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Q5U2X4

- DPEP3_RAT

UniProt

Q5U2X4 - DPEP3_RAT

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Protein
Dipeptidase 3
Gene
Dpep3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis By similarity.

Catalytic activityi

Hydrolysis of dipeptides.

Cofactori

Zinc By similarity.

Enzyme regulationi

Inhibited by L-penicillamine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi94 – 941Zinc 1; catalytic By similarity
Metal bindingi96 – 961Zinc 1; catalytic By similarity
Metal bindingi193 – 1931Zinc 1; catalytic By similarity
Metal bindingi193 – 1931Zinc 2; catalytic By similarity
Metal bindingi266 – 2661Zinc 2; catalytic By similarity
Metal bindingi287 – 2871Zinc 2; catalytic By similarity

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metalloexopeptidase activity Source: InterPro

GO - Biological processi

  1. male meiosis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Meiosis

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 3 (EC:3.4.13.19)
Gene namesi
Name:Dpep3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 19

Organism-specific databases

RGDi1305484. Dpep3.

Subcellular locationi

Membrane; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Chaini36 – 459424Dipeptidase 3
PRO_0000231615Add
BLAST
Propeptidei460 – 48728Removed in mature form Reviewed prediction
PRO_0000231616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi143 ↔ 222 By similarity
Disulfide bondi294 ↔ 326 By similarity
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi431 – 431Interchain By similarity
Lipidationi459 – 4591GPI-anchor amidated serine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ5U2X4.

Expressioni

Gene expression databases

GenevestigatoriQ5U2X4.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026809.

Structurei

3D structure databases

ProteinModelPortaliQ5U2X4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2355.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ5U2X4.
OMAiPHINHIR.
OrthoDBiEOG7SJD4N.
PhylomeDBiQ5U2X4.
TreeFamiTF324523.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2X4-1 [UniParc]FASTAAdd to Basket

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MQPTGPEGPR ALSLRPLGHR LSLLGVLLII PSLWVTCNQT TPSLSSAPTS    50
PGASSAMTTP GIPNDTTTSG VTSDPRLREQ ALALMRDFPL VDGHNDLPLL 100
LRELFQNKLQ DVNLHNFTRG QTSLDRLRDG LVGAQFWSAY IPCQTQDRDA 150
VRVALEQIDL IRRMCSAYPE LELVTSADGL NSTQKLACLI GLEGGHSLDT 200
SLAVLRSFYE LGVRYLTLTF TCSTPWAESA TKFRHHFYTN ISGLTSFGEK 250
VVEEMNRIGM MIDLSHASDT LVKQTLEASR APVIFSHSAA RSVCDNLLNV 300
PDDILQLLKK NGGIVMVTLS MGVLQCSLLA NVSTVADHFD HIRTVIGSEF 350
IGIGGSYDGS GRFPQGLEDV STYPVLLEEL LRRGWGEQEL QGVLRGNLLR 400
VFRQVEQVRE KSLGQSPVEV VFPERQQSST CHSHLLPQSQ DAHLKVTKLP 450
SSQVLQRASK APPCPLLGLV AAVTSPAFTL WLCCSGHR 488
Length:488
Mass (Da):53,370
Last modified:December 7, 2004 - v1
Checksum:iE22FCAC7902144C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085826 mRNA. Translation: AAH85826.1.
RefSeqiNP_001008384.1. NM_001008383.1.
XP_006255579.1. XM_006255517.1.
UniGeneiRn.111627.

Genome annotation databases

EnsembliENSRNOT00000026809; ENSRNOP00000026809; ENSRNOG00000019757.
GeneIDi364994.
KEGGirno:364994.
UCSCiRGD:1305484. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085826 mRNA. Translation: AAH85826.1 .
RefSeqi NP_001008384.1. NM_001008383.1.
XP_006255579.1. XM_006255517.1.
UniGenei Rn.111627.

3D structure databases

ProteinModelPortali Q5U2X4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026809.

Protein family/group databases

MEROPSi M19.011.

Proteomic databases

PRIDEi Q5U2X4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026809 ; ENSRNOP00000026809 ; ENSRNOG00000019757 .
GeneIDi 364994.
KEGGi rno:364994.
UCSCi RGD:1305484. rat.

Organism-specific databases

CTDi 64180.
RGDi 1305484. Dpep3.

Phylogenomic databases

eggNOGi COG2355.
GeneTreei ENSGT00390000017920.
HOGENOMi HOG000072016.
HOVERGENi HBG002339.
InParanoidi Q5U2X4.
OMAi PHINHIR.
OrthoDBi EOG7SJD4N.
PhylomeDBi Q5U2X4.
TreeFami TF324523.

Miscellaneous databases

NextBioi 686443.
PROi Q5U2X4.

Gene expression databases

Genevestigatori Q5U2X4.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDPEP3_RAT
AccessioniPrimary (citable) accession number: Q5U2X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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