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Protein

Mitochondrial ribonuclease P protein 1

Gene

Trmt10c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ribonuclease P protein 1 (EC:2.1.1.-)
Short name:
Mitochondrial RNase P protein 1
Alternative name(s):
RNA (guanine-9-)-methyltransferase domain-containing protein 1
tRNA methyltransferase 10 homolog C
Gene namesi
Name:Trmt10c
Synonyms:Mrpp1, Rg9mtd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1306333. Trmt10c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
ChainiPRO_000031131136 – 414Mitochondrial ribonuclease P protein 1Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2R4.
PRIDEiQ5U2R4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000039567.
GenevisibleiQ5U2R4. RN.

Interactioni

Subunit structurei

Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391. Interacts with GRSF1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi257741. 1 interactor.
STRINGi10116.ENSRNOP00000002198.

Structurei

3D structure databases

ProteinModelPortaliQ5U2R4.
SMRiQ5U2R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 378SAM-dependent MTase TRM10-typePROSITE-ProRule annotationAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili133 – 162Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase TRM10-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG2967. Eukaryota.
ENOG4111JE4. LUCA.
GeneTreeiENSGT00530000063169.
HOGENOMiHOG000088648.
HOVERGENiHBG108146.
InParanoidiQ5U2R4.
KOiK17654.
OMAiKTLMECV.
OrthoDBiEOG091G09AL.
PhylomeDBiQ5U2R4.
TreeFamiTF319795.

Family and domain databases

InterProiIPR025812. MRPP1.
IPR028564. MT_TRM10-typ.
IPR007356. tRNA_m1G_MeTrfase_euk.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PANTHERiPTHR13563. PTHR13563. 1 hit.
PTHR13563:SF5. PTHR13563:SF5. 1 hit.
PfamiPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PROSITEiPS51675. SAM_MT_TRM10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVTVRFLRP FARYLVPYTF HRTRSNSYSR VLQRYVSSKV PSLPCHNKDS
60 70 80 90 100
TSPPEQLELD GWKTTMKSSI QENGVSVVSD KDEDSLAATR ELIEMWRLLG
110 120 130 140 150
KEVPEHITEE ELKTLMECAS KSAKKKYLRY LYGKEMMKKA KQMKKEMKAA
160 170 180 190 200
AREEAKRARS LEPSTGEEQR DFMFLRLWDR QTNIALGWKG VQAMQFGQPL
210 220 230 240 250
VFDMAYDNYM KPSELQNTVS QLLESEGWNR RNVDPFHIYF CNLEVDGAYH
260 270 280 290 300
RELVKRYGEK WDKLLLTATE KSPVDLFPKD SIIYLTADSP NVMTTFKHDK
310 320 330 340 350
IYIIGSFVDK NTQTGTSLAK AKRQNLATEC LPLDKYLQWD VGNKNLTLDQ
360 370 380 390 400
MIRILLCLKN TGNWEEALKF VPRRKHTGYL EVPEHSQAAF RKLKKTKTLN
410
SFRKGSLNVH MWKR
Length:414
Mass (Da):48,293
Last modified:December 7, 2004 - v1
Checksum:iE43A3D273A43A469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085895 mRNA. Translation: AAH85895.1.
RefSeqiNP_001008338.1. NM_001008337.1.
UniGeneiRn.13590.

Genome annotation databases

EnsembliENSRNOT00000002198; ENSRNOP00000002198; ENSRNOG00000039567.
GeneIDi304012.
KEGGirno:304012.
UCSCiRGD:1306333. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085895 mRNA. Translation: AAH85895.1.
RefSeqiNP_001008338.1. NM_001008337.1.
UniGeneiRn.13590.

3D structure databases

ProteinModelPortaliQ5U2R4.
SMRiQ5U2R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi257741. 1 interactor.
STRINGi10116.ENSRNOP00000002198.

Proteomic databases

PaxDbiQ5U2R4.
PRIDEiQ5U2R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002198; ENSRNOP00000002198; ENSRNOG00000039567.
GeneIDi304012.
KEGGirno:304012.
UCSCiRGD:1306333. rat.

Organism-specific databases

CTDi54931.
RGDi1306333. Trmt10c.

Phylogenomic databases

eggNOGiKOG2967. Eukaryota.
ENOG4111JE4. LUCA.
GeneTreeiENSGT00530000063169.
HOGENOMiHOG000088648.
HOVERGENiHBG108146.
InParanoidiQ5U2R4.
KOiK17654.
OMAiKTLMECV.
OrthoDBiEOG091G09AL.
PhylomeDBiQ5U2R4.
TreeFamiTF319795.

Miscellaneous databases

PROiQ5U2R4.

Gene expression databases

BgeeiENSRNOG00000039567.
GenevisibleiQ5U2R4. RN.

Family and domain databases

InterProiIPR025812. MRPP1.
IPR028564. MT_TRM10-typ.
IPR007356. tRNA_m1G_MeTrfase_euk.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PANTHERiPTHR13563. PTHR13563. 1 hit.
PTHR13563:SF5. PTHR13563:SF5. 1 hit.
PfamiPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PROSITEiPS51675. SAM_MT_TRM10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRRP1_RAT
AccessioniPrimary (citable) accession number: Q5U2R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.