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Protein

Lebercilin

Gene

Lca5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Might be involved in minus end-directed microtubule transport.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lebercilin
Alternative name(s):
Leber congenital amaurosis 5 protein homolog
Gene namesi
Name:Lca5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1308555. Lca5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727LebercilinPRO_0000089548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2Y9.
PRIDEiQ5U2Y9.

Expressioni

Gene expression databases

ExpressionAtlasiQ5U2Y9. baseline.
GenevisibleiQ5U2Y9. RN.

Interactioni

Subunit structurei

Interacts with NINL. Interacts with OFD1. Interacts with FAM161A.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046841.

Structurei

3D structure databases

ProteinModelPortaliQ5U2Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili112 – 301190Sequence analysisAdd
BLAST
Coiled coili449 – 48032Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi618 – 64225Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the LCA5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKE1. Eukaryota.
ENOG4111R6E. LUCA.
GeneTreeiENSGT00560000077266.
HOGENOMiHOG000113290.
HOVERGENiHBG074315.
InParanoidiQ5U2Y9.
OMAiNGHHLQD.
OrthoDBiEOG7D85WN.
PhylomeDBiQ5U2Y9.
TreeFamiTF323306.

Family and domain databases

InterProiIPR026684. Lebercilin.
IPR026188. Lebercilin-like.
IPR028933. Lebercilin_dom.
[Graphical view]
PANTHERiPTHR16650. PTHR16650. 2 hits.
PTHR16650:SF10. PTHR16650:SF10. 2 hits.
PfamiPF15619. Lebercilin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U2Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGERDQSSDT DQERKGGKHP YSSHYSSDFG SSPQSSGPSS PVNTPPCASN
60 70 80 90 100
REKNPKRHLS DHHVRHQTVR KVSPKAIPNK KGVRVGFRSQ SLNREPLRKD
110 120 130 140 150
PDIVTKRVLS ARLLKITELQ NEVSELQVKL AQLLKENKAL KSLQYRQEKA
160 170 180 190 200
LSKFEDAENE ISQLIHRHNG EITALKERLR KSQEKERMAE KRVKDTEGEL
210 220 230 240 250
FRTKFSLQKL KKISEARHLP ERDDLAKKLV SAELKLDNTE RKIKELSKNL
260 270 280 290 300
ELSTNSFQRQ LLAERKRAFE AHDENKILQK ELQRLHHKLK EKEKELDIKN
310 320 330 340 350
IYANRLPKSS PKKEKEIARK HASCQSDFTD LCTKAVQTAE DFEPEEFPFT
360 370 380 390 400
AQTVLCYENR WDGSEYLPSY LEYQERNEHG SESLSSTLEQ EGKYSDDQDS
410 420 430 440 450
CTAKQETGKS ECEWEREELD KVKGKSSLLG RTEKLVLEAG SVQTESYQAQ
460 470 480 490 500
TIDKFQDEAE RLKTEMLLAK LNEINKELQD PQSLSRPLLP LLPNFESKLY
510 520 530 540 550
SPDRSLRPYT FSESLDRSFN GQHLSDMSFL TPRDEGQSPG LIRSPAPSDE
560 570 580 590 600
FSFGSYVPSF GKTPGKSNPP SQKNSLLDFQ SNMSEGLSKD SLDFISRKEK
610 620 630 640 650
KATLMEQLFG TSASASATNT SASTTTNTTT NTNTNTNTNT NTNCNVPSKS
660 670 680 690 700
IDSHFPAASR GDLDPLHFLS GDRSSRVREP DGEDEDLFLS EGRSFNPNRH
710 720
RLKHTSTKPT VTAVDSIDED IEEVTLR
Length:727
Mass (Da):82,610
Last modified:December 7, 2004 - v1
Checksum:i1332F2B14C7FC6B2
GO

Sequence cautioni

The sequence AAH83657.1 differs from that shown. Reason: Frameshift at position 241. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083657 mRNA. Translation: AAH83657.1. Frameshift.
BC085805 mRNA. Translation: AAH85805.1.
RefSeqiNP_001013976.1. NM_001013954.1.
XP_008764471.1. XM_008766249.1.
XP_008764472.1. XM_008766250.1.
XP_008764473.1. XM_008766251.1.
XP_008764474.1. XM_008766252.1.
XP_008764475.1. XM_008766253.1.
XP_008764477.1. XM_008766255.1.
XP_008764478.1. XM_008766256.1.
XP_008764479.1. XM_008766257.1.
XP_008764480.1. XM_008766258.1.
UniGeneiRn.208333.

Genome annotation databases

EnsembliENSRNOT00000044931; ENSRNOP00000046841; ENSRNOG00000009580.
ENSRNOT00000090139; ENSRNOP00000075180; ENSRNOG00000009580.
GeneIDi300866.
KEGGirno:300866.
UCSCiRGD:1308555. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083657 mRNA. Translation: AAH83657.1. Frameshift.
BC085805 mRNA. Translation: AAH85805.1.
RefSeqiNP_001013976.1. NM_001013954.1.
XP_008764471.1. XM_008766249.1.
XP_008764472.1. XM_008766250.1.
XP_008764473.1. XM_008766251.1.
XP_008764474.1. XM_008766252.1.
XP_008764475.1. XM_008766253.1.
XP_008764477.1. XM_008766255.1.
XP_008764478.1. XM_008766256.1.
XP_008764479.1. XM_008766257.1.
XP_008764480.1. XM_008766258.1.
UniGeneiRn.208333.

3D structure databases

ProteinModelPortaliQ5U2Y9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046841.

Proteomic databases

PaxDbiQ5U2Y9.
PRIDEiQ5U2Y9.

Protocols and materials databases

DNASUi300866.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044931; ENSRNOP00000046841; ENSRNOG00000009580.
ENSRNOT00000090139; ENSRNOP00000075180; ENSRNOG00000009580.
GeneIDi300866.
KEGGirno:300866.
UCSCiRGD:1308555. rat.

Organism-specific databases

CTDi167691.
RGDi1308555. Lca5.

Phylogenomic databases

eggNOGiENOG410IKE1. Eukaryota.
ENOG4111R6E. LUCA.
GeneTreeiENSGT00560000077266.
HOGENOMiHOG000113290.
HOVERGENiHBG074315.
InParanoidiQ5U2Y9.
OMAiNGHHLQD.
OrthoDBiEOG7D85WN.
PhylomeDBiQ5U2Y9.
TreeFamiTF323306.

Miscellaneous databases

NextBioi647670.
PROiQ5U2Y9.

Gene expression databases

ExpressionAtlasiQ5U2Y9. baseline.
GenevisibleiQ5U2Y9. RN.

Family and domain databases

InterProiIPR026684. Lebercilin.
IPR026188. Lebercilin-like.
IPR028933. Lebercilin_dom.
[Graphical view]
PANTHERiPTHR16650. PTHR16650. 2 hits.
PTHR16650:SF10. PTHR16650:SF10. 2 hits.
PfamiPF15619. Lebercilin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiLCA5_RAT
AccessioniPrimary (citable) accession number: Q5U2Y9
Secondary accession number(s): Q5XIM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: December 7, 2004
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.