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Protein

Mono [ADP-ribose] polymerase PARP16

Gene

Parp16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP-ribosyltransferases.By similarity

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei152NADBy similarity1
Binding sitei182NADBy similarity1
Sitei193Nicotinamide-stacking aromateBy similarity1
Binding sitei254NAD; may stabilize a reaction intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processUnfolded protein response
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Mono [ADP-ribose] polymerase PARP16Curated (EC:2.4.2.30By similarity)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 15
Poly [ADP-ribose] polymerase 16
Short name:
PARP-16
Gene namesi
Name:Parp16Imported
Synonyms:Artd15Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306243. Parp16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524391 – 322Mono [ADP-ribose] polymerase PARP16Add BLAST322

Post-translational modificationi

Auto-ADP-ribosylated.By similarity

Keywords - PTMi

ADP-ribosylation

Proteomic databases

PaxDbiQ5U2Q4.
PRIDEiQ5U2Q4.

Interactioni

Subunit structurei

Interacts with KPNB1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043841.

Structurei

3D structure databases

ProteinModelPortaliQ5U2Q4.
SMRiQ5U2Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 91PARP alpha-helicalAdd BLAST87
Domaini77 – 280PARP catalyticPROSITE-ProRule annotationAdd BLAST204

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi297 – 303Poly-Leu7

Domaini

The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF6E. Eukaryota.
ENOG410ZP73. LUCA.
HOVERGENiHBG058859.
InParanoidiQ5U2Q4.
KOiK00774.

Family and domain databases

InterProiView protein in InterPro
IPR012317. Poly(ADP-ribose)pol_cat_dom.
PfamiView protein in Pfam
PF00644. PARP. 1 hit.
PROSITEiView protein in PROSITE
PS51059. PARP_CATALYTIC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U2Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSNRAAAR ESVSRDVLAA DLRCSLFASA LQSYKRDSVL RPFPASYARH
60 70 80 90 100
DCKDFEALLA DTGRLPNLKE LLQSSRDTDK QTWDLVSWIL SSKILTIHSA
110 120 130 140 150
EKAEFEKIQQ LTGAPHTPVP IPDFLFEIEY FDPANARFYE TKGGRDLIYA
160 170 180 190 200
FHGSRLENFH SIIHNGLHCH LNKTSLFGEG TYLTSDLSLA LIYSPHGRGW
210 220 230 240 250
QHSLLGQTLS CVAVCEVIDH PDVKCQTKKK DSKEIDRSRA RIKHSEGGDV
260 270 280 290 300
PPKYFVVTNN QLLRVKYLLV YSQKQPKRAS SQLSWLCSHW FMVAMSLYLL
310 320
LLLIVSVTNS SAFQHFWNRL KR
Length:322
Mass (Da):36,712
Last modified:December 7, 2004 - v1
Checksum:i9D45121DB8D093CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085908 mRNA. Translation: AAH85908.1.
RefSeqiNP_001014115.1. NM_001014093.1.
XP_006243320.1. XM_006243258.3.
UniGeneiRn.23423.

Genome annotation databases

GeneIDi315760.
KEGGirno:315760.
UCSCiRGD:1306243. rat.

Similar proteinsi

Entry informationi

Entry nameiPAR16_RAT
AccessioniPrimary (citable) accession number: Q5U2Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 7, 2004
Last modified: August 30, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome