ID   P33MX_RAT               Reviewed;         304 AA.
AC   Q5U2R6; Q7TP81;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=Putative monooxygenase p33MONOX;
DE            EC=1.-.-.-;
DE   AltName: Full=liver regeneration-related protein LRRG011;
GN   Name=P33monox; ORFNames=Aa2-141;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Liver;
RA   Xu C.S., Li W.Q., Li Y.C., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P.,
RA   Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Shi J.B.,
RA   Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=21153684; DOI=10.1007/s11010-010-0690-4;
RA   Mishra M., Inoue N., Heese K.;
RT   "Characterizing the novel protein p33MONOX.";
RL   Mol. Cell. Biochem. 350:127-134(2011).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Potential NADPH-dependent oxidoreductase. May be involved in
CC       the regulation of neuronal survival, differentiation and axonal
CC       outgrowth (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with NELFB, NOL12 and PRNP.
CC       {ECO:0000250|UniProtKB:Q96A73}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21153684}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5U2R6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5U2R6-2; Sequence=VSP_028806, VSP_028807;
CC   -!- SIMILARITY: Belongs to the P33MONOX family. {ECO:0000305}.
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DR   EMBL; AY325163; AAP92564.1; -; mRNA.
DR   EMBL; BC085893; AAH85893.1; -; mRNA.
DR   RefSeq; NP_001014029.1; NM_001014007.1. [Q5U2R6-1]
DR   AlphaFoldDB; Q5U2R6; -.
DR   SMR; Q5U2R6; -.
DR   STRING; 10116.ENSRNOP00000023125; -.
DR   iPTMnet; Q5U2R6; -.
DR   PhosphoSitePlus; Q5U2R6; -.
DR   PaxDb; 10116-ENSRNOP00000023125; -.
DR   Ensembl; ENSRNOT00000098242.1; ENSRNOP00000085391.1; ENSRNOG00000017133.8. [Q5U2R6-1]
DR   Ensembl; ENSRNOT00055025704; ENSRNOP00055020972; ENSRNOG00055015016. [Q5U2R6-1]
DR   Ensembl; ENSRNOT00060031492; ENSRNOP00060025561; ENSRNOG00060018277. [Q5U2R6-1]
DR   Ensembl; ENSRNOT00065016903; ENSRNOP00065012943; ENSRNOG00065010427. [Q5U2R6-1]
DR   GeneID; 306766; -.
DR   KEGG; rno:306766; -.
DR   UCSC; RGD:1359256; rat. [Q5U2R6-1]
DR   AGR; RGD:1359256; -.
DR   CTD; 57179; -.
DR   RGD; 1359256; LOC306766.
DR   eggNOG; ENOG502QRB0; Eukaryota.
DR   GeneTree; ENSGT00390000000537; -.
DR   HOGENOM; CLU_079377_0_0_1; -.
DR   InParanoid; Q5U2R6; -.
DR   OMA; KQNSSAQ; -.
DR   OrthoDB; 5311228at2759; -.
DR   PhylomeDB; Q5U2R6; -.
DR   TreeFam; TF332226; -.
DR   PRO; PR:Q5U2R6; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000017133; Expressed in adult mammalian kidney and 19 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR026759; P33MONOX.
DR   PANTHER; PTHR28342; MONOOXYGENASE P33MONOX-RELATED; 1.
DR   PANTHER; PTHR28342:SF1; MONOOXYGENASE P33MONOX-RELATED; 1.
DR   Pfam; PF15302; P33MONOX; 1.
DR   Genevisible; Q5U2R6; RN.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; NADP; Oxidoreductase; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..304
FT                   /note="Putative monooxygenase p33MONOX"
FT                   /id="PRO_0000307733"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          38..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          159..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           68..78
FT                   /note="Flavin-containing monooxygenase motif"
FT   COMPBIAS        77..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..204
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..290
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         45
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DBN4"
FT   MOD_RES         183
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96A73"
FT   MOD_RES         184
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   VAR_SEQ         1..39
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028806"
FT   VAR_SEQ         40..54
FT                   /note="DPAPMTPPPSDMGSI -> MEPVTKTPELTWAAS (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028807"
SQ   SEQUENCE   304 AA;  32797 MW;  FD2D14A5894D266F CRC64;
     MASRQPEVPP ALAPSGPLSK MSLPIGMCRR AFSYDDALED PAPMTPPPSD MGSIPWKPVI
     PERKYQHLDK TEEGAASVSS LAVTPSTATD SSDKAPVVKA KATHIIMNSL ITKQTQESIQ
     RFEQQAGLRD AGYTPHKGLT TEETKYLRVA EALHKLKLQS GETTREEKHP ASAQSSPSST
     PHSSPKQKSR GWFPSGSSTA LPAPNPHSMD PGGGNDRNSA DKWSLFGPRP LQKSDSGFAI
     QAYKGAPKPS PMEVMRAQAT RAGEDPAVFK PPKMDVPVVE GKKQPPRTHN LKPRDLNVLT
     PTGF
//