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Protein

A-kinase anchor protein 2

Gene

Akap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).By similarity

GO - Molecular functioni

  • protein domain specific binding Source: RGD

GO - Biological processi

  • protein heterooligomerization Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 2
Short name:
AKAP-2
Gene namesi
Name:Akap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305135. Akap2.

Subcellular locationi

GO - Cellular componenti

  • protein complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003800901 – 870A-kinase anchor protein 2Add BLAST870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei122PhosphoserineCombined sources1
Modified residuei152PhosphoserineBy similarity1
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei347PhosphoserineCombined sources1
Modified residuei472PhosphoserineBy similarity1
Modified residuei476PhosphoserineCombined sources1
Modified residuei484PhosphoserineBy similarity1
Modified residuei528PhosphoserineBy similarity1
Modified residuei537PhosphothreonineBy similarity1
Modified residuei641PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1
Modified residuei758PhosphoserineBy similarity1
Modified residuei789PhosphoserineBy similarity1
Modified residuei796PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5U301.
PeptideAtlasiQ5U301.
PRIDEiQ5U301.

PTM databases

iPTMnetiQ5U301.
PhosphoSitePlusiQ5U301.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015576.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni576 – 589PKA-RII subunit binding domainBy similarityAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili213 – 307Sequence analysisAdd BLAST95
Coiled coili720 – 755Sequence analysisAdd BLAST36

Domaini

The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG9A. Eukaryota.
ENOG410ZMFZ. LUCA.
HOGENOMiHOG000231745.
InParanoidiQ5U301.

Family and domain databases

InterProiIPR029304. AKAP2_C.
[Graphical view]
PfamiPF15304. AKAP2_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIGVSVAEC KSVPGITSTP HSKDHSSPFY SPSHNGLLTD HHESLDNDVA
60 70 80 90 100
REIQYLDEVL EANCCDSSVD GTYNGISSPE PGAAILVSSL GSPAHSATKV
110 120 130 140 150
EPIEKASGRQ LPPHIELSRS PSDSMAEGER ANGHSTDQPQ DMLGNSLQAP
160 170 180 190 200
ASPSSSTSSH CSSRDGEFTL TTLKKEAKFE LRAFHEDKKP SKLFEEDEHE
210 220 230 240 250
KEQFCIRKVR PSEEMIELEK ERRELIRSQA VKKNPGIAAK WWNPPQKKTI
260 270 280 290 300
EEQLDEEHLE SHRKYKERKE KRAQQEQLQL QQQQQQQLQQ LQQLQQQQQQ
310 320 330 340 350
QLSTSQLCTA PAAHEHLDSI EHTKEDVVTE QIDFSAARKQ FQQMENSRQT
360 370 380 390 400
LAKGQSTPRL FSIKPFYKPL GSINSDKPPT ILRPATIGGT VEDSSTQAAK
410 420 430 440 450
EQKALCVSES QSAGAGTGNA ATQGKEGPYS EPSKRGPLSK LWAEDGEFTS
460 470 480 490 500
ARAVLTVVKD EDHGILDQFS RSVNVSLTQE ELDSGLDELS VRSQDTTVLE
510 520 530 540 550
TLSNDFSMDN ISDSGASNET PNALQENSLA DFSLPQTPQT DNPSEGREGV
560 570 580 590 600
SKSFSDHGFY SPSSTLGDSP SVDDPLEYQA GLLVQNAIQQ AIAEQVDKAE
610 620 630 640 650
VHTSKEGSEQ QEPGAMVEEA GSQAPGSEKP QGMFAPPQVS SPVQEKRDVL
660 670 680 690 700
PKILPGEDKT LREKGPSQPP TAVQPSGPVN MKETRPEGGY FSKYSEAAEL
710 720 730 740 750
RSTASLLATQ ESDVMVGPFK LRSRKQRTLS MIEEEIRAAQ EREEELKRQR
760 770 780 790 800
QVRQSTPSPR AQNAPSLPSR TTCYKTAPGK IEKVKPPPSP TTEGPSLQPD
810 820 830 840 850
LAPEEAAGAQ RPKNLMQTLM EDYETHKSKR RERMDDSSVL EATRVNRRKS
860 870
ALALRWEAGI YANQEEEDNE
Length:870
Mass (Da):95,941
Last modified:December 7, 2004 - v1
Checksum:i516C22DA6D7A2DD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085790 mRNA. Translation: AAH85790.1.
UniGeneiRn.101657.
Rn.162811.

Genome annotation databases

UCSCiRGD:1305135. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085790 mRNA. Translation: AAH85790.1.
UniGeneiRn.101657.
Rn.162811.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015576.

PTM databases

iPTMnetiQ5U301.
PhosphoSitePlusiQ5U301.

Proteomic databases

PaxDbiQ5U301.
PeptideAtlasiQ5U301.
PRIDEiQ5U301.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1305135. rat.

Organism-specific databases

RGDi1305135. Akap2.

Phylogenomic databases

eggNOGiENOG410IG9A. Eukaryota.
ENOG410ZMFZ. LUCA.
HOGENOMiHOG000231745.
InParanoidiQ5U301.

Miscellaneous databases

PROiQ5U301.

Family and domain databases

InterProiIPR029304. AKAP2_C.
[Graphical view]
PfamiPF15304. AKAP2_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKAP2_RAT
AccessioniPrimary (citable) accession number: Q5U301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.