Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5U2R6 (P33MX_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative monooxygenase p33MONOX

EC=1.-.-.-
Alternative name(s):
liver regeneration-related protein LRRG011
Gene names
Name:P33monox
ORF Names:Aa2-141
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth By similarity.

Subunit structure

Interacts with COBRA1, NOL12 and PRNP By similarity.

Subcellular location

Cytoplasm Ref.3.

Sequence similarities

Belongs to the P33MONOX family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5U2R6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5U2R6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     40-54: DPAPMTPPPSDMGSI → MEPVTKTPELTWAAS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Putative monooxygenase p33MONOX
PRO_0000307733

Regions

Motif68 – 7811Flavin-containing monooxygenase motif

Natural variations

Alternative sequence1 – 3939Missing in isoform 2.
VSP_028806
Alternative sequence40 – 5415DPAPM…DMGSI → MEPVTKTPELTWAAS in isoform 2.
VSP_028807

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: FD2D14A5894D266F

FASTA30432,797
        10         20         30         40         50         60 
MASRQPEVPP ALAPSGPLSK MSLPIGMCRR AFSYDDALED PAPMTPPPSD MGSIPWKPVI 

        70         80         90        100        110        120 
PERKYQHLDK TEEGAASVSS LAVTPSTATD SSDKAPVVKA KATHIIMNSL ITKQTQESIQ 

       130        140        150        160        170        180 
RFEQQAGLRD AGYTPHKGLT TEETKYLRVA EALHKLKLQS GETTREEKHP ASAQSSPSST 

       190        200        210        220        230        240 
PHSSPKQKSR GWFPSGSSTA LPAPNPHSMD PGGGNDRNSA DKWSLFGPRP LQKSDSGFAI 

       250        260        270        280        290        300 
QAYKGAPKPS PMEVMRAQAT RAGEDPAVFK PPKMDVPVVE GKKQPPRTHN LKPRDLNVLT 


PTGF 

« Hide

Isoform 2 [UniParc].

Checksum: 865371E33D72D01A
Show »

FASTA26528,772

References

« Hide 'large scale' references
[1]"Liver regeneration after PH."
Xu C.S., Li W.Q., Li Y.C., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Heart.
[3]"Characterizing the novel protein p33MONOX."
Mishra M., Inoue N., Heese K.
Mol. Cell. Biochem. 350:127-134(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY325163 mRNA. Translation: AAP92564.1.
BC085893 mRNA. Translation: AAH85893.1.
RefSeqNP_001014029.1. NM_001014007.1. [Q5U2R6-1]
UniGeneRn.162182.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000023026.

PTM databases

PhosphoSiteQ5U2R6.

Proteomic databases

PaxDbQ5U2R6.
PRIDEQ5U2R6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000023125; ENSRNOP00000023125; ENSRNOG00000017133. [Q5U2R6-2]
GeneID306766.
KEGGrno:306766.
UCSCRGD:1359256. rat. [Q5U2R6-1]

Organism-specific databases

RGD1359256. LOC306766.

Phylogenomic databases

eggNOGNOG82876.
GeneTreeENSGT00390000000537.
HOGENOMHOG000088653.
HOVERGENHBG055539.
InParanoidQ5U2R6.
OMAYRGAQKP.
OrthoDBEOG76MK94.
PhylomeDBQ5U2R6.
TreeFamTF332226.

Gene expression databases

GenevestigatorQ5U2R6.

Family and domain databases

InterProIPR026759. P33MONOX.
[Graphical view]
PfamPF15302. P33MONOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio656485.

Entry information

Entry nameP33MX_RAT
AccessionPrimary (citable) accession number: Q5U2R6
Secondary accession number(s): Q7TP81
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 7, 2004
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families