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Protein
Submitted name:

Nuclear factor kappa B subunit 2

Gene

Nfkb2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1810476 RIP-mediated NFkB activation via ZBP1
R-RNO-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-RNO-3214841 PKMTs methylate histone lysines
R-RNO-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-RNO-448706 Interleukin-1 processing
R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5676590 NIK-->noncanonical NF-kB signaling
R-RNO-933542 TRAF6 mediated NF-kB activation

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor kappa B subunit 2Imported
Submitted name:
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100Imported
Submitted name:
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_aImported
Gene namesi
Name:Nfkb2Imported
ORF Names:rCG_57816Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307189 Nfkb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ5U2Z4

Expressioni

Gene expression databases

BgeeiENSRNOG00000019311

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026235

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 224RHDInterPro annotationAdd BLAST190
Domaini486 – 698ANK_REP_REGIONInterPro annotationAdd BLAST213
Repeati486 – 508ANKPROSITE-ProRule annotationAdd BLAST23
Repeati525 – 557ANKPROSITE-ProRule annotationAdd BLAST33
Repeati598 – 630ANKPROSITE-ProRule annotationAdd BLAST33
Repeati632 – 665ANKPROSITE-ProRule annotationAdd BLAST34
Repeati666 – 698ANKPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili164 – 191Sequence analysisAdd BLAST28

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00500000044765
HOGENOMiHOG000004822
HOVERGENiHBG052613
KOiK04469
OMAiFRGHTPL
OrthoDBiEOG091G03PF
TreeFamiTF325632

Family and domain databases

CDDicd00204 ANK, 2 hits
cd01177 IPT_NFkappaB, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF00531 Death, 1 hit
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01415 ANKYRIN
PR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00005 DEATH, 1 hit
SM00429 IPT, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U2Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRCYDPGLD GIPEYDDFEF SPSIVEPKDP APETADGPYL VIVEQPKQRG
60 70 80 90 100
FRFRYGCEGP SHGGLPGASS EKGRKTYPTV KICNYEGPAK IEVDLVTHSD
110 120 130 140 150
PPRAHAHSLV GKQCSELGVC AVSVGPKDMT AQFNNLGVLH VTKKNMMEIM
160 170 180 190 200
IQKLQRQRLR SKPQGLTEAE RRELEQEAKE LKKVMDLSIV RLRFSAFLRA
210 220 230 240 250
SDGSFSLPLK PVISQPIHDS KSPGASNLKI SRMDKTAGSV RGGDEVYLLC
260 270 280 290 300
DKVQKDDIEV RFYEDDENGW QAFGDFSPTD VHKQYAIVFR TPPYHKMKIE
310 320 330 340 350
RPVTVFLQLK RKRGGDVSDS KQFTYYPLVE DKEEVQRKRR KALPTFSQPF
360 370 380 390 400
GGGSHMGGGS GGSAGGYGGA GGGGSLGFFS SFAYSPYQSG AAPMGCFPGG
410 420 430 440 450
GGGAQMAGSG RDAEAGEAEE QPRAPSEAPQ SEQQALDTLQ RAREYNARLF
460 470 480 490 500
GLAQRSARAL LDYGVTADAR ALLAGQRHLL MAQDENGDTP LHLAIIHGQT
510 520 530 540 550
GVIEQIAQVI YHAQYLGVIN LTNHLHQTPL HLAVITGQTR VVSFLLQVGA
560 570 580 590 600
DPTLLDRHGD SAVHLALRAG AAAPDLLQAV LHSGAHALPQ MLHMPDFEGL
610 620 630 640 650
YPVHLAVHAR SPECLDLLVD CGAEVEAAER QGGRTPLHLA TEMEELGLVT
660 670 680 690 700
HLVTKLHANV NARTFAGNTP LHLAAGLGSP TLTRLLLKAG ADIHAENEEP
710 720 730 740 750
LCPLPSPPTS GSDSDSEGPE TDTQRNFRGH TPLDLTRSTK VKTLLLNAAQ
760 770 780 790 800
NTTEPPLAPP SPAGPGLSLG DAALQNLEQL LDGPEAQGSW AELAERLGLR
810 820 830 840 850
SLVDTYRKTP SPSGSLLRSY KLAGGDLVGL LEALSDMGLH EGVRLLKAPE
860 870 880 890
TRDKLPSTEV KEDSAYGSQS VEQEAEKLCP PPEPPGGLCH GHPQPQVH
Length:898
Mass (Da):96,739
Last modified:December 7, 2004 - v1
Checksum:i13E06137B24A4CBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096600 Genomic DNA No translation available.
BC085800 mRNA Translation: AAH85800.1
CH473986 Genomic DNA Translation: EDL94341.1
CH473986 Genomic DNA Translation: EDL94342.1
RefSeqiNP_001008350.1, NM_001008349.1
XP_006231565.1, XM_006231503.3
UniGeneiRn.204814

Genome annotation databases

EnsembliENSRNOT00000026235; ENSRNOP00000026235; ENSRNOG00000019311
GeneIDi309452
KEGGirno:309452

Similar proteinsi

Entry informationi

Entry nameiQ5U2Z4_RAT
AccessioniPrimary (citable) accession number: Q5U2Z4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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