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Protein

Crk-like protein

Gene

Crkl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May mediate the transduction of intracellular signals.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-170968. Frs2-mediated activation.
R-RNO-186763. Downstream signal transduction.
R-RNO-912631. Regulation of signaling by CBL.

Names & Taxonomyi

Protein namesi
Recommended name:
Crk-like proteinBy similarity
Gene namesi
Name:CrklImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1308531. Crkl.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Crk-like proteinPRO_0000371244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei127 – 1271PhosphotyrosineBy similarity
Modified residuei207 – 2071PhosphotyrosineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2U2.
PRIDEiQ5U2U2.

PTM databases

PhosphoSiteiQ5U2U2.

Expressioni

Gene expression databases

GenevisibleiQ5U2U2. RN.

Interactioni

Subunit structurei

Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi252388. 2 interactions.
IntActiQ5U2U2. 1 interaction.
STRINGi10116.ENSRNOP00000002552.

Structurei

3D structure databases

ProteinModelPortaliQ5U2U2.
SMRiQ5U2U2. Positions 3-180, 237-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 10289SH2PROSITE-ProRule annotationAdd
BLAST
Domaini123 – 18361SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini235 – 29662SH3 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CRK family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG4792. Eukaryota.
ENOG4110574. LUCA.
GeneTreeiENSGT00820000127055.
HOGENOMiHOG000236288.
InParanoidiQ5U2U2.
KOiK04438.
OMAiTRMNISG.
OrthoDBiEOG7NW69P.
PhylomeDBiQ5U2U2.
TreeFamiTF321436.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U2U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL
60 70 80 90 100
SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE
110 120 130 140 150
PAPRYPNPPM GSVSAPNLST AEENLEYVRT LYDFPGNDAE DLPFKKGELL
160 170 180 190 200
VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI
210 220 230 240 250
PEPAHAYAQP QTTTPLPTVA STPGAAINPL PSTQNGPVFA KAIQKRVPCA
260 270 280 290 300
YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD

DNE
Length:303
Mass (Da):33,865
Last modified:December 7, 2004 - v1
Checksum:iB6E2916741FE56E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473999 Genomic DNA. Translation: EDL77890.1.
BC085865 mRNA. Translation: AAH85865.1.
RefSeqiNP_001008285.1. NM_001008284.1.
XP_003751143.1. XM_003751095.3.
UniGeneiRn.35110.

Genome annotation databases

EnsembliENSRNOT00000002552; ENSRNOP00000002552; ENSRNOG00000001868.
GeneIDi100911248.
287942.
KEGGirno:100911248.
rno:287942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473999 Genomic DNA. Translation: EDL77890.1.
BC085865 mRNA. Translation: AAH85865.1.
RefSeqiNP_001008285.1. NM_001008284.1.
XP_003751143.1. XM_003751095.3.
UniGeneiRn.35110.

3D structure databases

ProteinModelPortaliQ5U2U2.
SMRiQ5U2U2. Positions 3-180, 237-298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi252388. 2 interactions.
IntActiQ5U2U2. 1 interaction.
STRINGi10116.ENSRNOP00000002552.

PTM databases

PhosphoSiteiQ5U2U2.

Proteomic databases

PaxDbiQ5U2U2.
PRIDEiQ5U2U2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002552; ENSRNOP00000002552; ENSRNOG00000001868.
GeneIDi100911248.
287942.
KEGGirno:100911248.
rno:287942.

Organism-specific databases

CTDi1399.
RGDi1308531. Crkl.

Phylogenomic databases

eggNOGiKOG4792. Eukaryota.
ENOG4110574. LUCA.
GeneTreeiENSGT00820000127055.
HOGENOMiHOG000236288.
InParanoidiQ5U2U2.
KOiK04438.
OMAiTRMNISG.
OrthoDBiEOG7NW69P.
PhylomeDBiQ5U2U2.
TreeFamiTF321436.

Enzyme and pathway databases

ReactomeiR-RNO-170968. Frs2-mediated activation.
R-RNO-186763. Downstream signal transduction.
R-RNO-912631. Regulation of signaling by CBL.

Miscellaneous databases

NextBioi627271.
PROiQ5U2U2.

Gene expression databases

GenevisibleiQ5U2U2. RN.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway1 Publication.
    Tissue: HeartImported.
  3. Maurya D.K., Bhargava P.
    Submitted (MAR-2009) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-207, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCRKL_RAT
AccessioniPrimary (citable) accession number: Q5U2U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: December 7, 2004
Last modified: December 9, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.