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Q5U2R6

- P33MX_RAT

UniProt

Q5U2R6 - P33MX_RAT

Protein

Putative monooxygenase p33MONOX

Gene

P33monox

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth By similarity.By similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative monooxygenase p33MONOX (EC:1.-.-.-)
    Alternative name(s):
    liver regeneration-related protein LRRG011
    Gene namesi
    Name:P33monox
    ORF Names:Aa2-141
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi1359256. LOC306766.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304Putative monooxygenase p33MONOXPRO_0000307733Add
    BLAST

    Proteomic databases

    PaxDbiQ5U2R6.
    PRIDEiQ5U2R6.

    PTM databases

    PhosphoSiteiQ5U2R6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5U2R6.

    Interactioni

    Subunit structurei

    Interacts with COBRA1, NOL12 and PRNP.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000023026.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi68 – 7811Flavin-containing monooxygenase motifAdd
    BLAST

    Sequence similaritiesi

    Belongs to the P33MONOX family.Curated

    Phylogenomic databases

    eggNOGiNOG82876.
    GeneTreeiENSGT00390000000537.
    HOGENOMiHOG000088653.
    HOVERGENiHBG055539.
    InParanoidiQ5U2R6.
    OMAiYRGAQKP.
    OrthoDBiEOG76MK94.
    PhylomeDBiQ5U2R6.
    TreeFamiTF332226.

    Family and domain databases

    InterProiIPR026759. P33MONOX.
    [Graphical view]
    PfamiPF15302. P33MONOX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5U2R6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASRQPEVPP ALAPSGPLSK MSLPIGMCRR AFSYDDALED PAPMTPPPSD    50
    MGSIPWKPVI PERKYQHLDK TEEGAASVSS LAVTPSTATD SSDKAPVVKA 100
    KATHIIMNSL ITKQTQESIQ RFEQQAGLRD AGYTPHKGLT TEETKYLRVA 150
    EALHKLKLQS GETTREEKHP ASAQSSPSST PHSSPKQKSR GWFPSGSSTA 200
    LPAPNPHSMD PGGGNDRNSA DKWSLFGPRP LQKSDSGFAI QAYKGAPKPS 250
    PMEVMRAQAT RAGEDPAVFK PPKMDVPVVE GKKQPPRTHN LKPRDLNVLT 300
    PTGF 304
    Length:304
    Mass (Da):32,797
    Last modified:December 7, 2004 - v1
    Checksum:iFD2D14A5894D266F
    GO
    Isoform 2 (identifier: Q5U2R6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-39: Missing.
         40-54: DPAPMTPPPSDMGSI → MEPVTKTPELTWAAS

    Note: No experimental confirmation available.

    Show »
    Length:265
    Mass (Da):28,772
    Checksum:i865371E33D72D01A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3939Missing in isoform 2. 1 PublicationVSP_028806Add
    BLAST
    Alternative sequencei40 – 5415DPAPM…DMGSI → MEPVTKTPELTWAAS in isoform 2. 1 PublicationVSP_028807Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY325163 mRNA. Translation: AAP92564.1.
    BC085893 mRNA. Translation: AAH85893.1.
    RefSeqiNP_001014029.1. NM_001014007.1. [Q5U2R6-1]
    UniGeneiRn.162182.

    Genome annotation databases

    EnsembliENSRNOT00000023125; ENSRNOP00000023125; ENSRNOG00000017133. [Q5U2R6-2]
    GeneIDi306766.
    KEGGirno:306766.
    UCSCiRGD:1359256. rat. [Q5U2R6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY325163 mRNA. Translation: AAP92564.1 .
    BC085893 mRNA. Translation: AAH85893.1 .
    RefSeqi NP_001014029.1. NM_001014007.1. [Q5U2R6-1 ]
    UniGenei Rn.162182.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000023026.

    PTM databases

    PhosphoSitei Q5U2R6.

    Proteomic databases

    PaxDbi Q5U2R6.
    PRIDEi Q5U2R6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000023125 ; ENSRNOP00000023125 ; ENSRNOG00000017133 . [Q5U2R6-2 ]
    GeneIDi 306766.
    KEGGi rno:306766.
    UCSCi RGD:1359256. rat. [Q5U2R6-1 ]

    Organism-specific databases

    RGDi 1359256. LOC306766.

    Phylogenomic databases

    eggNOGi NOG82876.
    GeneTreei ENSGT00390000000537.
    HOGENOMi HOG000088653.
    HOVERGENi HBG055539.
    InParanoidi Q5U2R6.
    OMAi YRGAQKP.
    OrthoDBi EOG76MK94.
    PhylomeDBi Q5U2R6.
    TreeFami TF332226.

    Miscellaneous databases

    NextBioi 656485.

    Gene expression databases

    Genevestigatori Q5U2R6.

    Family and domain databases

    InterProi IPR026759. P33MONOX.
    [Graphical view ]
    Pfami PF15302. P33MONOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Liver regeneration after PH."
      Xu C.S., Li W.Q., Li Y.C., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Heart.
    3. Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiP33MX_RAT
    AccessioniPrimary (citable) accession number: Q5U2R6
    Secondary accession number(s): Q7TP81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3