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Protein

Peptidylprolyl isomerase

Gene

Fkbp5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidylprolyl isomerasePROSITE-ProRule annotation (EC:5.2.1.8PROSITE-ProRule annotation)
Gene namesi
Name:Fkbp5Imported
ORF Names:rCG_60597Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1309155. Fkbp5.

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSRNOG00000022523.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ5U2T9. 1 interactor.
STRINGi10116.ENSRNOP00000034024.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 138PPIase FKBP-typeInterPro annotationAdd BLAST89
Domaini165 – 251PPIase FKBP-typeInterPro annotationAdd BLAST87
Repeati268 – 301TPRPROSITE-ProRule annotationAdd BLAST34
Domaini317 – 384TPR_REGIONInterPro annotationAdd BLAST68
Repeati317 – 350TPRPROSITE-ProRule annotationAdd BLAST34
Repeati351 – 384TPRPROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

RepeatSAAS annotation, TPR repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0543. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000256916.
HOVERGENiHBG051624.
KOiK09571.
OMAiVCHLLCK.
OrthoDBiEOG091G07OA.
TreeFamiTF105292.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiView protein in InterPro
IPR031210. FKBP5.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
PANTHERiPTHR10516. PTHR10516. 1 hit.
PTHR10516:SF334. PTHR10516:SF334. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 2 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U2T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTDEGTSNN EENPAATVVE QGEDITTKKD RGVLKIVKRV GTSEETPMIG
60 70 80 90 100
DKVYVHYKGK LSNGKKFDSS RDRNEPFVFS LGKGQVIKAW DIGVSTMKKG
110 120 130 140 150
EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDSGIIR
160 170 180 190 200
RIKRKGEGYS NPNEGATVEV HLEGCCAGRV FDCRDVVFVI GEGEDHDIPI
210 220 230 240 250
GIDKALEKMQ REEQCILYLG PQYGFGEAGK PKFGIEPNAE LMYEVTLKSF
260 270 280 290 300
EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM
310 320 330 340 350
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN
360 370 380 390 400
EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISVCQRKAKE
410 420 430 440 450
HNERDRRVYA NMFKKFAEQD AKEEASKALS KKAVEGAAGK KHESQTMGEG

KAEGHV
Length:456
Mass (Da):50,965
Last modified:December 7, 2004 - v1
Checksum:iC63929D7A5FF2B85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072814 Genomic DNA. No translation available.
AC106225 Genomic DNA. No translation available.
BC085868 mRNA. Translation: AAH85868.1.
CH473988 Genomic DNA. Translation: EDL96926.1.
RefSeqiNP_001012174.1. NM_001012174.1.
XP_006256286.1. XM_006256224.3.
UniGeneiRn.144288.

Genome annotation databases

EnsembliENSRNOT00000033119; ENSRNOP00000034024; ENSRNOG00000022523.
GeneIDi361810.
KEGGirno:361810.
UCSCiRGD:1309155. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072814 Genomic DNA. No translation available.
AC106225 Genomic DNA. No translation available.
BC085868 mRNA. Translation: AAH85868.1.
CH473988 Genomic DNA. Translation: EDL96926.1.
RefSeqiNP_001012174.1. NM_001012174.1.
XP_006256286.1. XM_006256224.3.
UniGeneiRn.144288.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5U2T9. 1 interactor.
STRINGi10116.ENSRNOP00000034024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000033119; ENSRNOP00000034024; ENSRNOG00000022523.
GeneIDi361810.
KEGGirno:361810.
UCSCiRGD:1309155. rat.

Organism-specific databases

CTDi2289.
RGDi1309155. Fkbp5.

Phylogenomic databases

eggNOGiKOG0543. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000256916.
HOVERGENiHBG051624.
KOiK09571.
OMAiVCHLLCK.
OrthoDBiEOG091G07OA.
TreeFamiTF105292.

Gene expression databases

BgeeiENSRNOG00000022523.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiView protein in InterPro
IPR031210. FKBP5.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
PANTHERiPTHR10516. PTHR10516. 1 hit.
PTHR10516:SF334. PTHR10516:SF334. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 2 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5U2T9_RAT
AccessioniPrimary (citable) accession number: Q5U2T9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: May 10, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.