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Protein

Immunoglobulin superfamily member 11

Gene

Igsf11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 11
Short name:
IgSF11
Gene namesi
Name:Igsf11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1308758 Igsf11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 239ExtracellularSequence analysisAdd BLAST217
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 428CytoplasmicSequence analysisAdd BLAST168

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031737223 – 428Immunoglobulin superfamily member 11Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 120PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 215PROSITE-ProRule annotation
Modified residuei375Omega-N-methylarginineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PaxDbiQ5U2P2

PTM databases

iPTMnetiQ5U2P2
PhosphoSitePlusiQ5U2P2

Expressioni

Gene expression databases

BgeeiENSRNOG00000001525
GenevisibleiQ5U2P2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059779

Structurei

3D structure databases

ProteinModelPortaliQ5U2P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 136Ig-like V-typeAdd BLAST114
Domaini144 – 234Ig-like C2-typeAdd BLAST91

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJM9 Eukaryota
ENOG410Y8CN LUCA
GeneTreeiENSGT00760000119145
HOGENOMiHOG000111222
HOVERGENiHBG107996
InParanoidiQ5U2P2
KOiK06791
OMAiQHTHSYT
OrthoDBiEOG091G05PI
PhylomeDBiQ5U2P2
TreeFamiTF330875

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U2P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRRSALAS WLLLSLLGVA ASLEVSESPG SVQVARGQTA VLPCAFSTSA
60 70 80 90 100
ALLNLNVIWM VIPLSNANQP EQVILYQGGQ MFDGALRFHG RVGFTGTMPA
110 120 130 140 150
TNVSIFINNT QLSDTGTYQC LVNNLPDRGG RNIGVTGLTV LVPPSAPNCQ
160 170 180 190 200
IQGSQDIGSD VILLCSSEEG IPRPTYLWEK LDNTLKLPPT ATQDQVQGTV
210 220 230 240 250
TIRNISALSS GLYQCVASNA IGTSTCLLDL QVISPQPRSV GVIAGAVGTG
260 270 280 290 300
AVLIVICLAL TSGAFFYWRS KNKEEEEEEI PNEIREDDLP PKCSSAKAFH
310 320 330 340 350
TEISSSENNT LTSSNTYNSR YWNNNPKPHK NTESFNHFSD LRQSFSGNAV
360 370 380 390 400
IPSIYANGNH LVLGPHKTLV VTANRGSSPQ VMPRNNGSVS RKPWSQHTHS
410 420
YTVSQMTLER IGAVPVMVPA QSRAGSLV
Length:428
Mass (Da):46,021
Last modified:December 7, 2004 - v1
Checksum:iC628CEE36D03A1F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085929 mRNA Translation: AAH85929.1
RefSeqiNP_001013138.1, NM_001013120.1
UniGeneiRn.154553

Genome annotation databases

EnsembliENSRNOT00000066997; ENSRNOP00000059779; ENSRNOG00000001525
GeneIDi303926
KEGGirno:303926
UCSCiRGD:1308758 rat

Similar proteinsi

Entry informationi

Entry nameiIGS11_RAT
AccessioniPrimary (citable) accession number: Q5U2P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 7, 2004
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health