Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pre-mRNA 3'-end-processing factor FIP1

Gene

Fip1l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Enzyme and pathway databases

ReactomeiR-RNO-109688. Cleavage of Growing Transcript in the Termination Region.
R-RNO-72163. mRNA Splicing - Major Pathway.
R-RNO-72187. mRNA 3'-end processing.
R-RNO-77595. Processing of Intronless Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA 3'-end-processing factor FIP1
Alternative name(s):
FIP1-like 1 protein
Gene namesi
Name:Fip1l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1309336. Fip1l1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150401 – 536Pre-mRNA 3'-end-processing factor FIP1Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphoserineBy similarity1
Modified residuei86PhosphoserineBy similarity1
Modified residuei88PhosphoserineCombined sources1
Modified residuei366PhosphotyrosineBy similarity1
Modified residuei434PhosphoserineCombined sources1
Modified residuei436PhosphothreonineCombined sources1
Modified residuei438PhosphoserineBy similarity1
Modified residuei442PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U317.
PRIDEiQ5U317.

PTM databases

iPTMnetiQ5U317.
PhosphoSitePlusiQ5U317.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002275.
ExpressionAtlasiQ5U317. baseline and differential.
GenevisibleiQ5U317. RN.

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with CPSF1, CPSF4, CSTF2 and CSTF3. Interacts with AHCYL1 (when phosphorylated); the interaction is direct and associates AHCYL1 with the CPSF complex and RNA. Interacts with PAPOLA; the interaction seems to be increased by the interaction with AHCYL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049728.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 296Necessary for stimulating PAPOLA activityBy similarityAdd BLAST296
Regioni1 – 110Sufficient for interaction with PAPOLABy similarityAdd BLAST110
Regioni136 – 219Sufficient for interaction with CPSF4By similarityAdd BLAST84
Regioni383 – 536Sufficient for interaction with CPSF1 and CSTF3By similarityAdd BLAST154

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi296 – 346Pro-richAdd BLAST51
Compositional biasi396 – 504Arg-richAdd BLAST109
Compositional biasi412 – 536Glu-richAdd BLAST125

Sequence similaritiesi

Belongs to the FIP1 family.Curated

Phylogenomic databases

eggNOGiKOG1049. Eukaryota.
COG5213. LUCA.
GeneTreeiENSGT00730000111028.
HOGENOMiHOG000004854.
HOVERGENiHBG059889.
InParanoidiQ5U317.
KOiK14405.

Family and domain databases

InterProiView protein in InterPro
IPR007854. Fip1.
PfamiView protein in Pfam
PF05182. Fip1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGEVERLV ELSGGTGGDE EEEWLYGGPW DVHVHSDLAK DLDENEVERP
60 70 80 90 100
EEENASANPP SGIEEEAAEN GVAKPKVTET EDDSDSDSDD DEDDVHVTIG
110 120 130 140 150
DIKTGAPQYG SYGTAPVNLN IKAGGRVYGN TGTKVKGVDL DAPGSINGVP
160 170 180 190 200
LLEVDLDSFE DKPWRKPGAD LSDYFNYGFN EDTWKAYCEK QKRIRMGLEV
210 220 230 240 250
IPVTSTTNKI TVQQGRTGNS EKEAALPSTK AEFTSPPSLF KTGLPPSRRL
260 270 280 290 300
PGAIDVIGQT ITISRVEGRR RANENSNIQV LSDRSATEVD NNFSKPPPFF
310 320 330 340 350
PPGAPPTHLP PPPFLPPPPT VSTAPPLIPP PGFPPPPGAP PPSLIPTIES
360 370 380 390 400
GHSSGYDSRS ARAFPYGNVA FPHLTSSAPS WPSLVDTTKQ WDYYARREKD
410 420 430 440 450
RDRDRERDRD RERERDRDRE RERTRERERE RDHSPTPSVF NSDEERYRYR
460 470 480 490 500
EYAERGYERH RASREKEERH RERRHREKEE TRHKSSRSNS RRRHESEEGD
510 520 530
SHRRHKHKKS KRSKEGKEAG SEPVPEQEST EAAPAE
Length:536
Mass (Da):60,188
Last modified:December 7, 2004 - v1
Checksum:iB608BE48974164C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085767 mRNA. Translation: AAH85767.1.
RefSeqiNP_001008296.1. NM_001008295.1.
UniGeneiRn.138993.

Genome annotation databases

EnsembliENSRNOT00000045050; ENSRNOP00000049728; ENSRNOG00000002275.
GeneIDi289582.
KEGGirno:289582.
UCSCiRGD:1309336. rat.

Similar proteinsi

Entry informationi

Entry nameiFIP1_RAT
AccessioniPrimary (citable) accession number: Q5U317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 7, 2004
Last modified: September 27, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families