Q5U2U2 (CRKL_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Crk-like protein

Gene names

Name:

Crkl

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May mediate the transduction of intracellular signals By similarity. UniProtKB P46109
Subunit structure	Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4 By similarity. UniProtKB P46109
Sequence similarities	Belongs to the CRK family. Contains 1 SH2 domain. Contains 2 SH3 domains.

Ontologies

Keywords
Domain	Repeat SH2 domain SH3 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara blood vessel development Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara organ morphogenesis Inferred from electronic annotation. Source: Compara parathyroid gland development Inferred from electronic annotation. Source: Compara thymus development Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Crk-like protein		PRO_0000371244
Regions
	Domain	14 – 102	89	SH2
	Domain	123 – 183	61	SH3 1
	Domain	235 – 296	62	SH3 2
Amino acid modifications
	Modified residue	127	1	Phosphotyrosine By similarity
	Modified residue	132	1	Phosphotyrosine By similarity UniProtKB P47941
	Modified residue	207	1	Phosphotyrosine By similarity UniProtKB P47941
	Modified residue	251	1	Phosphotyrosine By similarity UniProtKB P47941

Sequences

	Sequence		Length	Mass (Da)
	Q5U2U2 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: B6E2916741FE56E0	FASTA	303	33,865
	10 20 30 40 50 60 MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH 70 80 90 100 110 120 YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPNPPM GSVSAPNLST 130 140 150 160 170 180 AEENLEYVRT LYDFPGNDAE DLPFKKGELL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK 190 200 210 220 230 240 LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPTVA STPGAAINPL PSTQNGPVFA 250 260 270 280 290 300 KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD DNE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Brown Norway. Tissue: Heart.
[3]	Maurya D.K., Bhargava P. Submitted (MAR-2009) to UniProtKB Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH473999 Genomic DNA. Translation: EDL77890.1. BC085865 mRNA. Translation: AAH85865.1.
IPI	IPI00361821.
RefSeq	NP_001008285.1. NM_001008284.1. XP_003751143.1. XM_003751095.1.
UniGene	Rn.35110.
3D structure databases
HSSP	HSSP built from PDB template 1JU5 based on UniProtKB Q64010.
ProteinModelPortal	Q5U2U2.
SMR	Q5U2U2. Positions 3-180, 237-298.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5U2U2. 1 interaction.
STRING	10116.ENSRNOP00000002552.
PTM databases
PhosphoSite	Q5U2U2.
Proteomic databases
PaxDb	Q5U2U2.
PRIDE	Q5U2U2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000002552; ENSRNOP00000002552; ENSRNOG00000001868.
GeneID	100911248. 287942.
KEGG	rno:100911248. rno:287942.
Organism-specific databases
CTD	1399.
RGD	1308531. Crkl.
Phylogenomic databases
eggNOG	NOG292767.
GeneTree	ENSGT00390000001475.
HOGENOM	HOG000236288.
InParanoid	Q5U2U2.
KO	K04438.
OMA	SRNSNSY.
OrthoDB	EOG4NS3C3.
Gene expression databases
Genevestigator	Q5U2U2.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR000980. SH2. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN.
SMART	SM00252. SH2. 1 hit. SM00326. SH3. 2 hits. [Graphical view]
SUPFAM	SSF50044. SH3. 2 hits.
PROSITE	PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	627271.

Entry information

Entry name

CRKL_RAT

Accession

Primary (citable) accession number: Q5U2U2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	December 7, 2004
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program