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Protein

Ankyrin repeat and SOCS box protein 2

Gene

Asb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 2
Short name:
ASB-2
Gene namesi
Name:Asb2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1306414. Asb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634Ankyrin repeat and SOCS box protein 2PRO_0000233304Add
BLAST

Proteomic databases

PaxDbiQ5U2S6.
PRIDEiQ5U2S6.

Expressioni

Gene expression databases

GenevisibleiQ5U2S6. RN.

Interactioni

Subunit structurei

Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2, Elongin BC complex (TCEB1 and TCEB2) and ASB2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012045.

Structurei

3D structure databases

ProteinModelPortaliQ5U2S6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 4520UIMCuratedAdd
BLAST
Repeati104 – 13330ANK 1Sequence analysisAdd
BLAST
Repeati137 – 16731ANK 2Sequence analysisAdd
BLAST
Repeati171 – 20030ANK 3Sequence analysisAdd
BLAST
Repeati204 – 23330ANK 4Sequence analysisAdd
BLAST
Repeati237 – 26630ANK 5Sequence analysisAdd
BLAST
Repeati270 – 29930ANK 6Sequence analysisAdd
BLAST
Repeati303 – 33230ANK 7Sequence analysisAdd
BLAST
Repeati336 – 36530ANK 8Sequence analysisAdd
BLAST
Repeati368 – 39730ANK 9Sequence analysisAdd
BLAST
Repeati410 – 43930ANK 10Sequence analysisAdd
BLAST
Repeati440 – 46930ANK 11Sequence analysisAdd
BLAST
Repeati476 – 50429ANK 12Sequence analysisAdd
BLAST
Domaini580 – 63455SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 12 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000034086.
HOVERGENiHBG104037.
InParanoidiQ5U2S6.
KOiK10324.
OMAiRPLAHLC.
OrthoDBiEOG77DJ5P.
PhylomeDBiQ5U2S6.
TreeFamiTF315127.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 8 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U2S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEISTRGR QRAIGHEEYS LYSSLSEEEL VQMAIEQSLA DKTRGPTPAE
60 70 80 90 100
TSVSSQTNHQ PGHIHPWTRS SSPPESPPAR APLGLFQGVM QKYSSNLFKT
110 120 130 140 150
SQMAAMDPVL KAIKEGDEEA LKAMIQDGKN LAEPNKEGWL PLHEAAYYGK
160 170 180 190 200
LGCLKVLQRA YPGTIDQRTL QEETALYLAT CREHLDCLLS LLQAGAEPDI
210 220 230 240 250
SNKSRETPLY KACERKNAEA VRILVQYNAD ANHRCNRGWT ALHESVSRND
260 270 280 290 300
LEVMEILVSG GAKVEAKNVY SITPLFVAAQ SGQLEALRFL AKHGADINTQ
310 320 330 340 350
ASDSASALYE ACKNEHEDVV EFLLSQGADA NKANKDGLLP LHVASKKGNY
360 370 380 390 400
RIVQMLLPVT SRTRVRRSGI SPLHLAAERN HDAVLEALLA ARFDVNTPLA
410 420 430 440 450
PERARLYEDR RTSALYFAVV NNNVYATELL LLAGADPNRD VISPLLVAIR
460 470 480 490 500
HGCLRTMQLL LDHGANIDAY IATHPTAFPA TIMFAMKCLS LLKFLMDLGC
510 520 530 540 550
DGEPCFSCLY GNGPHPPAPR SGRFNDAPVD DKAPSVVQFC EFLSAPEVSR
560 570 580 590 600
WAGPIIDVLL DYVGNVQLCS RLKEHIDSFE DWAVIKEKAE PPRPLAHLCR
610 620 630
LRVRKAIGKY RIKLLDTLPL PGRLIRYLKY ENTQ
Length:634
Mass (Da):70,205
Last modified:December 7, 2004 - v1
Checksum:iCB4E89389609C199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085882 mRNA. Translation: AAH85882.1.
RefSeqiNP_001011984.1. NM_001011984.1.
UniGeneiRn.98677.

Genome annotation databases

EnsembliENSRNOT00000085517; ENSRNOP00000071182; ENSRNOG00000051619.
GeneIDi299266.
KEGGirno:299266.
UCSCiRGD:1306414. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085882 mRNA. Translation: AAH85882.1.
RefSeqiNP_001011984.1. NM_001011984.1.
UniGeneiRn.98677.

3D structure databases

ProteinModelPortaliQ5U2S6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012045.

Proteomic databases

PaxDbiQ5U2S6.
PRIDEiQ5U2S6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000085517; ENSRNOP00000071182; ENSRNOG00000051619.
GeneIDi299266.
KEGGirno:299266.
UCSCiRGD:1306414. rat.

Organism-specific databases

CTDi51676.
RGDi1306414. Asb2.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000034086.
HOVERGENiHBG104037.
InParanoidiQ5U2S6.
KOiK10324.
OMAiRPLAHLC.
OrthoDBiEOG77DJ5P.
PhylomeDBiQ5U2S6.
TreeFamiTF315127.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ5U2S6.

Gene expression databases

GenevisibleiQ5U2S6. RN.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 8 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway.
    Tissue: Heart.

Entry informationi

Entry nameiASB2_RAT
AccessioniPrimary (citable) accession number: Q5U2S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.