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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Gene

Tab2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri663 – 69331RanBP2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1251985. Nuclear signaling by ERBB4.
R-RNO-168638. NOD1/2 Signaling Pathway.
R-RNO-202424. Downstream TCR signaling.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-RNO-446652. Interleukin-1 signaling.
R-RNO-450302. activated TAK1 mediates p38 MAPK activation.
R-RNO-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-RNO-5357956. TNFR1-induced NFkappaB signaling pathway.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-937042. IRAK2 mediated activation of TAK1 complex.
R-RNO-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
TGF-beta-activated kinase 1-binding protein 2
Gene namesi
Name:Tab2
Synonyms:Map3k7ip2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309527. Tab2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmcytosol By similarity

  • Note: Cytoplasmic when activated. Following IL1 stimulation, localized in the to cytosol (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693TGF-beta-activated kinase 1 and MAP3K7-binding protein 2PRO_0000225697Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei372 – 3721PhosphoserineBy similarity
Modified residuei450 – 4501PhosphoserineBy similarity
Modified residuei482 – 4821PhosphoserineBy similarity
Modified residuei524 – 5241PhosphoserineBy similarity
Modified residuei582 – 5821PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.Curated
Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5U303.
PRIDEiQ5U303.

PTM databases

iPTMnetiQ5U303.

Expressioni

Gene expression databases

GenevisibleiQ5U303. RN.

Interactioni

Subunit structurei

Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1 (By similarity). Interacts with TRIM5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ5U303. 1 interaction.
MINTiMINT-4581004.
STRINGi10116.ENSRNOP00000021904.

Structurei

3D structure databases

ProteinModelPortaliQ5U303.
SMRiQ5U303. Positions 5-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 5144CUEPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni675 – 68511Interaction with polyubiquitinBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili532 – 61988Sequence analysisAdd
BLAST

Domaini

The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins.By similarity

Sequence similaritiesi

Contains 1 CUE domain.PROSITE-ProRule annotation
Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri663 – 69331RanBP2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IK8E. Eukaryota.
ENOG410XPAC. LUCA.
GeneTreeiENSGT00530000063642.
HOGENOMiHOG000261646.
HOVERGENiHBG056952.
InParanoidiQ5U303.
KOiK04404.
OMAiVYHHGRE.
OrthoDBiEOG776SPP.
PhylomeDBiQ5U303.
TreeFamiTF332021.

Family and domain databases

InterProiIPR003892. CUE.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5U303-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES
60 70 80 90 100
TRYLYGEGDL NFSDESGISG LRNHMTSLNL DLQSQNVYHH GREGSRVNGS
110 120 130 140 150
RTLTHSVSDG QLQGGQSNNE LFQQEPQTAP AQVPQGFNVF GMPSTSGASN
160 170 180 190 200
STPHLGFHLG SKGTSNLSQQ TPRFNPIMVT LAPNIQTGRS TPTSLHIHGV
210 220 230 240 250
PPPVLNSPQG NSIYIRPYIT TPSGAARQTQ QHSGWVSQFN PVNPQQAYQP
260 270 280 290 300
SQPGPWTTYP ASNPLPHTST QQPNQQGHQT SHVYMPISSP TTPQPPTVHS
310 320 330 340 350
SASSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNSSSK LRSSGPRTAS
360 370 380 390 400
TSSLVNSQTL NRNQPTVYIA ASPPSTDEMI SRSQPKVYIS ANASTGDEQG
410 420 430 440 450
MRNQPTLFIS TNSGASAASR NMSGQVSMGP AFIHHHPPKS RVLGGNSAAS
460 470 480 490 500
PRVVVTQPNT KYTFKITVSP NKPPAVSPGV VSPTFELTNL LNHPDHYVET
510 520 530 540 550
ETIQHLTDPT LAHVDRVSEA RKLSMGSDDA AYTQALLVHQ KARMERLQRE
560 570 580 590 600
LEMQKKKLDK LKSEVNEMEN SLTRRRLKRS NSMSQIPSLE EMQQLRSCNR
610 620 630 640 650
QLQIDIDCLT KEIDLFQARG PHFNPSAIHN FYDNIGFVGP VPPKPKDQRS
660 670 680 690
TIKAPKTQDT EDEEGAQWNC TACTFLNHPA LIRCEQCEMP RHF
Note: No experimental confirmation available.
Length:693
Mass (Da):76,328
Last modified:March 7, 2006 - v2
Checksum:i2458318BAA02C0B4
GO
Isoform 2 (identifier: Q5U303-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-693: PHFNPSAIHN...CEQCEMPRHF → KVQCILS

Show »
Length:627
Mass (Da):68,795
Checksum:iE01561988548D1C4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei621 – 69373PHFNP…MPRHF → KVQCILS in isoform 2. 1 PublicationVSP_017421Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085788 mRNA. Translation: AAH85788.1.
CK364963 mRNA. No translation available.
RefSeqiNP_001012062.1. NM_001012062.1. [Q5U303-2]
XP_006227682.1. XM_006227620.2. [Q5U303-1]
UniGeneiRn.231700.

Genome annotation databases

EnsembliENSRNOT00000021905; ENSRNOP00000021904; ENSRNOG00000016054. [Q5U303-1]
ENSRNOT00000061999; ENSRNOP00000058709; ENSRNOG00000016054. [Q5U303-2]
GeneIDi308267.
KEGGirno:308267.
UCSCiRGD:1309527. rat. [Q5U303-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085788 mRNA. Translation: AAH85788.1.
CK364963 mRNA. No translation available.
RefSeqiNP_001012062.1. NM_001012062.1. [Q5U303-2]
XP_006227682.1. XM_006227620.2. [Q5U303-1]
UniGeneiRn.231700.

3D structure databases

ProteinModelPortaliQ5U303.
SMRiQ5U303. Positions 5-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5U303. 1 interaction.
MINTiMINT-4581004.
STRINGi10116.ENSRNOP00000021904.

PTM databases

iPTMnetiQ5U303.

Proteomic databases

PaxDbiQ5U303.
PRIDEiQ5U303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021905; ENSRNOP00000021904; ENSRNOG00000016054. [Q5U303-1]
ENSRNOT00000061999; ENSRNOP00000058709; ENSRNOG00000016054. [Q5U303-2]
GeneIDi308267.
KEGGirno:308267.
UCSCiRGD:1309527. rat. [Q5U303-1]

Organism-specific databases

CTDi23118.
RGDi1309527. Tab2.

Phylogenomic databases

eggNOGiENOG410IK8E. Eukaryota.
ENOG410XPAC. LUCA.
GeneTreeiENSGT00530000063642.
HOGENOMiHOG000261646.
HOVERGENiHBG056952.
InParanoidiQ5U303.
KOiK04404.
OMAiVYHHGRE.
OrthoDBiEOG776SPP.
PhylomeDBiQ5U303.
TreeFamiTF332021.

Enzyme and pathway databases

ReactomeiR-RNO-1251985. Nuclear signaling by ERBB4.
R-RNO-168638. NOD1/2 Signaling Pathway.
R-RNO-202424. Downstream TCR signaling.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-RNO-446652. Interleukin-1 signaling.
R-RNO-450302. activated TAK1 mediates p38 MAPK activation.
R-RNO-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-RNO-5357956. TNFR1-induced NFkappaB signaling pathway.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-937042. IRAK2 mediated activation of TAK1 complex.
R-RNO-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Miscellaneous databases

PROiQ5U303.

Gene expression databases

GenevisibleiQ5U303. RN.

Family and domain databases

InterProiIPR003892. CUE.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney.

Entry informationi

Entry nameiTAB2_RAT
AccessioniPrimary (citable) accession number: Q5U303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: July 6, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.