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Protein

Phospholipase B-like 1

Gene

Plbd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids. However, in view of the small size of the putative binding pocket, it has been proposed that it may act rather as an amidase or a peptidase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1482788 Acyl chain remodelling of PC
R-RNO-1482839 Acyl chain remodelling of PE
R-RNO-1482922 Acyl chain remodelling of PI
R-RNO-1483115 Hydrolysis of LPC

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase B-like 1 (EC:3.1.1.-)
Alternative name(s):
LAMA-like protein 1
Lamina ancestor homolog 1
Phospholipase B domain-containing protein 1
Cleaved into the following 3 chains:
Gene namesi
Name:Plbd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1308734 Plbd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39By similarityAdd BLAST39
ChainiPRO_000028610840 – 550Phospholipase B-like 1Add BLAST511
ChainiPRO_000042542940 – 209Phospholipase B-like 1 chain AAdd BLAST170
ChainiPRO_000042543094 – 209Phospholipase B-like 1 chain CAdd BLAST116
PropeptideiPRO_0000425431210 – 228Removed in mature formBy similarityAdd BLAST19
ChainiPRO_0000425432229 – 550Phospholipase B-like 1 chain BAdd BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi72N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1
Glycosylationi309N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi309N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1
Glycosylationi412N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi412N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1
Disulfide bondi471 ↔ 476By similarity
Disulfide bondi475 ↔ 490By similarity
Glycosylationi527N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi527N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1

Post-translational modificationi

The maturation cleavages that produces chains A and B are required to open the putative substrate binding pocket. Both chains A and B remain associated in the mature protein (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5U2V4
PRIDEiQ5U2V4

PTM databases

PhosphoSitePlusiQ5U2V4

Expressioni

Gene expression databases

BgeeiENSRNOG00000008933
GenevisibleiQ5U2V4 RN

Interactioni

Subunit structurei

May form a homodimer, each monomer is composed of a chain A and a chain B.By similarity

Protein-protein interaction databases

BioGridi255637, 1 interactor
IntActiQ5U2V4, 1 interactor
STRINGi10116.ENSRNOP00000011930

Structurei

3D structure databases

SMRiQ5U2V4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase B-like family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3774 Eukaryota
ENOG410XQRV LUCA
GeneTreeiENSGT00530000063509
HOGENOMiHOG000006903
HOVERGENiHBG108264
InParanoidiQ5U2V4
OMAiMKYIMRY
OrthoDBiEOG091G0G9H
PhylomeDBiQ5U2V4
TreeFamiTF315042

Family and domain databases

InterProiView protein in InterPro
IPR007000 PLipase_B-like
PANTHERiPTHR12370 PTHR12370, 1 hit
PfamiView protein in Pfam
PF04916 Phospholip_B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHRSHGRSL RPPSPLLLLL PLLLQSPWAA GAAEKHNSAG VHYATAYWLP
60 70 80 90 100
DTKAVEIKMV LDKKGDAYGF YNDSIQTTGW GVLEIKAGYG SQILSNEIIM
110 120 130 140 150
FLAGYLEGYL TALHMYDHFT NLYPQLIKNP SIVKKVQDFM EKQELWTRKN
160 170 180 190 200
IKDQKDDPFW RHTGYVVSQL DGMYLGAQKR ASEEEMKPMT MFQIQFLNAV
210 220 230 240 250
GDLLDLIPSL SPTKSSSLKK FKIWEMGHCS ALIKVLPGFE NIYFAHSSWY
260 270 280 290 300
TYAAMLRIYK HWDFNIKDKY TASNRLSFSS YPGFLESLDD FYILSSGLIL
310 320 330 340 350
LQTTNSVYNK TLLKLVVPES LLAWQRVRVA NMMAQGGKEW SQLFSMYNSG
360 370 380 390 400
TYNNQYMVLD LKKVTLKKSI DRGALYVVEQ IPTYVEYSDQ TNILRKGYWA
410 420 430 440 450
SYNIPFHKTV YNWSGYPLLV HKLGLDYSYD LAPRAKIFRR DQGTVTDMAS
460 470 480 490 500
MKHIMRYNNY KVDPYSKGDP CSTICCREDL NEASPSPGGC YDTKVADIFL
510 520 530 540 550
ASQYKAYAIS GPTVQNGLPP FNWNRFNDTL HQGMPDVFDF DFVTMKPILT
Length:550
Mass (Da):63,027
Last modified:December 7, 2004 - v1
Checksum:i09F979E6AA382AC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085851 mRNA Translation: AAH85851.1
RefSeqiNP_001013949.1, NM_001013927.1
UniGeneiRn.3413

Genome annotation databases

EnsembliENSRNOT00000011930; ENSRNOP00000011930; ENSRNOG00000008933
GeneIDi297694
KEGGirno:297694
UCSCiRGD:1308734 rat

Similar proteinsi

Entry informationi

Entry nameiPLBL1_RAT
AccessioniPrimary (citable) accession number: Q5U2V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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