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Q5U316 (RAB35_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ras-related protein Rab-35
Gene names
Name:Rab35
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge By similarity.

Subunit structure

Interacts with DENND1A and DENND1B in a nucleotide-dependent manner. The low binding to DENND1C is nucleotide-independent. All 3 DENND1 act as GEFs for RAB35 and thus activate the protein By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Membrane › clathrin-coated pit By similarity. Cytoplasmic vesicle › clathrin-coated vesicle By similarity. Endosome By similarity. Melanosome By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Ras-related protein Rab-35
PRO_0000121247

Regions

Nucleotide binding15 – 228GTP By similarity
Nucleotide binding63 – 675GTP By similarity
Nucleotide binding120 – 1234GTP By similarity
Motif37 – 459Effector region By similarity

Amino acid modifications

Lipidation2001S-geranylgeranyl cysteine By similarity
Lipidation2011S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5U316 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 31EB15D6D42E076E

FASTA20123,025
        10         20         30         40         50         60 
MARDYDHLFK LLIIGDSGVG KSSLLLRFAD NTFSGSYITT IGVDFKIRTV EINGEKVKLQ 

        70         80         90        100        110        120 
IWDTAGQERF RTITSTYYRG THGVIVVYDV TSAESFVNVK RWLHEINQNC DDVCRILVGN 

       130        140        150        160        170        180 
KNDDPERKVV ETEDAYKFAG QMGIQLFETS AKENVNVEEM FNCITELVLR AKKDNLAKQQ 

       190        200 
QQQQNDVVKL TKNSKRKKRC C

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC085769 mRNA. Translation: AAH85769.1.
IPIIPI00371187.
RefSeqNP_001013064.1. NM_001013046.1.
UniGeneRn.18008.

3D structure databases

ProteinModelPortalQ5U316.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000029070.

PTM databases

PhosphoSiteQ5U316.

Proteomic databases

PaxDbQ5U316.
PRIDEQ5U316.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000030031; ENSRNOP00000029070; ENSRNOG00000022014.
GeneID288700.
KEGGrno:288700.
UCSCRGD:1306362. rat.

Organism-specific databases

CTD11021.
RGD1306362. Rab35.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00700000104049.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ5U316.
KOK07876.
OrthoDBEOG4QVCD5.

Gene expression databases

GenevestigatorQ5U316.
GermOnlineENSRNOG00000022014. Rattus norvegicus.

Family and domain databases

InterProIPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio628573.

Entry information

Entry nameRAB35_RAT
AccessionPrimary (citable) accession number: Q5U316
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 7, 2004
Last modified: May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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