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Q5U309 (GT253_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene names
Name:Cercam
Synonyms:Ceecam1, Glt25d3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity By similarity.

Subcellular location

Endoplasmic reticulum lumen Potential.

Sequence similarities

Belongs to the glycosyltransferase 25 family.

Sequence caution

The sequence AAH85782.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentEndoplasmic reticulum
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

lipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Probable inactive glycosyltransferase 25 family member 3
PRO_0000309546

Regions

Motif569 – 5724Prevents secretion from ER Potential

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation2141N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5U309 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: ACBF436060A5D1E8

FASTA57265,223
        10         20         30         40         50         60 
MLFIIRARAC GGDARSWKQP DQLHPILFTN LRLPLQLIAS SAGGATDHNV DNTTGMLQEW 

        70         80         90        100        110        120 
LAAVGRDYAT VVWKSEDEAR SYPDEQGPKH WTRERHQFLM ELKQEALAFA RDWGADYILF 

       130        140        150        160        170        180 
ADTDNILTNN QTLRLLIDRQ LPVVAPMLDS QTYYSNFWCG ITPQGYYRRT AEYFPTKNRQ 

       190        200        210        220        230        240 
RQGCFRVPMV HSTFLVSLQT EETARLAFYP PHPNYTWPFD DIIVFAYACQ AAGVSVHVCN 

       250        260        270        280        290        300 
DHRYGYMNVG VKPHQGLEEE KTNFIHLILE ALVDGPPMMA SAHVSRPPKK PSKMGFDEVF 

       310        320        330        340        350        360 
VISLARRPQR RARMLSSLWE MEISARVVDA VDGRTLNSSI LKHLGVDLLP GYQDPYSGRT 

       370        380        390        400        410        420 
LTKGEVGCFL SHYSIWEEVV AKGLARVVVF EDDVRFEDNF RKRLERLMED VLTQKLSWDL 

       430        440        450        460        470        480 
IYLGRKQVNP EEEVAVEGLP GLVVAGYSYW TLAYTLSLAG ARKLLASQPL HRMLPVDEFL 

       490        500        510        520        530        540 
PVMFDRHPND QYKAHFWPRD LQAFSARPLL ASPTHYAGDT EWLSDTETSS PWDDDSGRLI 

       550        560        570 
SWTGSQKTLR GPYLHLAGSS GHSLHPHPRD EL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC085782 mRNA. Translation: AAH85782.1. Different initiation.
RefSeqNP_001011962.1. NM_001011962.1.
XP_006233831.1. XM_006233769.1.
XP_006233832.1. XM_006233770.1.
UniGeneRn.93530.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000031371.

Protein family/group databases

CAZyGT25. Glycosyltransferase Family 25.

Proteomic databases

PRIDEQ5U309.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000060969; ENSRNOP00000057689; ENSRNOG00000026604.
GeneID296616.
KEGGrno:296616.
UCSCRGD:1304778. rat.

Organism-specific databases

CTD51148.
RGD1304778. Cercam.

Phylogenomic databases

eggNOGNOG293154.
GeneTreeENSGT00550000074427.
HOGENOMHOG000007198.
HOVERGENHBG058097.
InParanoidQ5U309.
OMAEHRYGYM.
OrthoDBEOG7060RC.

Gene expression databases

GenevestigatorQ5U309.

Family and domain databases

InterProIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio641520.
PROQ5U309.

Entry information

Entry nameGT253_RAT
AccessionPrimary (citable) accession number: Q5U309
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families