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Protein

Decaprenyl-diphosphate synthase subunit 2

Gene

Pdss2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.By similarity

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-2142789. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Decaprenyl-diphosphate synthase subunit 2 (EC:2.5.1.91)
Alternative name(s):
All-trans-decaprenyl-diphosphate synthase subunit 2
Decaprenyl pyrophosphate synthase subunit 2
Gene namesi
Name:Pdss2
Synonyms:Dlp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1359372. Pdss2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Decaprenyl-diphosphate synthase subunit 2PRO_0000123980Add
BLAST

Proteomic databases

PaxDbiQ5U2R1.
PRIDEiQ5U2R1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000042962.
GenevisibleiQ5U2R1. RN.

Interactioni

Subunit structurei

Heterotetramer of 2 DPS1/TPRT and 2 DLP1 subunits.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059060.

Structurei

3D structure databases

ProteinModelPortaliQ5U2R1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

eggNOGiKOG0776. Eukaryota.
COG0142. LUCA.
GeneTreeiENSGT00530000063378.
HOGENOMiHOG000294216.
HOVERGENiHBG058860.
InParanoidiQ5U2R1.
KOiK12505.
OMAiKESYITD.
OrthoDBiEOG091G0B45.
PhylomeDBiQ5U2R1.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U2R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRQLLLRL SGYLGASGPP NRHWWYFRSL DTISSVGSWR GRSSRSPAHW
60 70 80 90 100
NQVVSEAEKI VGYPASFMSL RCLLSDELSN VAMQVRKLVG TQHPLLTTAR
110 120 130 140 150
GFVHDSRHNL QLRGLVVLLI SKAAGPSTRN SSSQNYDMVS GIYSCQRNLA
160 170 180 190 200
EITELIHTAL LVHRGIVNLS ELQSSDGPLK DMKFGNKIAV LSGDFLLANA
210 220 230 240 250
CNGLALLQNT KVVELLASAL MDLVQGIYQE NSASTQGNPI PDDIRISTWK
260 270 280 290 300
EQTFLSHCAL LAKSCKAAME LAKHDAAVQD MAFQYGKHMA MSHKINSDLQ
310 320 330 340 350
PFIKDKASDS KTFNLNSAPV VLHQEFLGRD LWIKQIGEAQ EKGRLNYTKL
360 370 380 390 400
RETIKAGKGV TSAIDLCRYH GNKALEALES FPPSEARSAL ENIVFAVTRF

S
Length:401
Mass (Da):44,295
Last modified:December 7, 2004 - v1
Checksum:i46F8D7D24CF3E874
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085898 mRNA. Translation: AAH85898.1.
RefSeqiNP_001014271.1. NM_001014249.1.
UniGeneiRn.20063.

Genome annotation databases

EnsembliENSRNOT00000067169; ENSRNOP00000059060; ENSRNOG00000042962.
GeneIDi365592.
KEGGirno:365592.
UCSCiRGD:1359372. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085898 mRNA. Translation: AAH85898.1.
RefSeqiNP_001014271.1. NM_001014249.1.
UniGeneiRn.20063.

3D structure databases

ProteinModelPortaliQ5U2R1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059060.

Proteomic databases

PaxDbiQ5U2R1.
PRIDEiQ5U2R1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067169; ENSRNOP00000059060; ENSRNOG00000042962.
GeneIDi365592.
KEGGirno:365592.
UCSCiRGD:1359372. rat.

Organism-specific databases

CTDi57107.
RGDi1359372. Pdss2.

Phylogenomic databases

eggNOGiKOG0776. Eukaryota.
COG0142. LUCA.
GeneTreeiENSGT00530000063378.
HOGENOMiHOG000294216.
HOVERGENiHBG058860.
InParanoidiQ5U2R1.
KOiK12505.
OMAiKESYITD.
OrthoDBiEOG091G0B45.
PhylomeDBiQ5U2R1.

Enzyme and pathway databases

UniPathwayiUPA00232.
ReactomeiR-RNO-2142789. Ubiquinol biosynthesis.

Miscellaneous databases

PROiQ5U2R1.

Gene expression databases

BgeeiENSRNOG00000042962.
GenevisibleiQ5U2R1. RN.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDLP1_RAT
AccessioniPrimary (citable) accession number: Q5U2R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.