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Q5U302

- Q5U302_RAT

UniProt

Q5U302 - Q5U302_RAT

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Protein
Submitted name:

Catenin (Cadherin associated protein), alpha 1

Gene

Ctnna1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. aging Source: RGD
  2. apical junction assembly Source: Ensembl
  3. axon regeneration Source: RGD
  4. cellular protein localization Source: Ensembl
  5. cellular response to indole-3-methanol Source: Ensembl
  6. epithelial cell-cell adhesion Source: Ensembl
  7. establishment or maintenance of cell polarity Source: Ensembl
  8. gap junction assembly Source: RGD
  9. male gonad development Source: RGD
  10. negative regulation of apoptotic process Source: Ensembl
  11. negative regulation of cell motility Source: Ensembl
  12. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  13. negative regulation of integrin-mediated signaling pathway Source: Ensembl
  14. negative regulation of neuroblast proliferation Source: Ensembl
  15. odontogenesis of dentin-containing tooth Source: RGD
  16. ovarian follicle development Source: RGD
  17. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  18. positive regulation of smoothened signaling pathway Source: Ensembl
  19. protein heterooligomerization Source: RGD
  20. response to estrogen Source: RGD
  21. response to organic cyclic compound Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_248864. CDO in myogenesis.
REACT_254281. Adherens junctions interactions.
REACT_256841. VEGFR2 mediated vascular permeability.

Names & Taxonomyi

Protein namesi
Submitted name:
Catenin (Cadherin associated protein), alpha 1Imported
Submitted name:
Catenin (Cadherin-associated protein), alpha 1, isoform CRA_bImported
Submitted name:
Protein Ctnna1Imported
Gene namesi
Name:Ctnna1Imported
Synonyms:Catna1Imported
ORF Names:rCG_49560Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi1359485. Ctnna1.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: RGD
  2. actin cytoskeleton Source: InterPro
  3. catenin complex Source: Ensembl
  4. cell-cell adherens junction Source: RGD
  5. cell-cell junction Source: RGD
  6. cytoplasm Source: RGD
  7. intercalated disc Source: Ensembl
  8. lamellipodium Source: Ensembl
  9. plasma membrane Source: RGD
  10. zonula adherens Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ5U302.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008041.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG240050.
GeneTreeiENSGT00550000074411.
HOGENOMiHOG000280724.
HOVERGENiHBG000069.
KOiK05691.
OMAiRTIANHC.
OrthoDBiEOG7HQN7B.
TreeFamiTF313686.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 1 hit.
PfamiPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 4 hits.
PROSITEiPS00663. VINCULIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U302-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAVHTGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK
60 70 80 90 100
KRGRSKKAHV LAASVEQATE NFLEKGDKIA KESQFLKEEL VAAVDDVRKQ
110 120 130 140 150
GDLMKSAAGE FADDPCSSVK RGNMVRAARA LLSAVTRLLI LADMADVYKL
160 170 180 190 200
LVQLKVVEDG ILKLRNAGNE QDLGIQYRAL KPEVDKLNIM AAKRQQELKD
210 220 230 240 250
VGHRDQMAAA RGILQKNVPI LYTASQACLQ HPDVAAYKAN RDLIYKQLQQ
260 270 280 290 300
AVTGISNAAQ ATASDDASQQ QGGGGGGGEL AYALNNFDKQ IIVDPLSFSE
310 320 330 340 350
ERFRPSLEER LESIISGAAL MADSSCTRDD RRERIVAECN AVRQALQDLL
360 370 380 390 400
SEYMGNAGRK ERSDALNSAI DKMTKKTRDL RRQLRKAVMD HVSDSFLETN
410 420 430 440 450
VPLLVLIEAA KNGNEKEVKE YAQVFREHAN KLIEVANLAC SISNNEEGVK
460 470 480 490 500
LVRMSASQLE ALCPQVINAA LALAAKPQSK LAQENMDLFK EQWEKQVRVL
510 520 530 540 550
TDAVDDITSI DDFLAVSENH ILEDVNKCVI ALQEKDVDGL DRTAGAIRGR
560 570 580 590 600
AARVIHVVTS EMDNYEPGVY TEKVLEATKL LSNTVMPRFT EQVEAAVEAL
610 620 630 640 650
SSDPAQPMDE NEFIDASRLV YDGIRDIRKA VLMIRTPEEL DDSDFETEDF
660 670 680 690 700
DVRSRTSVQT EDDQLIAGQS ARAIMAQLPQ EQKAKIAEQV ASFQEEKSKL
710 720 730 740 750
DAEVSKWDDS GNDIIVLAKQ MCMIMMEMTD FTRGKGPLKN TSDVISAAKK
760 770 780 790 800
IAEAGSRMDK LGRTIADHCP DSACKQDLLA YLQRIALYCH QLNICSKVKA
810 820 830 840 850
EVQNLGGELV VSGVDSAMSL IQAAKNLMNA VVQTVKASYV ASTKYQKSQG
860 870 880 890 900
MASLNLPAVS WKMKAPEKKP LVKREKQDET QTKIKRASQK KHVNPVQALS

EFKAMDSI
Length:908
Mass (Da):100,236
Last modified:December 7, 2004 - v1
Checksum:i247F212CF5C620C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06094581 Genomic DNA. No translation available.
AABR06094582 Genomic DNA. No translation available.
BC085789 mRNA. Translation: AAH85789.1.
CH473974 Genomic DNA. Translation: EDL76253.1.
RefSeqiNP_001007146.1. NM_001007145.1.
UniGeneiRn.103790.

Genome annotation databases

EnsembliENSRNOT00000008041; ENSRNOP00000008041; ENSRNOG00000005796.
GeneIDi307505.
KEGGirno:307505.
UCSCiRGD:1359485. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06094581 Genomic DNA. No translation available.
AABR06094582 Genomic DNA. No translation available.
BC085789 mRNA. Translation: AAH85789.1 .
CH473974 Genomic DNA. Translation: EDL76253.1 .
RefSeqi NP_001007146.1. NM_001007145.1.
UniGenei Rn.103790.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000008041 ; ENSRNOP00000008041 ; ENSRNOG00000005796 .
GeneIDi 307505.
KEGGi rno:307505.
UCSCi RGD:1359485. rat.

Organism-specific databases

CTDi 1495.
RGDi 1359485. Ctnna1.

Phylogenomic databases

eggNOGi NOG240050.
GeneTreei ENSGT00550000074411.
HOGENOMi HOG000280724.
HOVERGENi HBG000069.
KOi K05691.
OMAi RTIANHC.
OrthoDBi EOG7HQN7B.
TreeFami TF313686.

Enzyme and pathway databases

Reactomei REACT_248864. CDO in myogenesis.
REACT_254281. Adherens junctions interactions.
REACT_256841. VEGFR2 mediated vascular permeability.

Miscellaneous databases

NextBioi 657513.

Gene expression databases

Genevestigatori Q5U302.

Family and domain databases

InterProi IPR001033. Alpha_catenin.
IPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view ]
PANTHERi PTHR18914. PTHR18914. 1 hit.
Pfami PF01044. Vinculin. 2 hits.
[Graphical view ]
PRINTSi PR00805. ALPHACATENIN.
SUPFAMi SSF47220. SSF47220. 4 hits.
PROSITEi PS00663. VINCULIN_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ5U302_RAT
AccessioniPrimary (citable) accession number: Q5U302
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3