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Q5U315

- GLD2_RAT

UniProt

Q5U315 - GLD2_RAT

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Protein

Poly(A) RNA polymerase GLD2

Gene

Papd4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation (By similarity).By similarity

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi213 – 2131Magnesium or manganese; catalyticBy similarity
Metal bindingi215 – 2151Magnesium or manganese; catalyticBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. polynucleotide adenylyltransferase activity Source: UniProtKB

GO - Biological processi

  1. hematopoietic progenitor cell differentiation Source: Ensembl
  2. histone mRNA catabolic process Source: UniProtKB
  3. mRNA processing Source: UniProtKB-KW
  4. RNA polyadenylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) RNA polymerase GLD2 (EC:2.7.7.19)
Alternative name(s):
PAP-associated domain-containing protein 4
Gene namesi
Name:Papd4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1306438. Papd4.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Poly(A) RNA polymerase GLD2PRO_0000341551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei69 – 691PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U315.

Expressioni

Gene expression databases

GenevestigatoriQ5U315.

Interactioni

Subunit structurei

Interacts with CPEB1, CPEB2, CPSF1 and PABPC1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016135.

Structurei

3D structure databases

ProteinModelPortaliQ5U315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini386 – 44055PAP-associatedAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi76 – 9217Nuclear localization signalSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 PAP-associated domain.Curated

Phylogenomic databases

eggNOGiCOG5260.
GeneTreeiENSGT00550000074490.
HOGENOMiHOG000088606.
HOVERGENiHBG097533.
InParanoidiQ5U315.
KOiK14079.
OMAiCVEFDLN.
OrthoDBiEOG7DRJ2S.
PhylomeDBiQ5U315.
TreeFamiTF315661.

Family and domain databases

InterProiIPR002058. PAP_assoc.
[Graphical view]
PfamiPF03828. PAP_assoc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U315-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPNSILGRP PFTPTHQQHN NFFALSPTLY SHQQLIDAQF NFQNVDLSRA
60 70 80 90 100
VSLQPLTYGT VSPIQTSTSP LFRGRKRISD EKAFRLDGKR QRFHSPHQEP
110 120 130 140 150
TIINQLVPLS GDRRYSMPPL FHTHYVPEIV RCVPPLREIP LLEPREITLP
160 170 180 190 200
EAKDKLSQQI LELFETCQQQ ASDLKKKELC RAQLQREIQL LFPQSRLFLV
210 220 230 240 250
GSSLNGFGAR SSDGDLCLVV KEEPCFFQVN QKTEARHILT LVHKHFCTRL
260 270 280 290 300
SGYIERPQLI RAKVPIVKFR DKVSCVEFDL NVNNTVGIRN TFLLRTYAYL
310 320 330 340 350
ENRVRPLVLV IKKWASHHEI NDASRGTLSS YSLVLMVLHY LQTLPEPILP
360 370 380 390 400
SLQKIYPESF STSVQLHLVH HAPCNVPPYL SKNESSLGDL LLGFLKYYAT
410 420 430 440 450
EFDWNTQMIS VREAKAIPRP DDMEWRNKYI CVEEPFDGTN TARAVHEKQK
460 470 480
FDMIKDQFLK SWQRLKNKRD LNSVLPLRAA TLKR
Length:484
Mass (Da):56,007
Last modified:December 7, 2004 - v1
Checksum:i149E8B0C49142A60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085771 mRNA. Translation: AAH85771.1.
RefSeqiNP_001008373.1. NM_001008372.1.
XP_006231838.1. XM_006231776.2.
XP_008758861.1. XM_008760639.1.
UniGeneiRn.98477.

Genome annotation databases

EnsembliENSRNOT00000016135; ENSRNOP00000016135; ENSRNOG00000012099.
GeneIDi361878.
KEGGirno:361878.
UCSCiRGD:1306438. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085771 mRNA. Translation: AAH85771.1 .
RefSeqi NP_001008373.1. NM_001008372.1.
XP_006231838.1. XM_006231776.2.
XP_008758861.1. XM_008760639.1.
UniGenei Rn.98477.

3D structure databases

ProteinModelPortali Q5U315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016135.

Proteomic databases

PaxDbi Q5U315.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016135 ; ENSRNOP00000016135 ; ENSRNOG00000012099 .
GeneIDi 361878.
KEGGi rno:361878.
UCSCi RGD:1306438. rat.

Organism-specific databases

CTDi 167153.
RGDi 1306438. Papd4.

Phylogenomic databases

eggNOGi COG5260.
GeneTreei ENSGT00550000074490.
HOGENOMi HOG000088606.
HOVERGENi HBG097533.
InParanoidi Q5U315.
KOi K14079.
OMAi CVEFDLN.
OrthoDBi EOG7DRJ2S.
PhylomeDBi Q5U315.
TreeFami TF315661.

Miscellaneous databases

NextBioi 677940.
PROi Q5U315.

Gene expression databases

Genevestigatori Q5U315.

Family and domain databases

InterProi IPR002058. PAP_assoc.
[Graphical view ]
Pfami PF03828. PAP_assoc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiGLD2_RAT
AccessioniPrimary (citable) accession number: Q5U315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 7, 2004
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3