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Protein

LDLR chaperone MESD

Gene

Mesdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene namesi
Name:Mesdc2
Synonyms:Mesd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310344. Mesdc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 224195LDLR chaperone MESDPRO_0000240320Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5U2R7.
PRIDEiQ5U2R7.

Expressioni

Gene expression databases

GenevisibleiQ5U2R7. RN.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4580521.
STRINGi10116.ENSRNOP00000052447.

Structurei

3D structure databases

ProteinModelPortaliQ5U2R7.
SMRiQ5U2R7. Positions 89-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 155155Chaperone domainBy similarityAdd
BLAST
Regioni156 – 19540Escort domainBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi221 – 2244Prevents secretion from ER

Domaini

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.By similarity
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.By similarity

Sequence similaritiesi

Belongs to the MESD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG286690.
GeneTreeiENSGT00390000000993.
HOGENOMiHOG000230558.
InParanoidiQ5U2R7.
OMAiVEGQVYP.
OrthoDBiEOG7XPZ76.
PhylomeDBiQ5U2R7.
TreeFamiTF315614.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASSWLRAV LLFLCASDLL LLSPPEAYAT DTPGEAITPP RKKKDIRDYN
60 70 80 90 100
DADMARLLEQ WEKDDDIEEG DLPEHKRPSA PIDFSKLDPG KPESILKMTK
110 120 130 140 150
KGKTLMMFVT ISGNPTEKET EEITSLWQGS LFNANYDVQR FIVGSDRAIF
160 170 180 190 200
MLRDGSYAWE IKDFLVNQDR CAEVTLEGQM YPGKGGGSKE KNKTKPEKGK
210 220
KKEGDPKPRA SKEDNRAGSR REDL
Length:224
Mass (Da):25,216
Last modified:December 7, 2004 - v1
Checksum:i88B146EBB72B4EB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085892 mRNA. Translation: AAH85892.1.
RefSeqiNP_001008346.1. NM_001008345.1.
UniGeneiRn.41045.

Genome annotation databases

EnsembliENSRNOT00000055583; ENSRNOP00000052447; ENSRNOG00000012366.
GeneIDi308796.
KEGGirno:308796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085892 mRNA. Translation: AAH85892.1.
RefSeqiNP_001008346.1. NM_001008345.1.
UniGeneiRn.41045.

3D structure databases

ProteinModelPortaliQ5U2R7.
SMRiQ5U2R7. Positions 89-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4580521.
STRINGi10116.ENSRNOP00000052447.

Proteomic databases

PaxDbiQ5U2R7.
PRIDEiQ5U2R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055583; ENSRNOP00000052447; ENSRNOG00000012366.
GeneIDi308796.
KEGGirno:308796.

Organism-specific databases

CTDi23184.
RGDi1310344. Mesdc2.

Phylogenomic databases

eggNOGiNOG286690.
GeneTreeiENSGT00390000000993.
HOGENOMiHOG000230558.
InParanoidiQ5U2R7.
OMAiVEGQVYP.
OrthoDBiEOG7XPZ76.
PhylomeDBiQ5U2R7.
TreeFamiTF315614.

Miscellaneous databases

NextBioi659572.
PROiQ5U2R7.

Gene expression databases

GenevisibleiQ5U2R7. RN.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiMESD_RAT
AccessioniPrimary (citable) accession number: Q5U2R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 7, 2004
Last modified: June 24, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.