Q5U2Z4 (Q5U2Z4_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 EMBL AAH85800.1

Submitted name:
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a EMBL EDL94341.1
Submitted name:
Uncharacterized protein Ensembl ENSRNOP00000026235

Gene names

Name:	Nfkb2 Ensembl ENSRNOP00000026235 RGD 1307189 EMBL AAH85800.1
ORF Names:	rCG_57816 EMBL EDL94341.1

Organism

Rattus norvegicus (Rat) EMBL AAH85800.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	898 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 RHD (Rel-like) domain. RuleBase RU003997

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU003998
Domain	ANK repeat RuleBase RU003321 Repeat RuleBase RU003536
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aging Inferred from expression pattern. Source: RGD response to cytokine stimulus Inferred from expression pattern. Source: RGD response to lipopolysaccharide Inferred from expression pattern. Source: RGD signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from direct assay. Source: RGD nucleus Inferred from direct assay. Source: RGD
Molecular function	protein binding Inferred from physical interaction. Source: RGD sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5U2Z4 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 13E06137B24A4CBC	FASTA	898	96,739
	10 20 30 40 50 60 MDRCYDPGLD GIPEYDDFEF SPSIVEPKDP APETADGPYL VIVEQPKQRG FRFRYGCEGP 70 80 90 100 110 120 SHGGLPGASS EKGRKTYPTV KICNYEGPAK IEVDLVTHSD PPRAHAHSLV GKQCSELGVC 130 140 150 160 170 180 AVSVGPKDMT AQFNNLGVLH VTKKNMMEIM IQKLQRQRLR SKPQGLTEAE RRELEQEAKE 190 200 210 220 230 240 LKKVMDLSIV RLRFSAFLRA SDGSFSLPLK PVISQPIHDS KSPGASNLKI SRMDKTAGSV 250 260 270 280 290 300 RGGDEVYLLC DKVQKDDIEV RFYEDDENGW QAFGDFSPTD VHKQYAIVFR TPPYHKMKIE 310 320 330 340 350 360 RPVTVFLQLK RKRGGDVSDS KQFTYYPLVE DKEEVQRKRR KALPTFSQPF GGGSHMGGGS 370 380 390 400 410 420 GGSAGGYGGA GGGGSLGFFS SFAYSPYQSG AAPMGCFPGG GGGAQMAGSG RDAEAGEAEE 430 440 450 460 470 480 QPRAPSEAPQ SEQQALDTLQ RAREYNARLF GLAQRSARAL LDYGVTADAR ALLAGQRHLL 490 500 510 520 530 540 MAQDENGDTP LHLAIIHGQT GVIEQIAQVI YHAQYLGVIN LTNHLHQTPL HLAVITGQTR 550 560 570 580 590 600 VVSFLLQVGA DPTLLDRHGD SAVHLALRAG AAAPDLLQAV LHSGAHALPQ MLHMPDFEGL 610 620 630 640 650 660 YPVHLAVHAR SPECLDLLVD CGAEVEAAER QGGRTPLHLA TEMEELGLVT HLVTKLHANV 670 680 690 700 710 720 NARTFAGNTP LHLAAGLGSP TLTRLLLKAG ADIHAENEEP LCPLPSPPTS GSDSDSEGPE 730 740 750 760 770 780 TDTQRNFRGH TPLDLTRSTK VKTLLLNAAQ NTTEPPLAPP SPAGPGLSLG DAALQNLEQL 790 800 810 820 830 840 LDGPEAQGSW AELAERLGLR SLVDTYRKTP SPSGSLLRSY KLAGGDLVGL LEALSDMGLH 850 860 870 880 890 EGVRLLKAPE TRDKLPSTEV KEDSAYGSQS VEQEAEKLCP PPEPPGGLCH GHPQPQVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney EMBL AAH85800.1.
[2]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed: 15057822] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000026235.
[3]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed: 15632090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL94341.1.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000026235.
[5]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL94341.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC096363 Genomic DNA. No translation available. BC085800 mRNA. Translation: AAH85800.1. CH473986 Genomic DNA. Translation: EDL94341.1. CH473986 Genomic DNA. Translation: EDL94342.1.
IPI	IPI00196187.
RefSeq	NP_001008350.1. NM_001008349.1.
UniGene	Rn.204814.
3D structure databases
ProteinModelPortal	Q5U2Z4.
SMR	Q5U2Z4. Positions 37-327, 771-865.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5U2Z4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000026235; ENSRNOP00000026235; ENSRNOG00000019311.
GeneID	309452.
KEGG	rno:309452.
NMPDR	fig|10116.3.peg.4205.
UCSC	NM_001008349. rat.
Organism-specific databases
CTD	4791.
RGD	1307189. Nfkb2.
Phylogenomic databases
eggNOG	roNOG11784.
GeneTree	ENSGT00500000044765.
HOVERGEN	HBG052613.
InParanoid	Q5U2Z4.
OMA	VITGQTS.
OrthoDB	EOG4T4CV2.
PhylomeDB	Q5U2Z4.
Gene expression databases
ArrayExpress	Q5U2Z4.
Genevestigator	Q5U2Z4.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000488. Death. IPR011029. DEATH-like. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR002909. IPT_TIG_rcpt. IPR000451. NF_Rel_dor. IPR008967. p53-like_TF_DNA-bd. IPR011539. RHD. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:1.10.533.10. DEATH_like. 1 hit. G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:2.60.40.340. RHD. 1 hit.
KO	K04469.
Pfam	PF12796. Ank_2. 2 hits. PF00531. Death. 1 hit. PF00554. RHD. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN. PR00057. NFKBTNSCPFCT.
SMART	SM00248. ANK. 6 hits. SM00005. DEATH. 1 hit. SM00429. IPT. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF47986. DEATH_like. 1 hit. SSF81296. Ig_E-set. 1 hit. SSF49417. P53_like_DNA_bnd. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. PS01204. REL_1. 1 hit. PS50254. REL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	660810.

Entry information

Entry name

Q5U2Z4_RAT

Accession

Primary (citable) accession number: Q5U2Z4

Entry history

Integrated into UniProtKB/TrEMBL:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)