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Protein
Submitted name:

Lymphotoxin B receptor

Gene

Ltbr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

ReactomeiR-RNO-5668541. TNFR2 non-canonical NF-kB pathway.
R-RNO-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Lymphotoxin B receptorImported
Submitted name:
Lymphotoxin beta receptorImported
Submitted name:
Lymphotoxin beta receptor (TNFR superfamily, member 3)Imported
Gene namesi
Name:LtbrImported
ORF Names:rCG_29964Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1309448. Ltbr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei222 – 245HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_501050602428 – 416Sequence analysisAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 58PROSITE-ProRule annotation
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi62 ↔ 80PROSITE-ProRule annotation
Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
Disulfide bondi172 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000019264.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026184.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 80TNFR-CysInterPro annotationAdd BLAST39
Repeati42 – 80TNFR-CysPROSITE-ProRule annotationAdd BLAST39
Domaini82 – 124TNFR-CysInterPro annotationAdd BLAST43
Repeati82 – 124TNFR-CysPROSITE-ProRule annotationAdd BLAST43
Domaini171 – 212TNFR-CysInterPro annotationAdd BLAST42
Repeati171 – 212TNFR-CysPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IKNN. Eukaryota.
ENOG410YQJW. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000294180.
HOVERGENiHBG023187.
KOiK03159.
OMAiEDGKAWH.
OrthoDBiEOG091G03XW.
TreeFamiTF331157.

Family and domain databases

CDDicd10578. TNFRSF3. 1 hit.
InterProiView protein in InterPro
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR017349. TNFR_3_LTBR.
IPR033997. TNFRSF3_N.
PfamiView protein in Pfam
PF00020. TNFR_c6. 3 hits.
PIRSFiPIRSF037999. TNFR_3_LTBR. 1 hit.
PRINTSiPR01920. TNFACTORR3.
SMARTiView protein in SMART
SM00208. TNFR. 3 hits.
PROSITEiView protein in PROSITE
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q5U2S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPGASSPC GLVWGPLLLG FCGLLVASQP QLVPPYRIEN QTCWDPDKEY
60 70 80 90 100
YEPLHQVCCS RCPPGKFVHA VCSPSQDTVC KTCLHNSYNE HWNHLFSCQL
110 120 130 140 150
CRPCDSVLGF EEIAPCTSDR KPECRCKPGM SCVYLDNECV HCEEERLVLC
160 170 180 190 200
RPGTEAEVTD EIMDTEVNCV PCKPGHFQNT SSPRARCQPH TRCESQGLVE
210 220 230 240 250
AASGTSYSDT ICKNPPEAAG TMLLLAILLS LVFFLLFTTV LACAWMRHPS
260 270 280 290 300
LCRKLGTLLK RHPEGEESPP CQPPRANPHF RDLAEPLLPM SGDLSPAPAG
310 320 330 340 350
PPTAPSLEEV VLQQQSPLIQ ARELEAEPGE HGQVAHGANG IHVTGGSVTV
360 370 380 390 400
TGNIYIYNGP VLGGTRGPGD PPAPPEPPYP TPEEGAPGPS ELSTPYQEDG
410
KAWHLAETET LGCQDL
Length:416
Mass (Da):45,133
Last modified:December 7, 2004 - v1
Checksum:i77AC87D7E72FAE5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07062033 Genomic DNA. No translation available.
BC085880 mRNA. Translation: AAH85880.1.
CH473964 Genomic DNA. Translation: EDM01849.1.
RefSeqiNP_001008316.1. NM_001008315.1.
UniGeneiRn.19329.

Genome annotation databases

EnsembliENSRNOT00000026184; ENSRNOP00000026184; ENSRNOG00000019264.
GeneIDi297604.
KEGGirno:297604.
UCSCiRGD:1309448. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ5U2S8_RAT
AccessioniPrimary (citable) accession number: Q5U2S8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: June 7, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported