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Protein

Nucleosome assembly protein 1-like 4

Gene

Nap1l4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as histone chaperone in nucleosome assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 4
Gene namesi
Name:Nap1l4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305391 Nap1l4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002362142 – 386Nucleosome assembly protein 1-like 4Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei7PhosphoserineCombined sources1
Modified residuei49PhosphoserineBy similarity1
Modified residuei51PhosphothreonineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei54PhosphoserineBy similarity1
Modified residuei58PhosphothreonineBy similarity1
Modified residuei105N6-acetyllysineBy similarity1
Modified residuei125PhosphoserineCombined sources1
Modified residuei146N6-acetyllysineBy similarity1
Modified residuei304PhosphoserineBy similarity1

Post-translational modificationi

Polyglutamylated and polyglycylated. These 2 modifications occur exclusively on glutamate residues and result in either polyglutamate or polyglycine chains on the gamma-carboxyl group. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Polyglutamylated by TTLL4.By similarity
Phosphorylated at the G0/G1 boundary but it is not phosphorylated in S-phase. Phosphorylated protein remains in the cytoplasm in a complex with histones during the G0/G1 transition, whereas dephosphorylation triggers its transport into the nucleus at the G1/S-boundary.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5U2Z3
PRIDEiQ5U2Z3

PTM databases

iPTMnetiQ5U2Z3
PhosphoSitePlusiQ5U2Z3
SwissPalmiQ5U2Z3

Expressioni

Gene expression databases

BgeeiENSRNOG00000020615
ExpressionAtlasiQ5U2Z3 baseline and differential
GenevisibleiQ5U2Z3 RN

Interactioni

Subunit structurei

Interacts with core (H2A, H2B, H3, H4) and linker (H1) histones.By similarity

Protein-protein interaction databases

BioGridi262874, 2 interactors
IntActiQ5U2Z3, 2 interactors
STRINGi10116.ENSRNOP00000051745

Structurei

3D structure databases

ProteinModelPortaliQ5U2Z3
SMRiQ5U2Z3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi265 – 271Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi301 – 310Asp/Glu-rich (acidic)10
Compositional biasi347 – 370Asp/Glu-rich (acidic)Add BLAST24

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1507 Eukaryota
ENOG410XQN9 LUCA
GeneTreeiENSGT00480000042668
HOGENOMiHOG000171827
HOVERGENiHBG052653
InParanoidiQ5U2Z3
KOiK11282
OrthoDBiEOG091G0HVV

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENSLSDGG PADSVEAAKN ASNTEKLTDQ VMQNPQVLAA LQERLDNVSH
60 70 80 90 100
TPSSYIETLP KAVKRRINAL KQLQVRCAHI EAKFYEEVHD LERKYAALYQ
110 120 130 140 150
PLFDKRREFI TGDVEPTDAE SAWHSENEED DKLAGDMKNK VVIAEKEAAA
160 170 180 190 200
VEELNPKGIP EFWFTIFRNV DMLSELVQEY DEPILKHLQD IKVKFSDPGQ
210 220 230 240 250
PMSFVLEFHF EPNDYFTNPV LTKTYKMKSE PDKADPFSFE GPEIVDCDGC
260 270 280 290 300
TIDWKKGKNV TVKTIKKKQK HKGRGTVRTI TKQVPNESFF NFFSPLKASG
310 320 330 340 350
DGESLDEDSE FTLASDFEIG HFFRERIVPR AVLYFTGEAI EDDDNFEEGE
360 370 380
EGEEEELEGD EEGEDEDDAD VNPKKEPIQP AECKQQ
Length:386
Mass (Da):43,917
Last modified:December 7, 2004 - v1
Checksum:i7A7A5166964D7AFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085801 mRNA Translation: AAH85801.1
RefSeqiNP_001012170.1, NM_001012170.1
XP_006230885.1, XM_006230823.3
XP_006230886.1, XM_006230824.3
UniGeneiRn.3286

Genome annotation databases

EnsembliENSRNOT00000087961; ENSRNOP00000075200; ENSRNOG00000020615
GeneIDi361684
KEGGirno:361684
UCSCiRGD:1305391 rat

Similar proteinsi

Entry informationi

Entry nameiNP1L4_RAT
AccessioniPrimary (citable) accession number: Q5U2Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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