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Protein

ER lumen protein-retaining receptor 2

Gene

Kdelr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 2
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 2
Short name:
KDEL receptor 2
Gene namesi
Name:Kdelr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1304618. Kdelr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 110HelicalSequence analysisAdd BLAST14
Topological domaini111 – 117LumenalSequence analysis7
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Topological domaini169 – 178LumenalSequence analysis10
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 212CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • cis-Golgi network Source: MGI
  • endoplasmic reticulum Source: MGI
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941571 – 212ER lumen protein-retaining receptor 2Add BLAST212

Proteomic databases

PaxDbiQ5U305.
PRIDEiQ5U305.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001083.
GenevisibleiQ5U305. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4578167.
STRINGi10116.ENSRNOP00000001438.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiQ5U305.
KOiK10949.
OMAiYFTKVLQ.
OrthoDBiEOG091G0Q1H.
PhylomeDBiQ5U305.

Family and domain databases

InterProiView protein in InterPro
IPR000133. ER_ret_rcpt.
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiView protein in Pfam
PF00810. ER_lumen_recept. 1 hit.
PRINTSiPR00660. ERLUMENR.
PROSITEiView protein in PROSITE
PS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD
60 70 80 90 100
LFTSFISLYN TSMKLIYIAC SYATVYLIYM KFKATYDGNH DTFRVEFLVV
110 120 130 140 150
PVGGLSFLVN HDFSPLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH
160 170 180 190 200
YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA VVAGVVQTIL YCDFFYLYIT
210
KVLKGKKLSL PA
Length:212
Mass (Da):24,454
Last modified:December 7, 2004 - v1
Checksum:i774388DAF56FEC24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085786 mRNA. Translation: AAH85786.1.
RefSeqiNP_001013140.1. NM_001013122.1.
UniGeneiRn.4066.

Genome annotation databases

EnsembliENSRNOT00000001438; ENSRNOP00000001438; ENSRNOG00000001083.
GeneIDi304290.
KEGGirno:304290.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiERD22_RAT
AccessioniPrimary (citable) accession number: Q5U305
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: December 7, 2004
Last modified: June 7, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families