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Protein

LRP chaperone MESD

Gene

Mesd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LRP chaperone MESDCurated
Alternative name(s):
LDLR chaperone MESD
Mesoderm development candidate 2
Mesoderm development protein
Gene namesi
Name:Mesd
Synonyms:Mesdc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310344. Mesdc2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000024032030 – 224LRP chaperone MESDAdd BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5U2R7.
PRIDEiQ5U2R7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012366.
GenevisibleiQ5U2R7. RN.

Interactioni

Subunit structurei

Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP4; the interaction promotes glycosylation of LRP4 and its cell-surface expression.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-4580521.
STRINGi10116.ENSRNOP00000052447.

Structurei

3D structure databases

ProteinModelPortaliQ5U2R7.
SMRiQ5U2R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 155Chaperone domainBy similarityAdd BLAST155
Regioni156 – 195Escort domainBy similarityAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi221 – 224Prevents secretion from ER4

Domaini

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.By similarity
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.By similarity

Sequence similaritiesi

Belongs to the MESD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4357. Eukaryota.
ENOG4111SG4. LUCA.
GeneTreeiENSGT00390000000993.
HOGENOMiHOG000230558.
InParanoidiQ5U2R7.
OMAiIVGSNRA.
OrthoDBiEOG091G0TTK.
PhylomeDBiQ5U2R7.
TreeFamiTF315614.

Family and domain databases

InterProiView protein in InterPro
IPR019330. Mesoderm_development_cand-2.
PfamiView protein in Pfam
PF10185. Mesd. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASSWLRAV LLFLCASDLL LLSPPEAYAT DTPGEAITPP RKKKDIRDYN
60 70 80 90 100
DADMARLLEQ WEKDDDIEEG DLPEHKRPSA PIDFSKLDPG KPESILKMTK
110 120 130 140 150
KGKTLMMFVT ISGNPTEKET EEITSLWQGS LFNANYDVQR FIVGSDRAIF
160 170 180 190 200
MLRDGSYAWE IKDFLVNQDR CAEVTLEGQM YPGKGGGSKE KNKTKPEKGK
210 220
KKEGDPKPRA SKEDNRAGSR REDL
Length:224
Mass (Da):25,216
Last modified:December 7, 2004 - v1
Checksum:i88B146EBB72B4EB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085892 mRNA. Translation: AAH85892.1.
RefSeqiNP_001008346.1. NM_001008345.1.
UniGeneiRn.41045.

Genome annotation databases

EnsembliENSRNOT00000055583; ENSRNOP00000052447; ENSRNOG00000012366.
GeneIDi308796.
KEGGirno:308796.

Similar proteinsi

Entry informationi

Entry nameiMESD_RAT
AccessioniPrimary (citable) accession number: Q5U2R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 7, 2004
Last modified: November 22, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families