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Protein

Pre-mRNA 3'-end-processing factor FIP1

Gene

Fip1l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-109688. Cleavage of Growing Transcript in the Termination Region.
R-RNO-72163. mRNA Splicing - Major Pathway.
R-RNO-72187. mRNA 3'-end processing.
R-RNO-77595. Processing of Intronless Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA 3'-end-processing factor FIP1
Alternative name(s):
FIP1-like 1 protein
Gene namesi
Name:Fip1l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1309336. Fip1l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Pre-mRNA 3'-end-processing factor FIP1PRO_0000215040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841PhosphoserineBy similarity
Modified residuei86 – 861PhosphoserineBy similarity
Modified residuei88 – 881PhosphoserineCombined sources
Modified residuei366 – 3661PhosphotyrosineBy similarity
Modified residuei434 – 4341PhosphoserineCombined sources
Modified residuei436 – 4361PhosphothreonineCombined sources
Modified residuei438 – 4381PhosphoserineBy similarity
Modified residuei442 – 4421PhosphoserineCombined sources
Modified residuei496 – 4961PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U317.
PRIDEiQ5U317.

PTM databases

iPTMnetiQ5U317.
PhosphoSiteiQ5U317.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002275.
ExpressionAtlasiQ5U317. baseline and differential.
GenevisibleiQ5U317. RN.

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with CPSF1, CPSF4, CSTF2 and CSTF3. Interacts with AHCYL1 (when phosphorylated); the interaction is direct and associates AHCYL1 with the CPSF complex and RNA. Interacts with PAPOLA; the interaction seems to be increased by the interaction with AHCYL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049728.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 296296Necessary for stimulating PAPOLA activityBy similarityAdd
BLAST
Regioni1 – 110110Sufficient for interaction with PAPOLABy similarityAdd
BLAST
Regioni136 – 21984Sufficient for interaction with CPSF4By similarityAdd
BLAST
Regioni383 – 536154Sufficient for interaction with CPSF1 and CSTF3By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi296 – 34651Pro-richAdd
BLAST
Compositional biasi396 – 504109Arg-richAdd
BLAST
Compositional biasi412 – 536125Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the FIP1 family.Curated

Phylogenomic databases

eggNOGiKOG1049. Eukaryota.
COG5213. LUCA.
GeneTreeiENSGT00730000111028.
HOGENOMiHOG000004854.
HOVERGENiHBG059889.
InParanoidiQ5U317.
KOiK14405.

Family and domain databases

InterProiIPR007854. Fip1.
[Graphical view]
PfamiPF05182. Fip1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGEVERLV ELSGGTGGDE EEEWLYGGPW DVHVHSDLAK DLDENEVERP
60 70 80 90 100
EEENASANPP SGIEEEAAEN GVAKPKVTET EDDSDSDSDD DEDDVHVTIG
110 120 130 140 150
DIKTGAPQYG SYGTAPVNLN IKAGGRVYGN TGTKVKGVDL DAPGSINGVP
160 170 180 190 200
LLEVDLDSFE DKPWRKPGAD LSDYFNYGFN EDTWKAYCEK QKRIRMGLEV
210 220 230 240 250
IPVTSTTNKI TVQQGRTGNS EKEAALPSTK AEFTSPPSLF KTGLPPSRRL
260 270 280 290 300
PGAIDVIGQT ITISRVEGRR RANENSNIQV LSDRSATEVD NNFSKPPPFF
310 320 330 340 350
PPGAPPTHLP PPPFLPPPPT VSTAPPLIPP PGFPPPPGAP PPSLIPTIES
360 370 380 390 400
GHSSGYDSRS ARAFPYGNVA FPHLTSSAPS WPSLVDTTKQ WDYYARREKD
410 420 430 440 450
RDRDRERDRD RERERDRDRE RERTRERERE RDHSPTPSVF NSDEERYRYR
460 470 480 490 500
EYAERGYERH RASREKEERH RERRHREKEE TRHKSSRSNS RRRHESEEGD
510 520 530
SHRRHKHKKS KRSKEGKEAG SEPVPEQEST EAAPAE
Length:536
Mass (Da):60,188
Last modified:December 7, 2004 - v1
Checksum:iB608BE48974164C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085767 mRNA. Translation: AAH85767.1.
RefSeqiNP_001008296.1. NM_001008295.1.
UniGeneiRn.138993.

Genome annotation databases

EnsembliENSRNOT00000045050; ENSRNOP00000049728; ENSRNOG00000002275.
GeneIDi289582.
KEGGirno:289582.
UCSCiRGD:1309336. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085767 mRNA. Translation: AAH85767.1.
RefSeqiNP_001008296.1. NM_001008295.1.
UniGeneiRn.138993.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049728.

PTM databases

iPTMnetiQ5U317.
PhosphoSiteiQ5U317.

Proteomic databases

PaxDbiQ5U317.
PRIDEiQ5U317.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045050; ENSRNOP00000049728; ENSRNOG00000002275.
GeneIDi289582.
KEGGirno:289582.
UCSCiRGD:1309336. rat.

Organism-specific databases

CTDi81608.
RGDi1309336. Fip1l1.

Phylogenomic databases

eggNOGiKOG1049. Eukaryota.
COG5213. LUCA.
GeneTreeiENSGT00730000111028.
HOGENOMiHOG000004854.
HOVERGENiHBG059889.
InParanoidiQ5U317.
KOiK14405.

Enzyme and pathway databases

ReactomeiR-RNO-109688. Cleavage of Growing Transcript in the Termination Region.
R-RNO-72163. mRNA Splicing - Major Pathway.
R-RNO-72187. mRNA 3'-end processing.
R-RNO-77595. Processing of Intronless Pre-mRNAs.

Miscellaneous databases

PROiQ5U317.

Gene expression databases

BgeeiENSRNOG00000002275.
ExpressionAtlasiQ5U317. baseline and differential.
GenevisibleiQ5U317. RN.

Family and domain databases

InterProiIPR007854. Fip1.
[Graphical view]
PfamiPF05182. Fip1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFIP1_RAT
AccessioniPrimary (citable) accession number: Q5U317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.