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Protein

Tuftelin-interacting protein 11

Gene

Tfip11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization, mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Tuftelin-interacting protein 11
Alternative name(s):
Septin and tuftelin-interacting protein 1
Short name:
STIP-1
Gene namesi
Name:Tfip11
Synonyms:Stip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1311449. Tfip11.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 837837Tuftelin-interacting protein 11PRO_0000342278Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21PhosphoserineCombined sources
Modified residuei59 – 591PhosphoserineBy similarity
Modified residuei95 – 951PhosphoserineCombined sources
Modified residuei98 – 981PhosphoserineCombined sources
Modified residuei144 – 1441PhosphoserineBy similarity
Modified residuei210 – 2101PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2Y6.
PRIDEiQ5U2Y6.

PTM databases

iPTMnetiQ5U2Y6.
PhosphoSiteiQ5U2Y6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000663.
GenevisibleiQ5U2Y6. RN.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000828.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 19547G-patchPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5050Required for interaction with DHX15By similarityAdd
BLAST
Regioni710 – 73425Required for nuclear speckle localizationBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi700 – 7056Nuclear localization signalBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 195Poly-Asp

Sequence similaritiesi

Belongs to the TFP11/STIP family.Curated
Contains 1 G-patch domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2184. Eukaryota.
ENOG410XP4Y. LUCA.
GeneTreeiENSGT00390000012739.
HOGENOMiHOG000230470.
HOVERGENiHBG055868.
InParanoidiQ5U2Y6.
KOiK13103.
OMAiDECARVF.
OrthoDBiEOG091G04T2.
PhylomeDBiQ5U2Y6.
TreeFamiTF314887.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR022783. GCFC_dom.
IPR024933. STIP.
IPR022159. STIP/TFIP11_N.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF07842. GCFC. 1 hit.
PF12457. TIP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF017706. TFIP11. 1 hit.
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U2Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSHLYRDG EGHLDDDDDE RENFEITDWD LQNEFNPNRQ RHWQTKEEAT
60 70 80 90 100
YGVWAERDSD EERPSFGGKR ARDYSAPVNF ISAGLKKGAA EEADSEDSDA
110 120 130 140 150
EEKPVKQEDF PKDLGPKKLK TGGNFKPSQK GFAGGTKSFM DFGSWERHTK
160 170 180 190 200
GIGQKLLQKM GYVPGRGLGK NAQGIINPIE AKQRKGKGAV GAYGSERTTQ
210 220 230 240 250
SLQDFPVADS EEEAEEEFQK ELSQWRKDPS GSKKKPKYSY KTVEELKAKG
260 270 280 290 300
RVSKKLTAPQ KELSQVKVID MTGREQKVYY SYSQISHKHS VPDEGVPLLA
310 320 330 340 350
QLPPTAGKEA KVPGFALPEL EHNLQLLIER TEQEIIQSDR QLQYERDMVV
360 370 380 390 400
SLSHELEKTA EVLAHEERVI SNLSKVLALV EECEHRMQPH GADPLTLDEC
410 420 430 440 450
ARIFETLQDK YYEEYRLADR ADLAVAIVYP LVKDYFKDWH PLEDSNYGTQ
460 470 480 490 500
IISKWKSLLE NDQLLSHSSQ DLSSDAFHRL MWEVWMPFVR NVVAQWQPRN
510 520 530 540 550
CEPMVDFLDS WAHIIPVWIL DNILDQLIFP KLQKEVDNWN PLTDTVPIHS
560 570 580 590 600
WIHPWLPLMQ ARLEPLYSPV RSKLSSALQK WHPSDASAKL ILQPWKEVLT
610 620 630 640 650
PGSWEAFMLR NIVPKLGMCL GELVINPHQQ HMDAFYWVMD WEGMISVSSL
660 670 680 690 700
VGLLEKHFFP KWLQVLCSWL SNSPNYEEIT KWYLGWKSMF SDQVLAHPSV
710 720 730 740 750
KDKFNEALDI MNRAVSSNVG AYMQPGAREN IAYLTHTERR KDFQYEAMQE
760 770 780 790 800
RREAENMAQR GIGVAASSVP MNFKDLIETK AEEHNIVFMP VIGKRHEGKQ
810 820 830
LYTFGRIVIY IDRGVVFVQG EKTWVPTSLQ SLIDMAK
Length:837
Mass (Da):96,152
Last modified:December 7, 2004 - v1
Checksum:i512828055F41B243
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ342031 mRNA. Translation: ABC69923.1.
BC085809 mRNA. Translation: AAH85809.1.
RefSeqiNP_001008292.1. NM_001008291.1.
UniGeneiRn.161710.

Genome annotation databases

EnsembliENSRNOT00000000828; ENSRNOP00000000828; ENSRNOG00000000663.
GeneIDi288718.
KEGGirno:288718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ342031 mRNA. Translation: ABC69923.1.
BC085809 mRNA. Translation: AAH85809.1.
RefSeqiNP_001008292.1. NM_001008291.1.
UniGeneiRn.161710.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000828.

PTM databases

iPTMnetiQ5U2Y6.
PhosphoSiteiQ5U2Y6.

Proteomic databases

PaxDbiQ5U2Y6.
PRIDEiQ5U2Y6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000828; ENSRNOP00000000828; ENSRNOG00000000663.
GeneIDi288718.
KEGGirno:288718.

Organism-specific databases

CTDi24144.
RGDi1311449. Tfip11.

Phylogenomic databases

eggNOGiKOG2184. Eukaryota.
ENOG410XP4Y. LUCA.
GeneTreeiENSGT00390000012739.
HOGENOMiHOG000230470.
HOVERGENiHBG055868.
InParanoidiQ5U2Y6.
KOiK13103.
OMAiDECARVF.
OrthoDBiEOG091G04T2.
PhylomeDBiQ5U2Y6.
TreeFamiTF314887.

Miscellaneous databases

PROiQ5U2Y6.

Gene expression databases

BgeeiENSRNOG00000000663.
GenevisibleiQ5U2Y6. RN.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR022783. GCFC_dom.
IPR024933. STIP.
IPR022159. STIP/TFIP11_N.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF07842. GCFC. 1 hit.
PF12457. TIP_N. 1 hit.
[Graphical view]
PIRSFiPIRSF017706. TFIP11. 1 hit.
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTFP11_RAT
AccessioniPrimary (citable) accession number: Q5U2Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.