Q5U2Q4 (PAR16_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly [ADP-ribose] polymerase 16
Short name=PARP-16
EC=2.4.2.30

Gene names

Name:

Parp16

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 PARP catalytic domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Poly [ADP-ribose] polymerase 16		PRO_0000252439
Regions
	Transmembrane	285 – 305	21	Helical; Potential
	Domain	77 – 280	204	PARP catalytic
	Compositional bias	297 – 303	7	Poly-Leu

Sequences

	Sequence		Length	Mass (Da)
	Q5U2Q4 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 9D45121DB8D093CF	FASTA	322	36,712
	10 20 30 40 50 60 MQLSNRAAAR ESVSRDVLAA DLRCSLFASA LQSYKRDSVL RPFPASYARH DCKDFEALLA 70 80 90 100 110 120 DTGRLPNLKE LLQSSRDTDK QTWDLVSWIL SSKILTIHSA EKAEFEKIQQ LTGAPHTPVP 130 140 150 160 170 180 IPDFLFEIEY FDPANARFYE TKGGRDLIYA FHGSRLENFH SIIHNGLHCH LNKTSLFGEG 190 200 210 220 230 240 TYLTSDLSLA LIYSPHGRGW QHSLLGQTLS CVAVCEVIDH PDVKCQTKKK DSKEIDRSRA 250 260 270 280 290 300 RIKHSEGGDV PPKYFVVTNN QLLRVKYLLV YSQKQPKRAS SQLSWLCSHW FMVAMSLYLL 310 320 LLLIVSVTNS SAFQHFWNRL KR

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC085908 mRNA. Translation: AAH85908.1.
IPI	IPI00421316.
RefSeq	NP_001014115.1. NM_001014093.1.
UniGene	Rn.23423.
3D structure databases
ProteinModelPortal	Q5U2Q4.
ModBase	Search...
Proteomic databases
PRIDE	Q5U2Q4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	315760.
KEGG	rno:315760.
UCSC	NM_001014093. rat.
Organism-specific databases
CTD	54956.
RGD	1306243. Parp16.
Phylogenomic databases
eggNOG	roNOG13009.
HOVERGEN	HBG058859.
InParanoid	Q5U2Q4.
OrthoDB	EOG4FR0S0.
Gene expression databases
Genevestigator	Q5U2Q4.
GermOnline	ENSRNOG00000029127. Rattus norvegicus.
Family and domain databases
InterPro	IPR012317. Poly(ADP-ribose)pol_cat_dom. [Graphical view]
KO	K00774.
Pfam	PF00644. PARP. 1 hit. [Graphical view]
PROSITE	PS51059. PARP_CATALYTIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	669816.

Entry information

Entry name

PAR16_RAT

Accession

Primary (citable) accession number: Q5U2Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	December 7, 2004
Last modified:	November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program