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Protein

Putative monooxygenase p33MONOX

Gene

P33monox

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth (By similarity).By similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Putative monooxygenase p33MONOX (EC:1.-.-.-)
Alternative name(s):
liver regeneration-related protein LRRG011
Gene namesi
Name:P33monox
ORF Names:Aa2-141
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1359256. LOC306766.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Putative monooxygenase p33MONOXPRO_0000307733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2R6.
PRIDEiQ5U2R6.

PTM databases

PhosphoSiteiQ5U2R6.

Expressioni

Gene expression databases

GenevestigatoriQ5U2R6.

Interactioni

Subunit structurei

Interacts with COBRA1, NOL12 and PRNP.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023026.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi68 – 7811Flavin-containing monooxygenase motifAdd
BLAST

Sequence similaritiesi

Belongs to the P33MONOX family.Curated

Phylogenomic databases

eggNOGiNOG82876.
GeneTreeiENSGT00390000000537.
HOGENOMiHOG000088653.
HOVERGENiHBG055539.
InParanoidiQ5U2R6.
OMAiYRGAQKP.
OrthoDBiEOG76MK94.
PhylomeDBiQ5U2R6.
TreeFamiTF332226.

Family and domain databases

InterProiIPR026759. P33MONOX.
[Graphical view]
PfamiPF15302. P33MONOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5U2R6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRQPEVPP ALAPSGPLSK MSLPIGMCRR AFSYDDALED PAPMTPPPSD
60 70 80 90 100
MGSIPWKPVI PERKYQHLDK TEEGAASVSS LAVTPSTATD SSDKAPVVKA
110 120 130 140 150
KATHIIMNSL ITKQTQESIQ RFEQQAGLRD AGYTPHKGLT TEETKYLRVA
160 170 180 190 200
EALHKLKLQS GETTREEKHP ASAQSSPSST PHSSPKQKSR GWFPSGSSTA
210 220 230 240 250
LPAPNPHSMD PGGGNDRNSA DKWSLFGPRP LQKSDSGFAI QAYKGAPKPS
260 270 280 290 300
PMEVMRAQAT RAGEDPAVFK PPKMDVPVVE GKKQPPRTHN LKPRDLNVLT

PTGF
Length:304
Mass (Da):32,797
Last modified:December 6, 2004 - v1
Checksum:iFD2D14A5894D266F
GO
Isoform 2 (identifier: Q5U2R6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     40-54: DPAPMTPPPSDMGSI → MEPVTKTPELTWAAS

Note: No experimental confirmation available.

Show »
Length:265
Mass (Da):28,772
Checksum:i865371E33D72D01A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3939Missing in isoform 2. 1 PublicationVSP_028806Add
BLAST
Alternative sequencei40 – 5415DPAPM…DMGSI → MEPVTKTPELTWAAS in isoform 2. 1 PublicationVSP_028807Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325163 mRNA. Translation: AAP92564.1.
BC085893 mRNA. Translation: AAH85893.1.
RefSeqiNP_001014029.1. NM_001014007.1. [Q5U2R6-1]
UniGeneiRn.162182.

Genome annotation databases

EnsembliENSRNOT00000023125; ENSRNOP00000023125; ENSRNOG00000017133. [Q5U2R6-2]
GeneIDi306766.
KEGGirno:306766.
UCSCiRGD:1359256. rat. [Q5U2R6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325163 mRNA. Translation: AAP92564.1.
BC085893 mRNA. Translation: AAH85893.1.
RefSeqiNP_001014029.1. NM_001014007.1. [Q5U2R6-1]
UniGeneiRn.162182.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023026.

PTM databases

PhosphoSiteiQ5U2R6.

Proteomic databases

PaxDbiQ5U2R6.
PRIDEiQ5U2R6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023125; ENSRNOP00000023125; ENSRNOG00000017133. [Q5U2R6-2]
GeneIDi306766.
KEGGirno:306766.
UCSCiRGD:1359256. rat. [Q5U2R6-1]

Organism-specific databases

RGDi1359256. LOC306766.

Phylogenomic databases

eggNOGiNOG82876.
GeneTreeiENSGT00390000000537.
HOGENOMiHOG000088653.
HOVERGENiHBG055539.
InParanoidiQ5U2R6.
OMAiYRGAQKP.
OrthoDBiEOG76MK94.
PhylomeDBiQ5U2R6.
TreeFamiTF332226.

Miscellaneous databases

NextBioi656485.

Gene expression databases

GenevestigatoriQ5U2R6.

Family and domain databases

InterProiIPR026759. P33MONOX.
[Graphical view]
PfamiPF15302. P33MONOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Liver regeneration after PH."
    Xu C.S., Li W.Q., Li Y.C., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Heart.
  3. Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiP33MX_RAT
AccessioniPrimary (citable) accession number: Q5U2R6
Secondary accession number(s): Q7TP81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 22, 2007
Last sequence update: December 6, 2004
Last modified: March 3, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.