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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Gene

Tab2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri663 – 693RanBP2-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-168638. NOD1/2 Signaling Pathway.
R-RNO-202424. Downstream TCR signaling.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-RNO-446652. Interleukin-1 family signaling.
R-RNO-450302. activated TAK1 mediates p38 MAPK activation.
R-RNO-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-RNO-5357956. TNFR1-induced NFkappaB signaling pathway.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-937042. IRAK2 mediated activation of TAK1 complex.
R-RNO-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
TGF-beta-activated kinase 1-binding protein 2
Gene namesi
Name:Tab2
Synonyms:Map3k7ip2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309527. Tab2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256971 – 693TGF-beta-activated kinase 1 and MAP3K7-binding protein 2Add BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173Asymmetric dimethylarginineBy similarity1
Modified residuei372PhosphoserineBy similarity1
Modified residuei450PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei524PhosphoserineBy similarity1
Modified residuei582PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.Curated
Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5U303.
PRIDEiQ5U303.

PTM databases

iPTMnetiQ5U303.
PhosphoSitePlusiQ5U303.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016054.
GenevisibleiQ5U303. RN.

Interactioni

Subunit structurei

Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1 (By similarity). Interacts with TRIM5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ5U303. 1 interactor.
MINTiMINT-4581004.
STRINGi10116.ENSRNOP00000021904.

Structurei

3D structure databases

ProteinModelPortaliQ5U303.
SMRiQ5U303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 51CUEPROSITE-ProRule annotationAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni675 – 685Interaction with polyubiquitinBy similarityAdd BLAST11

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili532 – 619Sequence analysisAdd BLAST88

Domaini

The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri663 – 693RanBP2-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IK8E. Eukaryota.
ENOG410XPAC. LUCA.
GeneTreeiENSGT00530000063642.
HOGENOMiHOG000261646.
HOVERGENiHBG056952.
InParanoidiQ5U303.
KOiK04404.
OMAiVYHHGRE.
OrthoDBiEOG091G0AYA.
PhylomeDBiQ5U303.
TreeFamiTF332021.

Family and domain databases

InterProiView protein in InterPro
IPR003892. CUE.
IPR001876. Znf_RanBP2.
PfamiView protein in Pfam
PF02845. CUE. 1 hit.
SMARTiView protein in SMART
SM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
SUPFAMiSSF90209. SSF90209. 1 hit.
PROSITEiView protein in PROSITE
PS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5U303-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES
60 70 80 90 100
TRYLYGEGDL NFSDESGISG LRNHMTSLNL DLQSQNVYHH GREGSRVNGS
110 120 130 140 150
RTLTHSVSDG QLQGGQSNNE LFQQEPQTAP AQVPQGFNVF GMPSTSGASN
160 170 180 190 200
STPHLGFHLG SKGTSNLSQQ TPRFNPIMVT LAPNIQTGRS TPTSLHIHGV
210 220 230 240 250
PPPVLNSPQG NSIYIRPYIT TPSGAARQTQ QHSGWVSQFN PVNPQQAYQP
260 270 280 290 300
SQPGPWTTYP ASNPLPHTST QQPNQQGHQT SHVYMPISSP TTPQPPTVHS
310 320 330 340 350
SASSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNSSSK LRSSGPRTAS
360 370 380 390 400
TSSLVNSQTL NRNQPTVYIA ASPPSTDEMI SRSQPKVYIS ANASTGDEQG
410 420 430 440 450
MRNQPTLFIS TNSGASAASR NMSGQVSMGP AFIHHHPPKS RVLGGNSAAS
460 470 480 490 500
PRVVVTQPNT KYTFKITVSP NKPPAVSPGV VSPTFELTNL LNHPDHYVET
510 520 530 540 550
ETIQHLTDPT LAHVDRVSEA RKLSMGSDDA AYTQALLVHQ KARMERLQRE
560 570 580 590 600
LEMQKKKLDK LKSEVNEMEN SLTRRRLKRS NSMSQIPSLE EMQQLRSCNR
610 620 630 640 650
QLQIDIDCLT KEIDLFQARG PHFNPSAIHN FYDNIGFVGP VPPKPKDQRS
660 670 680 690
TIKAPKTQDT EDEEGAQWNC TACTFLNHPA LIRCEQCEMP RHF
Note: No experimental confirmation available.
Length:693
Mass (Da):76,328
Last modified:March 7, 2006 - v2
Checksum:i2458318BAA02C0B4
GO
Isoform 2 (identifier: Q5U303-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-693: PHFNPSAIHN...CEQCEMPRHF → KVQCILS

Show »
Length:627
Mass (Da):68,795
Checksum:iE01561988548D1C4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017421621 – 693PHFNP…MPRHF → KVQCILS in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085788 mRNA. Translation: AAH85788.1.
CK364963 mRNA. No translation available.
RefSeqiNP_001012062.1. NM_001012062.1. [Q5U303-2]
UniGeneiRn.231700.

Genome annotation databases

EnsembliENSRNOT00000021905; ENSRNOP00000021904; ENSRNOG00000016054. [Q5U303-1]
ENSRNOT00000061999; ENSRNOP00000058709; ENSRNOG00000016054. [Q5U303-2]
GeneIDi308267.
KEGGirno:308267.
UCSCiRGD:1309527. rat. [Q5U303-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTAB2_RAT
AccessioniPrimary (citable) accession number: Q5U303
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 27, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome