5U318. Positions 1-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8179DEDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 10710Microtubule-bindingSequence analysis
Regioni122 – 1298Microtubule-bindingSequence analysis

Sequence similaritiesi

Contains 1 DED (death effector) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00390000000230.
HOGENOMiHOG000049048.
HOVERGENiHBG053557.
InParanoidiQ5U318.
OMAiSPVMAEY.
OrthoDBiEOG091G0TNX.
PhylomeDBiQ5U318.
TreeFamiTF332405.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED_dom.
IPR029546. PEA15.
[Graphical view]
PANTHERiPTHR15094:SF0. PTHR15094:SF0. 1 hit.
PfamiPF01335. DED. 1 hit.
[Graphical view]
SMARTiSM00031. DED. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50168. DED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE
60 70 80 90 100
SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT
110 120 130
RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA
Length:130
Mass (Da):15,040
Last modified:December 7, 2004 - v1
Checksum:i8D0F93A40B299FB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243949 mRNA. Translation: CAB51573.1.
BC085766 mRNA. Translation: AAH85766.1.
RefSeqiNP_001013249.1. NM_001013231.1.
UniGeneiRn.155339.

Genome annotation databases

EnsembliENSRNOT00000070812; ENSRNOP00000064962; ENSRNOG00000046996.
GeneIDi364052.
KEGGirno:364052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243949 mRNA. Translation: CAB51573.1.
BC085766 mRNA. Translation: AAH85766.1.
RefSeqiNP_001013249.1. NM_001013231.1.
UniGeneiRn.155339.

3D structure databases

ProteinModelPortaliQ5U318.
SMRiQ5U318. Positions 1-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-57338N.
IntActiQ5U318. 1 interaction.
STRINGi10116.ENSRNOP00000064962.

PTM databases

iPTMnetiQ5U318.
PhosphoSiteiQ5U318.

Proteomic databases

PaxDbiQ5U318.
PRIDEiQ5U318.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000070812; ENSRNOP00000064962; ENSRNOG00000046996.
GeneIDi364052.
KEGGirno:364052.

Organism-specific databases

CTDi8682.
RGDi1306055. Pea15.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00390000000230.
HOGENOMiHOG000049048.
HOVERGENiHBG053557.
InParanoidiQ5U318.
OMAiSPVMAEY.
OrthoDBiEOG091G0TNX.
PhylomeDBiQ5U318.
TreeFamiTF332405.

Enzyme and pathway databases

ReactomeiR-RNO-112409. RAF-independent MAPK1/3 activation.
R-RNO-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

PROiQ5U318.

Gene expression databases

BgeeiENSRNOG00000046996.
GenevisibleiQ5U318. RN.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED_dom.
IPR029546. PEA15.
[Graphical view]
PANTHERiPTHR15094:SF0. PTHR15094:SF0. 1 hit.
PfamiPF01335. DED. 1 hit.
[Graphical view]
SMARTiSM00031. DED. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50168. DED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEA15_RAT
AccessioniPrimary (citable) accession number: Q5U318
Secondary accession number(s): Q78ZC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.