Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleosome assembly protein 1-like 4

Gene

Nap1l4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 4
Gene namesi
Name:Nap1l4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305391. Nap1l4.

Subcellular locationi

GO - Cellular componenti

  • dendrite Source: RGD
  • neuronal cell body Source: RGD
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 386385Nucleosome assembly protein 1-like 4PRO_0000236214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei5 – 51PhosphoserineBy similarity
Modified residuei7 – 71PhosphoserineCombined sources
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei51 – 511PhosphothreonineCombined sources
Modified residuei53 – 531PhosphoserineCombined sources
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei125 – 1251PhosphoserineCombined sources
Modified residuei146 – 1461N6-acetyllysineBy similarity
Modified residuei304 – 3041PhosphoserineBy similarity

Post-translational modificationi

Polyglutamylated and polyglycylated. These 2 modifications occur exclusively on glutamate residues and result in either polyglutamate or polyglycine chains on the gamma-carboxyl group. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Polyglutamylated by TTLL4.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5U2Z3.
PRIDEiQ5U2Z3.

PTM databases

iPTMnetiQ5U2Z3.
PhosphoSiteiQ5U2Z3.

Expressioni

Gene expression databases

ExpressionAtlasiQ5U2Z3. baseline and differential.
GenevisibleiQ5U2Z3. RN.

Interactioni

Protein-protein interaction databases

BioGridi262874. 1 interaction.
IntActiQ5U2Z3. 2 interactions.
STRINGi10116.ENSRNOP00000051745.

Structurei

3D structure databases

ProteinModelPortaliQ5U2Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi265 – 2717Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi301 – 31010Asp/Glu-rich (acidic)
Compositional biasi347 – 37024Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1507. Eukaryota.
ENOG410XQN9. LUCA.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiQ5U2Z3.
KOiK11282.
OMAiDDADVNP.
OrthoDBiEOG73Z2T8.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 2 hits.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENSLSDGG PADSVEAAKN ASNTEKLTDQ VMQNPQVLAA LQERLDNVSH
60 70 80 90 100
TPSSYIETLP KAVKRRINAL KQLQVRCAHI EAKFYEEVHD LERKYAALYQ
110 120 130 140 150
PLFDKRREFI TGDVEPTDAE SAWHSENEED DKLAGDMKNK VVIAEKEAAA
160 170 180 190 200
VEELNPKGIP EFWFTIFRNV DMLSELVQEY DEPILKHLQD IKVKFSDPGQ
210 220 230 240 250
PMSFVLEFHF EPNDYFTNPV LTKTYKMKSE PDKADPFSFE GPEIVDCDGC
260 270 280 290 300
TIDWKKGKNV TVKTIKKKQK HKGRGTVRTI TKQVPNESFF NFFSPLKASG
310 320 330 340 350
DGESLDEDSE FTLASDFEIG HFFRERIVPR AVLYFTGEAI EDDDNFEEGE
360 370 380
EGEEEELEGD EEGEDEDDAD VNPKKEPIQP AECKQQ
Length:386
Mass (Da):43,917
Last modified:December 7, 2004 - v1
Checksum:i7A7A5166964D7AFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085801 mRNA. Translation: AAH85801.1.
RefSeqiNP_001012170.1. NM_001012170.1.
XP_006230885.1. XM_006230823.2.
XP_006230886.1. XM_006230824.2.
UniGeneiRn.3286.

Genome annotation databases

EnsembliENSRNOT00000087961; ENSRNOP00000075200; ENSRNOG00000020615.
GeneIDi361684.
KEGGirno:361684.
UCSCiRGD:1305391. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085801 mRNA. Translation: AAH85801.1.
RefSeqiNP_001012170.1. NM_001012170.1.
XP_006230885.1. XM_006230823.2.
XP_006230886.1. XM_006230824.2.
UniGeneiRn.3286.

3D structure databases

ProteinModelPortaliQ5U2Z3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262874. 1 interaction.
IntActiQ5U2Z3. 2 interactions.
STRINGi10116.ENSRNOP00000051745.

PTM databases

iPTMnetiQ5U2Z3.
PhosphoSiteiQ5U2Z3.

Proteomic databases

PaxDbiQ5U2Z3.
PRIDEiQ5U2Z3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000087961; ENSRNOP00000075200; ENSRNOG00000020615.
GeneIDi361684.
KEGGirno:361684.
UCSCiRGD:1305391. rat.

Organism-specific databases

CTDi4676.
RGDi1305391. Nap1l4.

Phylogenomic databases

eggNOGiKOG1507. Eukaryota.
ENOG410XQN9. LUCA.
GeneTreeiENSGT00480000042668.
HOGENOMiHOG000171827.
HOVERGENiHBG052653.
InParanoidiQ5U2Z3.
KOiK11282.
OMAiDDADVNP.
OrthoDBiEOG73Z2T8.

Miscellaneous databases

PROiQ5U2Z3.

Gene expression databases

ExpressionAtlasiQ5U2Z3. baseline and differential.
GenevisibleiQ5U2Z3. RN.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 2 hits.
PfamiPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; THR-51; SER-53 AND SER-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNP1L4_RAT
AccessioniPrimary (citable) accession number: Q5U2Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.