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Protein

Protein phosphatase 1 regulatory subunit 3C

Gene

Ppp1r3c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types (By similarity).By similarity

GO - Molecular functioni

  • enzyme binding Source: RGD
  • protein phosphatase binding Source: UniProtKB
  • protein phosphatase regulator activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3C
Alternative name(s):
Protein phosphatase 1 regulatory subunit 5
Short name:
PP1 subunit R5
Protein targeting to glycogen
Short name:
PTG
Gene namesi
Name:Ppp1r3cImported
Synonyms:Ppp1r5By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309132. Ppp1r3c.

Subcellular locationi

GO - Cellular componenti

  • glycogen granule Source: RGD
  • intracellular membrane-bounded organelle Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Protein phosphatase 1 regulatory subunit 3CPRO_0000285929Add
BLAST

Post-translational modificationi

Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ5U2R5.

PTM databases

iPTMnetiQ5U2R5.
PhosphoSiteiQ5U2R5.

Interactioni

Subunit structurei

Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. Also interacts with EPM2A/laforin (By similarity).By similarity

GO - Molecular functioni

  • enzyme binding Source: RGD
  • protein phosphatase binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067720.

Structurei

3D structure databases

ProteinModelPortaliQ5U2R5.
SMRiQ5U2R5. Positions 127-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 257109CBM21PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni141 – 263123Interaction with EPM2ABy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi84 – 874PP1-binding motif

Domaini

The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.By similarity

Sequence similaritiesi

Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
HOGENOMiHOG000026799.
HOVERGENiHBG052744.
InParanoidiQ5U2R5.
KOiK07189.
PhylomeDBiQ5U2R5.

Family and domain databases

InterProiIPR005036. CBM21_dom.
IPR017434. Pase-1_reg-su_3B/C/D_met.
IPR030683. PP1_3C.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFiPIRSF038207. PP1_GT_animal. 1 hit.
PIRSF500813. PP1_PTG. 1 hit.
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U2R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCTRMIHVL DPRPLTSSVM PVDMAMRICL AHSPPLKSFL GPYNGLQRRH
60 70 80 90 100
FVNKPKPLKP CLSVKQEAKS QKEWKSPHSQ AKKRVVFADS KGLSLTAIHV
110 120 130 140 150
FSDLPEEPAW DLQFDLLDLN DISSSLKLHE EKNLVFDFPQ PSSDYLSFRD
160 170 180 190 200
RFQKNFVCLE NCSLQDRTVT GTVKVKNVSF EKKVQVRITF DTWKTYTDVD
210 220 230 240 250
CVYLKNVYGS SDSDTFSFAI DLPRVIPTEE KIEFCISYHA NGRVFWDNNE
260 270 280 290 300
AQNYRIVHVQ WKPDGVQTQV APKDCAFQQV PLKTELEPTV FGSPRLASGL
310
FPEWQSWGRV ENLASYR
Length:317
Mass (Da):36,413
Last modified:December 7, 2004 - v1
Checksum:i6B73930ED3537F5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085894 mRNA. Translation: AAH85894.1.
RefSeqiNP_001012072.1. NM_001012072.1.
UniGeneiRn.162528.

Genome annotation databases

GeneIDi309513.
KEGGirno:309513.
UCSCiRGD:1309132. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085894 mRNA. Translation: AAH85894.1.
RefSeqiNP_001012072.1. NM_001012072.1.
UniGeneiRn.162528.

3D structure databases

ProteinModelPortaliQ5U2R5.
SMRiQ5U2R5. Positions 127-264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067720.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

PTM databases

iPTMnetiQ5U2R5.
PhosphoSiteiQ5U2R5.

Proteomic databases

PaxDbiQ5U2R5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi309513.
KEGGirno:309513.
UCSCiRGD:1309132. rat.

Organism-specific databases

CTDi5507.
RGDi1309132. Ppp1r3c.

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
HOGENOMiHOG000026799.
HOVERGENiHBG052744.
InParanoidiQ5U2R5.
KOiK07189.
PhylomeDBiQ5U2R5.

Miscellaneous databases

PROiQ5U2R5.

Family and domain databases

InterProiIPR005036. CBM21_dom.
IPR017434. Pase-1_reg-su_3B/C/D_met.
IPR030683. PP1_3C.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PIRSFiPIRSF038207. PP1_GT_animal. 1 hit.
PIRSF500813. PP1_PTG. 1 hit.
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: HeartImported.

Entry informationi

Entry nameiPPR3C_RAT
AccessioniPrimary (citable) accession number: Q5U2R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 7, 2004
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.