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Q5U309

- GT253_RAT

UniProt

Q5U309 - GT253_RAT

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Protein

Probable inactive glycosyltransferase 25 family member 3

Gene
Cercam, Ceecam1, Glt25d3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene namesi
Name:Cercam
Synonyms:Ceecam1, Glt25d3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1304778. Cercam.

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Probable inactive glycosyltransferase 25 family member 3PRO_0000309546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi214 – 2141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi337 – 3371N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5U309.

Expressioni

Gene expression databases

GenevestigatoriQ5U309.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031371.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi569 – 5724Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG293154.
GeneTreeiENSGT00550000074427.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiQ5U309.
OMAiEHRYGYM.
OrthoDBiEOG7060RC.

Family and domain databases

InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U309-1 [UniParc]FASTAAdd to Basket

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MLFIIRARAC GGDARSWKQP DQLHPILFTN LRLPLQLIAS SAGGATDHNV    50
DNTTGMLQEW LAAVGRDYAT VVWKSEDEAR SYPDEQGPKH WTRERHQFLM 100
ELKQEALAFA RDWGADYILF ADTDNILTNN QTLRLLIDRQ LPVVAPMLDS 150
QTYYSNFWCG ITPQGYYRRT AEYFPTKNRQ RQGCFRVPMV HSTFLVSLQT 200
EETARLAFYP PHPNYTWPFD DIIVFAYACQ AAGVSVHVCN DHRYGYMNVG 250
VKPHQGLEEE KTNFIHLILE ALVDGPPMMA SAHVSRPPKK PSKMGFDEVF 300
VISLARRPQR RARMLSSLWE MEISARVVDA VDGRTLNSSI LKHLGVDLLP 350
GYQDPYSGRT LTKGEVGCFL SHYSIWEEVV AKGLARVVVF EDDVRFEDNF 400
RKRLERLMED VLTQKLSWDL IYLGRKQVNP EEEVAVEGLP GLVVAGYSYW 450
TLAYTLSLAG ARKLLASQPL HRMLPVDEFL PVMFDRHPND QYKAHFWPRD 500
LQAFSARPLL ASPTHYAGDT EWLSDTETSS PWDDDSGRLI SWTGSQKTLR 550
GPYLHLAGSS GHSLHPHPRD EL 572
Length:572
Mass (Da):65,223
Last modified:November 13, 2007 - v2
Checksum:iACBF436060A5D1E8
GO

Sequence cautioni

The sequence AAH85782.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085782 mRNA. Translation: AAH85782.1. Different initiation.
RefSeqiNP_001011962.1. NM_001011962.1.
XP_006233831.1. XM_006233769.1.
XP_006233832.1. XM_006233770.1.
UniGeneiRn.93530.

Genome annotation databases

EnsembliENSRNOT00000060969; ENSRNOP00000057689; ENSRNOG00000026604.
GeneIDi296616.
KEGGirno:296616.
UCSCiRGD:1304778. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085782 mRNA. Translation: AAH85782.1 . Different initiation.
RefSeqi NP_001011962.1. NM_001011962.1.
XP_006233831.1. XM_006233769.1.
XP_006233832.1. XM_006233770.1.
UniGenei Rn.93530.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000031371.

Protein family/group databases

CAZyi GT25. Glycosyltransferase Family 25.

Proteomic databases

PRIDEi Q5U309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000060969 ; ENSRNOP00000057689 ; ENSRNOG00000026604 .
GeneIDi 296616.
KEGGi rno:296616.
UCSCi RGD:1304778. rat.

Organism-specific databases

CTDi 51148.
RGDi 1304778. Cercam.

Phylogenomic databases

eggNOGi NOG293154.
GeneTreei ENSGT00550000074427.
HOGENOMi HOG000007198.
HOVERGENi HBG058097.
InParanoidi Q5U309.
OMAi EHRYGYM.
OrthoDBi EOG7060RC.

Miscellaneous databases

NextBioi 641520.
PROi Q5U309.

Gene expression databases

Genevestigatori Q5U309.

Family and domain databases

InterProi IPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01755. Glyco_transf_25. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiGT253_RAT
AccessioniPrimary (citable) accession number: Q5U309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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