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Q5U2R1 (DLP1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Decaprenyl-diphosphate synthase subunit 2
EC=2.5.1.91
Alternative name(s):
All-trans-decaprenyl-diphosphate synthase subunit 2
Decaprenyl pyrophosphate synthase subunit 2
Gene names
Name:Pdss2
Synonyms:Dlp1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10 By similarity.

Catalytic activity

(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis.

Subunit structure

Heterotetramer of 2 DPS1/TPRT and 2 DLP1 subunits By similarity.

Subcellular location

Mitochondrion Potential.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 401401Decaprenyl-diphosphate synthase subunit 2
PRO_0000123980

Sequences

Sequence LengthMass (Da)Tools
Q5U2R1 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 46F8D7D24CF3E874

FASTA40144,295
        10         20         30         40         50         60 
MSLRQLLLRL SGYLGASGPP NRHWWYFRSL DTISSVGSWR GRSSRSPAHW NQVVSEAEKI 

        70         80         90        100        110        120 
VGYPASFMSL RCLLSDELSN VAMQVRKLVG TQHPLLTTAR GFVHDSRHNL QLRGLVVLLI 

       130        140        150        160        170        180 
SKAAGPSTRN SSSQNYDMVS GIYSCQRNLA EITELIHTAL LVHRGIVNLS ELQSSDGPLK 

       190        200        210        220        230        240 
DMKFGNKIAV LSGDFLLANA CNGLALLQNT KVVELLASAL MDLVQGIYQE NSASTQGNPI 

       250        260        270        280        290        300 
PDDIRISTWK EQTFLSHCAL LAKSCKAAME LAKHDAAVQD MAFQYGKHMA MSHKINSDLQ 

       310        320        330        340        350        360 
PFIKDKASDS KTFNLNSAPV VLHQEFLGRD LWIKQIGEAQ EKGRLNYTKL RETIKAGKGV 

       370        380        390        400 
TSAIDLCRYH GNKALEALES FPPSEARSAL ENIVFAVTRF S

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC085898 mRNA. Translation: AAH85898.1.
IPIIPI00367901.
RefSeqNP_001014271.1. NM_001014249.1.
UniGeneRn.20063.

3D structure databases

ProteinModelPortalQ5U2R1.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000049086.

Proteomic databases

PRIDEQ5U2R1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000067169; ENSRNOP00000059060; ENSRNOG00000042962.
GeneID365592.
KEGGrno:365592.
UCSCRGD:1359372. rat.

Organism-specific databases

CTD57107.
RGD1359372. Pdss2.

Phylogenomic databases

eggNOGCOG0142.
GeneTreeENSGT00530000063378.
HOGENOMHOG000294216.
HOVERGENHBG058860.
KOK12505.
OrthoDBEOG44QT18.

Enzyme and pathway databases

UniPathwayUPA00232.

Gene expression databases

ArrayExpressQ5U2R1.
GenevestigatorQ5U2R1.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
PANTHERPTHR12001. PTHR12001. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. False negative.
PS00444. POLYPRENYL_SYNTHASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio687727.

Entry information

Entry nameDLP1_RAT
AccessionPrimary (citable) accession number: Q5U2R1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 7, 2004
Last modified: April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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