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Q5U309

- GT253_RAT

UniProt

Q5U309 - GT253_RAT

Protein

Probable inactive glycosyltransferase 25 family member 3

Gene

Cercam

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. lipopolysaccharide biosynthetic process Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Protein family/group databases

    CAZyiGT25. Glycosyltransferase Family 25.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable inactive glycosyltransferase 25 family member 3
    Alternative name(s):
    Cerebral endothelial cell adhesion molecule
    Gene namesi
    Name:Cercam
    Synonyms:Ceecam1, Glt25d3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1304778. Cercam.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Probable inactive glycosyltransferase 25 family member 3PRO_0000309546Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ5U309.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5U309.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000031371.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi569 – 5724Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the glycosyltransferase 25 family.Curated

    Phylogenomic databases

    eggNOGiNOG293154.
    GeneTreeiENSGT00550000074427.
    HOGENOMiHOG000007198.
    HOVERGENiHBG058097.
    InParanoidiQ5U309.
    OMAiEHRYGYM.
    OrthoDBiEOG7060RC.

    Family and domain databases

    InterProiIPR002654. Glyco_trans_25.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01755. Glyco_transf_25. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U309-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFIIRARAC GGDARSWKQP DQLHPILFTN LRLPLQLIAS SAGGATDHNV    50
    DNTTGMLQEW LAAVGRDYAT VVWKSEDEAR SYPDEQGPKH WTRERHQFLM 100
    ELKQEALAFA RDWGADYILF ADTDNILTNN QTLRLLIDRQ LPVVAPMLDS 150
    QTYYSNFWCG ITPQGYYRRT AEYFPTKNRQ RQGCFRVPMV HSTFLVSLQT 200
    EETARLAFYP PHPNYTWPFD DIIVFAYACQ AAGVSVHVCN DHRYGYMNVG 250
    VKPHQGLEEE KTNFIHLILE ALVDGPPMMA SAHVSRPPKK PSKMGFDEVF 300
    VISLARRPQR RARMLSSLWE MEISARVVDA VDGRTLNSSI LKHLGVDLLP 350
    GYQDPYSGRT LTKGEVGCFL SHYSIWEEVV AKGLARVVVF EDDVRFEDNF 400
    RKRLERLMED VLTQKLSWDL IYLGRKQVNP EEEVAVEGLP GLVVAGYSYW 450
    TLAYTLSLAG ARKLLASQPL HRMLPVDEFL PVMFDRHPND QYKAHFWPRD 500
    LQAFSARPLL ASPTHYAGDT EWLSDTETSS PWDDDSGRLI SWTGSQKTLR 550
    GPYLHLAGSS GHSLHPHPRD EL 572
    Length:572
    Mass (Da):65,223
    Last modified:November 13, 2007 - v2
    Checksum:iACBF436060A5D1E8
    GO

    Sequence cautioni

    The sequence AAH85782.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085782 mRNA. Translation: AAH85782.1. Different initiation.
    RefSeqiNP_001011962.1. NM_001011962.1.
    XP_006233831.1. XM_006233769.1.
    XP_006233832.1. XM_006233770.1.
    UniGeneiRn.93530.

    Genome annotation databases

    EnsembliENSRNOT00000060969; ENSRNOP00000057689; ENSRNOG00000026604.
    GeneIDi296616.
    KEGGirno:296616.
    UCSCiRGD:1304778. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085782 mRNA. Translation: AAH85782.1 . Different initiation.
    RefSeqi NP_001011962.1. NM_001011962.1.
    XP_006233831.1. XM_006233769.1.
    XP_006233832.1. XM_006233770.1.
    UniGenei Rn.93530.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000031371.

    Protein family/group databases

    CAZyi GT25. Glycosyltransferase Family 25.

    Proteomic databases

    PRIDEi Q5U309.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000060969 ; ENSRNOP00000057689 ; ENSRNOG00000026604 .
    GeneIDi 296616.
    KEGGi rno:296616.
    UCSCi RGD:1304778. rat.

    Organism-specific databases

    CTDi 51148.
    RGDi 1304778. Cercam.

    Phylogenomic databases

    eggNOGi NOG293154.
    GeneTreei ENSGT00550000074427.
    HOGENOMi HOG000007198.
    HOVERGENi HBG058097.
    InParanoidi Q5U309.
    OMAi EHRYGYM.
    OrthoDBi EOG7060RC.

    Miscellaneous databases

    NextBioi 641520.
    PROi Q5U309.

    Gene expression databases

    Genevestigatori Q5U309.

    Family and domain databases

    InterProi IPR002654. Glyco_trans_25.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01755. Glyco_transf_25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiGT253_RAT
    AccessioniPrimary (citable) accession number: Q5U309
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3