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Protein

Renalase

Gene

Rnls

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)+ (By similarity). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.By similarity2 Publications

Catalytic activityi

1,2-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2.By similarity
1,6-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2.By similarity

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12FADBy similarity1
Binding sitei42FADBy similarity1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of blood pressure Source: Ensembl
  • negative regulation of heart rate Source: Ensembl
  • response to catecholamine Source: RGD
  • response to epinephrine Source: RGD
  • response to ischemia Source: RGD
  • response to salt Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD, NADP

Enzyme and pathway databases

BRENDAi1.6.3.5. 5301.
ReactomeiR-RNO-197264. Nicotinamide salvaging.

Names & Taxonomyi

Protein namesi
Recommended name:
Renalase (EC:1.6.3.5By similarity)
Alternative name(s):
Monoamine oxidase-C
Short name:
MAO-C
alpha-NAD(P)H oxidase/anomerase
Gene namesi
Name:Rnls
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309804. Rnls.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001958918 – 315RenalaseAdd BLAST298

Proteomic databases

PaxDbiQ5U2W9.
PRIDEiQ5U2W9.

PTM databases

PhosphoSitePlusiQ5U2W9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020705.
GenevisibleiQ5U2W9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028098.

Structurei

3D structure databases

ProteinModelPortaliQ5U2W9.
SMRiQ5U2W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 62FAD-bindingBy similarity2

Sequence similaritiesi

Belongs to the renalase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE15. Eukaryota.
ENOG410XV8B. LUCA.
GeneTreeiENSGT00390000016052.
HOGENOMiHOG000007721.
InParanoidiQ5U2W9.
KOiK18208.
OMAiIKCQKWR.
OrthoDBiEOG091G0AJR.
PhylomeDBiQ5U2W9.
TreeFamiTF332799.

Family and domain databases

InterProiView protein in InterPro
IPR002937. Amino_oxidase.
IPR036188. FAD/NAD-bd_sf.
PfamiView protein in Pfam
PF01593. Amino_oxidase. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRVLVVGAG LTGSLCAALL RKEITAPLYL ALWDKAGDIG GRMTTANSPH
60 70 80 90 100
NPRCTADLGA QYITCTPHYA KKHQNFYEEL LAHGILEPLT SPIKGMEVKE
110 120 130 140 150
GESNFVAPHG VSSIIKYYLK ESGAEVFLRQ CVTQINLRDN KWEVSEDTGS
160 170 180 190 200
TQQFDLVILT MPAPQILGLQ GDIVNLISER QRQQLASVSY SSRYALGLFY
210 220 230 240 250
EAGMKIDVPW AGQYITSNPC IRFISIDSKK RNTESSECGP LLVVHTTVPF
260 270 280 290 300
GVTHLEHSEE DVQELITQQL ETILPGLPPP VATKCWKWRY SQVTNSAANS
310
PGQMTLHLNP FLIYI
Length:315
Mass (Da):34,951
Last modified:December 7, 2004 - v1
Checksum:iC4B606AC2F421698
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085833 mRNA. Translation: AAH85833.1.
RefSeqiNP_001014189.1. NM_001014167.1.
UniGeneiRn.15885.

Genome annotation databases

EnsembliENSRNOT00000028098; ENSRNOP00000028098; ENSRNOG00000020705.
GeneIDi361751.
KEGGirno:361751.
UCSCiRGD:1309804. rat.

Similar proteinsi

Entry informationi

Entry nameiRNLS_RAT
AccessioniPrimary (citable) accession number: Q5U2W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 7, 2004
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families