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Q5U315

- GLD2_RAT

UniProt

Q5U315 - GLD2_RAT

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Protein
Poly(A) RNA polymerase GLD2
Gene
Papd4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation By similarity.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi213 – 2131Magnesium or manganese; catalytic By similarity
Metal bindingi215 – 2151Magnesium or manganese; catalytic By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. polynucleotide adenylyltransferase activity Source: UniProtKB

GO - Biological processi

  1. RNA polyadenylation Source: UniProtKB
  2. histone mRNA catabolic process Source: UniProtKB
  3. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) RNA polymerase GLD2 (EC:2.7.7.19)
Alternative name(s):
PAP-associated domain-containing protein 4
Gene namesi
Name:Papd4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1306438. Papd4.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Poly(A) RNA polymerase GLD2
PRO_0000341551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621Phosphoserine By similarity
Modified residuei69 – 691Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U315.

Expressioni

Gene expression databases

GenevestigatoriQ5U315.

Interactioni

Subunit structurei

Interacts with CPEB1, CPEB2, CPSF1 and PABPC1 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016135.

Structurei

3D structure databases

ProteinModelPortaliQ5U315.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini386 – 44055PAP-associated
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi76 – 9217Nuclear localization signal Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5260.
GeneTreeiENSGT00550000074490.
HOGENOMiHOG000088606.
HOVERGENiHBG097533.
InParanoidiQ5U315.
KOiK14079.
OMAiCVEFDLN.
OrthoDBiEOG7DRJ2S.
PhylomeDBiQ5U315.
TreeFamiTF315661.

Family and domain databases

InterProiIPR002058. PAP_assoc.
[Graphical view]
PfamiPF03828. PAP_assoc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U315-1 [UniParc]FASTAAdd to Basket

« Hide

MFPNSILGRP PFTPTHQQHN NFFALSPTLY SHQQLIDAQF NFQNVDLSRA    50
VSLQPLTYGT VSPIQTSTSP LFRGRKRISD EKAFRLDGKR QRFHSPHQEP 100
TIINQLVPLS GDRRYSMPPL FHTHYVPEIV RCVPPLREIP LLEPREITLP 150
EAKDKLSQQI LELFETCQQQ ASDLKKKELC RAQLQREIQL LFPQSRLFLV 200
GSSLNGFGAR SSDGDLCLVV KEEPCFFQVN QKTEARHILT LVHKHFCTRL 250
SGYIERPQLI RAKVPIVKFR DKVSCVEFDL NVNNTVGIRN TFLLRTYAYL 300
ENRVRPLVLV IKKWASHHEI NDASRGTLSS YSLVLMVLHY LQTLPEPILP 350
SLQKIYPESF STSVQLHLVH HAPCNVPPYL SKNESSLGDL LLGFLKYYAT 400
EFDWNTQMIS VREAKAIPRP DDMEWRNKYI CVEEPFDGTN TARAVHEKQK 450
FDMIKDQFLK SWQRLKNKRD LNSVLPLRAA TLKR 484
Length:484
Mass (Da):56,007
Last modified:December 7, 2004 - v1
Checksum:i149E8B0C49142A60
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085771 mRNA. Translation: AAH85771.1.
RefSeqiNP_001008373.1. NM_001008372.1.
XP_006231838.1. XM_006231776.1.
XP_006231839.1. XM_006231777.1.
UniGeneiRn.98477.

Genome annotation databases

EnsembliENSRNOT00000016135; ENSRNOP00000016135; ENSRNOG00000012099.
GeneIDi361878.
KEGGirno:361878.
UCSCiRGD:1306438. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085771 mRNA. Translation: AAH85771.1 .
RefSeqi NP_001008373.1. NM_001008372.1.
XP_006231838.1. XM_006231776.1.
XP_006231839.1. XM_006231777.1.
UniGenei Rn.98477.

3D structure databases

ProteinModelPortali Q5U315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016135.

Proteomic databases

PaxDbi Q5U315.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016135 ; ENSRNOP00000016135 ; ENSRNOG00000012099 .
GeneIDi 361878.
KEGGi rno:361878.
UCSCi RGD:1306438. rat.

Organism-specific databases

CTDi 167153.
RGDi 1306438. Papd4.

Phylogenomic databases

eggNOGi COG5260.
GeneTreei ENSGT00550000074490.
HOGENOMi HOG000088606.
HOVERGENi HBG097533.
InParanoidi Q5U315.
KOi K14079.
OMAi CVEFDLN.
OrthoDBi EOG7DRJ2S.
PhylomeDBi Q5U315.
TreeFami TF315661.

Miscellaneous databases

NextBioi 677940.
PROi Q5U315.

Gene expression databases

Genevestigatori Q5U315.

Family and domain databases

InterProi IPR002058. PAP_assoc.
[Graphical view ]
Pfami PF03828. PAP_assoc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiGLD2_RAT
AccessioniPrimary (citable) accession number: Q5U315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 7, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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