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Q5U315 (GLD2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Poly(A) RNA polymerase GLD2
EC=2.7.7.19
Alternative name(s):
PAP-associated domain-containing protein 4
Gene names
Name:Papd4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation By similarity.

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactor

Magnesium or manganese By similarity.

Subunit structure

Interacts with CPEB1, CPEB2, CPSF1 and PABPC1 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.

Contains 1 PAP-associated domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Poly(A) RNA polymerase GLD2
PRO_0000341551

Regions

Domain386 – 44055PAP-associated
Motif76 – 9217Nuclear localization signal Potential

Sites

Metal binding2131Magnesium or manganese; catalytic By similarity
Metal binding2151Magnesium or manganese; catalytic By similarity

Amino acid modifications

Modified residue621Phosphoserine By similarity
Modified residue691Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5U315 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 149E8B0C49142A60

FASTA48456,007
        10         20         30         40         50         60 
MFPNSILGRP PFTPTHQQHN NFFALSPTLY SHQQLIDAQF NFQNVDLSRA VSLQPLTYGT 

        70         80         90        100        110        120 
VSPIQTSTSP LFRGRKRISD EKAFRLDGKR QRFHSPHQEP TIINQLVPLS GDRRYSMPPL 

       130        140        150        160        170        180 
FHTHYVPEIV RCVPPLREIP LLEPREITLP EAKDKLSQQI LELFETCQQQ ASDLKKKELC 

       190        200        210        220        230        240 
RAQLQREIQL LFPQSRLFLV GSSLNGFGAR SSDGDLCLVV KEEPCFFQVN QKTEARHILT 

       250        260        270        280        290        300 
LVHKHFCTRL SGYIERPQLI RAKVPIVKFR DKVSCVEFDL NVNNTVGIRN TFLLRTYAYL 

       310        320        330        340        350        360 
ENRVRPLVLV IKKWASHHEI NDASRGTLSS YSLVLMVLHY LQTLPEPILP SLQKIYPESF 

       370        380        390        400        410        420 
STSVQLHLVH HAPCNVPPYL SKNESSLGDL LLGFLKYYAT EFDWNTQMIS VREAKAIPRP 

       430        440        450        460        470        480 
DDMEWRNKYI CVEEPFDGTN TARAVHEKQK FDMIKDQFLK SWQRLKNKRD LNSVLPLRAA 


TLKR

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC085771 mRNA. Translation: AAH85771.1.
IPIIPI00372891.
RefSeqNP_001008373.1. NM_001008372.1.
UniGeneRn.98477.

3D structure databases

ProteinModelPortalQ5U315.
ModBaseSearch...

Proteomic databases

PaxDbQ5U315.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000016135; ENSRNOP00000016135; ENSRNOG00000012099.
GeneID361878.
KEGGrno:361878.
UCSCRGD:1306438. rat.

Organism-specific databases

CTD167153.
RGD1306438. Papd4.

Phylogenomic databases

eggNOGCOG5260.
GeneTreeENSGT00550000074490.
HOGENOMHOG000088606.
HOVERGENHBG097533.
InParanoidQ5U315.
KOK14079.
OMANQKTEAR.
OrthoDBEOG4P2Q22.

Gene expression databases

GenevestigatorQ5U315.

Family and domain databases

InterProIPR002058. PAP_assoc.
[Graphical view]
PfamPF03828. PAP_assoc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio677940.

Entry information

Entry nameGLD2_RAT
AccessionPrimary (citable) accession number: Q5U315
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 7, 2004
Last modified: April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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