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Protein

Methionine adenosyltransferase 2 subunit beta

Gene

Mat2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition.

Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.
Proteins known to be involved in this subpathway in this organism are:
  1. S-adenosylmethionine synthase (Mat1a), Methionine adenosyltransferase 2 subunit beta (Mat2b), S-adenosylmethionine synthase (Mat1a), S-adenosylmethionine synthase isoform type-2 (Mat2a), S-adenosylmethionine synthase isoform type-1 (Mat1a), S-adenosylmethionine synthase (Mat2a)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

One-carbon metabolism

Enzyme and pathway databases

ReactomeiR-RNO-156581. Methylation.
SABIO-RKQ5U2R0.
UniPathwayiUPA00315; UER00080.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine adenosyltransferase 2 subunit beta
Alternative name(s):
Methionine adenosyltransferase II beta
Short name:
MAT II beta
Gene namesi
Name:Mat2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1593534. Mat2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 334333Methionine adenosyltransferase 2 subunit betaPRO_0000287523Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5U2R0.
PRIDEiQ5U2R0.

Expressioni

Gene expression databases

ExpressionAtlasiQ5U2R0. baseline and differential.
GenevisibleiQ5U2R0. RN.

Interactioni

Subunit structurei

Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta subunit (MAT2B).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004269.

Structurei

3D structure databases

ProteinModelPortaliQ5U2R0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IQ9F. Eukaryota.
COG1091. LUCA.
GeneTreeiENSGT00390000006721.
HOGENOMiHOG000227713.
HOVERGENiHBG105851.
InParanoidiQ5U2R0.
KOiK00789.
OMAiFTKYEIC.
OrthoDBiEOG74FF26.
PhylomeDBiQ5U2R0.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005913. dTDP_dehydrorham_reduct.
IPR016040. NAD(P)-bd_dom.
IPR029903. RmlD-like-bd.
[Graphical view]
PANTHERiPTHR10491. PTHR10491. 1 hit.
PfamiPF04321. RmlD_sub_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGREKELSI HFVPGCCQLV EEEVNIPSRR VLITGATGLL GRAVYKEFQQ
60 70 80 90 100
SNWHAVGCGF RRARPKFEQV NLLDSEAVHH LIHDFQPHVI VHCAAERRPD
110 120 130 140 150
VVESQPDAAS QLNVGASGNL AKEAAAIGAF LIYISSDYVF DGTNPPYTEE
160 170 180 190 200
DIPSPLNLYG KTKLDGEKAV LENNLGAAVL RIPVLYGEVE KLEESAVTVM
210 220 230 240 250
FDKVQFSNKS ANMDHWQQRF PTHVKDVASV CRQLAEKRML DPSIKGTFHW
260 270 280 290 300
SGNEQMTKYE MACAIADAFN LPSSHLRPIT DSPVIGAQRP KNAQLDCSKL
310 320 330
ETLGIGQRTP FRIGIKESLW PFLIDKRWRQ TVFH
Length:334
Mass (Da):37,375
Last modified:December 7, 2004 - v1
Checksum:iFA65863830981734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085899 mRNA. Translation: AAH85899.1.
RefSeqiNP_001037747.1. NM_001044282.1.
UniGeneiRn.1752.

Genome annotation databases

EnsembliENSRNOT00000004269; ENSRNOP00000004269; ENSRNOG00000003177.
GeneIDi683630.
KEGGirno:683630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085899 mRNA. Translation: AAH85899.1.
RefSeqiNP_001037747.1. NM_001044282.1.
UniGeneiRn.1752.

3D structure databases

ProteinModelPortaliQ5U2R0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004269.

Proteomic databases

PaxDbiQ5U2R0.
PRIDEiQ5U2R0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004269; ENSRNOP00000004269; ENSRNOG00000003177.
GeneIDi683630.
KEGGirno:683630.

Organism-specific databases

CTDi27430.
RGDi1593534. Mat2b.

Phylogenomic databases

eggNOGiENOG410IQ9F. Eukaryota.
COG1091. LUCA.
GeneTreeiENSGT00390000006721.
HOGENOMiHOG000227713.
HOVERGENiHBG105851.
InParanoidiQ5U2R0.
KOiK00789.
OMAiFTKYEIC.
OrthoDBiEOG74FF26.
PhylomeDBiQ5U2R0.

Enzyme and pathway databases

UniPathwayiUPA00315; UER00080.
ReactomeiR-RNO-156581. Methylation.
SABIO-RKQ5U2R0.

Miscellaneous databases

PROiQ5U2R0.

Gene expression databases

ExpressionAtlasiQ5U2R0. baseline and differential.
GenevisibleiQ5U2R0. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005913. dTDP_dehydrorham_reduct.
IPR016040. NAD(P)-bd_dom.
IPR029903. RmlD-like-bd.
[Graphical view]
PANTHERiPTHR10491. PTHR10491. 1 hit.
PfamiPF04321. RmlD_sub_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiMAT2B_RAT
AccessioniPrimary (citable) accession number: Q5U2R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 7, 2004
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.