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Q5U2X4

- DPEP3_RAT

UniProt

Q5U2X4 - DPEP3_RAT

Protein

Dipeptidase 3

Gene

Dpep3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis By similarity.By similarity

    Catalytic activityi

    Hydrolysis of dipeptides.PROSITE-ProRule annotation

    Cofactori

    Zinc.PROSITE-ProRule annotation

    Enzyme regulationi

    Inhibited by L-penicillamine.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi94 – 941Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi96 – 961Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi193 – 1931Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi193 – 1931Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi266 – 2661Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi287 – 2871Zinc 2; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. dipeptidase activity Source: UniProtKB-KW
    2. dipeptidyl-peptidase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. metalloexopeptidase activity Source: InterPro

    GO - Biological processi

    1. male meiosis Source: UniProtKB

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Meiosis

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM19.011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidase 3 (EC:3.4.13.19)
    Gene namesi
    Name:Dpep3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 19

    Organism-specific databases

    RGDi1305484. Dpep3.

    Subcellular locationi

    Membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 459424Dipeptidase 3PRO_0000231615Add
    BLAST
    Propeptidei460 – 48728Removed in mature formSequence AnalysisPRO_0000231616Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi143 ↔ 222PROSITE-ProRule annotation
    Disulfide bondi294 ↔ 326PROSITE-ProRule annotation
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi431 – 431InterchainPROSITE-ProRule annotation
    Lipidationi459 – 4591GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiQ5U2X4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5U2X4.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.PROSITE-ProRule annotation

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026809.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U2X4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M19 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2355.
    GeneTreeiENSGT00390000017920.
    HOGENOMiHOG000072016.
    HOVERGENiHBG002339.
    InParanoidiQ5U2X4.
    OMAiPHINHIR.
    OrthoDBiEOG7SJD4N.
    PhylomeDBiQ5U2X4.
    TreeFamiTF324523.

    Family and domain databases

    InterProiIPR000180. Dipep_AS.
    IPR028533. Dpep3.
    IPR008257. Renal_dipep_fam.
    [Graphical view]
    PANTHERiPTHR10443. PTHR10443. 1 hit.
    PTHR10443:SF14. PTHR10443:SF14. 1 hit.
    PfamiPF01244. Peptidase_M19. 1 hit.
    [Graphical view]
    PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5U2X4-1 [UniParc]FASTAAdd to Basket

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    MQPTGPEGPR ALSLRPLGHR LSLLGVLLII PSLWVTCNQT TPSLSSAPTS    50
    PGASSAMTTP GIPNDTTTSG VTSDPRLREQ ALALMRDFPL VDGHNDLPLL 100
    LRELFQNKLQ DVNLHNFTRG QTSLDRLRDG LVGAQFWSAY IPCQTQDRDA 150
    VRVALEQIDL IRRMCSAYPE LELVTSADGL NSTQKLACLI GLEGGHSLDT 200
    SLAVLRSFYE LGVRYLTLTF TCSTPWAESA TKFRHHFYTN ISGLTSFGEK 250
    VVEEMNRIGM MIDLSHASDT LVKQTLEASR APVIFSHSAA RSVCDNLLNV 300
    PDDILQLLKK NGGIVMVTLS MGVLQCSLLA NVSTVADHFD HIRTVIGSEF 350
    IGIGGSYDGS GRFPQGLEDV STYPVLLEEL LRRGWGEQEL QGVLRGNLLR 400
    VFRQVEQVRE KSLGQSPVEV VFPERQQSST CHSHLLPQSQ DAHLKVTKLP 450
    SSQVLQRASK APPCPLLGLV AAVTSPAFTL WLCCSGHR 488
    Length:488
    Mass (Da):53,370
    Last modified:December 7, 2004 - v1
    Checksum:iE22FCAC7902144C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085826 mRNA. Translation: AAH85826.1.
    RefSeqiNP_001008384.1. NM_001008383.1.
    XP_006255579.1. XM_006255517.1.
    UniGeneiRn.111627.

    Genome annotation databases

    EnsembliENSRNOT00000026809; ENSRNOP00000026809; ENSRNOG00000019757.
    GeneIDi364994.
    KEGGirno:364994.
    UCSCiRGD:1305484. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085826 mRNA. Translation: AAH85826.1 .
    RefSeqi NP_001008384.1. NM_001008383.1.
    XP_006255579.1. XM_006255517.1.
    UniGenei Rn.111627.

    3D structure databases

    ProteinModelPortali Q5U2X4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026809.

    Protein family/group databases

    MEROPSi M19.011.

    Proteomic databases

    PRIDEi Q5U2X4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026809 ; ENSRNOP00000026809 ; ENSRNOG00000019757 .
    GeneIDi 364994.
    KEGGi rno:364994.
    UCSCi RGD:1305484. rat.

    Organism-specific databases

    CTDi 64180.
    RGDi 1305484. Dpep3.

    Phylogenomic databases

    eggNOGi COG2355.
    GeneTreei ENSGT00390000017920.
    HOGENOMi HOG000072016.
    HOVERGENi HBG002339.
    InParanoidi Q5U2X4.
    OMAi PHINHIR.
    OrthoDBi EOG7SJD4N.
    PhylomeDBi Q5U2X4.
    TreeFami TF324523.

    Miscellaneous databases

    NextBioi 686443.
    PROi Q5U2X4.

    Gene expression databases

    Genevestigatori Q5U2X4.

    Family and domain databases

    InterProi IPR000180. Dipep_AS.
    IPR028533. Dpep3.
    IPR008257. Renal_dipep_fam.
    [Graphical view ]
    PANTHERi PTHR10443. PTHR10443. 1 hit.
    PTHR10443:SF14. PTHR10443:SF14. 1 hit.
    Pfami PF01244. Peptidase_M19. 1 hit.
    [Graphical view ]
    PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiDPEP3_RAT
    AccessioniPrimary (citable) accession number: Q5U2X4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3