Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CDKN2A-interacting protein

Gene

Cdkn2aip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates DNA damage response and cell proliferation in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CDKN2A-interacting protein
Alternative name(s):
Collaborator of ARF
Gene namesi
Name:Cdkn2aip
Synonyms:Carf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1305302. Cdkn2aip.

Subcellular locationi

  • Nucleusnucleoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003243412 – 570CDKN2A-interacting proteinAdd BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei124PhosphoserineBy similarity1
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei234PhosphoserineBy similarity1
Modified residuei378PhosphoserineBy similarity1

Post-translational modificationi

May be ubiquitinated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5U2X0.
PeptideAtlasiQ5U2X0.
PRIDEiQ5U2X0.

PTM databases

iPTMnetiQ5U2X0.
PhosphoSitePlusiQ5U2X0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000022736.

Interactioni

Subunit structurei

Interacts with CDKN2A/p14ARF, p53/TP53 and MDM2. Interacts with CHEK2 and MAPK3. Interacts with XRN2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029705.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 117XTBDSequence analysisAdd BLAST99
Domaini452 – 527DRBMPROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi124 – 410Ser-richAdd BLAST287

Sequence similaritiesi

Belongs to the CARF family.Curated
Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation
Contains 1 XTBD domain.Curated

Phylogenomic databases

eggNOGiENOG410IE8W. Eukaryota.
ENOG4111PSZ. LUCA.
GeneTreeiENSGT00530000063234.
HOGENOMiHOG000111305.
HOVERGENiHBG101830.
InParanoidiQ5U2X0.
OMAiVSFSMAW.
OrthoDBiEOG091G0HNZ.
PhylomeDBiQ5U2X0.
TreeFamiTF333807.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR021859. XTBD.
[Graphical view]
PfamiPF11952. XTBD. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5U2X0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQEVSEYLS QNPRVAAWVE TLRCEGETDK HWRHRREFLL RNAGDLVPAT
60 70 80 90 100
EETADAESGA RSRQLQQLVS FSMAWANHVF LGCRYPQKVM DKILSMAEGI
110 120 130 140 150
KVTDAPIHTT RDELVAKVKK RGISSSNEGV EEPSKKRSIE GKNNSSVERD
160 170 180 190 200
HGKKSAKTDR SAQQENSSGS KGSSTKSESS GTSARSNSGV SHQNSSTSEG
210 220 230 240 250
DRSVCSQSSS NSSQVTSAGS GKASEPEAPD KHGSASFVSS LLKSSLNSHV
260 270 280 290 300
TKSTDSRQHS GSPRKNALEG SSVSVSQSSS EIEVPLLGSS GSSEVELPLL
310 320 330 340 350
SCKSSSETAS SGLTTKASSE ANISSSVSKN SSSSGTSLLM PKSSSTNTSL
360 370 380 390 400
LTSQVAASLL ASKSSSQSSG SVASKSTSLG SMSQLASKSS SQSSTSQLPS
410 420 430 440 450
KSTSQSSESS VKFTCRKLTN EDIKQKQPFF NRLYKTVAWK LVAVGGFSPN
460 470 480 490 500
VNHGELLNAA IEALKATLDV FFVPLKELAD LPQNKSSQES IVCELRCKSV
510 520 530 540 550
YLGTGCGKSK ENAKAVASRE ALKLFLKKKV VVKICKRKYR GNEIEDLVLL
560 570
DEESRPVNLP PALKHPQELL
Length:570
Mass (Da):60,744
Last modified:December 7, 2004 - v1
Checksum:iE31CB97382220015
GO
Isoform 2 (identifier: Q5U2X0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-119: VK → KG
     120-570: Missing.

Note: No experimental confirmation available.
Show »
Length:119
Mass (Da):13,512
Checksum:i52C65DF8C4D0B027
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032223118 – 119VK → KG in isoform 2. 1 Publication2
Alternative sequenceiVSP_032224120 – 570Missing in isoform 2. 1 PublicationAdd BLAST451

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085832 mRNA. Translation: AAH85832.1.
BC098694 mRNA. Translation: AAH98694.1.
RefSeqiNP_001014022.1. NM_001014000.1. [Q5U2X0-1]
XP_006253209.1. XM_006253147.3. [Q5U2X0-2]
UniGeneiRn.16007.

Genome annotation databases

EnsembliENSRNOT00000030519; ENSRNOP00000029705; ENSRNOG00000022736. [Q5U2X0-1]
GeneIDi306455.
KEGGirno:306455.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085832 mRNA. Translation: AAH85832.1.
BC098694 mRNA. Translation: AAH98694.1.
RefSeqiNP_001014022.1. NM_001014000.1. [Q5U2X0-1]
XP_006253209.1. XM_006253147.3. [Q5U2X0-2]
UniGeneiRn.16007.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029705.

PTM databases

iPTMnetiQ5U2X0.
PhosphoSitePlusiQ5U2X0.

Proteomic databases

PaxDbiQ5U2X0.
PeptideAtlasiQ5U2X0.
PRIDEiQ5U2X0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000030519; ENSRNOP00000029705; ENSRNOG00000022736. [Q5U2X0-1]
GeneIDi306455.
KEGGirno:306455.

Organism-specific databases

CTDi55602.
RGDi1305302. Cdkn2aip.

Phylogenomic databases

eggNOGiENOG410IE8W. Eukaryota.
ENOG4111PSZ. LUCA.
GeneTreeiENSGT00530000063234.
HOGENOMiHOG000111305.
HOVERGENiHBG101830.
InParanoidiQ5U2X0.
OMAiVSFSMAW.
OrthoDBiEOG091G0HNZ.
PhylomeDBiQ5U2X0.
TreeFamiTF333807.

Miscellaneous databases

PROiQ5U2X0.

Gene expression databases

BgeeiENSRNOG00000022736.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR021859. XTBD.
[Graphical view]
PfamiPF11952. XTBD. 1 hit.
[Graphical view]
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCARF_RAT
AccessioniPrimary (citable) accession number: Q5U2X0
Secondary accession number(s): Q4KM89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.