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Q5U302 (Q5U302_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Catenin (Cadherin-associated protein), alpha 1, isoform CRA_b EMBL EDL76253.1

Protein Ctnna1 Ensembl ENSRNOP00000008041
Gene names
Name:Ctnna1 RGD 1359485 EMBL AAH85789.1 Ensembl ENSRNOP00000008041
Synonyms:Catna1 RGD 1359485 EMBL EDL76253.1
ORF Names:rCG_49560 EMBL EDL76253.1
OrganismRattus norvegicus (Rat) [Reference proteome] EMBL AAH85789.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length908 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaging

Inferred from expression pattern PubMed 15178134. Source: RGD

apical junction assembly

Inferred from electronic annotation. Source: Ensembl

axon regeneration

Inferred from expression pattern PubMed 12387456. Source: RGD

cellular protein localization

Inferred from electronic annotation. Source: Ensembl

cellular response to indole-3-methanol

Inferred from electronic annotation. Source: Ensembl

epithelial cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

establishment or maintenance of cell polarity

Inferred from electronic annotation. Source: Ensembl

gap junction assembly

Inferred from mutant phenotype PubMed 12577316. Source: RGD

male gonad development

Inferred from expression pattern PubMed 7507830. Source: RGD

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell motility

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

negative regulation of integrin-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuroblast proliferation

Inferred from electronic annotation. Source: Ensembl

odontogenesis of dentin-containing tooth

Inferred from expression pattern PubMed 10681393. Source: RGD

ovarian follicle development

Inferred from expression pattern PubMed 10864803. Source: RGD

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

positive regulation of smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

protein heterooligomerization

Inferred from physical interaction PubMed 8834786. Source: RGD

response to estrogen

Inferred from expression pattern PubMed 10864803. Source: RGD

response to organic cyclic compound

Inferred from expression pattern PubMed 16678996. Source: RGD

   Cellular_componentacrosomal vesicle

Inferred from direct assay PubMed 16755864. Source: RGD

actin cytoskeleton

Inferred from electronic annotation. Source: InterPro

catenin complex

Inferred from electronic annotation. Source: Ensembl

cell-cell adherens junction

Inferred from direct assay PubMed 8834786. Source: RGD

cell-cell junction

Inferred from direct assay PubMed 15197645. Source: RGD

cytoplasm

Inferred from direct assay PubMed 16755864. Source: RGD

intercalated disc

Inferred from electronic annotation. Source: Ensembl

lamellipodium

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 17899156. Source: RGD

zonula adherens

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q5U302 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 247F212CF5C620C2

FASTA908100,236
        10         20         30         40         50         60 
MTAVHTGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK KRGRSKKAHV 

        70         80         90        100        110        120 
LAASVEQATE NFLEKGDKIA KESQFLKEEL VAAVDDVRKQ GDLMKSAAGE FADDPCSSVK 

       130        140        150        160        170        180 
RGNMVRAARA LLSAVTRLLI LADMADVYKL LVQLKVVEDG ILKLRNAGNE QDLGIQYRAL 

       190        200        210        220        230        240 
KPEVDKLNIM AAKRQQELKD VGHRDQMAAA RGILQKNVPI LYTASQACLQ HPDVAAYKAN 

       250        260        270        280        290        300 
RDLIYKQLQQ AVTGISNAAQ ATASDDASQQ QGGGGGGGEL AYALNNFDKQ IIVDPLSFSE 

       310        320        330        340        350        360 
ERFRPSLEER LESIISGAAL MADSSCTRDD RRERIVAECN AVRQALQDLL SEYMGNAGRK 

       370        380        390        400        410        420 
ERSDALNSAI DKMTKKTRDL RRQLRKAVMD HVSDSFLETN VPLLVLIEAA KNGNEKEVKE 

       430        440        450        460        470        480 
YAQVFREHAN KLIEVANLAC SISNNEEGVK LVRMSASQLE ALCPQVINAA LALAAKPQSK 

       490        500        510        520        530        540 
LAQENMDLFK EQWEKQVRVL TDAVDDITSI DDFLAVSENH ILEDVNKCVI ALQEKDVDGL 

       550        560        570        580        590        600 
DRTAGAIRGR AARVIHVVTS EMDNYEPGVY TEKVLEATKL LSNTVMPRFT EQVEAAVEAL 

       610        620        630        640        650        660 
SSDPAQPMDE NEFIDASRLV YDGIRDIRKA VLMIRTPEEL DDSDFETEDF DVRSRTSVQT 

       670        680        690        700        710        720 
EDDQLIAGQS ARAIMAQLPQ EQKAKIAEQV ASFQEEKSKL DAEVSKWDDS GNDIIVLAKQ 

       730        740        750        760        770        780 
MCMIMMEMTD FTRGKGPLKN TSDVISAAKK IAEAGSRMDK LGRTIADHCP DSACKQDLLA 

       790        800        810        820        830        840 
YLQRIALYCH QLNICSKVKA EVQNLGGELV VSGVDSAMSL IQAAKNLMNA VVQTVKASYV 

       850        860        870        880        890        900 
ASTKYQKSQG MASLNLPAVS WKMKAPEKKP LVKREKQDET QTKIKRASQK KHVNPVQALS 


EFKAMDSI 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney EMBL AAH85789.1.
[2]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000008041.
[3]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL76253.1.
[4]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL76253.1.
[5]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000008041.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06094581 Genomic DNA. No translation available.
AABR06094582 Genomic DNA. No translation available.
BC085789 mRNA. Translation: AAH85789.1.
CH473974 Genomic DNA. Translation: EDL76253.1.
RefSeqNP_001007146.1. NM_001007145.1.
UniGeneRn.103790.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000008041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000008041; ENSRNOP00000008041; ENSRNOG00000005796.
GeneID307505.
KEGGrno:307505.
UCSCRGD:1359485. rat.

Organism-specific databases

CTD1495.
RGD1359485. Ctnna1.

Phylogenomic databases

eggNOGNOG240050.
GeneTreeENSGT00550000074411.
HOGENOMHOG000280724.
HOVERGENHBG000069.
KOK05691.
OMARTIANHC.
OrthoDBEOG7HQN7B.
TreeFamTF313686.

Gene expression databases

GenevestigatorQ5U302.

Family and domain databases

InterProIPR001033. Alpha_catenin.
IPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view]
PANTHERPTHR18914. PTHR18914. 1 hit.
PfamPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSPR00805. ALPHACATENIN.
SUPFAMSSF47220. SSF47220. 4 hits.
PROSITEPS00663. VINCULIN_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio657513.

Entry information

Entry nameQ5U302_RAT
AccessionPrimary (citable) accession number: Q5U302
Entry history
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)