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Q5U315

- GLD2_RAT

UniProt

Q5U315 - GLD2_RAT

Protein

Poly(A) RNA polymerase GLD2

Gene

Papd4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation By similarity.By similarity

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi213 – 2131Magnesium or manganese; catalyticBy similarity
    Metal bindingi215 – 2151Magnesium or manganese; catalyticBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. polynucleotide adenylyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. histone mRNA catabolic process Source: UniProtKB
    2. mRNA processing Source: UniProtKB-KW
    3. RNA polyadenylation Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) RNA polymerase GLD2 (EC:2.7.7.19)
    Alternative name(s):
    PAP-associated domain-containing protein 4
    Gene namesi
    Name:Papd4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi1306438. Papd4.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Poly(A) RNA polymerase GLD2PRO_0000341551Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei62 – 621PhosphoserineBy similarity
    Modified residuei69 – 691PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5U315.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5U315.

    Interactioni

    Subunit structurei

    Interacts with CPEB1, CPEB2, CPSF1 and PABPC1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016135.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U315.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini386 – 44055PAP-associatedAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi76 – 9217Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PAP-associated domain.Curated

    Phylogenomic databases

    eggNOGiCOG5260.
    GeneTreeiENSGT00550000074490.
    HOGENOMiHOG000088606.
    HOVERGENiHBG097533.
    InParanoidiQ5U315.
    KOiK14079.
    OMAiCVEFDLN.
    OrthoDBiEOG7DRJ2S.
    PhylomeDBiQ5U315.
    TreeFamiTF315661.

    Family and domain databases

    InterProiIPR002058. PAP_assoc.
    [Graphical view]
    PfamiPF03828. PAP_assoc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U315-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPNSILGRP PFTPTHQQHN NFFALSPTLY SHQQLIDAQF NFQNVDLSRA    50
    VSLQPLTYGT VSPIQTSTSP LFRGRKRISD EKAFRLDGKR QRFHSPHQEP 100
    TIINQLVPLS GDRRYSMPPL FHTHYVPEIV RCVPPLREIP LLEPREITLP 150
    EAKDKLSQQI LELFETCQQQ ASDLKKKELC RAQLQREIQL LFPQSRLFLV 200
    GSSLNGFGAR SSDGDLCLVV KEEPCFFQVN QKTEARHILT LVHKHFCTRL 250
    SGYIERPQLI RAKVPIVKFR DKVSCVEFDL NVNNTVGIRN TFLLRTYAYL 300
    ENRVRPLVLV IKKWASHHEI NDASRGTLSS YSLVLMVLHY LQTLPEPILP 350
    SLQKIYPESF STSVQLHLVH HAPCNVPPYL SKNESSLGDL LLGFLKYYAT 400
    EFDWNTQMIS VREAKAIPRP DDMEWRNKYI CVEEPFDGTN TARAVHEKQK 450
    FDMIKDQFLK SWQRLKNKRD LNSVLPLRAA TLKR 484
    Length:484
    Mass (Da):56,007
    Last modified:December 7, 2004 - v1
    Checksum:i149E8B0C49142A60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085771 mRNA. Translation: AAH85771.1.
    RefSeqiNP_001008373.1. NM_001008372.1.
    XP_006231838.1. XM_006231776.1.
    XP_006231839.1. XM_006231777.1.
    UniGeneiRn.98477.

    Genome annotation databases

    EnsembliENSRNOT00000016135; ENSRNOP00000016135; ENSRNOG00000012099.
    GeneIDi361878.
    KEGGirno:361878.
    UCSCiRGD:1306438. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085771 mRNA. Translation: AAH85771.1 .
    RefSeqi NP_001008373.1. NM_001008372.1.
    XP_006231838.1. XM_006231776.1.
    XP_006231839.1. XM_006231777.1.
    UniGenei Rn.98477.

    3D structure databases

    ProteinModelPortali Q5U315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016135.

    Proteomic databases

    PaxDbi Q5U315.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000016135 ; ENSRNOP00000016135 ; ENSRNOG00000012099 .
    GeneIDi 361878.
    KEGGi rno:361878.
    UCSCi RGD:1306438. rat.

    Organism-specific databases

    CTDi 167153.
    RGDi 1306438. Papd4.

    Phylogenomic databases

    eggNOGi COG5260.
    GeneTreei ENSGT00550000074490.
    HOGENOMi HOG000088606.
    HOVERGENi HBG097533.
    InParanoidi Q5U315.
    KOi K14079.
    OMAi CVEFDLN.
    OrthoDBi EOG7DRJ2S.
    PhylomeDBi Q5U315.
    TreeFami TF315661.

    Miscellaneous databases

    NextBioi 677940.
    PROi Q5U315.

    Gene expression databases

    Genevestigatori Q5U315.

    Family and domain databases

    InterProi IPR002058. PAP_assoc.
    [Graphical view ]
    Pfami PF03828. PAP_assoc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiGLD2_RAT
    AccessioniPrimary (citable) accession number: Q5U315
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3