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Protein

MAGUK p55 subfamily member 7

Gene

Mpp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 7
Gene namesi
Name:Mpp7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1305675 Mpp7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003200291 – 576MAGUK p55 subfamily member 7Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei409PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2Y3
PRIDEiQ5U2Y3

PTM databases

iPTMnetiQ5U2Y3
PhosphoSitePlusiQ5U2Y3

Expressioni

Gene expression databases

BgeeiENSRNOG00000018760

Interactioni

Subunit structurei

Heterodimer; able to heterodimerize via its C-terminal L27 domain with LIN7A, LIN7B and LIN7C. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with DLG1 via its N-terminal L27 domain. Interacts with MPP5 and PATJ (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025458

Structurei

3D structure databases

ProteinModelPortaliQ5U2Y3
SMRiQ5U2Y3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 65L27 1PROSITE-ProRule annotationAdd BLAST56
Domaini67 – 122L27 2PROSITE-ProRule annotationAdd BLAST56
Domaini139 – 220PDZPROSITE-ProRule annotationAdd BLAST82
Domaini228 – 298SH3PROSITE-ProRule annotationAdd BLAST71
Domaini368 – 560Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST193

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034
HOVERGENiHBG001858
InParanoidiQ5U2Y3
OMAiKLETDTH
OrthoDBiEOG091G065I
PhylomeDBiQ5U2Y3

Family and domain databases

CDDicd12033 SH3_MPP7, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR035599 MPP7_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 2 hits
PF00595 PDZ, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U2Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALATGSAC DTGLYELLAA LPAQLQPHVD SQEDLTFLWD MFGEKSLHSL
60 70 80 90 100
VKIHEKLHYY EKQSPVPILH GAAALADDLA DELQNKPPNS EIRELLKLLS
110 120 130 140 150
KPNVKALLSV HDTVAQKSYD PVLPPMPDDI DDEEDSVKII RLVKNREPLG
160 170 180 190 200
ATIKKDEQTG AITVARIMRG GAADRSGLIH VGDELREVNG IPVEDKRPEE
210 220 230 240 250
IIQILSQSQG AITFKIIPST KEEIPSKEGK IFIKALFDYD PKEDKAIPCK
260 270 280 290 300
EAGLSFRKGD ILQIMSQDDA TWWQAKHEGD TNPRAGLIPS KHFQERRLAL
310 320 330 340 350
RRPEIVVQPL KLSNRKSSGF RRSFRLSRKD KKTNKSMYEC KKSEQYDTAD
360 370 380 390 400
VPTYEEVTPY RRQTHDKYRL VVLVGPVGVG LNELKRKLLM SDTQHYGVTV
410 420 430 440 450
PHTTRARRSQ ESDGVEYIFI SKHLFETDVQ NNKFIEYGEY KNNYYGTSID
460 470 480 490 500
SVRSVLAKNK VCLLDVQPHT VKHLRTLEFK PYVIFIKPPS IERLRETRKN
510 520 530 540 550
AKIISSRDDQ GTAKPFTEED FQEMIKSAQI MESQYGHLFD KIIINDDLTV
560 570
AFNELKTTFD KLETDAHWVP VSWLHS
Length:576
Mass (Da):65,623
Last modified:February 26, 2008 - v2
Checksum:i9A8E1C8D519D5507
GO

Sequence cautioni

The sequence AAH85813 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085813 mRNA Translation: AAH85813.1 Sequence problems.
CB580893 mRNA No translation available.
RefSeqiNP_001094045.1, NM_001100575.1
XP_017456053.1, XM_017600564.1
UniGeneiRn.21436

Genome annotation databases

EnsembliENSRNOT00000025458; ENSRNOP00000025458; ENSRNOG00000018760
GeneIDi307035
KEGGirno:307035
UCSCiRGD:1305675 rat

Similar proteinsi

Entry informationi

Entry nameiMPP7_RAT
AccessioniPrimary (citable) accession number: Q5U2Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 25, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health