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Q5U302

- Q5U302_RAT

UniProt

Q5U302 - Q5U302_RAT

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Protein
Submitted name: Catenin (Cadherin associated protein), alpha 1
Gene
Ctnna1, Catna1, rCG_49560
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: RGD
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. aging Source: RGD
  2. apical junction assembly Source: Ensembl
  3. axon regeneration Source: RGD
  4. cellular protein localization Source: Ensembl
  5. cellular response to indole-3-methanol Source: Ensembl
  6. epithelial cell-cell adhesion Source: Ensembl
  7. establishment or maintenance of cell polarity Source: Ensembl
  8. gap junction assembly Source: RGD
  9. male gonad development Source: RGD
  10. negative regulation of apoptotic process Source: Ensembl
  11. negative regulation of cell motility Source: Ensembl
  12. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  13. negative regulation of integrin-mediated signaling pathway Source: Ensembl
  14. negative regulation of neuroblast proliferation Source: Ensembl
  15. odontogenesis of dentin-containing tooth Source: RGD
  16. ovarian follicle development Source: RGD
  17. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  18. positive regulation of smoothened signaling pathway Source: Ensembl
  19. protein heterooligomerization Source: RGD
  20. response to estrogen Source: RGD
  21. response to organic cyclic compound Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Catenin (Cadherin associated protein), alpha 1Imported
Submitted name:
Catenin (Cadherin-associated protein), alpha 1, isoform CRA_bImported
Submitted name:
Protein Ctnna1Imported
Gene namesi
Name:Ctnna1Imported
Synonyms:Catna1Imported
ORF Names:rCG_49560Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi1359485. Ctnna1.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: RGD
  2. actin cytoskeleton Source: InterPro
  3. catenin complex Source: Ensembl
  4. cell-cell adherens junction Source: RGD
  5. cell-cell junction Source: RGD
  6. cytoplasm Source: RGD
  7. intercalated disc Source: Ensembl
  8. lamellipodium Source: Ensembl
  9. plasma membrane Source: RGD
  10. zonula adherens Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ5U302.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008041.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG240050.
GeneTreeiENSGT00550000074411.
HOGENOMiHOG000280724.
HOVERGENiHBG000069.
KOiK05691.
OMAiRTIANHC.
OrthoDBiEOG7HQN7B.
TreeFamiTF313686.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 1 hit.
PfamiPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 4 hits.
PROSITEiPS00663. VINCULIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U302-1 [UniParc]FASTAAdd to Basket

« Hide

MTAVHTGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK    50
KRGRSKKAHV LAASVEQATE NFLEKGDKIA KESQFLKEEL VAAVDDVRKQ 100
GDLMKSAAGE FADDPCSSVK RGNMVRAARA LLSAVTRLLI LADMADVYKL 150
LVQLKVVEDG ILKLRNAGNE QDLGIQYRAL KPEVDKLNIM AAKRQQELKD 200
VGHRDQMAAA RGILQKNVPI LYTASQACLQ HPDVAAYKAN RDLIYKQLQQ 250
AVTGISNAAQ ATASDDASQQ QGGGGGGGEL AYALNNFDKQ IIVDPLSFSE 300
ERFRPSLEER LESIISGAAL MADSSCTRDD RRERIVAECN AVRQALQDLL 350
SEYMGNAGRK ERSDALNSAI DKMTKKTRDL RRQLRKAVMD HVSDSFLETN 400
VPLLVLIEAA KNGNEKEVKE YAQVFREHAN KLIEVANLAC SISNNEEGVK 450
LVRMSASQLE ALCPQVINAA LALAAKPQSK LAQENMDLFK EQWEKQVRVL 500
TDAVDDITSI DDFLAVSENH ILEDVNKCVI ALQEKDVDGL DRTAGAIRGR 550
AARVIHVVTS EMDNYEPGVY TEKVLEATKL LSNTVMPRFT EQVEAAVEAL 600
SSDPAQPMDE NEFIDASRLV YDGIRDIRKA VLMIRTPEEL DDSDFETEDF 650
DVRSRTSVQT EDDQLIAGQS ARAIMAQLPQ EQKAKIAEQV ASFQEEKSKL 700
DAEVSKWDDS GNDIIVLAKQ MCMIMMEMTD FTRGKGPLKN TSDVISAAKK 750
IAEAGSRMDK LGRTIADHCP DSACKQDLLA YLQRIALYCH QLNICSKVKA 800
EVQNLGGELV VSGVDSAMSL IQAAKNLMNA VVQTVKASYV ASTKYQKSQG 850
MASLNLPAVS WKMKAPEKKP LVKREKQDET QTKIKRASQK KHVNPVQALS 900
EFKAMDSI 908
Length:908
Mass (Da):100,236
Last modified:December 7, 2004 - v1
Checksum:i247F212CF5C620C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06094581 Genomic DNA. No translation available.
AABR06094582 Genomic DNA. No translation available.
BC085789 mRNA. Translation: AAH85789.1.
CH473974 Genomic DNA. Translation: EDL76253.1.
RefSeqiNP_001007146.1. NM_001007145.1.
UniGeneiRn.103790.

Genome annotation databases

EnsembliENSRNOT00000008041; ENSRNOP00000008041; ENSRNOG00000005796.
GeneIDi307505.
KEGGirno:307505.
UCSCiRGD:1359485. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06094581 Genomic DNA. No translation available.
AABR06094582 Genomic DNA. No translation available.
BC085789 mRNA. Translation: AAH85789.1 .
CH473974 Genomic DNA. Translation: EDL76253.1 .
RefSeqi NP_001007146.1. NM_001007145.1.
UniGenei Rn.103790.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000008041 ; ENSRNOP00000008041 ; ENSRNOG00000005796 .
GeneIDi 307505.
KEGGi rno:307505.
UCSCi RGD:1359485. rat.

Organism-specific databases

CTDi 1495.
RGDi 1359485. Ctnna1.

Phylogenomic databases

eggNOGi NOG240050.
GeneTreei ENSGT00550000074411.
HOGENOMi HOG000280724.
HOVERGENi HBG000069.
KOi K05691.
OMAi RTIANHC.
OrthoDBi EOG7HQN7B.
TreeFami TF313686.

Miscellaneous databases

NextBioi 657513.

Gene expression databases

Genevestigatori Q5U302.

Family and domain databases

InterProi IPR001033. Alpha_catenin.
IPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view ]
PANTHERi PTHR18914. PTHR18914. 1 hit.
Pfami PF01044. Vinculin. 2 hits.
[Graphical view ]
PRINTSi PR00805. ALPHACATENIN.
SUPFAMi SSF47220. SSF47220. 4 hits.
PROSITEi PS00663. VINCULIN_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ5U302_RAT
AccessioniPrimary (citable) accession number: Q5U302
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi