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Q5U2X4

- DPEP3_RAT

UniProt

Q5U2X4 - DPEP3_RAT

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Protein

Dipeptidase 3

Gene

Dpep3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi94 – 941Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi96 – 961Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi193 – 1931Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi193 – 1931Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi266 – 2661Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi287 – 2871Zinc 2; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metalloexopeptidase activity Source: InterPro

GO - Biological processi

  1. male meiosis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Meiosis

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 3 (EC:3.4.13.19)
Gene namesi
Name:Dpep3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 19

Organism-specific databases

RGDi1305484. Dpep3.

Subcellular locationi

Membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 459424Dipeptidase 3PRO_0000231615Add
BLAST
Propeptidei460 – 48728Removed in mature formSequence AnalysisPRO_0000231616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi143 ↔ 222PROSITE-ProRule annotation
Disulfide bondi294 ↔ 326PROSITE-ProRule annotation
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi431 – 431InterchainPROSITE-ProRule annotation
Lipidationi459 – 4591GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ5U2X4.

Expressioni

Gene expression databases

GenevestigatoriQ5U2X4.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.PROSITE-ProRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026809.

Structurei

3D structure databases

ProteinModelPortaliQ5U2X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2355.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ5U2X4.
OMAiPHINHIR.
OrthoDBiEOG7SJD4N.
PhylomeDBiQ5U2X4.
TreeFamiTF324523.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2X4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPTGPEGPR ALSLRPLGHR LSLLGVLLII PSLWVTCNQT TPSLSSAPTS
60 70 80 90 100
PGASSAMTTP GIPNDTTTSG VTSDPRLREQ ALALMRDFPL VDGHNDLPLL
110 120 130 140 150
LRELFQNKLQ DVNLHNFTRG QTSLDRLRDG LVGAQFWSAY IPCQTQDRDA
160 170 180 190 200
VRVALEQIDL IRRMCSAYPE LELVTSADGL NSTQKLACLI GLEGGHSLDT
210 220 230 240 250
SLAVLRSFYE LGVRYLTLTF TCSTPWAESA TKFRHHFYTN ISGLTSFGEK
260 270 280 290 300
VVEEMNRIGM MIDLSHASDT LVKQTLEASR APVIFSHSAA RSVCDNLLNV
310 320 330 340 350
PDDILQLLKK NGGIVMVTLS MGVLQCSLLA NVSTVADHFD HIRTVIGSEF
360 370 380 390 400
IGIGGSYDGS GRFPQGLEDV STYPVLLEEL LRRGWGEQEL QGVLRGNLLR
410 420 430 440 450
VFRQVEQVRE KSLGQSPVEV VFPERQQSST CHSHLLPQSQ DAHLKVTKLP
460 470 480
SSQVLQRASK APPCPLLGLV AAVTSPAFTL WLCCSGHR
Length:488
Mass (Da):53,370
Last modified:December 7, 2004 - v1
Checksum:iE22FCAC7902144C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085826 mRNA. Translation: AAH85826.1.
RefSeqiNP_001008384.1. NM_001008383.1.
XP_006255579.1. XM_006255517.2.
XP_008770743.1. XM_008772521.1.
UniGeneiRn.111627.

Genome annotation databases

EnsembliENSRNOT00000026809; ENSRNOP00000026809; ENSRNOG00000019757.
GeneIDi364994.
KEGGirno:364994.
UCSCiRGD:1305484. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085826 mRNA. Translation: AAH85826.1 .
RefSeqi NP_001008384.1. NM_001008383.1.
XP_006255579.1. XM_006255517.2.
XP_008770743.1. XM_008772521.1.
UniGenei Rn.111627.

3D structure databases

ProteinModelPortali Q5U2X4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026809.

Protein family/group databases

MEROPSi M19.002.

Proteomic databases

PRIDEi Q5U2X4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026809 ; ENSRNOP00000026809 ; ENSRNOG00000019757 .
GeneIDi 364994.
KEGGi rno:364994.
UCSCi RGD:1305484. rat.

Organism-specific databases

CTDi 64180.
RGDi 1305484. Dpep3.

Phylogenomic databases

eggNOGi COG2355.
GeneTreei ENSGT00390000017920.
HOGENOMi HOG000072016.
HOVERGENi HBG002339.
InParanoidi Q5U2X4.
OMAi PHINHIR.
OrthoDBi EOG7SJD4N.
PhylomeDBi Q5U2X4.
TreeFami TF324523.

Miscellaneous databases

NextBioi 686443.
PROi Q5U2X4.

Gene expression databases

Genevestigatori Q5U2X4.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR028533. Dpep3.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
PTHR10443:SF14. PTHR10443:SF14. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDPEP3_RAT
AccessioniPrimary (citable) accession number: Q5U2X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 7, 2004
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3