Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat and SOCS box protein 2

Gene

Asb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-8951664 Neddylation
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 2
Short name:
ASB-2
Gene namesi
Name:Asb2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1306414 Asb2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333041 – 634Ankyrin repeat and SOCS box protein 2Add BLAST634

Proteomic databases

PaxDbiQ5U2S6
PRIDEiQ5U2S6

Expressioni

Gene expression databases

BgeeiENSRNOG00000051619
GenevisibleiQ5U2S6 RN

Interactioni

Subunit structurei

Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2, Elongin BC complex (ELOB and ELOC) and ASB2.By similarity

Protein-protein interaction databases

CORUMiQ5U2S6
STRINGi10116.ENSRNOP00000012045

Structurei

3D structure databases

ProteinModelPortaliQ5U2S6
SMRiQ5U2S6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 45UIMCuratedAdd BLAST20
Repeati104 – 133ANK 1Sequence analysisAdd BLAST30
Repeati137 – 167ANK 2Sequence analysisAdd BLAST31
Repeati171 – 200ANK 3Sequence analysisAdd BLAST30
Repeati204 – 233ANK 4Sequence analysisAdd BLAST30
Repeati237 – 266ANK 5Sequence analysisAdd BLAST30
Repeati270 – 299ANK 6Sequence analysisAdd BLAST30
Repeati303 – 332ANK 7Sequence analysisAdd BLAST30
Repeati336 – 365ANK 8Sequence analysisAdd BLAST30
Repeati368 – 397ANK 9Sequence analysisAdd BLAST30
Repeati410 – 439ANK 10Sequence analysisAdd BLAST30
Repeati440 – 469ANK 11Sequence analysisAdd BLAST30
Repeati476 – 504ANK 12Sequence analysisAdd BLAST29
Domaini580 – 634SOCS boxPROSITE-ProRule annotationAdd BLAST55

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00910000144044
HOGENOMiHOG000034086
HOVERGENiHBG104037
InParanoidiQ5U2S6
KOiK10324
OMAiNADTNHR
OrthoDBiEOG091G05RD
PhylomeDBiQ5U2S6
TreeFamiTF315127

Family and domain databases

CDDicd00204 ANK, 4 hits
cd03721 SOCS_ASB2, 1 hit
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037330 ASB2_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 3 hits
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 11 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 8 hits
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U2S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEISTRGR QRAIGHEEYS LYSSLSEEEL VQMAIEQSLA DKTRGPTPAE
60 70 80 90 100
TSVSSQTNHQ PGHIHPWTRS SSPPESPPAR APLGLFQGVM QKYSSNLFKT
110 120 130 140 150
SQMAAMDPVL KAIKEGDEEA LKAMIQDGKN LAEPNKEGWL PLHEAAYYGK
160 170 180 190 200
LGCLKVLQRA YPGTIDQRTL QEETALYLAT CREHLDCLLS LLQAGAEPDI
210 220 230 240 250
SNKSRETPLY KACERKNAEA VRILVQYNAD ANHRCNRGWT ALHESVSRND
260 270 280 290 300
LEVMEILVSG GAKVEAKNVY SITPLFVAAQ SGQLEALRFL AKHGADINTQ
310 320 330 340 350
ASDSASALYE ACKNEHEDVV EFLLSQGADA NKANKDGLLP LHVASKKGNY
360 370 380 390 400
RIVQMLLPVT SRTRVRRSGI SPLHLAAERN HDAVLEALLA ARFDVNTPLA
410 420 430 440 450
PERARLYEDR RTSALYFAVV NNNVYATELL LLAGADPNRD VISPLLVAIR
460 470 480 490 500
HGCLRTMQLL LDHGANIDAY IATHPTAFPA TIMFAMKCLS LLKFLMDLGC
510 520 530 540 550
DGEPCFSCLY GNGPHPPAPR SGRFNDAPVD DKAPSVVQFC EFLSAPEVSR
560 570 580 590 600
WAGPIIDVLL DYVGNVQLCS RLKEHIDSFE DWAVIKEKAE PPRPLAHLCR
610 620 630
LRVRKAIGKY RIKLLDTLPL PGRLIRYLKY ENTQ
Length:634
Mass (Da):70,205
Last modified:December 7, 2004 - v1
Checksum:iCB4E89389609C199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085882 mRNA Translation: AAH85882.1
RefSeqiNP_001011984.1, NM_001011984.1
UniGeneiRn.98677

Genome annotation databases

EnsembliENSRNOT00000085517; ENSRNOP00000071182; ENSRNOG00000051619
GeneIDi299266
KEGGirno:299266
UCSCiRGD:1306414 rat

Similar proteinsi

Entry informationi

Entry nameiASB2_RAT
AccessioniPrimary (citable) accession number: Q5U2S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health