Q5U2R6 (P33MX_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative monooxygenase p33MONOX
EC=1.-.-.-

Alternative name(s):
liver regeneration-related protein LRRG011

Gene names

Name:	P33monox
ORF Names:	Aa2-141

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth By similarity.
Subunit structure	Interacts with COBRA1, NOL12 and PRNP By similarity.
Subcellular location	Cytoplasm Ref.3.
Sequence similarities	Belongs to the P33MONOX family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5U2R6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5U2R6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     40-54: DPAPMTPPPSDMGSI → MEPVTKTPELTWAAS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Putative monooxygenase p33MONOX		PRO_0000307733
Regions
	Motif	68 – 78	11	Flavin-containing monooxygenase motif
Amino acid modifications
	Modified residue	184	1	Phosphoserine By similarity
	Modified residue	236	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 39	39	Missing in isoform 2.		VSP_028806
	Alternative sequence	40 – 54	15	DPAPM…DMGSI → MEPVTKTPELTWAAS in isoform 2.		VSP_028807

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: FD2D14A5894D266F	FASTA	304	32,797
	10 20 30 40 50 60 MASRQPEVPP ALAPSGPLSK MSLPIGMCRR AFSYDDALED PAPMTPPPSD MGSIPWKPVI 70 80 90 100 110 120 PERKYQHLDK TEEGAASVSS LAVTPSTATD SSDKAPVVKA KATHIIMNSL ITKQTQESIQ 130 140 150 160 170 180 RFEQQAGLRD AGYTPHKGLT TEETKYLRVA EALHKLKLQS GETTREEKHP ASAQSSPSST 190 200 210 220 230 240 PHSSPKQKSR GWFPSGSSTA LPAPNPHSMD PGGGNDRNSA DKWSLFGPRP LQKSDSGFAI 250 260 270 280 290 300 QAYKGAPKPS PMEVMRAQAT RAGEDPAVFK PPKMDVPVVE GKKQPPRTHN LKPRDLNVLT PTGF
	Isoform 2 [UniParc]. Checksum: 865371E33D72D01A	FASTA	265	28,772
	10 20 30 40 50 60 MEPVTKTPEL TWAASPWKPV IPERKYQHLD KTEEGAASVS SLAVTPSTAT DSSDKAPVVK 70 80 90 100 110 120 AKATHIIMNS LITKQTQESI QRFEQQAGLR DAGYTPHKGL TTEETKYLRV AEALHKLKLQ 130 140 150 160 170 180 SGETTREEKH PASAQSSPSS TPHSSPKQKS RGWFPSGSST ALPAPNPHSM DPGGGNDRNS 190 200 210 220 230 240 ADKWSLFGPR PLQKSDSGFA IQAYKGAPKP SPMEVMRAQA TRAGEDPAVF KPPKMDVPVV 250 260 EGKKQPPRTH NLKPRDLNVL TPTGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Liver regeneration after PH." Xu C.S., Li W.Q., Li Y.C., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Shi J.B., Rahman S., Wang Q.N., Zhang J.B. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Heart.
[3]	"Characterizing the novel protein p33MONOX." Mishra M., Inoue N., Heese K. Mol. Cell. Biochem. 350:127-134(2011) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY325163 mRNA. Translation: AAP92564.1. BC085893 mRNA. Translation: AAH85893.1.
IPI	IPI00212801. IPI00382251.
RefSeq	NP_001014029.1. NM_001014007.1.
UniGene	Rn.162182.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5U2R6.
Proteomic databases
PaxDb	Q5U2R6.
PRIDE	Q5U2R6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000023125; ENSRNOP00000023125; ENSRNOG00000017133.
GeneID	306766.
KEGG	rno:306766.
UCSC	RGD:1359256. rat.
Organism-specific databases
RGD	1359256. LOC306766.
Phylogenomic databases
eggNOG	NOG82876.
GeneTree	ENSGT00390000000537.
HOGENOM	HOG000088653.
HOVERGEN	HBG055539.
InParanoid	Q5U2R6.
Gene expression databases
ArrayExpress	Q5U2R6.
Genevestigator	Q5U2R6.
Family and domain databases
InterPro	IPR026759. P33MONOX. [Graphical view]
PANTHER	PTHR32113. PTHR32113. 1 hit.
ProtoNet	Search...
Other
NextBio	656485.

Entry information

Entry name

P33MX_RAT

Accession

Primary (citable) accession number: Q5U2R6
Secondary accession number(s): Q7TP81

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 7, 2004
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program