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Protein

Dipeptidase 3

Gene

Dpep3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Enzyme regulationi

Inhibited by L-penicillamine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi94Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi96Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi193Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi193Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi266Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi287Zinc 2; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDipeptidase, Hydrolase, Metalloprotease, Protease
Biological processMeiosis
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM19.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidase 3 (EC:3.4.13.19)
Gene namesi
Name:Dpep3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1305484. Dpep3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000023161536 – 459Dipeptidase 3Add BLAST424
PropeptideiPRO_0000231616460 – 487Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi143 ↔ 222PROSITE-ProRule annotation
Disulfide bondi294 ↔ 326PROSITE-ProRule annotation
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431InterchainPROSITE-ProRule annotation
Lipidationi459GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ5U2X4.
PRIDEiQ5U2X4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019757.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with TEX101; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm (By similarity).PROSITE-ProRule annotationBy similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026809.

Structurei

3D structure databases

ProteinModelPortaliQ5U2X4.
SMRiQ5U2X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
GeneTreeiENSGT00390000017920.
HOGENOMiHOG000072016.
HOVERGENiHBG002339.
InParanoidiQ5U2X4.
KOiK01273.
OMAiTHNCHNR.
OrthoDBiEOG091G09CU.
PhylomeDBiQ5U2X4.
TreeFamiTF324523.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiView protein in InterPro
IPR000180. Dipep_AS.
IPR032466. Metal_Hydrolase.
IPR008257. Pept_M19.
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiView protein in Pfam
PF01244. Peptidase_M19. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiView protein in PROSITE
PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPTGPEGPR ALSLRPLGHR LSLLGVLLII PSLWVTCNQT TPSLSSAPTS
60 70 80 90 100
PGASSAMTTP GIPNDTTTSG VTSDPRLREQ ALALMRDFPL VDGHNDLPLL
110 120 130 140 150
LRELFQNKLQ DVNLHNFTRG QTSLDRLRDG LVGAQFWSAY IPCQTQDRDA
160 170 180 190 200
VRVALEQIDL IRRMCSAYPE LELVTSADGL NSTQKLACLI GLEGGHSLDT
210 220 230 240 250
SLAVLRSFYE LGVRYLTLTF TCSTPWAESA TKFRHHFYTN ISGLTSFGEK
260 270 280 290 300
VVEEMNRIGM MIDLSHASDT LVKQTLEASR APVIFSHSAA RSVCDNLLNV
310 320 330 340 350
PDDILQLLKK NGGIVMVTLS MGVLQCSLLA NVSTVADHFD HIRTVIGSEF
360 370 380 390 400
IGIGGSYDGS GRFPQGLEDV STYPVLLEEL LRRGWGEQEL QGVLRGNLLR
410 420 430 440 450
VFRQVEQVRE KSLGQSPVEV VFPERQQSST CHSHLLPQSQ DAHLKVTKLP
460 470 480
SSQVLQRASK APPCPLLGLV AAVTSPAFTL WLCCSGHR
Length:488
Mass (Da):53,370
Last modified:December 7, 2004 - v1
Checksum:iE22FCAC7902144C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085826 mRNA. Translation: AAH85826.1.
RefSeqiNP_001008384.1. NM_001008383.1.
XP_006255579.1. XM_006255517.3.
XP_008770743.1. XM_008772521.1.
UniGeneiRn.111627.

Genome annotation databases

EnsembliENSRNOT00000026809; ENSRNOP00000026809; ENSRNOG00000019757.
GeneIDi364994.
KEGGirno:364994.
UCSCiRGD:1305484. rat.

Similar proteinsi

Entry informationi

Entry nameiDPEP3_RAT
AccessioniPrimary (citable) accession number: Q5U2X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 7, 2004
Last modified: November 22, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families