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Q5U2R7

- MESD_RAT

UniProt

Q5U2R7 - MESD_RAT

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Protein

LDLR chaperone MESD

Gene

Mesdc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction (By similarity).By similarity

GO - Biological processi

  1. protein folding Source: UniProtKB
  2. protein localization to cell surface Source: Ensembl
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene namesi
Name:Mesdc2
Synonyms:Mesd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1310344. Mesdc2.

Subcellular locationi

Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 224195LDLR chaperone MESDPRO_0000240320Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5U2R7.
PRIDEiQ5U2R7.

Expressioni

Gene expression databases

GenevestigatoriQ5U2R7.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4580521.
STRINGi10116.ENSRNOP00000052447.

Structurei

3D structure databases

ProteinModelPortaliQ5U2R7.
SMRiQ5U2R7. Positions 89-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 155155Chaperone domainBy similarityAdd
BLAST
Regioni156 – 19540Escort domainBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi221 – 2244Prevents secretion from ER

Domaini

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.By similarity
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.By similarity

Sequence similaritiesi

Belongs to the MESD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG286690.
GeneTreeiENSGT00390000000993.
HOGENOMiHOG000230558.
InParanoidiQ5U2R7.
OMAiNQERCAD.
OrthoDBiEOG7XPZ76.
PhylomeDBiQ5U2R7.
TreeFamiTF315614.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2R7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASSWLRAV LLFLCASDLL LLSPPEAYAT DTPGEAITPP RKKKDIRDYN
60 70 80 90 100
DADMARLLEQ WEKDDDIEEG DLPEHKRPSA PIDFSKLDPG KPESILKMTK
110 120 130 140 150
KGKTLMMFVT ISGNPTEKET EEITSLWQGS LFNANYDVQR FIVGSDRAIF
160 170 180 190 200
MLRDGSYAWE IKDFLVNQDR CAEVTLEGQM YPGKGGGSKE KNKTKPEKGK
210 220
KKEGDPKPRA SKEDNRAGSR REDL
Length:224
Mass (Da):25,216
Last modified:December 7, 2004 - v1
Checksum:i88B146EBB72B4EB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085892 mRNA. Translation: AAH85892.1.
RefSeqiNP_001008346.1. NM_001008345.1.
UniGeneiRn.41045.

Genome annotation databases

EnsembliENSRNOT00000055583; ENSRNOP00000052447; ENSRNOG00000012366.
GeneIDi308796.
KEGGirno:308796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC085892 mRNA. Translation: AAH85892.1 .
RefSeqi NP_001008346.1. NM_001008345.1.
UniGenei Rn.41045.

3D structure databases

ProteinModelPortali Q5U2R7.
SMRi Q5U2R7. Positions 89-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4580521.
STRINGi 10116.ENSRNOP00000052447.

Proteomic databases

PaxDbi Q5U2R7.
PRIDEi Q5U2R7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000055583 ; ENSRNOP00000052447 ; ENSRNOG00000012366 .
GeneIDi 308796.
KEGGi rno:308796.

Organism-specific databases

CTDi 23184.
RGDi 1310344. Mesdc2.

Phylogenomic databases

eggNOGi NOG286690.
GeneTreei ENSGT00390000000993.
HOGENOMi HOG000230558.
InParanoidi Q5U2R7.
OMAi NQERCAD.
OrthoDBi EOG7XPZ76.
PhylomeDBi Q5U2R7.
TreeFami TF315614.

Miscellaneous databases

NextBioi 659572.
PROi Q5U2R7.

Gene expression databases

Genevestigatori Q5U2R7.

Family and domain databases

InterProi IPR019330. Mesoderm_development_cand-2.
[Graphical view ]
Pfami PF10185. Mesd. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiMESD_RAT
AccessioniPrimary (citable) accession number: Q5U2R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3