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Protein

Transducin beta-like protein 3

Gene

Tbl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Transducin beta-like protein 3
Gene namesi
Name:Tbl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1305142. Tbl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 800799Transducin beta-like protein 3PRO_0000362981Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5U2W5.
PRIDEiQ5U2W5.

PTM databases

iPTMnetiQ5U2W5.

Expressioni

Gene expression databases

GenevisibleiQ5U2W5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018405.

Structurei

3D structure databases

ProteinModelPortaliQ5U2W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 10542WD 1Add
BLAST
Repeati107 – 14640WD 2Add
BLAST
Repeati149 – 19042WD 3Add
BLAST
Repeati193 – 23240WD 4Add
BLAST
Repeati245 – 28440WD 5Add
BLAST
Repeati290 – 32940WD 6Add
BLAST
Repeati332 – 37241WD 7Add
BLAST
Repeati374 – 41340WD 8Add
BLAST
Repeati419 – 45941WD 9Add
BLAST
Repeati477 – 51640WD 10Add
BLAST
Repeati519 – 56042WD 11Add
BLAST
Repeati562 – 60241WD 12Add
BLAST
Repeati604 – 64239WD 13Add
BLAST

Sequence similaritiesi

Contains 13 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0319. Eukaryota.
ENOG410XPQD. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000188765.
HOVERGENiHBG058869.
InParanoidiQ5U2W5.
KOiK14555.
OMAiTHHFRGS.
OrthoDBiEOG7J4461.
PhylomeDBiQ5U2W5.
TreeFamiTF314872.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR013934. SSU_processome_Utp13.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08625. Utp13. 1 hit.
PF00400. WD40. 9 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 13 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETAAGLCR FKANYAVERK IEPFYKGGKA QLDQTGRHLF CVCGTKVNIL
60 70 80 90 100
DVASGDLIRS LEQEDQEDIT AFDLSPDDEV LVTASRALLL AQWAWREGTV
110 120 130 140 150
ARLWKAIHTA PVASMAFDAT STLLATGGCD GAVRVWDIVQ HYGTHHFRGS
160 170 180 190 200
PGVVHLVAFH PDPTRLLLFS SAVDTSIRVW SLQDRSCLAV LTAHYSAVTS
210 220 230 240 250
LSFSEDGHTM LSSGRDKICI VWDLRSYETS RTVPVFESVE ASVLLPEEPA
260 270 280 290 300
LALGVKNSGL HFLTAGDQGI LRVWEAASGQ CVYTQPQMSG LRQELTHCTL
310 320 330 340 350
ARAAGLLLTV TADHNLLLYE ARSLQLQKQF AGYSEEVLDV RFLGPNDSHI
360 370 380 390 400
IVASNSPCLK VFELQTLACQ ILHGHTDIVL ALDVFRKGWL FASCAKDQSI
410 420 430 440 450
RIWRMNKAGQ VACVAQGSGH THSVGTICCS RLKESFLVTG SQDCTVKLWP
460 470 480 490 500
LPEALPSKNT ASDGDLIPLQ AQSTQRCHDK DINSLAVSPN DKLLATGSQD
510 520 530 540 550
RTAKLWALPQ CQLLGVFSGH RRGLWNVQFS PTDQVLATAS ADGTIKLWAL
560 570 580 590 600
QDFSCLKTFE GHDASVLKVA FVSRGAQLLS SGSDGLLKLW TIKSNECVRT
610 620 630 640 650
LDAHEDKVWG LHCSRLDDHA ITGGSDSRII LWKDVTEAEQ AEEQAKREEQ
660 670 680 690 700
VIKQQELDNL LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE
710 720 730 740 750
ATVLRLRRDQ KEALLRFCIT WNTNSRHCHE AQAVLGVLLR HEAPEELLAY
760 770 780 790 800
DGVRGALEAL LPYTERHFQR LSRTLQAATF LDFLWHNMKL SPLPAAPPAL
Length:800
Mass (Da):88,372
Last modified:December 7, 2004 - v1
Checksum:i3F1B4D1B3925D8C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085837 mRNA. Translation: AAH85837.1.
RefSeqiNP_001008278.1. NM_001008277.1.
UniGeneiRn.32013.

Genome annotation databases

EnsembliENSRNOT00000018405; ENSRNOP00000018405; ENSRNOG00000013429.
GeneIDi287120.
KEGGirno:287120.
UCSCiRGD:1305142. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085837 mRNA. Translation: AAH85837.1.
RefSeqiNP_001008278.1. NM_001008277.1.
UniGeneiRn.32013.

3D structure databases

ProteinModelPortaliQ5U2W5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018405.

PTM databases

iPTMnetiQ5U2W5.

Proteomic databases

PaxDbiQ5U2W5.
PRIDEiQ5U2W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018405; ENSRNOP00000018405; ENSRNOG00000013429.
GeneIDi287120.
KEGGirno:287120.
UCSCiRGD:1305142. rat.

Organism-specific databases

CTDi10607.
RGDi1305142. Tbl3.

Phylogenomic databases

eggNOGiKOG0319. Eukaryota.
ENOG410XPQD. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000188765.
HOVERGENiHBG058869.
InParanoidiQ5U2W5.
KOiK14555.
OMAiTHHFRGS.
OrthoDBiEOG7J4461.
PhylomeDBiQ5U2W5.
TreeFamiTF314872.

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ5U2W5.

Gene expression databases

GenevisibleiQ5U2W5. RN.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR013934. SSU_processome_Utp13.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08625. Utp13. 1 hit.
PF00400. WD40. 9 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 13 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTBL3_RAT
AccessioniPrimary (citable) accession number: Q5U2W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: December 7, 2004
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.