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Protein

Metal transporter CNNM2

Gene

Cnnm2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg2+ > Co2+ > Mn2+ > Sr2+ > Ba2+ > Cu2+ > Fe2+.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Metal transporter CNNM2
Alternative name(s):
Ancient conserved domain-containing protein 2
Cyclin-M2
Gene namesi
Name:Cnnm2
Synonyms:Acdp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308162. Cnnm2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 250250ExtracellularSequence analysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence analysisAdd
BLAST
Topological domaini272 – 31342CytoplasmicSequence analysisAdd
BLAST
Intramembranei314 – 33421HelicalSequence analysisAdd
BLAST
Topological domaini335 – 3384CytoplasmicSequence analysis
Transmembranei339 – 35921HelicalSequence analysisAdd
BLAST
Topological domaini360 – 3689ExtracellularSequence analysis
Transmembranei369 – 38921HelicalSequence analysisAdd
BLAST
Topological domaini390 – 875486CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Metal transporter CNNM2PRO_0000295762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Modified residuei761 – 7611PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5U2P1.

PTM databases

iPTMnetiQ5U2P1.
PhosphoSiteiQ5U2P1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020113.
GenevisibleiQ5U2P1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051583.

Structurei

3D structure databases

ProteinModelPortaliQ5U2P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini258 – 430173DUF21Add
BLAST
Domaini450 – 51162CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini518 – 58467CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ACDP family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation
Contains 1 DUF21 domain.Curated

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2118. Eukaryota.
COG1253. LUCA.
GeneTreeiENSGT00390000002383.
HOGENOMiHOG000231947.
HOVERGENiHBG074775.
InParanoidiQ5U2P1.
KOiK16302.
OMAiVMASRMD.
OrthoDBiEOG091G02YS.
PhylomeDBiQ5U2P1.
TreeFamiTF101012.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR000644. CBS_dom.
IPR002550. DUF21.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF01595. DUF21. 1 hit.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U2P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGCGACEPE VKMAGGQAAA ALPTWKMAAR RSLSARGRGV LQAAAGRLLP
60 70 80 90 100
LLLLSCCCSA GGCTAAGENE ETVIIGLRLE DTNDVSFMEG GALRVSERTR
110 120 130 140 150
VKLRVYGQNI NNETWSRIAF TEHERRRHTP GERGLGGPAP PEPDSGPQRC
160 170 180 190 200
GIRTSDIIIL PHIILNRRTS GIIEIEIKPL RKMEKSKSYY LCTSLSTPAL
210 220 230 240 250
GAGGSGSASG TVGGKGGAGV AGLPPPPWAE TTWIYHDGED TKMIVGEEKK
260 270 280 290 300
FLLPFWLQVI FISLLLCLSG MFSGLNLGLM ALDPMELRIV QNCGTEKEKN
310 320 330 340 350
YAKRIEPVRR QGNYLLCSLL LGNVLVNTTL TILLDDIAGS GLVAVVVSTI
360 370 380 390 400
GIVIFGEIVP QAICSRHGLA VGANTIFLTK FFMMMTFPAS YPVSKLLDCV
410 420 430 440 450
LGQEIGTVYN REKLLEMLRV TDPYNDLVKE ELNIIQGALE LRTKTVEDVM
460 470 480 490 500
TPLRDCFMIT GEAILDFNTM SEIMESGYTR IPVFEGERSN IVDLLFVKDL
510 520 530 540 550
AFVDPDDCTP LKTITKFYNH PLHFVFNDTK LDAMLEEFKK GKSHLAIVQR
560 570 580 590 600
VNNEGEGDPF YEVLGIVTLE DVIEEIIKSE ILDETDLYTD NRTKKKVAHR
610 620 630 640 650
ERKQDFSAFK QTDSETKVKI SPQLLLAMHR FLATEVEAFS PSQMSEKILL
660 670 680 690 700
RLLKHPNVIQ ELKYDEKNKK APECYLYQRN KPVDYFVLIL QGKVEVEAGK
710 720 730 740 750
EGMKFEASAF SYYGVMALTA SPVPLSLSRT FVVSRTEVLA AGSPGENKSP
760 770 780 790 800
PRPCGLNHSD SLSRSDRIDA MTPTLGSSNN QLSSSFLQVY IPDYSVRALS
810 820 830 840 850
DLQFVKISRQ QYQNALMASR MDKTPQSSDS ENTKIELTLT EMHDGLPDET
860 870
ANLLNEQNCV SHNKANHSLH SEGAI
Length:875
Mass (Da):96,609
Last modified:December 7, 2004 - v1
Checksum:i67F24F5315D6BD11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085930 mRNA. Translation: AAH85930.1.
RefSeqiNP_001011942.1. NM_001011942.1.
UniGeneiRn.205139.

Genome annotation databases

EnsembliENSRNOT00000054699; ENSRNOP00000051583; ENSRNOG00000020113.
GeneIDi294014.
KEGGirno:294014.
UCSCiRGD:1308162. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085930 mRNA. Translation: AAH85930.1.
RefSeqiNP_001011942.1. NM_001011942.1.
UniGeneiRn.205139.

3D structure databases

ProteinModelPortaliQ5U2P1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051583.

PTM databases

iPTMnetiQ5U2P1.
PhosphoSiteiQ5U2P1.

Proteomic databases

PaxDbiQ5U2P1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054699; ENSRNOP00000051583; ENSRNOG00000020113.
GeneIDi294014.
KEGGirno:294014.
UCSCiRGD:1308162. rat.

Organism-specific databases

CTDi54805.
RGDi1308162. Cnnm2.

Phylogenomic databases

eggNOGiKOG2118. Eukaryota.
COG1253. LUCA.
GeneTreeiENSGT00390000002383.
HOGENOMiHOG000231947.
HOVERGENiHBG074775.
InParanoidiQ5U2P1.
KOiK16302.
OMAiVMASRMD.
OrthoDBiEOG091G02YS.
PhylomeDBiQ5U2P1.
TreeFamiTF101012.

Miscellaneous databases

PROiQ5U2P1.

Gene expression databases

BgeeiENSRNOG00000020113.
GenevisibleiQ5U2P1. RN.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR000644. CBS_dom.
IPR002550. DUF21.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF01595. DUF21. 1 hit.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNNM2_RAT
AccessioniPrimary (citable) accession number: Q5U2P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.