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Q5U2R7 (MESD_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene names
Name:Mesdc2
Synonyms:Mesd
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction By similarity.

Subunit structure

Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Domain

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6 By similarity.

The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding By similarity.

Sequence similarities

Belongs to the MESD family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionChaperone
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

protein folding

Inferred from sequence or structural similarity. Source: UniProtKB

protein localization to cell surface

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 224195LDLR chaperone MESD
PRO_0000240320

Regions

Region1 – 155155Chaperone domain By similarity
Region156 – 19540Escort domain By similarity
Motif221 – 2244Prevents secretion from ER

Amino acid modifications

Glycosylation1921N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5U2R7 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 88B146EBB72B4EB8

FASTA22425,216
        10         20         30         40         50         60 
MAASSWLRAV LLFLCASDLL LLSPPEAYAT DTPGEAITPP RKKKDIRDYN DADMARLLEQ 

        70         80         90        100        110        120 
WEKDDDIEEG DLPEHKRPSA PIDFSKLDPG KPESILKMTK KGKTLMMFVT ISGNPTEKET 

       130        140        150        160        170        180 
EEITSLWQGS LFNANYDVQR FIVGSDRAIF MLRDGSYAWE IKDFLVNQDR CAEVTLEGQM 

       190        200        210        220 
YPGKGGGSKE KNKTKPEKGK KKEGDPKPRA SKEDNRAGSR REDL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC085892 mRNA. Translation: AAH85892.1.
RefSeqNP_001008346.1. NM_001008345.1.
UniGeneRn.41045.

3D structure databases

ProteinModelPortalQ5U2R7.
SMRQ5U2R7. Positions 89-184.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4580521.
STRING10116.ENSRNOP00000052447.

Proteomic databases

PaxDbQ5U2R7.
PRIDEQ5U2R7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000055583; ENSRNOP00000052447; ENSRNOG00000012366.
GeneID308796.
KEGGrno:308796.

Organism-specific databases

CTD23184.
RGD1310344. Mesdc2.

Phylogenomic databases

eggNOGNOG286690.
GeneTreeENSGT00390000000993.
HOGENOMHOG000230558.
OMAIVGSNRA.
OrthoDBEOG7XPZ76.
PhylomeDBQ5U2R7.
TreeFamTF315614.

Gene expression databases

GenevestigatorQ5U2R7.

Family and domain databases

InterProIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamPF10185. Mesd. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio659572.
PROQ5U2R7.

Entry information

Entry nameMESD_RAT
AccessionPrimary (citable) accession number: Q5U2R7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families