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Protein

Astrocytic phosphoprotein PEA-15

Gene

Pea15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis, Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-112409 RAF-independent MAPK1/3 activation
R-RNO-5673001 RAF/MAP kinase cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Astrocytic phosphoprotein PEA-15
Alternative name(s):
15 kDa phosphoprotein enriched in astrocytes
Gene namesi
Name:Pea15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1306055 Pea15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002526821 – 130Astrocytic phosphoprotein PEA-15Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U318
PRIDEiQ5U318

PTM databases

iPTMnetiQ5U318
PhosphoSitePlusiQ5U318

Expressioni

Gene expression databases

BgeeiENSRNOG00000046996
GenevisibleiQ5U318 RN

Interactioni

Subunit structurei

Binds RPS6KA3, MAPK3 and MAPK1. Interacts with CASP8 and FADD. Transient interaction with PLD1 and PLD2 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-57338N
IntActiQ5U318, 2 interactors
MINTiQ5U318
STRINGi10116.ENSRNOP00000064962

Structurei

3D structure databases

ProteinModelPortaliQ5U318
SMRiQ5U318
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81DEDPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 107Microtubule-bindingSequence analysis10
Regioni122 – 129Microtubule-bindingSequence analysis8

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00390000000230
HOGENOMiHOG000049048
HOVERGENiHBG053557
InParanoidiQ5U318
OMAiSPVMAEY
OrthoDBiEOG091G0TNX
PhylomeDBiQ5U318
TreeFamiTF332405

Family and domain databases

CDDicd08338 DED_PEA15, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
IPR029546 PEA15
PANTHERiPTHR15094 PTHR15094, 1 hit
PfamiView protein in Pfam
PF01335 DED, 1 hit
SMARTiView protein in SMART
SM00031 DED, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50168 DED, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE
60 70 80 90 100
SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT
110 120 130
RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA
Length:130
Mass (Da):15,040
Last modified:December 7, 2004 - v1
Checksum:i8D0F93A40B299FB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243949 mRNA Translation: CAB51573.1
BC085766 mRNA Translation: AAH85766.1
RefSeqiNP_001013249.1, NM_001013231.1
UniGeneiRn.155339

Genome annotation databases

EnsembliENSRNOT00000070812; ENSRNOP00000064962; ENSRNOG00000046996
GeneIDi364052
KEGGirno:364052

Similar proteinsi

Entry informationi

Entry nameiPEA15_RAT
AccessioniPrimary (citable) accession number: Q5U318
Secondary accession number(s): Q78ZC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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