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Protein

Immunoglobulin superfamily member 11

Gene

Igsf11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 11
Short name:
IgSF11
Gene namesi
Name:Igsf11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1308758. Igsf11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 239ExtracellularSequence analysisAdd BLAST217
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 428CytoplasmicSequence analysisAdd BLAST168

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031737223 – 428Immunoglobulin superfamily member 11Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 120PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi165 ↔ 215PROSITE-ProRule annotation
Modified residuei375Omega-N-methylarginineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PaxDbiQ5U2P2.

PTM databases

iPTMnetiQ5U2P2.
PhosphoSitePlusiQ5U2P2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001525.
GenevisibleiQ5U2P2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059779.

Structurei

3D structure databases

ProteinModelPortaliQ5U2P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 136Ig-like V-typeAdd BLAST114
Domaini144 – 234Ig-like C2-typeAdd BLAST91

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJM9. Eukaryota.
ENOG410Y8CN. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG107996.
InParanoidiQ5U2P2.
KOiK06791.
OMAiQHTHSYT.
OrthoDBiEOG091G05PI.
PhylomeDBiQ5U2P2.
TreeFamiTF330875.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRRSALAS WLLLSLLGVA ASLEVSESPG SVQVARGQTA VLPCAFSTSA
60 70 80 90 100
ALLNLNVIWM VIPLSNANQP EQVILYQGGQ MFDGALRFHG RVGFTGTMPA
110 120 130 140 150
TNVSIFINNT QLSDTGTYQC LVNNLPDRGG RNIGVTGLTV LVPPSAPNCQ
160 170 180 190 200
IQGSQDIGSD VILLCSSEEG IPRPTYLWEK LDNTLKLPPT ATQDQVQGTV
210 220 230 240 250
TIRNISALSS GLYQCVASNA IGTSTCLLDL QVISPQPRSV GVIAGAVGTG
260 270 280 290 300
AVLIVICLAL TSGAFFYWRS KNKEEEEEEI PNEIREDDLP PKCSSAKAFH
310 320 330 340 350
TEISSSENNT LTSSNTYNSR YWNNNPKPHK NTESFNHFSD LRQSFSGNAV
360 370 380 390 400
IPSIYANGNH LVLGPHKTLV VTANRGSSPQ VMPRNNGSVS RKPWSQHTHS
410 420
YTVSQMTLER IGAVPVMVPA QSRAGSLV
Length:428
Mass (Da):46,021
Last modified:December 7, 2004 - v1
Checksum:iC628CEE36D03A1F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085929 mRNA. Translation: AAH85929.1.
RefSeqiNP_001013138.1. NM_001013120.1.
UniGeneiRn.154553.

Genome annotation databases

EnsembliENSRNOT00000066997; ENSRNOP00000059779; ENSRNOG00000001525.
GeneIDi303926.
KEGGirno:303926.
UCSCiRGD:1308758. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085929 mRNA. Translation: AAH85929.1.
RefSeqiNP_001013138.1. NM_001013120.1.
UniGeneiRn.154553.

3D structure databases

ProteinModelPortaliQ5U2P2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059779.

PTM databases

iPTMnetiQ5U2P2.
PhosphoSitePlusiQ5U2P2.

Proteomic databases

PaxDbiQ5U2P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000066997; ENSRNOP00000059779; ENSRNOG00000001525.
GeneIDi303926.
KEGGirno:303926.
UCSCiRGD:1308758. rat.

Organism-specific databases

CTDi152404.
RGDi1308758. Igsf11.

Phylogenomic databases

eggNOGiENOG410IJM9. Eukaryota.
ENOG410Y8CN. LUCA.
GeneTreeiENSGT00760000119145.
HOGENOMiHOG000111222.
HOVERGENiHBG107996.
InParanoidiQ5U2P2.
KOiK06791.
OMAiQHTHSYT.
OrthoDBiEOG091G05PI.
PhylomeDBiQ5U2P2.
TreeFamiTF330875.

Miscellaneous databases

PROiQ5U2P2.

Gene expression databases

BgeeiENSRNOG00000001525.
GenevisibleiQ5U2P2. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGS11_RAT
AccessioniPrimary (citable) accession number: Q5U2P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.