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Q5U302

- Q5U302_RAT

UniProt

Q5U302 - Q5U302_RAT

Protein
Submitted name:

Catenin (Cadherin associated protein), alpha 1

Gene

Ctnna1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: RGD
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. aging Source: RGD
    2. apical junction assembly Source: Ensembl
    3. axon regeneration Source: RGD
    4. cellular protein localization Source: Ensembl
    5. cellular response to indole-3-methanol Source: Ensembl
    6. epithelial cell-cell adhesion Source: Ensembl
    7. establishment or maintenance of cell polarity Source: Ensembl
    8. gap junction assembly Source: RGD
    9. male gonad development Source: RGD
    10. negative regulation of apoptotic process Source: Ensembl
    11. negative regulation of cell motility Source: Ensembl
    12. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    13. negative regulation of integrin-mediated signaling pathway Source: Ensembl
    14. negative regulation of neuroblast proliferation Source: Ensembl
    15. odontogenesis of dentin-containing tooth Source: RGD
    16. ovarian follicle development Source: RGD
    17. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    18. positive regulation of smoothened signaling pathway Source: Ensembl
    19. protein heterooligomerization Source: RGD
    20. response to estrogen Source: RGD
    21. response to organic cyclic compound Source: RGD

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Catenin (Cadherin associated protein), alpha 1Imported
    Submitted name:
    Catenin (Cadherin-associated protein), alpha 1, isoform CRA_bImported
    Submitted name:
    Protein Ctnna1Imported
    Gene namesi
    Name:Ctnna1Imported
    Synonyms:Catna1Imported
    ORF Names:rCG_49560Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi1359485. Ctnna1.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: RGD
    2. actin cytoskeleton Source: InterPro
    3. catenin complex Source: Ensembl
    4. cell-cell adherens junction Source: RGD
    5. cell-cell junction Source: RGD
    6. cytoplasm Source: RGD
    7. intercalated disc Source: Ensembl
    8. lamellipodium Source: Ensembl
    9. plasma membrane Source: RGD
    10. zonula adherens Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ5U302.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000008041.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG240050.
    GeneTreeiENSGT00550000074411.
    HOGENOMiHOG000280724.
    HOVERGENiHBG000069.
    KOiK05691.
    OMAiRTIANHC.
    OrthoDBiEOG7HQN7B.
    TreeFamiTF313686.

    Family and domain databases

    InterProiIPR001033. Alpha_catenin.
    IPR006077. Vinculin/catenin.
    IPR000633. Vinculin_CS.
    [Graphical view]
    PANTHERiPTHR18914. PTHR18914. 1 hit.
    PfamiPF01044. Vinculin. 2 hits.
    [Graphical view]
    PRINTSiPR00805. ALPHACATENIN.
    SUPFAMiSSF47220. SSF47220. 4 hits.
    PROSITEiPS00663. VINCULIN_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U302-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAVHTGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK    50
    KRGRSKKAHV LAASVEQATE NFLEKGDKIA KESQFLKEEL VAAVDDVRKQ 100
    GDLMKSAAGE FADDPCSSVK RGNMVRAARA LLSAVTRLLI LADMADVYKL 150
    LVQLKVVEDG ILKLRNAGNE QDLGIQYRAL KPEVDKLNIM AAKRQQELKD 200
    VGHRDQMAAA RGILQKNVPI LYTASQACLQ HPDVAAYKAN RDLIYKQLQQ 250
    AVTGISNAAQ ATASDDASQQ QGGGGGGGEL AYALNNFDKQ IIVDPLSFSE 300
    ERFRPSLEER LESIISGAAL MADSSCTRDD RRERIVAECN AVRQALQDLL 350
    SEYMGNAGRK ERSDALNSAI DKMTKKTRDL RRQLRKAVMD HVSDSFLETN 400
    VPLLVLIEAA KNGNEKEVKE YAQVFREHAN KLIEVANLAC SISNNEEGVK 450
    LVRMSASQLE ALCPQVINAA LALAAKPQSK LAQENMDLFK EQWEKQVRVL 500
    TDAVDDITSI DDFLAVSENH ILEDVNKCVI ALQEKDVDGL DRTAGAIRGR 550
    AARVIHVVTS EMDNYEPGVY TEKVLEATKL LSNTVMPRFT EQVEAAVEAL 600
    SSDPAQPMDE NEFIDASRLV YDGIRDIRKA VLMIRTPEEL DDSDFETEDF 650
    DVRSRTSVQT EDDQLIAGQS ARAIMAQLPQ EQKAKIAEQV ASFQEEKSKL 700
    DAEVSKWDDS GNDIIVLAKQ MCMIMMEMTD FTRGKGPLKN TSDVISAAKK 750
    IAEAGSRMDK LGRTIADHCP DSACKQDLLA YLQRIALYCH QLNICSKVKA 800
    EVQNLGGELV VSGVDSAMSL IQAAKNLMNA VVQTVKASYV ASTKYQKSQG 850
    MASLNLPAVS WKMKAPEKKP LVKREKQDET QTKIKRASQK KHVNPVQALS 900
    EFKAMDSI 908
    Length:908
    Mass (Da):100,236
    Last modified:December 7, 2004 - v1
    Checksum:i247F212CF5C620C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06094581 Genomic DNA. No translation available.
    AABR06094582 Genomic DNA. No translation available.
    BC085789 mRNA. Translation: AAH85789.1.
    CH473974 Genomic DNA. Translation: EDL76253.1.
    RefSeqiNP_001007146.1. NM_001007145.1.
    UniGeneiRn.103790.

    Genome annotation databases

    EnsembliENSRNOT00000008041; ENSRNOP00000008041; ENSRNOG00000005796.
    GeneIDi307505.
    KEGGirno:307505.
    UCSCiRGD:1359485. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06094581 Genomic DNA. No translation available.
    AABR06094582 Genomic DNA. No translation available.
    BC085789 mRNA. Translation: AAH85789.1 .
    CH473974 Genomic DNA. Translation: EDL76253.1 .
    RefSeqi NP_001007146.1. NM_001007145.1.
    UniGenei Rn.103790.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000008041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000008041 ; ENSRNOP00000008041 ; ENSRNOG00000005796 .
    GeneIDi 307505.
    KEGGi rno:307505.
    UCSCi RGD:1359485. rat.

    Organism-specific databases

    CTDi 1495.
    RGDi 1359485. Ctnna1.

    Phylogenomic databases

    eggNOGi NOG240050.
    GeneTreei ENSGT00550000074411.
    HOGENOMi HOG000280724.
    HOVERGENi HBG000069.
    KOi K05691.
    OMAi RTIANHC.
    OrthoDBi EOG7HQN7B.
    TreeFami TF313686.

    Miscellaneous databases

    NextBioi 657513.

    Gene expression databases

    Genevestigatori Q5U302.

    Family and domain databases

    InterProi IPR001033. Alpha_catenin.
    IPR006077. Vinculin/catenin.
    IPR000633. Vinculin_CS.
    [Graphical view ]
    PANTHERi PTHR18914. PTHR18914. 1 hit.
    Pfami PF01044. Vinculin. 2 hits.
    [Graphical view ]
    PRINTSi PR00805. ALPHACATENIN.
    SUPFAMi SSF47220. SSF47220. 4 hits.
    PROSITEi PS00663. VINCULIN_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: KidneyImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ5U302_RAT
    AccessioniPrimary (citable) accession number: Q5U302
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 7, 2004
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3