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Protein

Poly(A) RNA polymerase GLD2

Gene

Papd4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation (By similarity).By similarity

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi213Magnesium or manganese; catalyticBy similarity1
Metal bindingi215Magnesium or manganese; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • dark adaptation Source: RGD
  • hematopoietic progenitor cell differentiation Source: Ensembl
  • hippocampus development Source: RGD
  • histone mRNA catabolic process Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • neuron differentiation Source: RGD
  • retina development in camera-type eye Source: RGD
  • RNA polyadenylation Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processmRNA processing
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) RNA polymerase GLD2 (EC:2.7.7.19)
Alternative name(s):
PAP-associated domain-containing protein 4
Gene namesi
Name:Papd4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1306438 Papd4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415511 – 484Poly(A) RNA polymerase GLD2Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Modified residuei95PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U315

Expressioni

Gene expression databases

BgeeiENSRNOG00000012099
GenevisibleiQ5U315 RN

Interactioni

Subunit structurei

Interacts with CPEB1, CPEB2, CPSF1 and PABPC1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016135

Structurei

3D structure databases

ProteinModelPortaliQ5U315
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini386 – 440PAP-associatedAdd BLAST55

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 92Nuclear localization signalSequence analysisAdd BLAST17

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2277 Eukaryota
COG5260 LUCA
GeneTreeiENSGT00550000074490
HOGENOMiHOG000088606
HOVERGENiHBG097533
InParanoidiQ5U315
KOiK14079
OMAiWASHHEI
OrthoDBiEOG091G0BUD
PhylomeDBiQ5U315
TreeFamiTF315661

Family and domain databases

InterProiView protein in InterPro
IPR002058 PAP_assoc
PfamiView protein in Pfam
PF03828 PAP_assoc, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U315-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPNSILGRP PFTPTHQQHN NFFALSPTLY SHQQLIDAQF NFQNVDLSRA
60 70 80 90 100
VSLQPLTYGT VSPIQTSTSP LFRGRKRISD EKAFRLDGKR QRFHSPHQEP
110 120 130 140 150
TIINQLVPLS GDRRYSMPPL FHTHYVPEIV RCVPPLREIP LLEPREITLP
160 170 180 190 200
EAKDKLSQQI LELFETCQQQ ASDLKKKELC RAQLQREIQL LFPQSRLFLV
210 220 230 240 250
GSSLNGFGAR SSDGDLCLVV KEEPCFFQVN QKTEARHILT LVHKHFCTRL
260 270 280 290 300
SGYIERPQLI RAKVPIVKFR DKVSCVEFDL NVNNTVGIRN TFLLRTYAYL
310 320 330 340 350
ENRVRPLVLV IKKWASHHEI NDASRGTLSS YSLVLMVLHY LQTLPEPILP
360 370 380 390 400
SLQKIYPESF STSVQLHLVH HAPCNVPPYL SKNESSLGDL LLGFLKYYAT
410 420 430 440 450
EFDWNTQMIS VREAKAIPRP DDMEWRNKYI CVEEPFDGTN TARAVHEKQK
460 470 480
FDMIKDQFLK SWQRLKNKRD LNSVLPLRAA TLKR
Length:484
Mass (Da):56,007
Last modified:December 7, 2004 - v1
Checksum:i149E8B0C49142A60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085771 mRNA Translation: AAH85771.1
RefSeqiNP_001008373.1, NM_001008372.1
XP_008758861.1, XM_008760639.1
UniGeneiRn.98477

Genome annotation databases

EnsembliENSRNOT00000016135; ENSRNOP00000016135; ENSRNOG00000012099
GeneIDi361878
KEGGirno:361878
UCSCiRGD:1306438 rat

Entry informationi

Entry nameiGLD2_RAT
AccessioniPrimary (citable) accession number: Q5U315
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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