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Protein

FERM domain-containing protein 8

Gene

Frmd8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 8
Gene namesi
Name:Frmd8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310323. Frmd8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466FERM domain-containing protein 8PRO_0000295780Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei24 – 241PhosphoserineCombined sources
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei409 – 4091PhosphoserineBy similarity
Modified residuei420 – 4201PhosphothreonineBy similarity
Modified residuei440 – 4401PhosphoserineCombined sources
Modified residuei447 – 4471PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5U2R3.
PRIDEiQ5U2R3.

Expressioni

Gene expression databases

GenevisibleiQ5U2R3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028331.

Structurei

3D structure databases

ProteinModelPortaliQ5U2R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 377348FERMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4335. Eukaryota.
ENOG410ZV6V. LUCA.
GeneTreeiENSGT00530000063721.
HOGENOMiHOG000285969.
HOVERGENiHBG104171.
InParanoidiQ5U2R3.
OMAiAFFHGEV.
OrthoDBiEOG79PJP6.
PhylomeDBiQ5U2R3.
TreeFamiTF317921.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U2R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGAEGNAGQ PGPAERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLS
60 70 80 90 100
SISAHELHRA VREVLQLPDM ALEAFALWLV SPLLEVQLKP KHQPYKLGRQ
110 120 130 140 150
WPELLLRFTD ASDDDIAMDE PSLQFRRNVF FPKRRELQVH DEEVLRLLYE
160 170 180 190 200
EAKGNVLTAR YPCDLEDCEV LGGLVCRVQL GPYQPGQPAA CTVREKLDSF
210 220 230 240 250
LPAHLCKRGH GLFAAFRGRG AKTGPCEQGL LNAYRQVKEM AGGDSERETT
260 270 280 290 300
LGSHYRAYLL KCHELPFYGC AFFHGEVDKP TQGFLHRGGR KPVTVAISLE
310 320 330 340 350
GVHVIDNREK HVLLGLRFQE LSWDHTSPEE EEPVLWLEFD GDSEGTPVNK
360 370 380 390 400
LLRIYSKQAE LMSVLIEYCI ELSQAAEPAL PQESASGPQE APSPSSAPTQ
410 420 430 440 450
RPKLRRQGSV VCSRIQHLST IDYVEDGSGI KRVKPKRTTS FFSRQLSSSH
460
GSYTVVQPND NSPEQG
Length:466
Mass (Da):51,782
Last modified:December 7, 2004 - v1
Checksum:i40EC0764715C5222
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085896 mRNA. Translation: AAH85896.1.
RefSeqiNP_001008349.1. NM_001008348.1.
UniGeneiRn.1260.

Genome annotation databases

EnsembliENSRNOT00000028331; ENSRNOP00000028331; ENSRNOG00000020881.
GeneIDi309172.
KEGGirno:309172.
UCSCiRGD:1310323. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085896 mRNA. Translation: AAH85896.1.
RefSeqiNP_001008349.1. NM_001008348.1.
UniGeneiRn.1260.

3D structure databases

ProteinModelPortaliQ5U2R3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028331.

Proteomic databases

PaxDbiQ5U2R3.
PRIDEiQ5U2R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028331; ENSRNOP00000028331; ENSRNOG00000020881.
GeneIDi309172.
KEGGirno:309172.
UCSCiRGD:1310323. rat.

Organism-specific databases

CTDi83786.
RGDi1310323. Frmd8.

Phylogenomic databases

eggNOGiKOG4335. Eukaryota.
ENOG410ZV6V. LUCA.
GeneTreeiENSGT00530000063721.
HOGENOMiHOG000285969.
HOVERGENiHBG104171.
InParanoidiQ5U2R3.
OMAiAFFHGEV.
OrthoDBiEOG79PJP6.
PhylomeDBiQ5U2R3.
TreeFamiTF317921.

Miscellaneous databases

NextBioi660334.
PROiQ5U2R3.

Gene expression databases

GenevisibleiQ5U2R3. RN.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24 AND SER-440, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFRMD8_RAT
AccessioniPrimary (citable) accession number: Q5U2R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 7, 2004
Last modified: November 11, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.