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Protein

MAGUK p55 subfamily member 7

Gene

Mpp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 7
Gene namesi
Name:Mpp7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1305675. Mpp7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576MAGUK p55 subfamily member 7PRO_0000320029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei409 – 4091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2Y3.
PRIDEiQ5U2Y3.

PTM databases

iPTMnetiQ5U2Y3.
PhosphoSiteiQ5U2Y3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018760.

Interactioni

Subunit structurei

Heterodimer; able to heterodimerize via its C-terminal L27 domain with LIN7A, LIN7B and LIN7C. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with DLG1 via its N-terminal L27 domain. Interacts with MPP5 and INADL/PATJ (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025458.

Structurei

3D structure databases

ProteinModelPortaliQ5U2Y3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 6556L27 1PROSITE-ProRule annotationAdd
BLAST
Domaini67 – 12256L27 2PROSITE-ProRule annotationAdd
BLAST
Domaini139 – 22082PDZPROSITE-ProRule annotationAdd
BLAST
Domaini228 – 29871SH3PROSITE-ProRule annotationAdd
BLAST
Domaini368 – 560193Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ5U2Y3.
OMAiSDPQHFS.
OrthoDBiEOG091G065I.
PhylomeDBiQ5U2Y3.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U2Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALATGSAC DTGLYELLAA LPAQLQPHVD SQEDLTFLWD MFGEKSLHSL
60 70 80 90 100
VKIHEKLHYY EKQSPVPILH GAAALADDLA DELQNKPPNS EIRELLKLLS
110 120 130 140 150
KPNVKALLSV HDTVAQKSYD PVLPPMPDDI DDEEDSVKII RLVKNREPLG
160 170 180 190 200
ATIKKDEQTG AITVARIMRG GAADRSGLIH VGDELREVNG IPVEDKRPEE
210 220 230 240 250
IIQILSQSQG AITFKIIPST KEEIPSKEGK IFIKALFDYD PKEDKAIPCK
260 270 280 290 300
EAGLSFRKGD ILQIMSQDDA TWWQAKHEGD TNPRAGLIPS KHFQERRLAL
310 320 330 340 350
RRPEIVVQPL KLSNRKSSGF RRSFRLSRKD KKTNKSMYEC KKSEQYDTAD
360 370 380 390 400
VPTYEEVTPY RRQTHDKYRL VVLVGPVGVG LNELKRKLLM SDTQHYGVTV
410 420 430 440 450
PHTTRARRSQ ESDGVEYIFI SKHLFETDVQ NNKFIEYGEY KNNYYGTSID
460 470 480 490 500
SVRSVLAKNK VCLLDVQPHT VKHLRTLEFK PYVIFIKPPS IERLRETRKN
510 520 530 540 550
AKIISSRDDQ GTAKPFTEED FQEMIKSAQI MESQYGHLFD KIIINDDLTV
560 570
AFNELKTTFD KLETDAHWVP VSWLHS
Length:576
Mass (Da):65,623
Last modified:February 26, 2008 - v2
Checksum:i9A8E1C8D519D5507
GO

Sequence cautioni

The sequence AAH85813 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085813 mRNA. Translation: AAH85813.1. Sequence problems.
CB580893 mRNA. No translation available.
RefSeqiNP_001094045.1. NM_001100575.1.
XP_006254200.1. XM_006254138.2.
UniGeneiRn.21436.

Genome annotation databases

EnsembliENSRNOT00000025458; ENSRNOP00000025458; ENSRNOG00000018760.
GeneIDi307035.
KEGGirno:307035.
UCSCiRGD:1305675. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085813 mRNA. Translation: AAH85813.1. Sequence problems.
CB580893 mRNA. No translation available.
RefSeqiNP_001094045.1. NM_001100575.1.
XP_006254200.1. XM_006254138.2.
UniGeneiRn.21436.

3D structure databases

ProteinModelPortaliQ5U2Y3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025458.

PTM databases

iPTMnetiQ5U2Y3.
PhosphoSiteiQ5U2Y3.

Proteomic databases

PaxDbiQ5U2Y3.
PRIDEiQ5U2Y3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025458; ENSRNOP00000025458; ENSRNOG00000018760.
GeneIDi307035.
KEGGirno:307035.
UCSCiRGD:1305675. rat.

Organism-specific databases

CTDi143098.
RGDi1305675. Mpp7.

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ5U2Y3.
OMAiSDPQHFS.
OrthoDBiEOG091G065I.
PhylomeDBiQ5U2Y3.

Miscellaneous databases

PROiQ5U2Y3.

Gene expression databases

BgeeiENSRNOG00000018760.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPP7_RAT
AccessioniPrimary (citable) accession number: Q5U2Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.