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Q5U2R7

- MESD_RAT

UniProt

Q5U2R7 - MESD_RAT

Protein

LDLR chaperone MESD

Gene

Mesdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction By similarity.By similarity

    GO - Biological processi

    1. protein folding Source: UniProtKB
    2. protein localization to cell surface Source: Ensembl
    3. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LDLR chaperone MESD
    Alternative name(s):
    Mesoderm development candidate 2
    Mesoderm development protein
    Gene namesi
    Name:Mesdc2
    Synonyms:Mesd
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1310344. Mesdc2.

    Subcellular locationi

    Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 224195LDLR chaperone MESDPRO_0000240320Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5U2R7.
    PRIDEiQ5U2R7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5U2R7.

    Interactioni

    Subunit structurei

    Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane By similarity.By similarity

    Protein-protein interaction databases

    MINTiMINT-4580521.
    STRINGi10116.ENSRNOP00000052447.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U2R7.
    SMRiQ5U2R7. Positions 89-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 155155Chaperone domainBy similarityAdd
    BLAST
    Regioni156 – 19540Escort domainBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi221 – 2244Prevents secretion from ER

    Domaini

    The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.By similarity
    The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.By similarity

    Sequence similaritiesi

    Belongs to the MESD family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG286690.
    GeneTreeiENSGT00390000000993.
    HOGENOMiHOG000230558.
    OMAiNQERCAD.
    OrthoDBiEOG7XPZ76.
    PhylomeDBiQ5U2R7.
    TreeFamiTF315614.

    Family and domain databases

    InterProiIPR019330. Mesoderm_development_cand-2.
    [Graphical view]
    PfamiPF10185. Mesd. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5U2R7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASSWLRAV LLFLCASDLL LLSPPEAYAT DTPGEAITPP RKKKDIRDYN    50
    DADMARLLEQ WEKDDDIEEG DLPEHKRPSA PIDFSKLDPG KPESILKMTK 100
    KGKTLMMFVT ISGNPTEKET EEITSLWQGS LFNANYDVQR FIVGSDRAIF 150
    MLRDGSYAWE IKDFLVNQDR CAEVTLEGQM YPGKGGGSKE KNKTKPEKGK 200
    KKEGDPKPRA SKEDNRAGSR REDL 224
    Length:224
    Mass (Da):25,216
    Last modified:December 7, 2004 - v1
    Checksum:i88B146EBB72B4EB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085892 mRNA. Translation: AAH85892.1.
    RefSeqiNP_001008346.1. NM_001008345.1.
    UniGeneiRn.41045.

    Genome annotation databases

    EnsembliENSRNOT00000055583; ENSRNOP00000052447; ENSRNOG00000012366.
    GeneIDi308796.
    KEGGirno:308796.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC085892 mRNA. Translation: AAH85892.1 .
    RefSeqi NP_001008346.1. NM_001008345.1.
    UniGenei Rn.41045.

    3D structure databases

    ProteinModelPortali Q5U2R7.
    SMRi Q5U2R7. Positions 89-184.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4580521.
    STRINGi 10116.ENSRNOP00000052447.

    Proteomic databases

    PaxDbi Q5U2R7.
    PRIDEi Q5U2R7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000055583 ; ENSRNOP00000052447 ; ENSRNOG00000012366 .
    GeneIDi 308796.
    KEGGi rno:308796.

    Organism-specific databases

    CTDi 23184.
    RGDi 1310344. Mesdc2.

    Phylogenomic databases

    eggNOGi NOG286690.
    GeneTreei ENSGT00390000000993.
    HOGENOMi HOG000230558.
    OMAi NQERCAD.
    OrthoDBi EOG7XPZ76.
    PhylomeDBi Q5U2R7.
    TreeFami TF315614.

    Miscellaneous databases

    NextBioi 659572.
    PROi Q5U2R7.

    Gene expression databases

    Genevestigatori Q5U2R7.

    Family and domain databases

    InterProi IPR019330. Mesoderm_development_cand-2.
    [Graphical view ]
    Pfami PF10185. Mesd. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiMESD_RAT
    AccessioniPrimary (citable) accession number: Q5U2R7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3